CD61 (Integrin beta 3) Monoclonal Antibody (2C9.G3), eBioscience | Invitrogen 14-0611-85 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD61 (Integrin beta 3) Monoclonal Antibody (2C9.G3), eBioscience

catalog :

14-0611-85

quantity :

500 ug

price :

US 300.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

2C9.G3

reactivity :

mouse, rat

application :

immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section

citations: 22

Reference
Wei L, Yang Y, Gupta P, Wang A, Zhao M, Zhao Y, et al. A Small Molecule Inhibitor, OGP46, Is Effective against Imatinib-Resistant BCR-ABL Mutations via the BCR-ABL/JAK-STAT Pathway. Mol Ther Oncolytics. 2020;18:137-148 pubmed publisher
Dukinfield M, Maniati E, Reynolds L, Aubdool A, Baliga R, D Amico G, et al. Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. J Pathol. 2019;249:523-535 pubmed publisher
Santoro A, Vlachou T, Luzi L, Melloni G, Mazzarella L, D Elia E, et al. p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. Cell Rep. 2019;26:624-638.e8 pubmed publisher
Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, et al. Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer. Gut. 2019;68:693-707 pubmed publisher
Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, et al. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018;142:1894-1908.e7 pubmed publisher
Chen J, Zhong M, Guo H, Davidson D, Mishel S, Lu Y, et al. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017;544:493-497 pubmed publisher
Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, et al. Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Cancer Cell. 2017;31:549-562.e11 pubmed publisher
Benito JardÃ³n M, Klapproth S, Gimeno LLuch I, Petzold T, Bharadwaj M, MÃ¼ller D, et al. The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes. elife. 2017;6: pubmed publisher
Chen Z, Ding X, Jin S, Pitt B, Zhang L, Billiar T, et al. WISP1-?v?3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury. Sci Rep. 2016;6:28841 pubmed publisher
Liu H, Zhang A, Xu J, Chen Y, Zhu Y. H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets. J Hematol Oncol. 2016;9:13 pubmed publisher
Rowley J, Chappaz S, Corduan A, Chong M, Campbell R, Khoury A, et al. Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood. 2016;127:1743-51 pubmed publisher
Jun J, Kim K, Lau L. The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing. Nat Commun. 2015;6:7386 pubmed publisher
Gawden Bone C, West M, Morrison V, Edgar A, McMillan S, Dill B, et al. A crucial role for ?2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells. J Cell Sci. 2014;127:4213-24 pubmed publisher
Gerber E, Gallo E, Fontana S, Davis E, Wigley F, Huso D, et al. Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma. Nature. 2013;503:126-30 pubmed publisher
Kaanta A, Virtanen C, Selfors L, Brugge J, Neel B. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res. 2013;15:R65 pubmed
Meves A, Stremmel C, Böttcher R, Fassler R. ?1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis. J Invest Dermatol. 2013;133:2722-2731 pubmed publisher
Borisova M, Shi Y, Buntru A, Wörner S, Ziegler W, Hauck C. Integrin-mediated internalization of Staphylococcus aureus does not require vinculin. BMC Cell Biol. 2013;14:2 pubmed publisher
Sprague L, Muccioli M, Pate M, Meles E, McGinty J, Nandigam H, et al. The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells. BMC Immunol. 2011;12:35 pubmed publisher
Kim S, Goel S, Alexander C. Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept. PLoS ONE. 2011;6:e19310 pubmed publisher
Pedroja B, Kang L, Imas A, Carmeliet P, Bernstein A. Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling. J Biol Chem. 2009;284:20708-17 pubmed publisher
Nohara K, Pan X, Tsukumo S, Hida A, Ito T, Nagai H, et al. Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes. J Immunol. 2005;174:2770-7 pubmed
Yasuda M, Hasunuma Y, Adachi H, Sekine C, Sakanishi T, Hashimoto H, et al. Expression and function of fibronectin binding integrins on rat mast cells. Int Immunol. 1995;7:251-8 pubmed

product information

Product Type :

Antibody

Product Name :

CD61 (Integrin beta 3) Monoclonal Antibody (2C9.G3), eBioscience

Catalog # :

14-0611-85

Quantity :

500 ug

Price :

US 300.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse, Rat

Applications :

Flow Cytometry: 0.5 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse, Rat

Clone :

2C9.G3

Isotype :

IgG

Storage :

4 C

Description :

CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa