CD41a Monoclonal Antibody (HIP8), eBioscience™ | Invitrogen 14-0419-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD41a Monoclonal Antibody (HIP8), eBioscience™

catalog :

14-0419-80

quantity :

25 µg

price :

US 66

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HIP8

reactivity :

human

application :

immunohistochemistry, flow cytometry

citations: 15

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 1	Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska T, Papac Milicevic N, et al. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res. 2015;56:440-8 pubmed publisher
	Niklaus M, Klingler P, Weber K, Koessler A, Kuhn S, Böeck M, et al. Platelet Toll-Like-Receptor-2 and -4 Mediate Different Immune-Related Responses to Bacterial Ligands. TH Open. 2022;6:e156-e167 pubmed publisher
	Sahai A, Bhandari R, Koupenova M, Freedman J, Godwin M, McIntyre T, et al. SARS-CoV-2 Receptors are Expressed on Human Platelets and the Effect of Aspirin on Clinical Outcomes in COVID-19 Patients. Res Sq. 2020;: pubmed publisher
	Zimmer N, Krebs F, Zimmer S, Mitzel Rink H, Kumm E, Jurk K, et al. Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis. Cancers (Basel). 2020;12: pubmed publisher
	Koupenova M, Corkrey H, Vitseva O, Manni G, Pang C, Clancy L, et al. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019;10:1780 pubmed publisher
	Singel K, Grzankowski K, Khan A, Grimm M, D Auria A, Morrell K, et al. Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. Br J Cancer. 2019;120:207-217 pubmed publisher
	Garcia Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, et al. Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest. 2016;126:859-64 pubmed publisher
	Xie R, Hu P, Li W, Ren Y, Yang J, Yang Y, et al. The effect of platelet-derived microparticles in stored apheresis platelet concentrates on polymorphonuclear leucocyte respiratory burst. Vox Sang. 2014;106:234-41 pubmed publisher
	Balduini A, Di Buduo C, Malara A, Lecchi A, Rebuzzini P, Currao M, et al. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. Haematologica. 2012;97:1657-65 pubmed publisher
	Ekser B, Lin C, Long C, Echeverri G, Hara H, Ezzelarab M, et al. Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation. Transpl Int. 2012;25:882-96 pubmed publisher
	Dayananda K, Singh I, Mondal N, Neelamegham S. von Willebrand factor self-association on platelet GpIbalpha under hydrodynamic shear: effect on shear-induced platelet activation. Blood. 2010;116:3990-8 pubmed publisher
	Blue R, Kowalska M, Hirsch J, Murcia M, Janczak C, Harrington A, et al. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 2009;114:195-201 pubmed publisher
	Shah M, Bergeron A, Dong J, LÃ³pez J. Flow cytometric measurement of microparticles: pitfalls and protocol modifications. Platelets. 2008;19:365-72 pubmed publisher
	Arimura Y, Vang T, Tautz L, Williams S, Mustelin T. TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses. Mol Immunol. 2008;45:3074-84 pubmed publisher
	Rajesh D, Chinnasamy N, Mitalipov S, Wolf D, Slukvin I, Thomson J, et al. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells. 2007;25:490-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD41a Monoclonal Antibody (HIP8), eBioscience™

Catalog # :

14-0419-80

Quantity :

25 µg

Price :

US 66

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry: Assay-Dependent

Species :

Human

Clone :

HIP8

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry: Assay-Dependent

Aliases :

AI172977; alpha IIb; alphaIIb; alphaIIb protein; BDPLT16; BDPLT2; CD41; CD41B; form 1; form 2; GP IIb; GP2B; GPalpha IIb; GPIIb; GT; GTA; HPA3; integrin alpha 2b; integrin alpha 2b (Cd41b); Integrin alpha-IIb; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2; integrin subunit alpha 2b; integrin, alpha 2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/II Ia complex; platelet glycoprotein IIb of IIb/IIIa complex; platelet membrane glycoprotein IIb; platelet-specific antigen BAK; PPP1R93; protein phosphatase 1, regulatory subunit 93