CD45RO Monoclonal Antibody (UCHL1), eBioscience | Invitrogen 14-0457-37 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45RO Monoclonal Antibody (UCHL1), eBioscience

catalog :

14-0457-37

quantity :

2 mg

price :

US 1372.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

UCHL1

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; fig 4g	Liu X, Kong W, Peterson C, McGrail D, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135 pubmed publisher
flow cytometry; human; loading ...; fig e4d	Lynn R, Weber E, Sotillo E, Gennert D, Xu P, Good Z, et al. c-Jun overexpression in CAR T cells induces exhaustion resistance. Nature. 2019;576:293-300 pubmed publisher
	Gartner M, Gorry P, Tumpach C, Zhou J, Dantanarayana A, Chang J, et al. Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection. Retrovirology. 2020;17:24 pubmed publisher
	de Macedo Abdo L, Barros L, Saldanha Viegas M, Vieira Codeço Marques L, de Sousa Ferreira P, Chicaybam L, et al. Development of CAR-T cell therapy for B-ALL using a point-of-care approach. Oncoimmunology. 2020;9:1752592 pubmed publisher
	Singh M, Kasna S, Roy S, Aldosary S, Saeedan A, Ansari M, et al. Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling. BMC Cancer. 2019;19:996 pubmed publisher
	Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
	Yiwen Z, Shilin G, Yingshi C, Lishi S, Baohong L, Chao L, et al. Efficient generation of antigen-specific CTLs by the BAFF-activated human B Lymphocytes as APCs: a novel approach for immunotherapy. Oncotarget. 2016;7:77732-77748 pubmed publisher
	Marina R, Sturgill D, Bailly M, Thenoz M, Varma G, Prigge M, et al. TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing. EMBO J. 2016;35:335-55 pubmed publisher
	Alfaro C, Echeveste J, Rodriguez Ruiz M, Solorzano J, Perez Gracia J, Idoate M, et al. Functional expression of CD137 (4-1BB) on T helper follicular cells. Oncoimmunology. 2015;4:e1054597 pubmed
	Ramstead A, Schepetkin I, Todd K, Loeffelholz J, Berardinelli J, Quinn M, et al. Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B. Int Immunopharmacol. 2015;26:367-77 pubmed publisher
	Komori H, Hart T, Lamere S, Chew P, Salomon D. Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation. J Immunol. 2015;194:1565-79 pubmed publisher
	Bai A, Moss A, Kokkotou E, Usheva A, Sun X, Cheifetz A, et al. CD39 and CD161 modulate Th17 responses in Crohn's disease. J Immunol. 2014;193:3366-77 pubmed publisher
	Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, et al. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res. 2014;20:3422-33 pubmed publisher
	Fogal B, Yi T, Wang C, Rao D, Lebastchi A, Kulkarni S, et al. Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells. J Immunol. 2011;187:6268-80 pubmed publisher
	Poulin L, Salio M, Griessinger E, Anjos Afonso F, Craciun L, Chen J, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med. 2010;207:1261-71 pubmed publisher
	Kawamata N, Xu B, Nishijima H, Aoyama K, Kusumoto M, Takeuchi T, et al. Expression of endothelia and lymphocyte adhesion molecules in bronchus-associated lymphoid tissue (BALT) in adult human lung. Respir Res. 2009;10:97 pubmed publisher
	Butte M, Pena Cruz V, Kim M, Freeman G, Sharpe A. Interaction of human PD-L1 and B7-1. Mol Immunol. 2008;45:3567-72 pubmed publisher
	Arimura Y, Vang T, Tautz L, Williams S, Mustelin T. TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses. Mol Immunol. 2008;45:3074-84 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45RO Monoclonal Antibody (UCHL1), eBioscience

Catalog # :

14-0457-37

Quantity :

2 mg

Price :

US 1372.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Paraffin): 5 µg/mL

Species :

Human

Clone :

UCHL1

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Paraffin): 5 µg/mL

Aliases :

B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen

more info or order :

Invitrogen product webpage