CD62P (P-Selectin) Monoclonal Antibody (AK-4), eBioscience™ | Invitrogen 14-0628-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD62P (P-Selectin) Monoclonal Antibody (AK-4), eBioscience™

catalog :

14-0628-80

quantity :

25 µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AK-4

reactivity :

human

application :

ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
ELISA; human; fig 2d	Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini E, et al. Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity. Sci Rep. 2016;6:37953 pubmed publisher
	Maione F, Cicala C, Liverani E, Mascolo N, Perretti M, D Acquisto F. IL-17A increases ADP-induced platelet aggregation. Biochem Biophys Res Commun. 2011;408:658-62 pubmed publisher
	Kapp K, Maul J, Hostmann A, Mundt P, Preiss J, Wenzel A, et al. Modulation of systemic antigen-specific immune responses by oral antigen in humans. Eur J Immunol. 2010;40:3128-37 pubmed publisher
	Chen W, Evans E, McEver R, Zhu C. Monitoring receptor-ligand interactions between surfaces by thermal fluctuations. Biophys J. 2008;94:694-701 pubmed
	Sinauridze E, Kireev D, Popenko N, Pichugin A, Panteleev M, Krymskaya O, et al. Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost. 2007;97:425-34 pubmed
	Skinner M, Lucas C, Burns G, Chesterman C, Berndt M. GMP-140 binding to neutrophils is inhibited by sulfated glycans. J Biol Chem. 1991;266:5371-4 pubmed

product information

Product Type :

Antibody

Product Name :

CD62P (P-Selectin) Monoclonal Antibody (AK-4), eBioscience™

Catalog # :

14-0628-80

Quantity :

25 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunocytochemistry: 5 µg/ml, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human

Clone :

AK-4

Isotype :

IgG1, kappa

Storage :

4° C

Description :

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunocytochemistry: 5 µg/ml, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; CD62P; CD62 homolog; FLJ45155; GMP140; GMP-140; GMRP; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; Grmp; LECAM3; leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; PSEL; PSELECT; P-selectin; P-selectin precursor; RP1-86F14.2; selectin P; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet; Selp

more info or order :

Invitrogen product webpage