This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD5 Monoclonal Antibody (53-7.3), eBioscience™
catalog :
14-0051-85
quantity :
500 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
53-7.3
reactivity :
mouse
application :
immunohistochemistry, immunoprecipitation, flow cytometry
citations: 38
Reference
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. elife. 2018;7: pubmed publisher
Niemeyer B, Oko L, Medina E, Oldenburg D, White D, Cool C, et al. Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis. J Virol. 2018;92: pubmed publisher
Freitas C, Hamblin G, Raymond C, Weber K. Naïve helper T cells with high CD5 expression have increased calcium signaling. PLoS ONE. 2017;12:e0178799 pubmed publisher
Murphy P, Wang J, Bhagwat S, MUNGER J, Janssen W, Wright T, et al. CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages. Cell Death Differ. 2017;24:559-570 pubmed publisher
Alrefai H, Muhammad K, Rudolf R, Pham D, Klein Hessling S, Patra A, et al. NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun. 2016;7:11724 pubmed publisher
Cao W, Guo J, Wen X, Miao L, Lin F, Xu G, et al. CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation. Nat Commun. 2016;7:11687 pubmed publisher
Pietras E, Mirantes Barbeito C, Fong S, Loeffler D, Kovtonyuk L, Zhang S, et al. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nat Cell Biol. 2016;18:607-18 pubmed publisher
Monticelli L, Buck M, Flamar A, Saenz S, Tait Wojno E, Yudanin N, et al. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol. 2016;17:656-65 pubmed publisher
Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, et al. LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest. 2016;126:1267-81 pubmed publisher
Tang C, Zundell J, Ranatunga S, Lin C, Nefedova Y, Del Valle J, et al. Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells. Cancer Res. 2016;76:2137-52 pubmed publisher
Harmon D, Srikakulapu P, Kaplan J, Oldham S, McSkimming C, Garmey J, et al. Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016;36:682-91 pubmed publisher
Saulep Easton D, Vincent F, Quah P, Wei A, Ting S, Croce C, et al. The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells. Leukemia. 2016;30:163-72 pubmed publisher
Mohapatra A, Van Dyken S, Schneider C, Nussbaum J, Liang H, Locksley R. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol. 2016;9:275-86 pubmed publisher
Tamehiro N, Oda H, Shirai M, Suzuki H. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE. 2015;10:e0131047 pubmed publisher
Pone E, Lam T, Lou Z, Wang R, Chen Y, Liu D, et al. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015;194:3065-78 pubmed publisher
Mackley E, Houston S, Marriott C, Halford E, LUCAS B, Cerovic V, et al. CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nat Commun. 2015;6:5862 pubmed publisher
Hansell C, Maclellan L, Oldham R, Doonan J, Chapple K, Anderson E, et al. The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunol Cell Biol. 2015;93:167-76 pubmed publisher
Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, et al. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. elife. 2014;3:e04177 pubmed publisher
Zvezdova E, Lee J, El Khoury D, Barr V, Akpan I, Samelson L, et al. In vivo functional mapping of the conserved protein domains within murine Themis1. Immunol Cell Biol. 2014;92:721-8 pubmed publisher
Derderian S, Togarrati P, King C, Moradi P, Reynaud D, Czechowicz A, et al. In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice. Blood. 2014;124:973-80 pubmed publisher
Tang C, Ranatunga S, Kriss C, Cubitt C, Tao J, Pinilla Ibarz J, et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014;124:2585-98 pubmed publisher
Cho J, Kim H, Kim K, Yang D, Surh C, Sprent J. Unique features of naive CD8+ T cell activation by IL-2. J Immunol. 2013;191:5559-73 pubmed publisher
Florian M, Nattamai K, Dörr K, Marka G, Uberle B, Vas V, et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature. 2013;503:392-6 pubmed publisher
Kerenyi M, Shao Z, Hsu Y, Guo G, Luc S, O Brien K, et al. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. elife. 2013;2:e00633 pubmed publisher
Jordan S, Ruzsics Z, Mitrović M, Baranek T, Arapović J, Krmpotić A, et al. Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection. Cell Host Microbe. 2013;13:535-545 pubmed publisher
Roediger B, Kyle R, Yip K, Sumaria N, Guy T, Kim B, et al. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol. 2013;14:564-73 pubmed publisher
Zhong M, Veillette A. Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity. Mol Cell Biol. 2013;33:1223-32 pubmed publisher
Mandl J, Monteiro J, Vrisekoop N, Germain R. T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity. 2013;38:263-274 pubmed publisher
Bezman N, Kim C, Sun J, Min oo G, Hendricks D, Kamimura Y, et al. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012;13:1000-9 pubmed publisher
Do J, Valujskikh A, Vignali D, Fairchild R, Min B. Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proc Natl Acad Sci U S A. 2012;109:12698-703 pubmed publisher
Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, et al. PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ. 2012;19:1722-32 pubmed publisher
Chaplin J, Kasahara S, Clark E, Ledbetter J. Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway. J Immunol. 2011;187:4199-209 pubmed publisher
Zhong X, Rothstein T. L2pB1: a new player in autoimmunity. Mol Immunol. 2011;48:1292-300 pubmed publisher
Smith S, Haas K, Poe J, Yanaba K, Ward C, Migone T, et al. B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. Int Immunol. 2010;22:681-91 pubmed publisher
Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, et al. Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood. 2010;115:995-1005 pubmed publisher
Gross A, Lyandres J, Panigrahi A, Prak E, DeFranco A. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009;182:5382-92 pubmed publisher
Sabnis A, Cheung L, Dail M, Kang H, Santaguida M, Hermiston M, et al. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009;7:e59 pubmed publisher
Wang C, McDonald K, McDonough J, Newberry R. Murine isolated lymphoid follicles contain follicular B lymphocytes with a mucosal phenotype. Am J Physiol Gastrointest Liver Physiol. 2006;291:G595-604 pubmed
product information
Product Type :
Antibody
Product Name :
CD5 Monoclonal Antibody (53-7.3), eBioscience™
Catalog # :
14-0051-85
Quantity :
500 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-Dependent
Species :
Mouse
Clone :
53-7.3
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-Dependent
Aliases :
CD antigen CD5; CD5; CD5 antigen; CD5 antigen (p56-62); CD5 antigen p56-62; Cd5 molecule; CD5 protein; CD74 antigen, invariant polypeptide of major; fCD5; LEU1; Ly-1; Ly-12; Ly-A; Lymphocyte antigen 1; Lymphocyte antigen CD5; lymphocyte antigen T1/Leu-1; Lyt-1; Pan T cell; T1; T-cell surface glycoprotein CD5; unnamed protein product
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA