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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD86 (B7-2) Monoclonal Antibody (GL1), eBioscience™
catalog :
14-0862-81
quantity :
50µg
price :
US 62
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
GL1
reactivity :
mouse
application :
immunohistochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 96
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2d
Ano Y, Ohya R, Takaichi Y, Washinuma T, Uchida K, Takashima A, et al. β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline. J Alzheimers Dis. 2020;73:1331-1342 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b, 1e
Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki I, et al. PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation. Front Immunol. 2019;10:630 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Lee Y, Ju J, Shon W, Oh S, Min C, Kang M, et al. Skewed Dendritic Cell Differentiation of MyD88-Deficient Donor Bone Marrow Cells, Instead of Massive Expansion as Myeloid-Derived Suppressor Cells, Aggravates GVHD. Immune Netw. 2018;18:e44 pubmed publisher
  • flow cytometry; mouse; loading ...; fig e5c
Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2a
Singla B, Ghoshal P, Lin H, Wei Q, Dong Z, Csanyi G. PKCδ-Mediated Nox2 Activation Promotes Fluid-Phase Pinocytosis of Antigens by Immature Dendritic Cells. Front Immunol. 2018;9:537 pubmed publisher
  • flow cytometry; mouse; fig 2d
Wasiuk A, Testa J, Weidlick J, Sisson C, Vitale L, Widger J, et al. CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy. J Immunol. 2017;199:4110-4123 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Shrestha B, You D, Saravia J, Siefker D, Jaligama S, Lee G, et al. IL-4R? on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. J Leukoc Biol. 2017;102:153-161 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Kitada S, Kayama H, Okuzaki D, Koga R, Kobayashi M, Arima Y, et al. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J Exp Med. 2017;214:1313-1331 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3a
Hellström Erkenstam N, Smith P, Fleiss B, Nair S, Svedin P, Wang W, et al. Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury. Front Cell Neurosci. 2016;10:286 pubmed publisher
  • flow cytometry; mouse; fig 2
Levit Zerdoun E, Becker M, Pohlmeyer R, Wilhelm I, Maity P, Rajewsky K, et al. Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function. J Immunol. 2016;196:2348-60 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 2
Schachtner H, Weimershaus M, Stache V, Plewa N, Legler D, Höpken U, et al. Loss of Gadkin Affects Dendritic Cell Migration In Vitro. PLoS ONE. 2015;10:e0143883 pubmed publisher
  • flow cytometry; mouse; fig s3
Carmi Y, Spitzer M, Linde I, Burt B, Prestwood T, Perlman N, et al. Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature. 2015;521:99-104 pubmed publisher
  • flow cytometry; mouse; fig 2
Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
  • flow cytometry; mouse; tbl s3
Pannu J, Belle J, Forster M, Duerr C, Shen S, Kane L, et al. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. PLoS ONE. 2015;10:e0117304 pubmed publisher
  • flow cytometry; mouse; fig 3
Sun H, Zhang J, Chen F, Chen X, Zhou Z, Wang H. Activation of RAW264.7 macrophages by the polysaccharide from the roots of Actinidia eriantha and its molecular mechanisms. Carbohydr Polym. 2015;121:388-402 pubmed publisher
  • flow cytometry; mouse
Cousens L, Najafian N, Martin W, De Groot A. Tregitope: Immunomodulation powerhouse. Hum Immunol. 2014;75:1139-46 pubmed publisher
  • flow cytometry; mouse; fig 2
McDonnell A, Lesterhuis W, Khong A, Nowak A, Lake R, Currie A, et al. Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy. Eur J Immunol. 2015;45:49-59 pubmed publisher
  • flow cytometry; mouse
Chen M, Chen Y, Wu M, Yu G, Lin W, Tan T, et al. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS ONE. 2014;9:e107505 pubmed publisher
  • flow cytometry; mouse; fig 3
Alsadeq A, Hobeika E, Medgyesi D, Kläsener K, Reth M. The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling. J Immunol. 2014;193:268-76 pubmed publisher
  • flow cytometry; mouse
Dupont C, Christian D, Selleck E, Pepper M, Leney Greene M, Harms Pritchard G, et al. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. PLoS Pathog. 2014;10:e1004047 pubmed publisher
  • flow cytometry; mouse; fig 3
Harimoto H, Shimizu M, Nakagawa Y, Nakatsuka K, Wakabayashi A, Sakamoto C, et al. Inactivation of tumor-specific CD8? CTLs by tumor-infiltrating tolerogenic dendritic cells. Immunol Cell Biol. 2013;91:545-55 pubmed publisher
  • flow cytometry; mouse; fig 6
Sadri N, Lu J, Badura M, Schneider R. AUF1 is involved in splenic follicular B cell maintenance. BMC Immunol. 2010;11:1 pubmed publisher
  • flow cytometry; mouse; fig 4
Ellestad K, Tsutsui S, Noorbakhsh F, Warren K, Yong V, Pittman Q, et al. Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells. J Immunol. 2009;183:298-309 pubmed publisher
  • flow cytometry; mouse
Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott H, Matsumoto M, et al. Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol. 2007;8:304-11 pubmed
Fujii S, Yoshida S, Inagaki E, Hatou S, Tsubota K, Takahashi M, et al. Immunological properties of neural crest cells derived from human induced pluripotent stem cells. Stem Cells Dev. 2018;: pubmed publisher
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
Guo M, Xiao J, Sheng X, Zhang X, Tie Y, Wang L, et al. Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype. Front Pharmacol. 2018;9:464 pubmed publisher
Lee S, Shi X, Fan A, West B, Zhang J. Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain. Mol Pain. 2018;14:1744806918764979 pubmed publisher
Pan Y, Yu Y, Lin C, Lanier L, Chu C. Fc?RI ?-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells. Front Immunol. 2017;8:1424 pubmed publisher
Wang J, Gao Z, Qin S, Liu C, Zou L. Calreticulin is an effective immunologic adjuvant to tumor-associated antigens. Exp Ther Med. 2017;14:3399-3406 pubmed publisher
Wang J, Dai X, Hsu C, Ming C, He Y, Zhang J, et al. Discrimination of the heterogeneity of bone marrow‑derived dendritic cells. Mol Med Rep. 2017;16:6787-6793 pubmed publisher
Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, et al. C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci U S A. 2017;114:E540-E549 pubmed publisher
Zhou Z, Tang Y, Jin X, Chen C, Lu Y, Liu L, et al. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NF?B Pathway Suppression. J Diabetes Res. 2016;2016:4847812 pubmed
Kang J, Lee J, Chang J. Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells. PLoS ONE. 2016;11:e0157015 pubmed publisher
Li J, DU Y, Yan Z, Yan J, Zhuansun Y, Chen R, et al. CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice. Exp Ther Med. 2016;11:878-884 pubmed
Xu X, Gao Y, Zhai Z, Zhang S, Shan F, Feng J. Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS. Hum Vaccin Immunother. 2016;12:2169-2180 pubmed
Rota G, Ludigs K, Siegert S, Tardivel A, Morgado L, Reith W, et al. T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels. J Immunol. 2016;196:2939-46 pubmed publisher
Lund L, Ingmer H, Frøkiær H. D-Alanylation of Teichoic Acids and Loss of Poly-N-Acetyl Glucosamine in Staphylococcus aureus during Exponential Growth Phase Enhance IL-12 Production in Murine Dendritic Cells. PLoS ONE. 2016;11:e0149092 pubmed publisher
Yue Y, Huang W, Liang J, Guo J, Ji J, Yao Y, et al. IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production. PLoS ONE. 2015;10:e0142979 pubmed publisher
Lobo P, Schlegel K, Bajwa A, Huang L, Kurmaeva E, Wang B, et al. Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation. J Immunol. 2015;195:5215-26 pubmed publisher
Moniaga C, Watanabe S, Honda T, Nielsen S, Hara Chikuma M. Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity. Sci Rep. 2015;5:15319 pubmed publisher
Wilson K, Goding S, Neely H, Harris K, Antony P. Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells. Oncoimmunology. 2015;4:e1019196 pubmed
Roberts R, Eitas T, Byrne J, Johnson B, Short P, McKinnon K, et al. Towards programming immune tolerance through geometric manipulation of phosphatidylserine. Biomaterials. 2015;72:1-10 pubmed publisher
Bencherif S, Warren Sands R, Ali O, Li W, Lewin S, Braschler T, et al. Injectable cryogel-based whole-cell cancer vaccines. Nat Commun. 2015;6:7556 pubmed publisher
Chastain E, Getts D, Miller S. Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity. MBio. 2015;6:e01175 pubmed publisher
Wahid H, Dorian C, Chin P, Hutchinson M, Rice K, Olson D, et al. Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice. Endocrinology. 2015;156:3828-41 pubmed publisher
Huang L, Kong Y, Wang J, Sun J, Shi Q, Qiu Y. Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway. Mol Med Rep. 2015;12:4187-4195 pubmed publisher
Aikawa T, Mogushi K, Iijima Tsutsui K, Ishikawa K, Sakurai M, Tanaka H, et al. Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model. Hum Mol Genet. 2015;24:4780-91 pubmed publisher
Flynn R, Allen J, Luznik L, MacDonald K, Paz K, Alexander K, et al. Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. Blood. 2015;125:4085-94 pubmed publisher
Dalton J, Glover A, Hoodless L, Lim E, Beattie L, Kirby A, et al. The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection. PLoS Pathog. 2015;11:e1004681 pubmed publisher
Hong Y, Manoharan I, Suryawanshi A, Majumdar T, Angus Hill M, Koni P, et al. β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells. Cancer Res. 2015;75:656-665 pubmed publisher
Kim J, Li W, Choi Y, Lewin S, Verbeke C, Dranoff G, et al. Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy. Nat Biotechnol. 2015;33:64-72 pubmed publisher
Qin Q, Wang Z, Pan P, Cao Z, Xia Q, Tan H, et al. Lung dendritic cells undergo maturation and polarization towards a T helper type 2-stimulating phenotype in a mouse model of asthma: Role of nerve growth factor. Exp Ther Med. 2014;8:1402-1408 pubmed
von Buttlar H, Siegemund S, Büttner M, Alber G. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells. PLoS ONE. 2014;9:e106188 pubmed publisher
Dai M, Yip Y, Hellstrom I, Hellstrom K. Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies. Clin Cancer Res. 2015;21:1127-38 pubmed publisher
Lee Chang C, Bodogai M, Moritoh K, Olkhanud P, Chan A, Croft M, et al. Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood. 2014;124:1450-9 pubmed publisher
Hu J, Oda S, Shotts K, Donovan E, Strauch P, Pujanauski L, et al. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014;193:85-95 pubmed publisher
Yoo J, MANICONE A, McGuire J, Wang Y, Parks W. Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis. J Inflamm Res. 2014;7:29-38 pubmed publisher
Attridge K, Kenefeck R, Wardzinski L, Qureshi O, Wang C, Manzotti C, et al. IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells. J Immunol. 2014;192:2195-201 pubmed publisher
Yang M, Rainone A, Shi X, Fournier S, Zhang J. A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome. Acta Neuropathol Commun. 2014;2:5 pubmed publisher
Bakhru P, Sirisaengtaksin N, Soudani E, Mukherjee S, Khan A, Jagannath C. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol. 2014;287:53-61 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Maseda D, Candando K, Smith S, Kalampokis I, Weaver C, Plevy S, et al. Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-?+CD4+ T cell numbers during colitis development in mice. J Immunol. 2013;191:2780-2795 pubmed publisher
Thomas D, Wong F, Zaccone P, Green E, Wallberg M. Protection of islet grafts through transforming growth factor-?-induced tolerogenic dendritic cells. Diabetes. 2013;62:3132-42 pubmed publisher
Kannan V, Brouwer N, Hanisch U, Regen T, Eggen B, Boddeke H. Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. J Neurosci Res. 2013;91:1133-42 pubmed publisher
Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, et al. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood. 2013;121:4595-602 pubmed publisher
Pang I, Ichinohe T, Iwasaki A. IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus. Nat Immunol. 2013;14:246-53 pubmed publisher
Chen Z, Zhang T, Li H, Chen F, Zou X, Ji J, et al. Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS ONE. 2013;8:e51268 pubmed publisher
Wanderley J, Thorpe P, Barcinski M, Soong L. Phosphatidylserine exposure on the surface of Leishmania amazonensis amastigotes modulates in vivo infection and dendritic cell function. Parasite Immunol. 2013;35:109-119 pubmed publisher
Zhang W, Wang X, Xia X, Liu X, Suo S, Guo J, et al. Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages. Eur J Immunol. 2013;43:258-69 pubmed publisher
Tewalt E, Cohen J, Rouhani S, Guidi C, Qiao H, Fahl S, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012;120:4772-82 pubmed publisher
Parsa R, Andresen P, Gillett A, Mia S, Zhang X, Mayans S, et al. Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice. Diabetes. 2012;61:2881-92 pubmed publisher
Ribot J, deBarros A, Mancio Silva L, Pamplona A, Silva Santos B. B7-CD28 costimulatory signals control the survival and proliferation of murine and human ?? T cells via IL-2 production. J Immunol. 2012;189:1202-8 pubmed publisher
Kamphuis T, Meijerhof T, Stegmann T, Lederhofer J, Wilschut J, de Haan A. Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice. PLoS ONE. 2012;7:e36812 pubmed publisher
Nouri Shirazi M, Guinet E. Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination. J Immunol. 2012;188:2359-70 pubmed publisher
Horikawa M, Minard Colin V, Matsushita T, Tedder T. Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. J Clin Invest. 2011;121:4268-80 pubmed publisher
Hoves S, Sutton V, Haynes N, Hawkins E, Fernández Ruiz D, Baschuk N, et al. A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. J Immunol. 2011;187:1166-75 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD86 (B7-2) Monoclonal Antibody (GL1), eBioscience™
Catalog # :
14-0862-81
Quantity :
50µg
Price :
US 62
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Neutralization: Assay-Dependent
Species :
Mouse
Clone :
GL1
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
Activation B7-2 antigen; B7; B7.2; B70; B7-2; B-lymphocyte activation antigen B7-2; BOS_829; BU63; Cd28l2; CD28LG2; Cd86; CD86 antigen; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2; early T cell costimulatory molecule-1; Early T-cell costimulatory molecule 1; ETC-1; FUN-1; LAB72; Ly58; Ly-58; MB7; MB7-2; membrane glycoprotein; MGC34413; T-lymphocyte activation antigen CD86; TS/A-2
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA