This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD20 Monoclonal Antibody (L26), eBioscience
catalog :
14-0202-95
quantity :
10 mg
price :
US 3705.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
L26

The same clone is also sold as:
reactivity :
crab eating macaque, human, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 9
Reference
Zwart E, van Ee T, Doppenberg D, Farina A, Wilmink J, Versteijne E, et al. The immune microenvironment after neoadjuvant therapy compared to upfront surgery in patients with pancreatic cancer. J Cancer Res Clin Oncol. 2023;149:14731-14743 pubmed publisher
Radovic S, Meng W, Chen L, Paniz Mondolfi A, Bryce C, Grimes Z, et al. SARS-CoV-2 infection of kidney tissues from severe COVID-19 patients. J Med Virol. 2023;95:e28566 pubmed publisher
Smirnova N, Riemondy K, Bueno M, Collins S, Suresh P, Wang X, et al. Single-cell transcriptome mapping identifies a local, innate B cell population driving chronic rejection after lung transplantation. JCI Insight. 2022;7: pubmed publisher
Moysi E, Del Rio Estrada P, Torres Ruiz F, Reyes Teran G, Koup R, Petrovas C. In Situ Characterization of Human Lymphoid Tissue Immune Cells by Multispectral Confocal Imaging and Quantitative Image Analysis; Implications for HIV Reservoir Characterization. Front Immunol. 2021;12:683396 pubmed publisher
Pascal L, Dhir R, Balasubramani G, Chen W, Hudson C, Srivastava P, et al. Claudin-1 down-regulation in the prostate is associated with aging and increased infiltration of inflammatory cells in BPH. Am J Clin Exp Urol. 2021;9:53-64 pubmed
Ferrando Martinez S, Moysi E, Pegu A, Andrews S, Nganou Makamdop K, Ambrozak D, et al. Accumulation of follicular CD8+ T cells in pathogenic SIV infection. J Clin Invest. 2018;128:2089-2103 pubmed publisher
Iguchi T, Takaori K, Mii A, Sato Y, Suzuki Y, Yoshifuji H, et al. Glucocorticoid receptor expression in resident and hematopoietic cells in IgG4-related disease. Mod Pathol. 2018;31:890-899 pubmed publisher
Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, et al. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight. 2016;1:e87680 pubmed publisher
Peperzak V, Slinger E, Ter Burg J, Eldering E. Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling. Cell Death Differ. 2017;24:111-119 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD20 Monoclonal Antibody (L26), eBioscience
Catalog # :
14-0202-95
Quantity :
10 mg
Price :
US 3705.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Cynomolgus Monkey, Human, Rhesus Monkey
Applications :
Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 0.5 ug/mL
Species :
Cynomolgus Monkey, Human, Rhesus Monkey
Clone :
L26
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 0.5 ug/mL
Aliases :
AA960661; APY; ATOPY; B1; B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; Cd20; CD20 antigen; CD20 cell surface protein; CD20 receptor; CVID5; EGK_06167; Fc epsilon receptor I beta chain; Fc Fragment of IgE high affinity I receptor for beta polypeptide; FCER1B; High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; IGEL; IGER; IGHER; LEU16; LEU-16; Leukocyte surface antigen Leu-16; Ly44; Ly-44; Lymphocyte antigen 44; membrane spanning 4-domains A1; membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; MGC3969; MS4A1; MS4A2; S7
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA