CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), eBioscience™ | Invitrogen 14-0619-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), eBioscience™

catalog :

14-0619-82

quantity :

100 µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

VI-PL2

reactivity :

crab eating macaque, human, mouse, dogs, rhesus macaque

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2a	Jürets A, Le Bras M, Staffler G, Stein G, Leitner L, Neuhofer A, et al. Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage. PLoS ONE. 2016;11:e0148333 pubmed publisher
flow cytometry; mouse	Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang S, et al. P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. J Thromb Haemost. 2013;11:149-60 pubmed publisher
	Li R, Nguyen N, Tablin F. Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs. BMC Vet Res. 2019;15:245 pubmed publisher
	Shropshire S, Olver C, Lappin M. Characteristics of hemostasis during experimental Ehrlichia canis infection. J Vet Intern Med. 2018;32:1334-1342 pubmed publisher
	Zhao Y, Masiello D, McMillian M, Nguyen C, Wu Y, Melendez E, et al. CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells. Oncogene. 2016;35:3705-17 pubmed publisher
	Wang S, Guo L, Ge J, Yu L, Cai T, Tian R, et al. Excess Integrins Cause Lung Entrapment of Mesenchymal Stem Cells. Stem Cells. 2015;33:3315-26 pubmed publisher
	Barrett L, Dai C, Gamberg J, Gallant M, Grant M. Circulating CD14-CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10. J Leukoc Biol. 2007;82:152-60 pubmed
	Roberts M, Woods A, Dale T, van der Sluijs P, Norman J. Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol Cell Biol. 2004;24:1505-15 pubmed
	Ciarlet M, Crawford S, Cheng E, Blutt S, Rice D, Bergelson J, et al. VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002;76:1109-23 pubmed

product information

Product Type :

Antibody

Product Name :

CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), eBioscience™

Catalog # :

14-0619-82

Quantity :

100 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey

Applications :

Flow Cytometry: 0.125 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent

Species :

Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey

Clone :

VI-PL2

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent

Aliases :

antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa

more info or order :

Invitrogen product webpage