product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD25 Monoclonal Antibody (PC61.5), eBioscience
catalog :
14-0251-86
quantity :
1 mg
price :
US 351
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
PC61.5
reactivity :
mouse
application :
western blot, immunocytochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 355
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig 3f
Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, et al. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun. 2021;12:3754 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 7a
Borges P, Waclawiak I, Georgii J, Fraga Junior V, Barros J, Lemos F, et al. Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation. Front Immunol. 2021;12:651740 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1l
Melin N, Sánchez Taltavull D, Fahrner R, Keogh A, Dosch M, Büchi I, et al. Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury. Cell Death Dis. 2021;12:366 pubmed publisher
  • flow cytometry; mouse
Chu A, Kok S, TSUI J, Lin M, Aguirre B, Wadehra M. Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface. J Reprod Immunol. 2021;145:103309 pubmed publisher
  • flow cytometry; mouse; loading ...
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4h
Svensson M, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody K, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020;6:eaba4353 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Steer C, Mathä L, Shim H, Takei F. Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period. JCI Insight. 2020;5: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Zhou S, Wu W, Wang Z, Wang Z, Su Q, Li X, et al. RelB regulates the homeostatic proliferation but not the function of Tregs. BMC Immunol. 2020;21:37 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6s1
Canel M, Taggart D, Sims A, Lonergan D, Waizenegger I, Serrels A. T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; fig s3
Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher
  • flow cytometry; mouse; loading ...; fig e4d
Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019;576:143-148 pubmed publisher
  • flow cytometry; mouse; loading ...
Di Pilato M, Kim E, Cadilha B, Prüßmann J, Nasrallah M, Seruggia D, et al. Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. Nature. 2019;570:112-116 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7a
Kawalkowska J, Ogbechi J, Venables P, Williams R. cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs. Sci Adv. 2019;5:eaaw5422 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Visekruna A, Hartmann S, Sillke Y, Glauben R, Fischer F, Raifer H, et al. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019;129:1972-1983 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1e
Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, et al. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med. 2019;: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8a
Li F, Zeng Z, Xing S, Gullicksrud J, Shan Q, Choi J, et al. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018;9:5452 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4e
Cheng Y, Zhu X, Wang X, Zhuang Q, Huyan X, Sun X, et al. Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Front Immunol. 2018;9:1566 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Baens M, Stirparo R, Lampi Y, Verbeke D, Vandepoel R, Cools J, et al. Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice. Eur J Immunol. 2018;48:1728-1738 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 4c
Splitt S, Souza S, Valentine K, Castellanos B, Curd A, Hoyer K, et al. PD-L1, TIM-3, and CTLA-4 Blockade Fails To Promote Resistance to Secondary Infection with Virulent Strains of Toxoplasma gondii. Infect Immun. 2018;86: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Turner D, Goldklang M, Cvetkovski F, Paik D, Trischler J, Barahona J, et al. Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma. J Immunol. 2018;200:1561-1569 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Ferdinand J, Richard A, Meylan F, Al Shamkhani A, Siegel R. Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells. J Immunol. 2018;200:1360-1369 pubmed publisher
  • flow cytometry; mouse; 1:1000; loading ...; fig 2f
Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2c
Ibitokou S, Dillon B, Sinha M, Szczesny B, Delgadillo A, Reda Abdelrahman D, et al. Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection. J Immunol. 2018;200:643-656 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6f
Harly C, Cam M, Kaye J, Bhandoola A. Development and differentiation of early innate lymphoid progenitors. J Exp Med. 2018;215:249-262 pubmed publisher
  • flow cytometry; mouse; fig 9c
Wasiuk A, Testa J, Weidlick J, Sisson C, Vitale L, Widger J, et al. CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy. J Immunol. 2017;199:4110-4123 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Capece T, Walling B, Lim K, Kim K, Bae S, Chung H, et al. A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation. J Cell Biol. 2017;216:3817-3829 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Francis N, Every A, Ayodele B, Pike R, Mackie E, Pagel C. A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development. Int J Biochem Cell Biol. 2017;92:95-103 pubmed publisher
  • flow cytometry; mouse; fig 5a
Strandt H, Pinheiro D, Kaplan D, Wirth D, GRATZ I, Hammerl P, et al. Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance. J Immunol. 2017;199:1626-1634 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3e
Levine A, Mendoza A, Hemmers S, Moltedo B, Niec R, Schizas M, et al. Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017;546:421-425 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d
Li C, Leng Y, Zhao B, Gao C, Du F, Jin N, et al. Human iPSC-MSC-Derived Xenografts Modulate Immune Responses by Inhibiting the Cleavage of Caspases. Stem Cells. 2017;35:1719-1732 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Chien C, Yu H, Chen S, Chiang B. Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells. Sci Rep. 2017;7:46348 pubmed publisher
  • flow cytometry; mouse; loading ...
Bouziat R, Hinterleitner R, Brown J, Stencel Baerenwald J, Ikizler M, Mayassi T, et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017;356:44-50 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
van der Vlugt L, Obieglo K, Ozir Fazalalikhan A, Sparwasser T, Haeberlein S, Smits H. Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function. Int J Parasitol. 2017;47:545-554 pubmed publisher
  • flow cytometry; mouse; fig 1a
Bruce D, Stefanski H, Vincent B, Dant T, Reisdorf S, Bommiasamy H, et al. Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease. J Clin Invest. 2017;127:1813-1825 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 1a
Katerndahl C, Heltemes Harris L, Willette M, Henzler C, Frietze S, Yang R, et al. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol. 2017;18:694-704 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7b
Leech J, Lacey K, Mulcahy M, Medina E, McLoughlin R. IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections. J Immunol. 2017;198:2352-2365 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Araujo L, Khim P, Mkhikian H, Mortales C, Demetriou M. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. elife. 2017;6: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Engler J, Kursawe N, Solano M, Patas K, Wehrmann S, Heckmann N, et al. Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. Proc Natl Acad Sci U S A. 2017;114:E181-E190 pubmed publisher
  • flow cytometry; mouse; loading ...
Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
  • flow cytometry; mouse; loading ...
Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, et al. GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal. Cell Death Dis. 2016;7:e2478 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7a
Ju X, Silveira P, Hsu W, Elgundi Z, Alingcastre R, Verma N, et al. The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population. J Immunol. 2016;197:4613-4625 pubmed
  • flow cytometry; mouse; fig 4d
Cummings R, Barbet G, Bongers G, Hartmann B, Gettler K, Muniz L, et al. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs. Nature. 2016;539:565-569 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2e
Massaad M, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, et al. Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest. 2016;126:4219-4236 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Butcher M, Filipowicz A, Waseem T, McGary C, Crow K, Magilnick N, et al. Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFN?+ Th1/Tregs. Circ Res. 2016;119:1190-1203 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, et al. Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion. J Exp Med. 2016;213:1881-900 pubmed publisher
  • flow cytometry; mouse; fig s1
Pizzolla A, Oh D, Luong S, Prickett S, Henstridge D, Febbraio M, et al. High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance. PLoS ONE. 2016;11:e0160407 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Cheng H, Gaddis D, Wu R, McSkimming C, Haynes L, Taylor A, et al. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest. 2016;126:3236-46 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  • flow cytometry; mouse; fig 5c
Keil M, Sonner J, Lanz T, Oezen I, Bunse T, Bittner S, et al. General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation. J Neuroimmunol. 2016;297:117-26 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1c
De Grove K, Provoost S, Hendriks R, McKenzie A, Seys L, Kumar S, et al. Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses. J Allergy Clin Immunol. 2017;139:246-257.e4 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3b
Sujino T, London M, Hoytema van Konijnenburg D, Rendon T, Buch T, Silva H, et al. Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science. 2016;352:1581-6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Stier M, Bloodworth M, Toki S, Newcomb D, Goleniewska K, Boyd K, et al. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. J Allergy Clin Immunol. 2016;138:814-824.e11 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Galloway A, Saveliev A, Łukasiak S, Hodson D, Bolland D, Balmanno K, et al. RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence. Science. 2016;352:453-9 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig S2c
O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d
Chandrasekaran U, Yi W, Gupta S, Weng C, Giannopoulou E, Chinenov Y, et al. Regulation of Effector Treg Cells in Murine Lupus. Arthritis Rheumatol. 2016;68:1454-66 pubmed publisher
  • flow cytometry; mouse; fig 3b
Bothur E, Raifer H, Haftmann C, Stittrich A, Brüstle A, Brenner D, et al. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun. 2015;6:8576 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2a
Metz P, Lopez J, Kim S, Akimoto K, Ohno S, Chang J. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep. 2016;6:19182 pubmed publisher
  • flow cytometry; mouse; loading ...
Jabara H, Boyden S, Chou J, Ramesh N, Massaad M, Benson H, et al. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016;48:74-8 pubmed publisher
  • flow cytometry; mouse; fig s7
Brasseit J, Althaus Steiner E, Faderl M, Dickgreber N, Saurer L, Genitsch V, et al. CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis. Mucosal Immunol. 2016;9:689-701 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Guo L, Huang Y, Chen X, Hu Li J, Urban J, Paul W. Innate immunological function of TH2 cells in vivo. Nat Immunol. 2015;16:1051-9 pubmed publisher
  • flow cytometry; mouse
Xin L, Jiang T, Kinder J, Ertelt J, Way S. Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice. Aging Cell. 2015;14:1122-6 pubmed publisher
  • flow cytometry; mouse; fig 1
Berent Maoz B, Montecino Rodriguez E, Fice M, Casero D, Seet C, Crooks G, et al. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS ONE. 2015;10:e0125414 pubmed publisher
  • flow cytometry; mouse; 1:500; fig 4
Rouhani S, Eccles J, Riccardi P, Peske J, Tewalt E, Cohen J, et al. Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. Nat Commun. 2015;6:6771 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6b
Lal G, Nakayama Y, Sethi A, Singh A, Burrell B, Kulkarni N, et al. Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance. Transplantation. 2015;99:1817-28 pubmed publisher
  • flow cytometry; mouse; fig 4e
Hu Lieskovan S, Mok S, Homet Moreno B, Tsoi J, Robert L, Goedert L, et al. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci Transl Med. 2015;7:279ra41 pubmed publisher
  • flow cytometry; mouse; fig s2
Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
  • western blot; mouse; 1:100; fig 5,6
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed publisher
  • flow cytometry; mouse
Triplett T, Tucker C, Triplett K, Alderman Z, Sun L, Ling L, et al. STAT3 Signaling Is Required for Optimal Regression of Large Established Tumors in Mice Treated with Anti-OX40 and TGFβ Receptor Blockade. Cancer Immunol Res. 2015;3:526-35 pubmed publisher
  • flow cytometry; mouse; fig s2
Clouthier D, Zhou A, Wortzman M, Luft O, Levy G, Watts T. GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection. PLoS Pathog. 2015;11:e1004517 pubmed publisher
  • flow cytometry; mouse
Teixeira L, Moreira J, Melo J, Bezerra F, Marques R, Ferreirinha P, et al. Immune response in the adipose tissue of lean mice infected with the protozoan parasite Neospora caninum. Immunology. 2015;145:242-57 pubmed publisher
  • flow cytometry; mouse; tbl 1
Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, et al. Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. J Neuroinflammation. 2015;12:208 pubmed publisher
  • flow cytometry; mouse; fig s5
Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed publisher
  • flow cytometry; mouse; 1:1000
Lees J, Duffy S, Perera C, Moalem Taylor G. Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury. Cytokine. 2015;71:207-14 pubmed publisher
  • flow cytometry; mouse; fig 4
Guo X, Tanaka Y, Kondo M. Thymic precursors of TCRαβ(+)CD8αα(+) intraepithelial lymphocytes are negative for CD103. Immunol Lett. 2015;163:40-8 pubmed publisher
  • flow cytometry; mouse; 1:100
Maneva Radicheva L, Amatya C, Parker C, Ellefson J, Radichev I, Raghavan A, et al. Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. PLoS ONE. 2014;9:e107213 pubmed publisher
  • flow cytometry; mouse; fig 2
Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F, et al. Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. PLoS ONE. 2014;9:e102804 pubmed publisher
  • flow cytometry; mouse; fig 1
Au Yeung B, Melichar H, Ross J, Cheng D, Zikherman J, Shokat K, et al. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014;15:687-94 pubmed publisher
  • flow cytometry; mouse
Geem D, Medina Contreras O, McBride M, Newberry R, Koni P, Denning T. Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes. J Immunol. 2014;193:431-8 pubmed publisher
  • flow cytometry; mouse
Cochain C, Chaudhari S, Koch M, Wiendl H, Eckstein H, Zernecke A. Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice. PLoS ONE. 2014;9:e93280 pubmed publisher
  • flow cytometry; mouse; 1:100
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, et al. Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun. 2014;5:3436 pubmed publisher
  • flow cytometry; mouse
Vanoaica L, Richman L, Jaworski M, Darshan D, Luther S, Kühn L. Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations. PLoS ONE. 2014;9:e89270 pubmed publisher
  • flow cytometry; mouse
Lee J, Walsh M, Hoehn K, James D, Wherry E, Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol. 2014;192:3190-9 pubmed publisher
  • flow cytometry; mouse
Xiong H, Maraver A, Latkowski J, Henderson T, Schlessinger K, Ding Y, et al. Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells. PLoS ONE. 2013;8:e84841 pubmed publisher
  • flow cytometry; mouse
Salem H, Trojanowski B, Fiedler K, Maier H, Schirmbeck R, Wagner M, et al. Long-term IKK2/NF-?B signaling in pancreatic ?-cells induces immune-mediated diabetes. Diabetes. 2014;63:960-75 pubmed publisher
  • flow cytometry; mouse; fig 3
Chopra M, Lang I, Salzmann S, Pachel C, Kraus S, Bäuerlein C, et al. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS ONE. 2013;8:e75737 pubmed publisher
  • flow cytometry; mouse; fig 5a
Redecke V, Wu R, Zhou J, Finkelstein D, Chaturvedi V, High A, et al. Hematopoietic progenitor cell lines with myeloid and lymphoid potential. Nat Methods. 2013;10:795-803 pubmed publisher
  • flow cytometry; mouse
Kipari T, Hadoke P, Iqbal J, Man T, Miller E, Coutinho A, et al. 11?-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis. FASEB J. 2013;27:1519-31 pubmed publisher
  • flow cytometry; mouse
Golias J, Schwarzer M, Wallner M, Kverka M, Kozakova H, Srůtková D, et al. Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy. PLoS ONE. 2012;7:e37156 pubmed publisher
  • flow cytometry; mouse; fig 3
Tousif S, Singh Y, Prasad D, Sharma P, Van Kaer L, Das G. T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection. PLoS ONE. 2011;6:e19864 pubmed publisher
  • flow cytometry; mouse; fig 1
Goldstein J, Balderas R, Marodon G. Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus. PLoS ONE. 2011;6:e19038 pubmed publisher
  • flow cytometry; mouse
Imada M, Masuda K, Satoh R, Ito Y, Goto Y, Matsuoka T, et al. Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses. Int Immunol. 2009;21:1151-61 pubmed publisher
  • flow cytometry; mouse; fig 5
Schartner J, Singh A, Dahlberg P, Nettenstrom L, Seroogy C. Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures. Clin Exp Immunol. 2009;155:348-56 pubmed publisher
  • flow cytometry; mouse
Sheng H, Wang Y, Jin Y, Zhang Q, Zhang Y, Wang L, et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res. 2008;18:846-57 pubmed publisher
  • flow cytometry; mouse
Park S, Han Y, Aleyas A, George J, Yoon H, Lee J, et al. Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure. Immunology. 2008;123:426-37 pubmed
  • flow cytometry; mouse; fig 3A
Stephens G, Andersson J, Shevach E. Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol. 2007;178:6901-11 pubmed
  • flow cytometry; mouse; fig 2
Huang B, Zhao J, Shen S, Li H, He K, Shen G, et al. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res. 2007;67:4346-52 pubmed
  • flow cytometry; mouse
Hamdy S, Elamanchili P, Alshamsan A, Molavi O, Satou T, Samuel J. Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D,L-lactic-co-glycolic acid) nanoparticles. J Biomed Mater Res A. 2007;81:652-62 pubmed
  • flow cytometry; mouse; fig 4
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product information
Product Type :
Antibody
Product Name :
CD25 Monoclonal Antibody (PC61.5), eBioscience
Catalog # :
14-0251-86
Quantity :
1 mg
Price :
US 351
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
PC61.5
Isotype :
IgG1, lambda
Storage :
4° C
Description :
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
ADA; ADA1; Adenosine aminohydrolase; adenosine deaminase; CD25; CD25 antigen; cytokine receptor; IDDM10; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; il-2 receptor alpha; IL-2 Receptor alpha chain; IL-2 receptor alpha subunit; IL2 receptor subunit alpha; IL-2 receptor subunit alpha; IL2R; IL-2R alpha; IL-2R alpha chain; IL2R subunit alpha; IL-2R subunit alpha; Il2ra; IL-2RA; IL-2-RA; IL2-RA; Il2ra antibody; IL2RAC; IMD41; interleukin 2 receptor; interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha; interleukin-2 receptor alpha chain; interleukin-2 receptor alpha subunit; interleukin-2 receptor beta chain; Interleukin2 receptor subunit alpha; interleukin-2 receptor subunit alpha; Ly-43; p55; p55 chain; sIL 2R; soluble IL 2 receptor; TAC antigen; TCGFR
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA