product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD68 Monoclonal Antibody (FA-11), eBioscience
catalog :
14-0681-82
quantity :
100 ug
price :
US 262.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
FA-11
reactivity :
human, mouse, rat
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:100; loading ...; fig 4b
Klemke L, De Oliveira T, Witt D, Winkler N, Bohnenberger H, Bucala R, et al. Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer. Cell Death Dis. 2021;12:155 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 2a
da Silva S, Marchi F, Su J, Yang L, Valverde L, Hier J, et al. Co-Overexpression of TWIST1-CSF1 Is a Common Event in Metastatic Oral Cancer and Drives Biologically Aggressive Phenotype. Cancers (Basel). 2021;13: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 5a
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol. 2020;140:513-534 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4s1
Madel M, Ibáñez L, Ciucci T, Halper J, Rouleau M, Boutin A, et al. Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1. elife. 2020;9: pubmed publisher
  • immunohistochemistry; rat; 1:500
Sun J, Wang Z, Wang X. Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice. Organogenesis. 2018;14:13-24 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2d
Dunst J, Azzouz N, Liu X, Tsukita S, Seeberger P, Kamena F. Interaction between Plasmodium Glycosylphosphatidylinositol and the Host Protein Moesin Has No Implication in Malaria Pathology. Front Cell Infect Microbiol. 2017;7:183 pubmed publisher
  • flow cytometry; mouse; fig s3
Sim C, Cho Y, Kim B, Baek I, Kim Y, Lee M. 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. Cancer Immunol Immunother. 2016;65:663-75 pubmed publisher
Guo M, Xia Z, Hong Y, Ji H, Li F, Liu W, et al. The TFPI2-PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice. J Inflamm (Lond). 2023;20:35 pubmed publisher
Liang W, Sagar S, Ravindran R, Najor R, Quiles J, Chi L, et al. Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired. Nat Commun. 2023;14:5031 pubmed publisher
Li Y, Li N, Liu W, Prominski A, Kang S, Dai Y, et al. Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design. Nat Commun. 2023;14:4488 pubmed publisher
Grunz E, Jones B, Lateef O, Sen S, Wilkinson K, Joshi T, et al. Adventitial macrophage accumulation impairs perivascular nerve function in mesenteric arteries with inflammatory bowel disease. Front Physiol. 2023;14:1198066 pubmed publisher
Takenaka T, Ohnishi Y, Yamamoto M, Setoyama D, Kishima H. Glycolytic System in Axons Supplement Decreased ATP Levels after Axotomy of the Peripheral Nerve. Eneuro. 2023;10: pubmed publisher
Li Q, Du Y, Xiang P, Chen G, Qian X, Li S, et al. Re-Visiting Antioxidant Therapy in Murine Advanced Atherosclerosis with Brussels Chicory, a Typical Vegetable in Mediterranean Diets. Nutrients. 2023;15: pubmed publisher
Bai Y, Yang F, Luo P, Xie L, Chen J, Guan Y, et al. Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice. Mil Med Res. 2023;10:7 pubmed publisher
Dundee J, Puigdell xed vol M, Butler R, Cockram T, Brown G. P2Y6 receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging. Aging Cell. 2023;22:e13761 pubmed publisher
Tomimatsu M, Matsumoto K, Ashizuka M, Kumagai S, Tanaka S, Nakae T, et al. Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling. Sci Rep. 2022;12:16656 pubmed publisher
Kleffman K, Levinson G, Rose I, Blumenberg L, Shadaloey S, Dhabaria A, et al. Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis. Cancer Discov. 2022;12:1314-1335 pubmed publisher
de León Guerrero S, Salazar León J, Meza Sosa K, Valle García D, Aguilar Leon D, Pedraza Alva G, et al. An enriched environment reestablishes metabolic homeostasis by reducing obesity-induced inflammation. Dis Model Mech. 2022;: pubmed publisher
Zorzin S, Corsi A, Ciarpella F, Bottani E, Dolci S, Malpeli G, et al. Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling. Int J Mol Sci. 2021;22: pubmed publisher
Golden G, Toledo A, Marki A, Sorrentino J, Morris C, Riley R, et al. Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis. MBio. 2021;12:e0118121 pubmed publisher
Li M, McGhee E, Shinno L, Lee K, Lin Y. Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo. Am J Pathol. 2021;191:1822-1836 pubmed publisher
He J, Ma M, Li D, Wang K, Wang Q, Li Q, et al. Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis. Cell Death Dis. 2021;12:626 pubmed publisher
Wei H, Zhao H, Li R, Yang F, Wu Y. Rhinovirus impairs the immune response of alveolar macrophages to facilitate Streptococcus pneumonia infection. Pathog Dis. 2020;78: pubmed publisher
Yin N, Gao Q, Tao W, Chen J, Bi J, Ding F, et al. Paeoniflorin relieves LPS-induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1. J Leukoc Biol. 2020;108:229-241 pubmed publisher
Han S, Xu S, Zhou J, Qiao A, Boriboun C, Ma W, et al. Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. J Mol Cell Cardiol. 2019;137:82-92 pubmed publisher
Urner S, Planas Paz L, Hilger L, Henning C, Branopolski A, Kelly Goss M, et al. Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth. EMBO J. 2019;38: pubmed publisher
Tan Y, Li J, Goh C, Lee B, Kwok I, Ng W, et al. Streamlining volumetric multi-channel image cytometry using hue-saturation-brightness-based surface creation. Commun Biol. 2018;1:136 pubmed publisher
Roy S, Bag A, Dutta S, Polavaram N, Islam R, Schellenburg S, et al. Macrophage-Derived Neuropilin-2 Exhibits Novel Tumor-Promoting Functions. Cancer Res. 2018;78:5600-5617 pubmed publisher
Mucci A, Lopez Rodriguez E, Hetzel M, Liu S, Suzuki T, Happle C, et al. iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice. Stem Cell Reports. 2018;11:696-710 pubmed publisher
Vasamsetti S, Florentin J, Coppin E, Stiekema L, Zheng K, Nisar M, et al. Sympathetic Neuronal Activation Triggers Myeloid Progenitor Proliferation and Differentiation. Immunity. 2018;49:93-106.e7 pubmed publisher
Chi B, Wang S, Bi S, Qin W, Wu D, Luo Z, et al. Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures. Exp Ther Med. 2018;15:847-853 pubmed publisher
Masola V, Zaza G, Bellin G, Dall Olmo L, Granata S, Vischini G, et al. Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury. FASEB J. 2018;32:742-756 pubmed publisher
Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, et al. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017;37: pubmed publisher
Stevens S, von Gise A, VanDusen N, Zhou B, Pu W. Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016;413:153-159 pubmed publisher
Baruch K, Rosenzweig N, Kertser A, Deczkowska A, Sharif A, Spinrad A, et al. Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology. Nat Commun. 2015;6:7967 pubmed publisher
Cha S, Park K, Srinivasan P, Schindler C, Van Rooijen N, Stins M, et al. CD68 acts as a major gateway for malaria sporozoite liver infection. J Exp Med. 2015;212:1391-403 pubmed publisher
Kidder D, Richards H, Lyons P, Crocker P. Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice. Arthritis Res Ther. 2013;15:R175 pubmed publisher
Fischer M, Davies M, Reider I, Heipertz E, Epler M, Sei J, et al. CD11b?, Ly6G? cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection. PLoS Pathog. 2011;7:e1002374 pubmed publisher
Kurushima H, Ramprasad M, Kondratenko N, Foster D, Quehenberger O, Steinberg D. Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J Leukoc Biol. 2000;67:104-8 pubmed
Smith M, Koch G. Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes. J Cell Sci. 1987;87 ( Pt 1):113-9 pubmed
Rabinowitz S, Gordon S. Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J Exp Med. 1991;174:827-36 pubmed
product information
Product Type :
Antibody
Product Name :
CD68 Monoclonal Antibody (FA-11), eBioscience
Catalog # :
14-0681-82
Quantity :
100 ug
Price :
US 262.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 5 ug/mL
Species :
Mouse
Clone :
FA-11
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 5 ug/mL
Aliases :
CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA