product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD62L (L-Selectin) Monoclonal Antibody (DREG-56 (DREG56)), eBioscience™
catalog :
14-0629-82
quantity :
100 µg
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DREG-56 (DREG56)
reactivity :
human, mouse
application :
western blot, immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 68
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 5
Su S, Hu B, Shao J, Shen B, Du J, Du Y, et al. CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep. 2016;6:20070 pubmed publisher
  • immunohistochemistry; human; 1:100
  • western blot; human; 1:500
Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. J Virol. 2015;89:5687-700 pubmed publisher
  • flow cytometry; human; fig s3
Obiero J, Shekalaghe S, Hermsen C, Mpina M, Bijker E, Roestenberg M, et al. Impact of malaria preexposure on antiparasite cellular and humoral immune responses after controlled human malaria infection. Infect Immun. 2015;83:2185-96 pubmed publisher
  • flow cytometry; human; fig s1
Severson J, Serracino H, Mateescu V, Raeburn C, McIntyre R, Sams S, et al. PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res. 2015;3:620-30 pubmed publisher
  • flow cytometry; human; fig s1
Teirlinck A, McCall M, Roestenberg M, Scholzen A, Woestenenk R, de Mast Q, et al. Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans. PLoS Pathog. 2011;7:e1002389 pubmed publisher
  • flow cytometry; mouse; fig 3
Markley J, Sadelain M. IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood. 2010;115:3508-19 pubmed publisher
  • flow cytometry; human
Kemp T, Ludwig A, Earel J, Moore J, Vanoosten R, Moses B, et al. Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L. Blood. 2005;106:3474-82 pubmed
Yang C, Siebert J, Burns R, Gerbec Z, Bonacci B, Rymaszewski A, et al. Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome. Nat Commun. 2019;10:3931 pubmed publisher
Wu K, Zou J, Lin C, Jie Z. MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling. Biosci Rep. 2019;: pubmed publisher
Wu B, Wang L, Jiang L, Dong L, Xu F, Lu Y, et al. n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils. Mol Med Rep. 2017;: pubmed publisher
Rathod K, Kapil V, Velmurugan S, Khambata R, Siddique U, Khan S, et al. Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. J Clin Invest. 2017;127:169-182 pubmed publisher
Lafouresse F, Bellard E, Laurent C, Moussion C, Fournié J, Ysebaert L, et al. L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo. Blood. 2015;126:1336-45 pubmed publisher
Lomakina E, Marsh G, Waugh R. Cell surface topography is a regulator of molecular interactions during chemokine-induced neutrophil spreading. Biophys J. 2014;107:1302-12 pubmed publisher
Achour A, Baychelier F, Besson C, Arnoux A, Marty M, Hannoun L, et al. Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients. J Immunol. 2014;192:503-11 pubmed publisher
Sutavani R, Bradley R, Ramage J, Jackson A, Durrant L, Spendlove I. CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype. J Immunol. 2013;191:5895-903 pubmed publisher
Gaborski T, Sealander M, Waugh R, McGrath J. Dynamics of adhesion molecule domains on neutrophil membranes: surfing the dynamic cell topography. Eur Biophys J. 2013;42:851-5 pubmed publisher
Cany J, van der Waart A, Tordoir M, Franssen G, Hangalapura B, De Vries J, et al. Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice. PLoS ONE. 2013;8:e64384 pubmed publisher
Fossati Jimack L, Ling G, Cortini A, Szajna M, Malik T, McDonald J, et al. Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PLoS ONE. 2013;8:e57082 pubmed publisher
Himmel M, Macdonald K, Garcia R, Steiner T, Levings M. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol. 2013;190:2001-8 pubmed publisher
Lang J, Kelly M, Freed B, McCarter M, Kedl R, Torres R, et al. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013;190:2090-101 pubmed publisher
McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed publisher
Lim O, Lee Y, Chung H, Her J, Kang S, Jung M, et al. GMP-compliant, large-scale expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells in vitro and in vivo. PLoS ONE. 2013;8:e53611 pubmed publisher
Domaica C, Fuertes M, Uriarte I, Girart M, Sardañons J, Comas D, et al. Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development. PLoS ONE. 2012;7:e51677 pubmed publisher
Vinet J, van Zwam M, Dijkstra I, Brouwer N, van Weering H, Watts A, et al. Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. Br J Pharmacol. 2013;168:1375-87 pubmed publisher
Herrera García A, Domínguez Luis M, Arce Franco M, Lopez Fernandez J, Feria M, Barreiro O, et al. In vivo modulation of the inflammatory response by nonsteroidal antiinflammatory drug-related compounds that trigger L-selectin shedding. Eur J Immunol. 2013;43:55-64 pubmed publisher
Na I, Wittenbecher F, Dziubianau M, Herholz A, Mensen A, Kunkel D, et al. Rabbit antithymocyte globulin (thymoglobulin) impairs the thymic output of both conventional and regulatory CD4+ T cells after allogeneic hematopoietic stem cell transplantation in adult patients. Haematologica. 2013;98:23-30 pubmed publisher
Trabanelli S, Ocadlikova D, Gulinelli S, Curti A, Salvestrini V, Vieira R, et al. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol. 2012;189:1303-10 pubmed publisher
Leoratti F, Trevelin S, Cunha F, Rocha B, Costa P, Gravina H, et al. Neutrophil paralysis in Plasmodium vivax malaria. PLoS Negl Trop Dis. 2012;6:e1710 pubmed publisher
Martorelli D, Guidoboni M, De Re V, Muraro E, Turrini R, Merlo A, et al. IGKV3 proteins as candidate "off-the-shelf" vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas. Clin Cancer Res. 2012;18:4080-91 pubmed publisher
Norling L, Dalli J, Flower R, Serhan C, Perretti M. Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol. 2012;32:1970-8 pubmed publisher
Cuda C, Li S, Liang S, Yin Y, Potula H, Xu Z, et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol. 2012;188:604-14 pubmed publisher
Ngoma A, Ikeda K, Hashimoto Y, Mochizuki K, Takahashi H, Sano H, et al. Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation. Int J Hematol. 2012;95:86-94 pubmed publisher
Kamburova E, Koenen H, Boon L, Hilbrands L, Joosten I. In vitro?effects of rituximab on the proliferation, activation and differentiation of human B cells. Am J Transplant. 2012;12:341-50 pubmed publisher
Hildebrandt M, Dijkstra D, Gollasch H, Daemen K, Stevanovic Meyer M, Ludwig W. Apheresis-related enrichment of CD26++ T lymphocytes: phenotypic characterization and correlation with unfavorable outcome in autologous hematopoietic progenitor cell transplantation. Transfusion. 2012;52:765-76 pubmed publisher
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Plet A, et al. Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice. Eur J Immunol. 2011;41:2883-93 pubmed publisher
Hoerning A, Koss K, Datta D, Boneschansker L, Jones C, Wong I, et al. Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. Eur J Immunol. 2011;41:2291-302 pubmed publisher
Claassen M, de Knegt R, Janssen H, Boonstra A. Retention of CD4+ CD25+ FoxP3+ regulatory T cells in the liver after therapy-induced hepatitis C virus eradication in humans. J Virol. 2011;85:5323-30 pubmed publisher
Mackroth M, Malhotra I, Mungai P, Koech D, Muchiri E, King C. Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens. J Immunol. 2011;186:2780-91 pubmed publisher
Rogers N, Kireta S, Coates P. Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo. Clin Exp Immunol. 2010;162:460-73 pubmed publisher
Beriou G, Bradshaw E, Lozano E, Costantino C, Hastings W, Orban T, et al. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010;185:46-54 pubmed publisher
Li Y, Lee P, Kellner E, Paulus M, Switanek J, Xu Y, et al. Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus. Arthritis Res Ther. 2010;12:R90 pubmed publisher
Freeman C, Han M, Martinez F, Murray S, Liu L, Chensue S, et al. Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol. 2010;184:6504-13 pubmed publisher
Gaborski T, Sealander M, Ehrenberg M, Waugh R, McGrath J. Image correlation microscopy for uniform illumination. J Microsc. 2010;237:39-50 pubmed publisher
Kavousanaki M, Makrigiannakis A, Boumpas D, Verginis P. Novel role of plasmacytoid dendritic cells in humans: induction of interleukin-10-producing Treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy. Arthritis Rheum. 2010;62:53-63 pubmed publisher
Flanagan K, Halliday A, Burl S, Landgraf K, Jagne Y, Noho Konteh F, et al. The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth. Eur J Immunol. 2010;40:1062-72 pubmed publisher
Kvistborg P, Boegh M, Pedersen A, Claesson M, Zocca M. Fast generation of dendritic cells. Cell Immunol. 2009;260:56-62 pubmed publisher
Hocdé S, Hyrien O, Waugh R. Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM. Biophys J. 2009;97:379-87 pubmed publisher
Huarte E, Fisher J, Turk M, Mellinger D, Foster C, Wolf B, et al. Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma. Cancer Lett. 2009;285:80-8 pubmed publisher
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
Matthews K, Lim Z, Afzali B, Pearce L, Abdallah A, Kordasti S, et al. Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab. Haematologica. 2009;94:956-66 pubmed publisher
Li Y, Lee P, Sobel E, Narain S, Satoh M, Segal M, et al. Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus. Arthritis Res Ther. 2009;11:R6 pubmed publisher
Wang J, Liu H. Systemic hypoxia enhances bactericidal activities of human polymorphonuclear leuocytes. Clin Sci (Lond). 2009;116:805-17 pubmed publisher
Azevedo R, Soares M, Barata J, Tendeiro R, Serra Caetano A, Victorino R, et al. IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner. Blood. 2009;113:2999-3007 pubmed publisher
Koyama K, Kagamu H, Miura S, Hiura T, Miyabayashi T, Itoh R, et al. Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage. Clin Cancer Res. 2008;14:6770-9 pubmed publisher
Figueroa Tentori D, Querol S, Dodi I, Madrigal A, Duggleby R. High purity and yield of natural Tregs from cord blood using a single step selection method. J Immunol Methods. 2008;339:228-35 pubmed publisher
Gaborski T, Clark A, Waugh R, McGrath J. Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils. Biophys J. 2008;95:4934-47 pubmed publisher
Xu T, Chen L, Shang X, Cui L, Luo J, Chen C, et al. Critical role of Lck in L-selectin signaling induced by sulfatides engagement. J Leukoc Biol. 2008;84:1192-201 pubmed publisher
Huarte E, Cubillos Ruiz J, Nesbeth Y, Scarlett U, Martinez D, Engle X, et al. PILAR is a novel modulator of human T-cell expansion. Blood. 2008;112:1259-68 pubmed publisher
Silva A, Andrews D, Brooks A, Smyth M, Hayakawa Y. Application of CD27 as a marker for distinguishing human NK cell subsets. Int Immunol. 2008;20:625-30 pubmed publisher
van Mierlo G, Scherer H, Hameetman M, Morgan M, Flierman R, Huizinga T, et al. Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol. 2008;180:2747-51 pubmed
Nishikawa H, Tsuji T, Jager E, Briones G, Ritter G, Old L, et al. Induction of regulatory T cell-resistant helper CD4+ T cells by bacterial vector. Blood. 2008;111:1404-12 pubmed
Chen C, Shang X, Xu T, Cui L, Luo J, Ba X, et al. c-Abl is required for the signaling transduction induced by L-selectin ligation. Eur J Immunol. 2007;37:3246-58 pubmed
Chen W, Evans E, McEver R, Zhu C. Monitoring receptor-ligand interactions between surfaces by thermal fluctuations. Biophys J. 2008;94:694-701 pubmed
Humblet Baron S, Sather B, Anover S, Becker Herman S, Kasprowicz D, Khim S, et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. 2007;117:407-18 pubmed
Simons M, Moore J, Kemp T, Griffith T. Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Infect Immun. 2007;75:1265-71 pubmed
Zhao Y, Huang Z, Qi M, Lazzarini P, Mazzone T. Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. Immunol Lett. 2007;108:78-87 pubmed
Jutila M, Kurk S, Jackiw L, Knibbs R, Stoolman L. L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts. J Immunol. 2002;169:1768-73 pubmed
Kishimoto T, Jutila M, Butcher E. Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc Natl Acad Sci U S A. 1990;87:2244-8 pubmed
product information
Product Type :
Antibody
Product Name :
CD62L (L-Selectin) Monoclonal Antibody (DREG-56 (DREG56)), eBioscience™
Catalog # :
14-0629-82
Quantity :
100 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Human
Clone :
DREG-56 (DREG56)
Isotype :
IgG1, kappa
Storage :
4° C
Description :
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
A.11; AI528707; CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LECAM1; LECAM-1; LEU8; Leu-8; Leukocyte adhesion molecule 1; leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; L-selectin; Ly22; Ly-22; LYAM1; Lyam-1; Ly-m22; Lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; pln homing receptor; PLNHR; SELE; selectin E (endothelial adhesion molecule 1); selectin L; selectin L (lymphocyte adhesion molecule 1); selectin, lymphocyte; Sell; TQ1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA