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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD34 Monoclonal Antibody (4H11), eBioscience™
catalog :
14-0349-82
quantity :
100µg
price :
US 117
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4H11
reactivity :
human
application :
western blot, neutralization, flow cytometry
more info or order :
Invitrogen product webpage
citations: 25
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:500; loading ...; fig 2e
Shao Q, Esseltine J, Huang T, Novielli Kuntz N, Ching J, SAMPSON J, et al. Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence. Biomolecules. 2019;9: pubmed publisher
  • flow cytometry; human; fig 2a
Weng S, Matsuura S, Mowery C, Stoner S, Lam K, Ran D, et al. Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity. Leukemia. 2017;31:159-169 pubmed publisher
  • flow cytometry; human
Moriarity B, Rahrmann E, Beckmann D, Conboy C, Watson A, Carlson D, et al. Simple and efficient methods for enrichment and isolation of endonuclease modified cells. PLoS ONE. 2014;9:e96114 pubmed publisher
  • flow cytometry; human; 1:50
Bareja A, Holt J, Luo G, Chang C, Lin J, Hinken A, et al. Human and mouse skeletal muscle stem cells: convergent and divergent mechanisms of myogenesis. PLoS ONE. 2014;9:e90398 pubmed publisher
Böiers C, Richardson S, Laycock E, Zriwil A, Turati V, Brown J, et al. A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Dev Cell. 2018;44:362-377.e7 pubmed publisher
Yang H, Wu S, Feng R, Huang J, Liu L, Liu F, et al. Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats. Stem Cell Res Ther. 2017;8:267 pubmed publisher
Zhou H, Mak P, Mu H, Mak D, Zeng Z, Cortes J, et al. Combined inhibition of ?-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo. Leukemia. 2017;31:2065-2074 pubmed publisher
Li J, Mao Q, He J, She H, Zhang Z, Yin C. Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism. Stem Cell Res Ther. 2017;8:55 pubmed publisher
Buchrieser J, James W, Moore M. Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages. Stem Cell Reports. 2017;8:334-345 pubmed publisher
Yang C, Ma R, Axton R, Jackson M, Taylor A, Fidanza A, et al. Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells. Stem Cells. 2017;35:886-897 pubmed publisher
Jackson M, Ma R, Taylor A, Axton R, Easterbrook J, Kydonaki M, et al. Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells. Stem Cells Transl Med. 2016;5:981-90 pubmed publisher
Juneja S, Viswanathan S, Ganguly M, Veillette C. A Simplified Method for the Aspiration of Bone Marrow from Patients Undergoing Hip and Knee Joint Replacement for Isolating Mesenchymal Stem Cells and In Vitro Chondrogenesis. Bone Marrow Res. 2016;2016:3152065 pubmed publisher
Muntión S, Ramos T, Diez Campelo M, Rosón B, Sánchez Abarca L, Misiewicz Krzeminska I, et al. Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic Patients. PLoS ONE. 2016;11:e0146722 pubmed publisher
Zhu N, Wang H, Wang B, Wei J, Shan W, Feng J, et al. A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Int. 2016;2016:5687589 pubmed publisher
Oliva Olivera W, Leiva Gea A, Lhamyani S, Coín Aragüez L, Alcaide Torres J, Bernal López M, et al. Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome. Endocrinology. 2015;156:4492-501 pubmed publisher
Han L, Qiu P, Zeng Z, Jorgensen J, Mak D, Burks J, et al. Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells. Cytometry A. 2015;87:346-56 pubmed publisher
Gallipoli P, Cook A, Rhodes S, Hopcroft L, Wheadon H, Whetton A, et al. JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo. Blood. 2014;124:1492-501 pubmed publisher
Rosu Myles M, McCully J, Fair J, Mehic J, Menendez P, Rodriguez R, et al. The globoseries glycosphingolipid SSEA-4 is a marker of bone marrow-derived clonal multipotent stromal cells in vitro and in vivo. Stem Cells Dev. 2013;22:1387-97 pubmed publisher
Liu R, Ratajczak M. Enumeration of very small embryonic-like stem cells in peripheral blood. Methods Mol Biol. 2012;904:207-19 pubmed publisher
Rosu Myles M, She Y, Fair J, Muradia G, Mehic J, Menendez P, et al. Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells. PLoS ONE. 2012;7:e38954 pubmed publisher
Velazquez V, Hon H, Ibegbu C, Knechtle S, Kirk A, Grakoui A. Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection. Hepatology. 2012;56:2071-81 pubmed publisher
Groh J, Weis J, Zieger H, Stanley E, Heuer H, Martini R. Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X. Brain. 2012;135:88-104 pubmed publisher
Elknerová K, Lacinova Z, Soucek J, Marinov I, Stockbauer P. Growth inhibitory effect of the antibody to hematopoietic stem cell antigen CD34 in leukemic cell lines. Neoplasma. 2007;54:311-20 pubmed
Baumheter S, Singer M, Henzel W, Hemmerich S, Renz M, Rosen S, et al. Binding of L-selectin to the vascular sialomucin CD34. Science. 1993;262:436-8 pubmed
Sutherland D, Watt S, Dowden G, Karhi K, Baker M, Greaves M, et al. Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34. Leukemia. 1988;2:793-803 pubmed
product information
Product Type :
Antibody
Product Name :
CD34 Monoclonal Antibody (4H11), eBioscience™
Catalog # :
14-0349-82
Quantity :
100µg
Price :
US 117
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Human
Clone :
4H11
Isotype :
IgG1, kappa
Storage :
4° C
Description :
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
AU040960; CD34; CD34 antigen; CD34 molecule; cluster designation 34; Hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; LOC100343670; Mucosialin; RP11-328D5.2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA