CD40 Monoclonal Antibody (5C3), eBioscience | Invitrogen 14-0409-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD40 Monoclonal Antibody (5C3), eBioscience

catalog :

14-0409-82

quantity :

100 ug

price :

US 136.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5C3

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1a	Richardson J, Armbruster N, Günter M, Henes J, Autenrieth S. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018;9:2603 pubmed publisher
blocking or activating experiments; human; loading ...; fig 7a	Harfuddin Z, Dharmadhikari B, Wong S, Duan K, Poidinger M, Kwajah S, et al. Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype. Sci Rep. 2016;6:29712 pubmed publisher
flow cytometry; human; fig st1	Leitch C, Natafji E, Yu C, Abdul Ghaffar S, Madarasingha N, Venables Z, et al. Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells. J Allergy Clin Immunol. 2016;138:482-490.e7 pubmed publisher
flow cytometry; human; fig 1	Boltjes A, van Montfoort N, Biesta P, Op den Brouw M, Kwekkeboom J, van der Laan L, et al. Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function. J Infect Dis. 2015;211:1268-78 pubmed publisher
	Li L, Liao Z, Ye M, Jiang J. Recombinant human IL-37 inhibited endometriosis development in a mouse model through increasing Th1/Th2 ratio by inducing the maturation of dendritic cells. Reprod Biol Endocrinol. 2021;19:128 pubmed publisher
	Nasser J, Bergman D, Fulco C, Guckelberger P, Doughty B, Patwardhan T, et al. Genome-wide enhancer maps link risk variants to disease genes. Nature. 2021;593:238-243 pubmed publisher
	Chevrier S, Zurbuchen Y, Cervia C, Adamo S, Raeber M, de Souza N, et al. A distinct innate immune signature marks progression from mild to severe COVID-19. Cell Rep Med. 2021;2:100166 pubmed publisher
	Carstensen M, Christensen T, Stilund M, Møller H, Petersen E, Petersen T. Activated monocytes and markers of inflammation in newly diagnosed multiple sclerosis. Immunol Cell Biol. 2020;98:549-562 pubmed publisher
	Ventura Ferreira M, Bienert M, Muller K, Rath B, Goecke T, Opländer C, et al. Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta. Stem Cell Res Ther. 2018;9:28 pubmed publisher
	Chevrier S, Levine J, Zanotelli V, Silina K, Schulz D, Bacac M, et al. An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell. 2017;169:736-749.e18 pubmed publisher
	Pathangey L, McCurry D, Gendler S, Dominguez A, Gorman J, Pathangey G, et al. Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens. Oncotarget. 2017;8:10785-10808 pubmed publisher
	Boulter N, Suarez F, Schibeci S, Sunderland T, Tolhurst O, Hunter T, et al. A simple, accurate and universal method for quantification of PCR. BMC Biotechnol. 2016;16:27 pubmed publisher
	de Haar C, Plantinga M, Blokland N, van Til N, Flinsenberg T, Van Tendeloo V, et al. Generation of a cord blood-derived Wilms Tumor 1 dendritic cell vaccine for AML patients treated with allogeneic cord blood transplantation. Oncoimmunology. 2015;4:e1023973 pubmed
	Zhang G, Huang H, Zhu Y, Yu G, Gao X, Xu Y, et al. A novel subset of B7-H3+CD14+HLA-DR-/low myeloid-derived suppressor cells are associated with progression of human NSCLC. Oncoimmunology. 2015;4:e977164 pubmed
	Watchmaker P, Lahl K, Lee M, Baumjohann D, Morton J, Kim S, et al. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014;15:98-108 pubmed publisher
	van de Laar L, van den Bosch A, Boonstra A, Binda R, Buitenhuis M, Janssen H, et al. PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function. Blood. 2012;120:4982-91 pubmed publisher
	Poulin L, Salio M, Griessinger E, Anjos Afonso F, Craciun L, Chen J, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med. 2010;207:1261-71 pubmed publisher
	Pound J, Challa A, Holder M, Armitage R, Dower S, Fanslow W, et al. Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells. Int Immunol. 1999;11:11-20 pubmed

product information

Product Type :

Antibody

Product Name :

CD40 Monoclonal Antibody (5C3), eBioscience

Catalog # :

14-0409-82

Quantity :

100 ug

Price :

US 136.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 ug/test, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Human

Clone :

5C3

Isotype :

IgG1, kappa

Storage :

4 C

Description :

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5

more info or order :

Invitrogen product webpage