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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD27 Monoclonal Antibody (O323), eBioscience
catalog :
14-0279-37
quantity :
2 mg
price :
US 1372.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
O323
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 24
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 4j
Brown G, Ca xf1 ete P, Wang H, Medhavy A, Bones J, Roco J, et al. TLR7 gain-of-function genetic variation causes human lupus. Nature. 2022;605:349-356 pubmed publisher
  • flow cytometry; human; loading ...; fig 4d
Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, et al. Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration. Cell Death Dis. 2020;11:973 pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
Liu G, Yu Y, Feng F, Zhu P, Zhang H, Zhang D, et al. Human CD8+CD28- T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo. BMC Immunol. 2020;21:23 pubmed publisher
Koers J, Marsman C, Steuten J, Tol S, Derksen N, ten Brinke A, et al. Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination. Front Immunol. 2022;13:1082154 pubmed publisher
Dhariwala M, Karthikeyan D, Vasquez K, Farhat S, Weckel A, Taravati K, et al. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020;1:100132 pubmed publisher
Wang Q, Sun Q, Chen Q, Li H, Liu D. Expression of CD27 and CD28 on γδ T cells from the peripheral blood of patients with allergic rhinitis. Exp Ther Med. 2020;20:224 pubmed publisher
Shi Z, Zhang Q, Yan H, Yang Y, Wang P, Zhang Y, et al. More than one antibody of individual B cells revealed by single-cell immune profiling. Cell Discov. 2019;5:64 pubmed publisher
Rosenberg B, Depla M, Freije C, Gaucher D, Mazouz S, Boisvert M, et al. Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance. PLoS Pathog. 2018;14:e1007290 pubmed publisher
Wallin E, Hill D, Linterman M, Wood K. The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells. Front Immunol. 2018;9:1184 pubmed publisher
Wang Z, Zhu L, Nguyen T, Wan Y, Sant S, Quiñones Parra S, et al. Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease. Nat Commun. 2018;9:824 pubmed publisher
Nguyen T, Sant S, Bird N, Grant E, Clemens E, Koutsakos M, et al. Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly. J Leukoc Biol. 2017;: pubmed publisher
Kong F, Feng B, Zhang H, Rao H, Wang J, Cong X, et al. Abnormal phenotypic features of IgM+B cell subsets in patients with chronic hepatitis C virus infection. Exp Ther Med. 2017;14:1846-1852 pubmed publisher
Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, et al. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities. Oncoimmunology. 2017;6:e1283460 pubmed publisher
Nguyen T, Bird N, Grant E, Miles J, Thomas P, Kotsimbos T, et al. Maintenance of the EBV-specific CD8+ TCR?? repertoire in immunosuppressed lung transplant recipients. Immunol Cell Biol. 2017;95:77-86 pubmed publisher
Cairo C, Longinaker N, Cappelli G, Leke R, Ondo M, Djokam R, et al. Cord blood V?2V?2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity. J Infect Dis. 2014;209:1653-62 pubmed publisher
Ndungu F, Lundblom K, Rono J, Illingworth J, Eriksson S, Farnert A. Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers. Eur J Immunol. 2013;43:2919-29 pubmed publisher
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
Illingworth J, Butler N, Roetynck S, Mwacharo J, Pierce S, Bejon P, et al. Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol. 2013;190:1038-47 pubmed publisher
Perreau M, Savoye A, De Crignis E, Corpataux J, Cubas R, Haddad E, et al. Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J Exp Med. 2013;210:143-56 pubmed publisher
Mahnke Y, Beddall M, Roederer M. OMIP-013: differentiation of human T-cells. Cytometry A. 2012;81:935-6 pubmed publisher
Scheeren F, Van Geelen C, Yasuda E, Spits H, Beaumont T. Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5. PLoS ONE. 2011;6:e17189 pubmed publisher
Kuzin I, Sun H, Moshkani S, Feng C, Mantalaris A, Wu J, et al. Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor. Biotechnol Bioeng. 2011;108:1430-40 pubmed publisher
Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, et al. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol. 2009;183:5407-17 pubmed publisher
Humblet Baron S, Sather B, Anover S, Becker Herman S, Kasprowicz D, Khim S, et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. 2007;117:407-18 pubmed
product information
Product Type :
Antibody
Product Name :
CD27 Monoclonal Antibody (O323), eBioscience
Catalog # :
14-0279-37
Quantity :
2 mg
Price :
US 1372.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test
Species :
Human
Clone :
O323
Isotype :
IgG1, kappa
Storage :
4° C
Description :
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test
Aliases :
CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; LPFS2; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA