product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD68 Monoclonal Antibody (KP1), eBioscience
catalog :
14-0688-80
quantity :
25 µg
price :
US 104.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
KP1
reactivity :
human, mouse, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, mass cytometry
more info or order :
citations: 43
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:100; fig 1
Azzimonti B, Raimondo L, Squarzanti D, Rosso T, Zanetta P, Aluffi Valletti P, et al. Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma. Ann Med. 2021;53:541-550 pubmed publisher
  • immunohistochemistry; pigs ; 1:100; loading ...; fig 6h
Fang B, Ren X, Wang Y, Li Z, Zhao L, Zhang M, et al. Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs. Dis Model Mech. 2018;11: pubmed publisher
  • immunohistochemistry - paraffin section; human; tbl s7
Chevrier S, Levine J, Zanotelli V, Silina K, Schulz D, Bacac M, et al. An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell. 2017;169:736-749.e18 pubmed publisher
  • mass cytometry; human; loading ...; fig 1j
See P, Dutertre C, Chen J, Günther P, McGovern N, Irac S, et al. Mapping the human DC lineage through the integration of high-dimensional techniques. Science. 2017;356: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig s2b
de Jong R, Paulin N, Lemnitzer P, Viola J, Winter C, Ferraro B, et al. Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:312-315 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 1
Chuang T, Guo Y, Seki S, Rosen A, Johanson D, Mandell J, et al. LRP1 expression in microglia is protective during CNS autoimmunity. Acta Neuropathol Commun. 2016;4:68 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; fig 1
Liu K, Yang K, Wu B, Chen H, Chen X, Chen X, et al. Tumor-Infiltrating Immune Cells Are Associated With Prognosis of Gastric Cancer. Medicine (Baltimore). 2015;94:e1631 pubmed publisher
  • immunohistochemistry - paraffin section; human
Prata T, Bonin C, Ferreira A, Padovani C, Fernandes C, Machado A, et al. Local immunosuppression induced by high viral load of human papillomavirus: characterization of cellular phenotypes producing interleukin-10 in cervical neoplastic lesions. Immunology. 2015;146:113-21 pubmed publisher
Mou J, Zheng W, Wei D, Li D, Fan R, Tang Q. CD200-CD200R affects cisplatin and paclitaxel sensitivity by regulating cathepsin K-mediated p65 NF-κB signaling in cervical cancer. Heliyon. 2023;9:e19220 pubmed publisher
Chini A, Guha P, Malladi V, Guo Z, Mandal S. Novel long non-coding RNAs associated with inflammation and macrophage activation in human. Sci Rep. 2023;13:4036 pubmed publisher
Radovic S, Meng W, Chen L, Paniz Mondolfi A, Bryce C, Grimes Z, et al. SARS-CoV-2 infection of kidney tissues from severe COVID-19 patients. J Med Virol. 2023;95:e28566 pubmed publisher
DeMarino C, Lee M, Cowen M, Steiner J, Inati S, Shah A, et al. Detection of SARS-CoV-2 Nucleocapsid and Microvascular Disease in the Brain: A Case Report. Neurology. 2023;100:624-628 pubmed publisher
Liu D, Xu W, Tang Y, Cao J, Chen R, Wu D, et al. Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling. Respir Res. 2022;23:380 pubmed publisher
Wang Y, Guo B, Guo Y, Qi N, Lv Y, Ye Y, et al. A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads. Front Endocrinol (Lausanne). 2022;13:1036517 pubmed publisher
Meng W, Guo S, Cao S, Shuda M, Robinson McCarthy L, McCarthy K, et al. Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp). J Med Virol. 2022;: pubmed publisher
Zhang H, Zhang N, Wu W, Wang Z, Dai Z, Liang X, et al. Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma. iScience. 2022;25:104918 pubmed publisher
Wang Y, Huang Y, Cai W, Tao Q. Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature. Exp Ther Med. 2022;24:593 pubmed publisher
Fernandez Castaneda A, Lu P, Geraghty A, Song E, Lee M, WOOD J, et al. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022;185:2452-2468.e16 pubmed publisher
Dakkak Y, van Dijk B, Jansen F, Wisse L, Reijnierse M, van der Helm van Mil A, et al. Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study. Arthritis Res Ther. 2022;24:154 pubmed publisher
Strand K, Stiglund N, Haugst xf8 yl M, Kamyab Z, Langhelle V, Lawrence Archer L, et al. Subtype-Specific Surface Proteins on Adipose Tissue Macrophages and Their Association to Obesity-Induced Insulin Resistance. Front Endocrinol (Lausanne). 2022;13:856530 pubmed publisher
Ganan Gomez I, Yang H, Ma F, Montalban Bravo G, Thongon N, Marchica V, et al. Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy. Nat Med. 2022;28:557-567 pubmed publisher
Hirani D, Alvira C, Danopoulos S, Milla C, Donato M, Tian L, et al. Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia. Eur Respir J. 2022;59: pubmed publisher
Rajagopalan A, Venkatesh I, Aslam R, Kirchenbuechler D, Khanna S, Cimbaluk D, et al. SeqStain is an efficient method for multiplexed, spatialomic profiling of human and murine tissues. Cell Rep Methods. 2021;1: pubmed publisher
Parekh P, Solano Gonzàlez E, Martins M, Ma X, Tighe K, Casildo A, et al. DUOX2, a New Biomarker for Disseminated Gastric Cancer's Response to Low Dose Radiation in Mice. Cancers (Basel). 2021;13: pubmed publisher
Chevrier S, Zurbuchen Y, Cervia C, Adamo S, Raeber M, de Souza N, et al. A distinct innate immune signature marks progression from mild to severe COVID-19. Cell Rep Med. 2021;2:100166 pubmed publisher
Fudaba H, Momii Y, Hirakawa T, Onishi K, Asou D, Matsushita W, et al. Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients. Sci Rep. 2021;11:1206 pubmed publisher
M xe9 n xe9 gaut L, Jalil A, Pilot T, Van Dongen K, Crespy V, Steinmetz E, et al. Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors. Br J Pharmacol. 2021;178:3124-3139 pubmed publisher
Shin C, Byun J, Lee K, Kim B, Noh Y, Tran N, et al. Exosomal miRNA-19a and miRNA-614 Induced by Air Pollutants Promote Proinflammatory M1 Macrophage Polarization via Regulation of RORα Expression in Human Respiratory Mucosal Microenvironment. J Immunol. 2020;205:3179-3190 pubmed publisher
Bogie J, Grajchen E, Wouters E, Broux B, Stinissen P, Van Wijmeersch B, et al. CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis. Ther Adv Chronic Dis. 2020;11:2040622320947378 pubmed publisher
Duan F, Guo L, Yang L, Han Y, Thakur A, Nilsson Payant B, et al. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2. Res Sq. 2020;: pubmed publisher
Grajchen E, Wouters E, van de Haterd B, Haidar M, Hardonnière K, Dierckx T, et al. CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation. J Neuroinflammation. 2020;17:224 pubmed publisher
Ménégaut L, Thomas C, Jalil A, Julla J, Magnani C, Ceroi A, et al. Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages. Cell Rep. 2020;31:107665 pubmed publisher
Devalaraja S, To T, Folkert I, Natesan R, Alam M, Li M, et al. Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression. Cell. 2020;180:1098-1114.e16 pubmed publisher
Bogie J, Grajchen E, Wouters E, Corrales A, Dierckx T, Vanherle S, et al. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. J Exp Med. 2020;217: pubmed publisher
Bowman A, Bogie J, Hendriks J, Haidar M, Belov M, Heeren R, et al. Evaluation of lipid coverage and high spatial resolution MALDI-imaging capabilities of oversampling combined with laser post-ionisation. Anal Bioanal Chem. 2020;412:2277-2289 pubmed publisher
Kursawe R, Dixit V, Scherer P, Santoro N, Narayan D, Gordillo R, et al. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes. 2016;65:610-8 pubmed publisher
Ok Atılgan A, Özdemir B, Akçay E, Ataol Demirkan Ã, Tekindal M, ÖzkardeÅŸ H. Role of tumor-associated macrophages in the Hexim1 and TGFβ/SMAD pathway, and their influence on progression of prostatic adenocarcinoma. Pathol Res Pract. 2016;212:83-92 pubmed publisher
Song K, Herzog B, Sheng M, Fu J, McDaniel J, Chen H, et al. Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma. Cancer Res. 2013;73:7254-64 pubmed publisher
Bentley J, Sajjan U, Dzaman M, Jarjour N, Lee W, Gern J, et al. Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans. J Allergy Clin Immunol. 2013;132:758-761.e3 pubmed publisher
Eventov Friedman S, Tchorsh D, Katchman H, Shezen E, Aronovich A, Hecht G, et al. Embryonic pig pancreatic tissue transplantation for the treatment of diabetes. PLoS Med. 2006;3:e215 pubmed
Kunisch E, Fuhrmann R, Roth A, Winter R, Lungershausen W, Kinne R. Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. Ann Rheum Dis. 2004;63:774-84 pubmed
Pulford K, Rigney E, Micklem K, Jones M, Stross W, Gatter K, et al. KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol. 1989;42:414-21 pubmed
Horny H, Schaumburg Lever G, Bolz S, Geerts M, Kaiserling E. Use of monoclonal antibody KP1 for identifying normal and neoplastic human mast cells. J Clin Pathol. 1990;43:719-22 pubmed
product information
Product Type :
Antibody
Product Name :
CD68 Monoclonal Antibody (KP1), eBioscience
Catalog # :
14-0688-80
Quantity :
25 µg
Price :
US 104.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 µg/ml, Immunohistochemistry (Frozen): 1 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Human
Clone :
KP1
Isotype :
IgG1, kappa
Storage :
4° C
Description :
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 µg/ml, Immunohistochemistry (Frozen): 1 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA