CD38 Monoclonal Antibody (90), eBioscience | Invitrogen 14-0381-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD38 Monoclonal Antibody (90), eBioscience

catalog :

14-0381-85

quantity :

500 ug

price :

US 316.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

reactivity :

mouse

application :

immunohistochemistry, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 32

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 4h	Sindhava V, Oropallo M, Moody K, Naradikian M, Higdon L, Zhou L, et al. A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest. 2017;127:1651-1663 pubmed publisher
flow cytometry; mouse; loading ...; fig 3b	Cockrell D, Long C, Robertson S, Shannon J, Miller H, Myers L, et al. Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages. PLoS ONE. 2017;12:e0173528 pubmed publisher
flow cytometry; mouse; loading ...; fig 3a	Jones D, Gaudette B, Wilmore J, Chernova I, Bortnick A, Weiss B, et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J Clin Invest. 2016;126:4250-4261 pubmed publisher
flow cytometry; mouse; loading ...; fig 2a	Chen S, Miyazaki M, Chandra V, Fisch K, Chang A, Murre C. Id3 Orchestrates Germinal Center B Cell Development. Mol Cell Biol. 2016;36:2543-52 pubmed publisher
blocking or activating experiments; mouse; fig 2	Levit Zerdoun E, Becker M, Pohlmeyer R, Wilhelm I, Maity P, Rajewsky K, et al. Survival of IgÎ±-Deficient Mature B Cells Requires BAFF-R Function. J Immunol. 2016;196:2348-60 pubmed publisher
flow cytometry; mouse	Chen M, Chen Y, Wu M, Yu G, Lin W, Tan T, et al. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS ONE. 2014;9:e107505 pubmed publisher
blocking or activating experiments; mouse; 10 ug/ml; fig 3	Alsadeq A, Hobeika E, Medgyesi D, Kläsener K, Reth M. The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling. J Immunol. 2014;193:268-76 pubmed publisher
flow cytometry; mouse	Roehrich M, Spicher A, Milano G, Vassalli G. Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity. Biomed Res Int. 2013;2013:503047 pubmed publisher
flow cytometry; mouse; fig 2	Matsuda J, Zhang Q, Ndonye R, Richardson S, Howell A, Gapin L. T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells. Blood. 2006;107:2797-805 pubmed
	Korotkaja K, Jansons J, Spunde K, Rudevica Z, Zajakina A. Establishment and Characterization of Free-Floating 3D Macrophage Programming Model in the Presence of Cancer Cell Spheroids. Int J Mol Sci. 2023;24: pubmed publisher
	He Z, Yue C, Chen X, Li X, Zhang L, Tan S, et al. Integrative Analysis Identified CD38 As a Key Node That Correlates Highly with Immunophenotype, Chemoradiotherapy Resistance, And Prognosis of Head and Neck Cancer. J Cancer. 2023;14:72-87 pubmed publisher
	Lander V, Belle J, Kingston N, Herndon J, Hogg G, Liu X, et al. Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade. Cancer Discov. 2022;12:2774-2799 pubmed publisher
	Wang Y, Feswick A, Apostolou V, Petkov P, Moser E, Tibbetts S. Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses. Proc Natl Acad Sci U S A. 2022;119:e2123362119 pubmed publisher
	Krawetz R, Abubacker S, Leonard C, Masson A, Shah S, Narendran N, et al. Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration. NPJ Regen Med. 2022;7:32 pubmed publisher
	Nguyen T, Niaz Z, Kruzel M, Actor J. Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice. Arch Immunol Ther Exp (Warsz). 2022;70:9 pubmed publisher
	Trofimova O, Korotkaja K, Skrastina D, Jansons J, Spunde K, Isaguliants M, et al. Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model. Vaccines (Basel). 2021;9: pubmed publisher
	Bernasconi R, Thriene K, Romero Fernández E, Gretzmeier C, Kühl T, Maler M, et al. Pro-inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang-(1-7). EMBO Mol Med. 2021;13:e14392 pubmed publisher
	Nasarre P, Garcia D, Siegel J, Bonilla I, Mukherjee R, Hilliard E, et al. Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma. Cancers (Basel). 2021;13: pubmed publisher
	Sim H, Jeong D, Kim H, Pak S, Thapa B, Kwon H, et al. CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages. Immune Netw. 2021;21:e13 pubmed publisher
	Rivas M, Meydan C, Chin C, Challman M, Kim D, Bhinder B, et al. Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation. Nat Immunol. 2021;22:240-253 pubmed publisher
	Rodda L, Netland J, Shehata L, Pruner K, Morawski P, Thouvenel C, et al. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021;184:169-183.e17 pubmed publisher
	Nguyen T, d Aigle J, Chinea L, Niaz Z, Hunter R, Hwang S, et al. Mycobacterial Trehalose 6,6'-Dimycolate-Induced M1-Type Inflammation. Am J Pathol. 2020;190:286-294 pubmed publisher
	Zeng W, Chen X, Duren Z, Wang Y, Jiang R, Wong W. DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data. Nat Commun. 2019;10:4613 pubmed publisher
	Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann Kleiter N, et al. CHK1 dosage in germinal center B cells controls humoral immunity. Cell Death Differ. 2019;: pubmed publisher
	Beguelin W, Rivas M, Calvo Fernández M, Teater M, Purwada A, Redmond D, et al. EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop. Nat Commun. 2017;8:877 pubmed publisher
	Bemark M, Hazanov H, Strömberg A, Komban R, Holmqvist J, Köster S, et al. Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization. Nat Commun. 2016;7:12698 pubmed publisher
	Funakoshi S, Shimizu T, Numata O, Ato M, Melchers F, Ohnishi K. BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. PLoS ONE. 2015;10:e0117566 pubmed publisher
	Limon J, So L, Jellbauer S, Chiu H, Corado J, Sykes S, et al. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Proc Natl Acad Sci U S A. 2014;111:E5076-85 pubmed publisher
	Dai X, James R, Habib T, Singh S, Jackson S, Khim S, et al. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest. 2013;123:2024-36 pubmed publisher
	Oliver A, Grimaldi J, Howard M, Kearney J. Independently ligating CD38 and Fc gammaRIIB relays a dominant negative signal to B cells. Hybridoma. 1999;18:113-9 pubmed
	Oliver A, Martin F, Gartland G, Carter R, Kearney J. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur J Immunol. 1997;27:2366-74 pubmed
	Oliver A, Martin F, Kearney J. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol. 1997;158:1108-15 pubmed

product information

Product Type :

Antibody

Product Name :

CD38 Monoclonal Antibody (90), eBioscience

Catalog # :

14-0381-85

Quantity :

500 ug

Price :

US 316.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Species :

Mouse

Clone :

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Aliases :

2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; Cd38; CD38 antigen; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38 antigen (p45); CD38 antigen p45; CD38 molecule; CD38H; Cd38-rs1; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; I-19; NAD(+) nucleosidase; NAD+ nucleosidase; NIM-R5 antigen; T10

more info or order :

Invitrogen product webpage