This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD25 Monoclonal Antibody (PC61.5), eBioscience™
catalog :
14-0251-81
quantity :
50 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
PC61.5
reactivity :
mouse
application :
flow cytometry
citations: 159
Reference
Walker J, Clark P, Crisp A, Barlow J, Szeto A, Ferreira A, et al. Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow. Immunity. 2019;: pubmed publisher
Xu W, Cherrier D, Chea S, Vosshenrich C, Serafini N, Petit M, et al. An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials. Immunity. 2019;50:1054-1068.e3 pubmed publisher
Xu Y, Tang X, Yang M, Zhang S, Li S, Chen Y, et al. Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway. Mediators Inflamm. 2019;2019:4652596 pubmed publisher
Lee H, Lee J, Kim D, Lim S, Kang I, Choi J. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis. Nat Commun. 2019;10:709 pubmed publisher
Ng K, Yui M, Mehta A, Siu S, Irwin B, Pease S, et al. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. elife. 2018;7: pubmed publisher
Chen J, Yang N, Liu H, Yao H, Wang J, Yang Y, et al. Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model. Oncol Lett. 2018;16:3022-3028 pubmed publisher
Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Yokoyama I, et al. Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice. J Neuroimmunol. 2018;319:80-92 pubmed publisher
Brasseit J, Kwong Chung C, Noti M, Zysset D, Hoheisel Dickgreber N, Genitsch V, et al. Divergent Roles of Interferon-γ and Innate Lymphoid Cells in Innate and Adaptive Immune Cell-Mediated Intestinal Inflammation. Front Immunol. 2018;9:23 pubmed publisher
Wei Y, Zhang Z, Wang F, Zhou S. Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma. Exp Ther Med. 2018;15:649-656 pubmed publisher
Tamura R, Uemoto S, Tabata Y. Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model. Inflamm Regen. 2016;36:26 pubmed publisher
Singh P, Pua H, Happ H, Schneider C, von Moltke J, Locksley R, et al. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 2017;214:3627-3643 pubmed publisher
Taylor A, Rothstein D, Rudd C. Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy. Cancer Res. 2018;78:706-717 pubmed publisher
Wang Q, Ning H, Peng H, Wei L, Hou R, Hoft D, et al. Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses. Nat Commun. 2017;8:867 pubmed publisher
Huang S, Wei P, Hwang Verslues W, Kuo W, Jeng Y, Hu C, et al. TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. EMBO Mol Med. 2017;9:1660-1680 pubmed publisher
Alzubi J, Pallant C, Mussolino C, Howe S, Thrasher A, Cathomen T. Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Sci Rep. 2017;7:12475 pubmed publisher
Levine A, Mendoza A, Hemmers S, Moltedo B, Niec R, Schizas M, et al. Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017;546:421-425 pubmed publisher
Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjo Y, et al. Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities. Oncol Rep. 2017;38:449-455 pubmed publisher
Xiong Y, Brinkman C, Famulski K, Mongodin E, Lord C, Hippen K, et al. A robust in vitro model for trans-lymphatic endothelial migration. Sci Rep. 2017;7:1633 pubmed publisher
Chen J, Zhang M, Zhou F, Wang J, Niu B, Zhang W. Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model. Oncol Lett. 2017;13:2323-2329 pubmed publisher
Zhu F, Willette Brown J, Song N, Lomada D, Song Y, Xue L, et al. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe. 2017;21:478-493.e7 pubmed publisher
Chien C, Yu H, Chen S, Chiang B. Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells. Sci Rep. 2017;7:46348 pubmed publisher
Wilbers R, Westerhof L, van Noort K, Obieglo K, Driessen N, Everts B, et al. Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants. Sci Rep. 2017;7:45910 pubmed publisher
Chapman L, Ture S, Field D, Morrell C. miR-451 limits CD4+ T cell proliferative responses to infection in mice. Immunol Res. 2017;65:828-840 pubmed publisher
Bardina S, Brown J, Michlmayr D, Hoffman K, Sum J, Pletnev A, et al. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017;91: pubmed publisher
Gebauer C, Pignolet B, Yshii L, Mauré E, Bauer J, Liblau R. CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model. Oncoimmunology. 2017;6:e1260212 pubmed publisher
Scharschmidt T, Vasquez K, Pauli M, Leitner E, Chu K, Truong H, et al. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe. 2017;21:467-477.e5 pubmed publisher
Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
Leech J, Lacey K, Mulcahy M, Medina E, McLoughlin R. IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections. J Immunol. 2017;198:2352-2365 pubmed publisher
Kim M, Kim T, Kim H, Doh J, Lee K. Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster. Sci Rep. 2017;7:40623 pubmed publisher
Araujo L, Khim P, Mkhikian H, Mortales C, Demetriou M. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. elife. 2017;6: pubmed publisher
Engler J, Kursawe N, Solano M, Patas K, Wehrmann S, Heckmann N, et al. Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. Proc Natl Acad Sci U S A. 2017;114:E181-E190 pubmed publisher
Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, et al. GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal. Cell Death Dis. 2016;7:e2478 pubmed publisher
Kleinpeter P, Fend L, Thioudellet C, Geist M, Sfrontato N, Koerper V, et al. Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition. Oncoimmunology. 2016;5:e1220467 pubmed
Ju X, Silveira P, Hsu W, Elgundi Z, Alingcastre R, Verma N, et al. The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population. J Immunol. 2016;197:4613-4625 pubmed
Massaad M, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, et al. Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest. 2016;126:4219-4236 pubmed publisher
Itamura H, Shindo T, Tawara I, Kubota Y, Kariya R, Okada S, et al. The MEK inhibitor trametinib separates murine graft-versus-host disease from graft-versus-tumor effects. JCI Insight. 2016;1:e86331 pubmed publisher
Ruan G, Tao B, Wang D, Li Y, Wu J, Yin G. Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model. Exp Ther Med. 2016;12:1428-1434 pubmed
Massoud A, Charbonnier L, Lopez D, Pellegrini M, Phipatanakul W, Chatila T. An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. Nat Med. 2016;22:1013-22 pubmed publisher
Stifter K, Schuster C, Schlosser M, Boehm B, Schirmbeck R. Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination. Sci Rep. 2016;6:29419 pubmed publisher
Pane J, Fleming F, Graham K, Thomas H, Kay T, Coulson B. Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling. Sci Rep. 2016;6:29697 pubmed publisher
Chen L, Nicholson Y, Rosborough B, Thomson A, Raimondi G. A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells. J Immunol. 2016;197:1137-47 pubmed publisher
Keil M, Sonner J, Lanz T, Oezen I, Bunse T, Bittner S, et al. General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation. J Neuroimmunol. 2016;297:117-26 pubmed publisher
Allison K, Sajti E, Collier J, Gosselin D, Troutman T, Stone E, et al. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. elife. 2016;5: pubmed publisher
do Canto F, Campos S, Granato A, da Silva R, de Paiva L, Nóbrega A, et al. Enlarged colitogenic T cell population paradoxically supports colitis prevention through the B-lymphocyte-dependent peripheral generation of CD4(+)Foxp3(+) Treg cells. Sci Rep. 2016;6:28573 pubmed publisher
Lee H, Kim J, Quan W, Lee J, Kim M, Kim S, et al. Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis. Autophagy. 2016;12:1390-403 pubmed publisher
Brinkman C, Iwami D, Hritzo M, Xiong Y, Ahmad S, Simon T, et al. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration. Nat Commun. 2016;7:12021 pubmed publisher
Gu L, Deng W, Sun X, Zhou H, Xu Q. Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance. Mol Med Rep. 2016;14:1153-61 pubmed publisher
Su Y, Connolly M, Marketon A, Heiland T. CryJ-LAMP DNA Vaccines for Japanese Red Cedar Allergy Induce Robust Th1-Type Immune Responses in Murine Model. J Immunol Res. 2016;2016:4857869 pubmed publisher
Cao W, Guo J, Wen X, Miao L, Lin F, Xu G, et al. CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation. Nat Commun. 2016;7:11687 pubmed publisher
Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisher
O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher
Monticelli L, Buck M, Flamar A, Saenz S, Tait Wojno E, Yudanin N, et al. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol. 2016;17:656-65 pubmed publisher
Yue Y, Li P, Song N, Li B, Li Z, Guo Y, et al. Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model. Mol Med Rep. 2016;13:4183-90 pubmed publisher
Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, et al. LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest. 2016;126:1267-81 pubmed publisher
Foy S, Mandl S, dela Cruz T, Cote J, Gordon E, Trent E, et al. Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells. Cancer Immunol Immunother. 2016;65:537-49 pubmed publisher
Kim A, Kim H, Kim D, Nam S, Kim H, Park Y, et al. Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow's milk casein-induced allergic responses in mice. Sci Rep. 2016;6:19685 pubmed publisher
Metz P, Lopez J, Kim S, Akimoto K, Ohno S, Chang J. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep. 2016;6:19182 pubmed publisher
McDonald P, Read K, Baker C, Anderson A, Powell M, Ballesteros Tato A, et al. IL-7 signalling represses Bcl-6 and the TFH gene program. Nat Commun. 2016;7:10285 pubmed publisher
Mujal A, Gilden J, Gérard A, Kinoshita M, Krummel M. A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Nat Immunol. 2016;17:315-22 pubmed publisher
Traka M, Podojil J, McCarthy D, Miller S, Popko B. Oligodendrocyte death results in immune-mediated CNS demyelination. Nat Neurosci. 2016;19:65-74 pubmed publisher
Zhong Y, Tang H, Wang X, Zeng Q, Liu Y, Zhao X, et al. Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis. Clin Exp Immunol. 2016;183:452-68 pubmed publisher
Zhou S, Jin X, Chen X, Zhu J, Xu Z, Wang X, et al. Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis Japonica. PLoS ONE. 2015;10:e0139133 pubmed publisher
Kawahara M, Takaku H. A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells. Cancer Biol Ther. 2015;16:1616-25 pubmed publisher
Mitagami Y, Yasunaga J, Kinosada H, Ohshima K, Matsuoka M. Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice. PLoS Pathog. 2015;11:e1005120 pubmed publisher
Derkow K, Krüger C, Dembny P, Lehnardt S. Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation. PLoS ONE. 2015;10:e0135898 pubmed publisher
Fabbiano S, Menacho Márquez M, Robles Valero J, Pericacho M, Matesanz Marín A, García Macías C, et al. Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions. Mol Cell Biol. 2015;35:3528-46 pubmed publisher
Singh K, Kadesjö E, Lindroos J, Hjort M, Lundberg M, Espes D, et al. Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells. Sci Rep. 2015;5:12633 pubmed publisher
Laidlaw B, Cui W, Amezquita R, Gray S, Guan T, Lu Y, et al. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015;16:871-9 pubmed publisher
Tamehiro N, Oda H, Shirai M, Suzuki H. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE. 2015;10:e0131047 pubmed publisher
Tähtinen S, Kaikkonen S, Merisalo Soikkeli M, Grönberg Vähä Koskela S, Kanerva A, Parviainen S, et al. Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors. PLoS ONE. 2015;10:e0131242 pubmed publisher
Khan I, Perrard X, Brunner G, Lui H, Sparks L, Smith S, et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. Int J Obes (Lond). 2015;39:1607-18 pubmed publisher
Voisinne G, Nixon B, Melbinger A, Gasteiger G, Vergassola M, Altan Bonnet G. T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens. Cell Rep. 2015;11:1208-19 pubmed
Walker J, Oliphant C, Englezakis A, Yu Y, Clare S, Rodewald H, et al. Bcl11b is essential for group 2 innate lymphoid cell development. J Exp Med. 2015;212:875-82 pubmed publisher
Park H, Park J, Jeong Y, Son J, Ban Y, Lee B, et al. PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells. J Immunol. 2015;194:5801-11 pubmed publisher
Rouhani S, Eccles J, Riccardi P, Peske J, Tewalt E, Cohen J, et al. Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. Nat Commun. 2015;6:6771 pubmed publisher
Cuadrado Castano S, Ayllon J, Mansour M, de la Iglesia Vicente J, Jordan S, Tripathi S, et al. Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models. Mol Cancer Ther. 2015;14:1247-58 pubmed publisher
Metz P, Arsenio J, Kakaradov B, Kim S, Remedios K, Oakley K, et al. Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι. J Immunol. 2015;194:2249-59 pubmed publisher
Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, et al. Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. J Neuroinflammation. 2015;12:208 pubmed publisher
Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, et al. Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation. Nat Commun. 2014;5:5780 pubmed publisher
Rashkovan M, Vadnais C, Ross J, Gigoux M, Suh W, Gu W, et al. Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination. Proc Natl Acad Sci U S A. 2014;111:E5411-9 pubmed publisher
Hongo D, Tang X, Baker J, Engleman E, Strober S. Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance. Am J Transplant. 2014;14:2467-77 pubmed publisher
Donaldson D, Bradford B, Artis D, Mabbott N. Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23. Mucosal Immunol. 2015;8:582-95 pubmed publisher
Schmoeckel K, Traffehn S, Eger C, Pötschke C, Bröker B. Full activation of CD4+ T cells early during sepsis requires specific antigen. Shock. 2015;43:192-200 pubmed publisher
May S, Zhou Q, Lewellen M, Carter C, Coffey D, Highfill S, et al. Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. PLoS ONE. 2014;9:e100629 pubmed publisher
Xiao N, Eto D, Elly C, Peng G, Crotty S, Liu Y. The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Nat Immunol. 2014;15:657-66 pubmed publisher
Bhadra R, Moretto M, Castillo J, Petrovas C, Ferrando Martinez S, Shokal U, et al. Intrinsic TGF-? signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. J Clin Invest. 2014;124:2441-55 pubmed publisher
Liu Y, Liu A, Iikuni N, Xu H, Shi F, La Cava A. Regulatory CD4+ T cells promote B cell anergy in murine lupus. J Immunol. 2014;192:4069-73 pubmed publisher
Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V. Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. J Immunol. 2014;192:3618-25 pubmed publisher
Arsenio J, Kakaradov B, Metz P, Kim S, Yeo G, Chang J. Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Nat Immunol. 2014;15:365-372 pubmed publisher
Takiishi T, Ding L, Baeke F, Spagnuolo I, Sebastiani G, Laureys J, et al. Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term. Diabetes. 2014;63:2026-36 pubmed publisher
Ribes S, Meister T, Ott M, Redlich S, Janova H, Hanisch U, et al. Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection. J Neuroinflammation. 2014;11:14 pubmed publisher
Liu H, Liu Z, Chao H, Li Z, Song Z, Yang Y, et al. High-dose interferon-? promotes abortion in mice by suppressing Treg and Th17 polarization. J Interferon Cytokine Res. 2014;34:394-403 pubmed publisher
Zanello G, Goethel A, Forster K, Geddes K, Philpott D, Croitoru K. Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis. PLoS ONE. 2013;8:e82623 pubmed publisher
Chen L, Zhou S, Qin J, Hu H, Ma H, Liu B, et al. Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma. Mol Cancer. 2013;12:153 pubmed publisher
Duwaerts C, Sun E, Cheng C, Van Rooijen N, Gregory S. Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction. PLoS ONE. 2013;8:e79702 pubmed publisher
Duarte J, Di Meglio P, Hirota K, Ahlfors H, Stockinger B. Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo. PLoS ONE. 2013;8:e79819 pubmed publisher
Diaz de Durana Y, Lau J, Knee D, Filippi C, Londei M, McNamara P, et al. IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes. PLoS ONE. 2013;8:e78483 pubmed publisher
Sledzińska A, Hemmers S, Mair F, Gorka O, Ruland J, Fairbairn L, et al. TGF-? signalling is required for CD4? T cell homeostasis but dispensable for regulatory T cell function. PLoS Biol. 2013;11:e1001674 pubmed publisher
Fulton R, Weiss K, Pewe L, Harty J, Varga S. Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection. J Virol. 2013;87:12694-700 pubmed publisher
Hong C, Nam A, Keller H, Ligons D, Park J, Yoon H, et al. Interleukin-6 expands homeostatic space for peripheral T cells. Cytokine. 2013;64:532-40 pubmed publisher
Yu K, Zhu P, Dong Q, Zhong Y, Zhu Z, Lin Y, et al. Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice. J Am Heart Assoc. 2013;2:e000391 pubmed publisher
Redecke V, Wu R, Zhou J, Finkelstein D, Chaturvedi V, High A, et al. Hematopoietic progenitor cell lines with myeloid and lymphoid potential. Nat Methods. 2013;10:795-803 pubmed publisher
Tao X, Ma J, Zhang Y, Yu J, Cai L, Wang J, et al. Neutralization of IL-4 and IFN-? Facilitates inducing TGF-?-induced CD4(+)Foxp3(+) Regulatory Cells. Int J Biomed Sci. 2008;4:52-7 pubmed
Hu J, Zhang L, Wang N, Ding R, Cui S, Zhu F, et al. Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions. Kidney Int. 2013;84:521-31 pubmed publisher
Roy S, Stevens M, So L, Edinger A. Reciprocal effects of rab7 deletion in activated and neglected T cells. Autophagy. 2013;9:1009-23 pubmed publisher
Guo C, Kogan S, Amano S, Wang M, Dagdeviren S, Friedline R, et al. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab. 2013;304:E951-63 pubmed publisher
Zhu M, Nagavalli A, Su M. Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res. 2013;73:2104-16 pubmed publisher
Izhak L, Ambrosino E, Kato S, Parish S, O Konek J, Weber H, et al. Delicate balance among three types of T cells in concurrent regulation of tumor immunity. Cancer Res. 2013;73:1514-23 pubmed publisher
Barr K, Jing W, Hallett W, Gershan J, Johnson B. Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity. J Immunother. 2013;36:41-51 pubmed publisher
Wan W, Lionakis M, Liu Q, Roffe E, Murphy P. Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice. Cardiovasc Res. 2013;97:580-8 pubmed publisher
Alari Pahissa E, Notario L, Lorente E, Vega Ramos J, Justel A, Lopez D, et al. CD69 does not affect the extent of T cell priming. PLoS ONE. 2012;7:e48593 pubmed publisher
Castillo E, Dekonenko A, Arko Mensah J, Mandell M, Dupont N, Jiang S, et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A. 2012;109:E3168-76 pubmed publisher
Tewalt E, Cohen J, Rouhani S, Guidi C, Qiao H, Fahl S, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012;120:4772-82 pubmed publisher
van der Marel S, Majowicz A, Kwikkers K, van Logtenstein R, te Velde A, De Groot A, et al. Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis. World J Gastroenterol. 2012;18:4288-99 pubmed publisher
Koga T, Ichinose K, Mizui M, Crispin J, Tsokos G. Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. J Immunol. 2012;189:3490-6 pubmed
Bezman N, Kim C, Sun J, Min oo G, Hendricks D, Kamimura Y, et al. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012;13:1000-9 pubmed publisher
Schallenberg S, Petzold C, Tsai P, Sparwasser T, Kretschmer K. Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells. PLoS ONE. 2012;7:e41971 pubmed publisher
Manta C, Heupel E, Radulovic K, Rossini V, Garbi N, Riedel C, et al. CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 2013;6:177-88 pubmed publisher
Ettinger M, Peckl Schmid D, Gruber C, Laimer M, Thalhamer J, Hintner H, et al. Transcutaneous gene gun delivery of hNC16A Induces BPAG2-specific tolerance. J Invest Dermatol. 2012;132:1665-71 pubmed publisher
Jhunjhunwala S, Balmert S, Raimondi G, Dons E, Nichols E, Thomson A, et al. Controlled release formulations of IL-2, TGF-?1 and rapamycin for the induction of regulatory T cells. J Control Release. 2012;159:78-84 pubmed publisher
Hickman H, Li L, Reynoso G, Rubin E, Skon C, Mays J, et al. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med. 2011;208:2511-24 pubmed publisher
Wang R, Xie H, Huang Z, Ma J, Fang X, Ding Y, et al. T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway. J Immunol. 2011;187:5964-73 pubmed publisher
Grigorian A, Araujo L, Naidu N, Place D, Choudhury B, Demetriou M. N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis. J Biol Chem. 2011;286:40133-41 pubmed publisher
Van Belle T, Esplugues E, Liao J, Juntti T, Flavell R, Von Herrath M. Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol. 2011;187:2915-22 pubmed publisher
Hoves S, Sutton V, Haynes N, Hawkins E, Fernández Ruiz D, Baschuk N, et al. A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. J Immunol. 2011;187:1166-75 pubmed publisher
Woller N, Knocke S, Mundt B, Gürlevik E, Strüver N, Kloos A, et al. Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice. J Clin Invest. 2011;121:2570-82 pubmed publisher
Gaddis D, Michalek S, Katz J. TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B. J Immunol. 2011;186:5772-83 pubmed publisher
Ramer Tait A, Petersen C, Jones D. IL-2 limits IL-12 enhanced lymphocyte proliferation during Leishmania amazonensis infection. Cell Immunol. 2011;270:32-9 pubmed publisher
Hall J, Cannons J, Grainger J, Dos Santos L, Hand T, Naik S, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 2011;34:435-47 pubmed publisher
McFarland A, Savan R, Wagage S, Addison A, Ramakrishnan K, Karwan M, et al. Localized delivery of interferon-? by Lactobacillus exacerbates experimental colitis. PLoS ONE. 2011;6:e16967 pubmed publisher
Chen Y, Scheuplein F, Driver J, Hewes A, Reifsnyder P, Leiter E, et al. Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. J Immunol. 2011;186:4278-84 pubmed publisher
Divekar A, Dubey S, Gangalum P, Singh R. Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu. J Immunol. 2011;186:924-30 pubmed publisher
Cheng C, Duwaerts C, Rooijen N, Wintermeyer P, Mott S, Gregory S. NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism. J Hepatol. 2011;54:746-52 pubmed publisher
Thorburn A, O Sullivan B, Thomas R, Kumar R, Foster P, Gibson P, et al. Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease. Thorax. 2010;65:1053-60 pubmed publisher
McCarl C, Khalil S, Ma J, Oh Hora M, Yamashita M, Roether J, et al. Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol. 2010;185:5845-58 pubmed publisher
Zhu Y, Ju S, Chen E, Dai S, Li C, MOREL P, et al. T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol. 2010;185:3174-83 pubmed publisher
Ramadani F, Bolland D, Garcon F, Emery J, Vanhaesebroeck B, Corcoran A, et al. The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development. Sci Signal. 2010;3:ra60 pubmed publisher
Schmidt N, Butler N, Badovinac V, Harty J. Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. PLoS Pathog. 2010;6:e1000998 pubmed publisher
Grimm M, Gasser M, Bueter M, Strehl J, Wang J, Nichiporuk E, et al. Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases. BMC Cancer. 2010;10:82 pubmed publisher
Yang Z, Zhang B, Li D, Lv M, Huang C, Shen G, et al. Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS ONE. 2010;5:e8922 pubmed publisher
Armstrong A, Gebre A, Parks J, Hedrick C. ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. J Immunol. 2010;184:173-83 pubmed publisher
Feuerer M, Shen Y, Littman D, Benoist C, Mathis D. How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity. 2009;31:654-64 pubmed publisher
Marks B, Nowyhed H, Choi J, Poholek A, Odegard J, Flavell R, et al. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat Immunol. 2009;10:1125-32 pubmed publisher
Koch M, Tucker Heard G, Perdue N, Killebrew J, Urdahl K, Campbell D. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol. 2009;10:595-602 pubmed publisher
Tao R, Hancock W. Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival. PLoS ONE. 2008;3:e2321 pubmed publisher
Couper K, Blount D, Wilson M, Hafalla J, Belkaid Y, Kamanaka M, et al. IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog. 2008;4:e1000004 pubmed publisher
Lee S, Grigorian A, Pawling J, Chen I, Gao G, Mozaffar T, et al. N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem. 2007;282:33725-34 pubmed
Heffner M, Fearon D. Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte. Proc Natl Acad Sci U S A. 2007;104:13414-9 pubmed
Sun C, Hall J, Blank R, Bouladoux N, Oukka M, Mora J, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007;204:1775-85 pubmed
Tuve S, Chen B, Liu Y, Cheng T, Toure P, Sow P, et al. Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses. Cancer Res. 2007;67:5929-39 pubmed
Sather B, Treuting P, Perdue N, Miazgowicz M, Fontenot J, Rudensky A, et al. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med. 2007;204:1335-47 pubmed
Huang B, Zhao J, Shen S, Li H, He K, Shen G, et al. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res. 2007;67:4346-52 pubmed
Humblet Baron S, Sather B, Anover S, Becker Herman S, Kasprowicz D, Khim S, et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. 2007;117:407-18 pubmed
Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007;204:57-63 pubmed
Li W, Green W. The role of CD4 T cells in the pathogenesis of murine AIDS. J Virol. 2006;80:5777-89 pubmed
So T, Song J, Sugie K, Altman A, Croft M. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A. 2006;103:3740-5 pubmed
Knoechel B, Lohr J, Kahn E, Bluestone J, Abbas A. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med. 2005;202:1375-86 pubmed
Zou L, Barnett B, Safah H, Larussa V, Evdemon Hogan M, Mottram P, et al. Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals. Cancer Res. 2004;64:8451-5 pubmed
product information
Product Type :
Antibody
Product Name :
CD25 Monoclonal Antibody (PC61.5), eBioscience™
Catalog # :
14-0251-81
Quantity :
50 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
PC61.5
Isotype :
IgG1, lambda
Storage :
4° C
Description :
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
CD25; cytokine receptor; IDDM10; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; il-2 receptor alpha; IL-2 Receptor alpha chain; IL-2 receptor alpha subunit; IL2 receptor subunit alpha; IL-2 receptor subunit alpha; IL2R; IL-2R alpha; IL-2R alpha chain; IL2R subunit alpha; IL-2R subunit alpha; Il2ra; IL-2RA; IL-2-RA; IL2-RA; Il2ra antibody; IL2RAC; IMD41; interleukin 2 receptor; interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha; interleukin-2 receptor alpha chain; interleukin-2 receptor beta chain; Interleukin2 receptor subunit alpha; interleukin-2 receptor subunit alpha; Ly-43; p55; p55 chain; sIL 2R; soluble IL 2 receptor; TAC antigen; TCGFR
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA