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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD20 Monoclonal Antibody (2H7), eBioscience
catalog :
14-0209-37
quantity :
2 mg
price :
US 1378.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2H7
reactivity :
human
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 37
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 4b
Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, et al. Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration. Cell Death Dis. 2020;11:973 pubmed publisher
Liu R, Luo Q, Luo W, Wan L, Zhu Q, Yin X, et al. A Soluble NK-CAR Mediates the Specific Cytotoxicity of NK Cells toward the Target CD20+ Lymphoma Cells. Aging Dis. 2022;13:1576-1588 pubmed publisher
Müller M, Gräbnitz F, Barandun N, Shen Y, Wendt F, Steiner S, et al. Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks. Nat Commun. 2021;12:7036 pubmed publisher
Chen C, Huang X, Zhu W, Ding C, Huang P, Li R. TRPA1 triggers hyperalgesia and inflammation after tooth bleaching. Sci Rep. 2021;11:17418 pubmed publisher
Perez F, Ruera C, Miculán E, Carasi P, Dubois Camacho K, Garbi L, et al. IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease. Front Immunol. 2020;11:581445 pubmed publisher
Huot N, Rascle P, Petitdemange C, Contreras V, Palgen J, Stahl Hennig C, et al. Non-human Primate Determinants of Natural Killer Cells in Tissues at Steady-State and During Simian Immunodeficiency Virus Infection. Front Immunol. 2020;11:2134 pubmed publisher
Tian J, Ma K, Pei C, Zhang S, Li X, Zhou Y, et al. Relative safety of various spermatogenic stem cell purification methods for application in spermatogenic stem cell transplantation. Stem Cell Res Ther. 2019;10:382 pubmed publisher
Caeser R, Di Re M, Krupka J, Gao J, Lara Chica M, Dias J, et al. Genetic modification of primary human B cells to model high-grade lymphoma. Nat Commun. 2019;10:4543 pubmed publisher
Colonna L, Peterson C, Schell J, Carlson J, Tkachev V, Brown M, et al. Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation. Nat Commun. 2018;9:4438 pubmed publisher
Somasundaram R, Zhang G, Fukunaga Kalabis M, Perego M, Krepler C, Xu X, et al. Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Nat Commun. 2017;8:607 pubmed publisher
Yeap W, Wong K, Shimasaki N, Teo E, Quek J, Yong H, et al. CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. Sci Rep. 2016;6:34310 pubmed publisher
Care M, Stephenson S, Barnes N, Fan I, Zougman A, El Sherbiny Y, et al. Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity. J Immunol. 2016;197:1447-59 pubmed publisher
Vaccari M, Gordon S, Fourati S, Schifanella L, Liyanage N, Cameron M, et al. Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. Nat Med. 2016;22:762-70 pubmed publisher
Shahaf G, Zisman Rozen S, Benhamou D, Melamed D, Mehr R. B Cell Development in the Bone Marrow Is Regulated by Homeostatic Feedback Exerted by Mature B Cells. Front Immunol. 2016;7:77 pubmed publisher
Phuah J, Wong E, Gideon H, Maiello P, Coleman M, Hendricks M, et al. Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques. Infect Immun. 2016;84:1301-1311 pubmed publisher
Geherin S, Gómez D, Glabman R, Ruthel G, Hamann A, Debes G. IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin. J Immunol. 2016;196:2514-2525 pubmed publisher
Wingender G, Kronenberg M. OMIP-030: Characterization of human T cell subsets via surface markers. Cytometry A. 2015;87:1067-9 pubmed publisher
Venkatasubramanian S, Tripathi D, Tucker T, Paidipally P, Cheekatla S, Welch E, et al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. Eur J Immunol. 2016;46:464-79 pubmed publisher
Chen X, Li J, Zeng L, Zhang X, Lu X, Zuo M, et al. Sexual Differences in Cell Loss during the Post-Hatch Development of Song Control Nuclei in the Bengalese Finch. PLoS ONE. 2015;10:e0125802 pubmed publisher
Jochems S, Jacquelin B, Chauveau L, Huot N, Petitjean G, Lepelley A, et al. Plasmacytoid Dendritic Cell Infection and Sensing Capacity during Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infection. J Virol. 2015;89:6918-27 pubmed publisher
Bachanova V, Frankel A, Cao Q, Lewis D, Grzywacz B, Verneris M, et al. Phase I study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies. Clin Cancer Res. 2015;21:1267-72 pubmed publisher
Jochems S, Petitjean G, Kunkel D, Liovat A, Ploquin M, Barré Sinoussi F, et al. Modulation of type I interferon-associated viral sensing during acute simian immunodeficiency virus infection in African green monkeys. J Virol. 2015;89:751-62 pubmed publisher
Jacquelin B, Petitjean G, Kunkel D, Liovat A, Jochems S, Rogers K, et al. Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection. PLoS Pathog. 2014;10:e1004241 pubmed publisher
Harfuddin Z, Kwajah S, Chong Nyi Sim A, MacAry P, Schwarz H. CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses. Oncoimmunology. 2013;2:e26859 pubmed
Lam T, Thomas L, White C, Li G, Pone E, Xu Z, et al. Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS ONE. 2013;8:e80414 pubmed publisher
Jensen K, Brusletto B, Aass H, Olstad O, Kierulf P, Gautvik K. Transcriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations. PLoS ONE. 2013;8:e70721 pubmed publisher
Chicaybam L, Sodré A, Curzio B, Bonamino M. An efficient low cost method for gene transfer to T lymphocytes. PLoS ONE. 2013;8:e60298 pubmed publisher
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
Sestak K, Feely S, Fey B, Dufour J, Hargitt E, Alvarez X, et al. Experimental inoculation of juvenile rhesus macaques with primate enteric caliciviruses. PLoS ONE. 2012;7:e37973 pubmed publisher
Heidt S, Hester J, Shankar S, Friend P, Wood K. B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naïve B cells. Am J Transplant. 2012;12:1784-92 pubmed publisher
Kean L, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, et al. Significant mobilization of both conventional and regulatory T cells with AMD3100. Blood. 2011;118:6580-90 pubmed publisher
De Gobbi M, Garrick D, Lynch M, Vernimmen D, Hughes J, Goardon N, et al. Generation of bivalent chromatin domains during cell fate decisions. Epigenetics Chromatin. 2011;4:9 pubmed publisher
Mattila J, Diedrich C, Lin P, Phuah J, Flynn J. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol. 2011;186:3527-37 pubmed publisher
Larsen C, Page A, Linzie K, Russell M, Deane T, Stempora L, et al. An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching. Am J Transplant. 2010;10:2396-409 pubmed publisher
Shimizu R, Kikuchi J, Wada T, Ozawa K, Kano Y, Furukawa Y. HDAC inhibitors augment cytotoxic activity of rituximab by upregulating CD20 expression on lymphoma cells. Leukemia. 2010;24:1760-8 pubmed publisher
Poulin L, Salio M, Griessinger E, Anjos Afonso F, Craciun L, Chen J, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med. 2010;207:1261-71 pubmed publisher
Brown K, Barratt Boyes S. Surface phenotype and rapid quantification of blood dendritic cell subsets in the rhesus macaque. J Med Primatol. 2009;38:272-8 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD20 Monoclonal Antibody (2H7), eBioscience
Catalog # :
14-0209-37
Quantity :
2 mg
Price :
US 1378.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): Assay-Dependent
Species :
Human
Clone :
2H7
Isotype :
IgG2b, kappa
Storage :
4° C
Description :
CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): Assay-Dependent
Aliases :
AA960661; APY; ATOPY; B1; B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; Cd20; CD20 antigen; CD20 cell surface protein; CD20 receptor; CVID5; EGK_06167; Fc epsilon receptor I beta chain; Fc Fragment of IgE high affinity I receptor for beta polypeptide; FCER1B; High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; IGEL; IGER; IGHER; LEU16; LEU-16; Leukocyte surface antigen Leu-16; Ly44; Ly-44; Lymphocyte antigen 44; membrane spanning 4-domains A1; membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; MGC3969; MS4A1; MS4A2; S7
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA