CD95 (APO-1/Fas) Monoclonal Antibody (DX2), eBioscience | Invitrogen 14-0959-37 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD95 (APO-1/Fas) Monoclonal Antibody (DX2), eBioscience

catalog :

14-0959-37

quantity :

2 mg

price :

US 1482.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DX2

The same clone is also sold as:

BioLegend: 305649, 305667, 305618, 305615, 305669, 305664, 305661, 305676, 305655, 305668, 305616, 305651, 305665, 305671, 305631, 305670, 305645, 305622, 305659, 305635, 305643, 305607, 305611, 305673, 305674, 305627, 305623, 305640, 305624, 305663, 305648, 305641, 305636, 305658, 305637, 305612, 987102, 305628, 305619, 260384, 305610, 305642, 305629, 305644, 305656, 305653, 305638, 305657, 305662, 305647, 305604, 305606, 305666, 305675, 305639, 305672, 305605, 305633, 305634, 305630, 305608, 305602, 305621, 305646
R&D Systems: MAB142
OriGene: AM08165LE-N, AM08165AC-N, AM08165PU-N, AM08165BT-N, AM08165RP-N, AM08165FC-N
BD Biosciences: 556640, 561635, 555674, 556641, 555671, 340479, 340480, 555673, 561976, 555672, 562395, 561975, 561633, 555670, 340481, 558814, 559773, 561636, 561977, 561978, 561632

reactivity :

human, dogs

application :

immunohistochemistry, flow cytometry

citations: 13

Reference
Li X, Zhang B, Wang H, Zhao X, Zhang Z, Ding G, et al. Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells. J Int Med Res. 2020;48:300060520930853 pubmed publisher
Gulbranson D, Crisman L, Lee M, Ouyang Y, Menasche B, Demmitt B, et al. AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis. Dev Cell. 2019;50:436-446.e5 pubmed publisher
Zhang M, Wang J, Jia L, Huang J, He C, Hu F, et al. Transmembrane TNF-? promotes activation-induced cell death by forward and reverse signaling. Oncotarget. 2017;8:63799-63812 pubmed publisher
Kong F, Feng B, Zhang H, Rao H, Wang J, Cong X, et al. Abnormal phenotypic features of IgM+B cell subsets in patients with chronic hepatitis C virus infection. Exp Ther Med. 2017;14:1846-1852 pubmed publisher
Mou H, Moore J, Malonia S, Li Y, Ozata D, Hough S, et al. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2017;114:3648-3653 pubmed publisher
Sun J, Shen Q, Lu H, Jiang Z, Xu W, Feng L, et al. Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance. Oncotarget. 2015;6:41997-2007 pubmed publisher
Connick E, Folkvord J, Lind K, Rakasz E, Miles B, Wilson N, et al. Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL. J Immunol. 2014;193:5613-25 pubmed publisher
Shi L, Wang H, Wang F, Feng M, Wang M, Guan W. Effects of gastrokineâ€‘2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways. Mol Med Rep. 2014;10:2898-904 pubmed publisher
Khalid M, Yu H, Sauter D, Usmani S, Schmökel J, Feldman J, et al. Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. J Virol. 2012;86:4906-20 pubmed publisher
Kean L, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, et al. Significant mobilization of both conventional and regulatory T cells with AMD3100. Blood. 2011;118:6580-90 pubmed publisher
Dompe N, Rivers C, Li L, Cordes S, Schwickart M, Punnoose E, et al. A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2011;108:E943-51 pubmed publisher
Orbach A, Rachmilewitz J, Shani N, Isenberg Y, Parnas M, Huang J, et al. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. Am J Pathol. 2010;177:3159-68 pubmed publisher
Larsen C, Page A, Linzie K, Russell M, Deane T, Stempora L, et al. An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching. Am J Transplant. 2010;10:2396-409 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD95 (APO-1/Fas) Monoclonal Antibody (DX2), eBioscience

Catalog # :

14-0959-37

Quantity :

2 mg

Price :

US 1482.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Canine, Human

Applications :

Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Species :

Canine, Human

Clone :

DX2

Isotype :

IgG1, kappa

Storage :

4 C

Description :

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Aliases :

AI196731; ALPS1A; APO1; APO-1; Apo1 antigen; Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; FAS; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas cell surface death receptor; Fas receptor; FAS1; FASLG receptor; FASTM; lpr; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; TNFR6; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 26; Tumor necrosis factor receptor superfamily, member 6