CD70 Monoclonal Antibody (FR70), eBioscience™ | Invitrogen 14-0701-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD70 Monoclonal Antibody (FR70), eBioscience™

catalog :

14-0701-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

FR70

reactivity :

mouse

application :

neutralization, immunoprecipitation, flow cytometry

citations: 4

Reference
Kuka M, Munitic I, Giardino Torchia M, Ashwell J. CD70 is downregulated by interaction with CD27. J Immunol. 2013;191:2282-9 pubmed publisher
Bak S, Barnkob M, Bai A, Higham E, Wittrup K, Chen J. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol. 2012;189:1708-16 pubmed publisher
Ballesteros Tato A, León B, Lund F, Randall T. Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. Nat Immunol. 2010;11:216-24 pubmed publisher
Beishuizen C, Kragten N, Boon L, Nolte M, van Lier R, van Gisbergen K. Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions. J Immunol. 2009;183:6442-51 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD70 Monoclonal Antibody (FR70), eBioscience™

Catalog # :

14-0701-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

FR70

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

CD27 ligand; Cd27l; CD27-L; CD27LG; CD70; CD70 antigen; Cd70 molecule; Ki-24 antigen; surface antigen CD70; Tnfsf7; TNLG8A; tumor necrosis factor (ligand) superfamily, member 7; tumor necrosis factor ligand 8A; tumor necrosis factor ligand superfamily member 7