This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD41a Monoclonal Antibody (HIP8), eBioscience
catalog :
14-0419-37
quantity :
2 mg
price :
US 1474.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HIP8

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry, flow cytometry
citations: 7
Reference
Niklaus M, Klingler P, Weber K, Koessler A, Kuhn S, Böeck M, et al. Platelet Toll-Like-Receptor-2 and -4 Mediate Different Immune-Related Responses to Bacterial Ligands. TH Open. 2022;6:e156-e167 pubmed publisher
Louka E, Povinelli B, Rodriguez Meira A, Buck G, Wen W, Wang G, et al. Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia. J Exp Med. 2021;218: pubmed publisher
Sahai A, Bhandari R, Koupenova M, Freedman J, Godwin M, McIntyre T, et al. SARS-CoV-2 Receptors are Expressed on Human Platelets and the Effect of Aspirin on Clinical Outcomes in COVID-19 Patients. Res Sq. 2020;: pubmed publisher
Zimmer N, Krebs F, Zimmer S, Mitzel Rink H, Kumm E, Jurk K, et al. Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis. Cancers (Basel). 2020;12: pubmed publisher
Koupenova M, Corkrey H, Vitseva O, Manni G, Pang C, Clancy L, et al. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019;10:1780 pubmed publisher
Singel K, Grzankowski K, Khan A, Grimm M, D Auria A, Morrell K, et al. Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. Br J Cancer. 2019;120:207-217 pubmed publisher
Garcia Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, et al. Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest. 2016;126:859-64 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD41a Monoclonal Antibody (HIP8), eBioscience
Catalog # :
14-0419-37
Quantity :
2 mg
Price :
US 1474.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 0.5 ug/test, Immunohistochemistry: Assay-Dependent
Species :
Human
Clone :
HIP8
Isotype :
IgG1, kappa
Storage :
4 C
Description :
CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test, Immunohistochemistry: Assay-Dependent
Aliases :
AI172977; alpha IIb; alphaIIb; alphaIIb protein; BDPLT16; BDPLT2; CD41; CD41B; form 1; form 2; GP IIb; GP2B; GPalpha IIb; GPIIb; GT; GTA; HPA3; integrin alpha 2b; integrin alpha 2b (Cd41b); integrin alpha-IIb; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2; integrin subunit alpha 2b; integrin subunit alpha IIb; integrin, alpha 2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet glycoprotein IIb of IIb/IIIa complex; platelet membrane glycoprotein IIb; platelet-specific antigen BAK; PPP1R93; protein phosphatase 1, regulatory subunit 93
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA