product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (OKT4 (OKT-4)), eBioscience™
catalog :
14-0048-80
quantity :
25 µg
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OKT4 (OKT-4)
reactivity :
African green monkey, human, rat, rhesus macaque
application :
immunoprecipitation, flow cytometry
more info or order :
citations: 143
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 6c
Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, et al. Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration. Cell Death Dis. 2020;11:973 pubmed publisher
  • flow cytometry; human; loading ...; fig 2a
Brouwer P, Caniels T, van der Straten K, Snitselaar J, Aldon Y, Bangaru S, et al. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability. Science. 2020;369:643-650 pubmed publisher
  • flow cytometry; human; loading ...; fig 1c
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed publisher
  • flow cytometry; human; loading ...; fig 2e
Boardman D, Philippeos C, Fruhwirth G, Ibrahim M, Hannen R, Cooper D, et al. Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection. Am J Transplant. 2017;17:931-943 pubmed publisher
  • flow cytometry; human; loading ...
Stikvoort A, Sundin M, Uzunel M, Gertow J, Sundberg B, Schaffer M, et al. Long-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant?. PLoS ONE. 2016;11:e0154737 pubmed publisher
  • flow cytometry; human; loading ...; fig 1c
James E, Gates T, LaFond R, Yamamoto S, Ni C, Mai D, et al. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. PLoS Pathog. 2016;12:e1005375 pubmed publisher
  • flow cytometry; human; fig 4, 5
Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed publisher
  • flow cytometry; human
Broos C, van Nimwegen M, Kleinjan A, Ten Berge B, Muskens F, In t Veen J, et al. Impaired survival of regulatory T cells in pulmonary sarcoidosis. Respir Res. 2015;16:108 pubmed publisher
  • flow cytometry; human
Cousens L, Najafian N, Martin W, De Groot A. Tregitope: Immunomodulation powerhouse. Hum Immunol. 2014;75:1139-46 pubmed publisher
  • flow cytometry; human
Wilson E, Singh A, Hullsiek K, Gibson D, Henry W, Lichtenstein K, et al. Monocyte-activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection. J Infect Dis. 2014;210:1396-406 pubmed publisher
  • flow cytometry; African green monkey; loading ...; fig 1c
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
  • flow cytometry; rhesus macaque
Klatt N, Estes J, Sun X, Ortiz A, Barber J, Harris L, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 2012;5:646-57 pubmed publisher
  • flow cytometry; human
Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, MacDonald A, et al. Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE. 2012;7:e35466 pubmed publisher
  • flow cytometry; human; fig s1
Teirlinck A, McCall M, Roestenberg M, Scholzen A, Woestenenk R, de Mast Q, et al. Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans. PLoS Pathog. 2011;7:e1002389 pubmed publisher
  • flow cytometry; rhesus macaque; loading ...; fig 2a
Taaffe J, Bosinger S, Del Prete G, Else J, Ratcliffe S, Ward C, et al. CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques. J Med Primatol. 2012;41:24-42 pubmed publisher
  • flow cytometry; rat; 12 ug/ml; tbl 2
Wu Y, Ren M, Yang R, Liang X, Ma Y, Tang Y, et al. Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis. Arthritis Res Ther. 2011;13:R29 pubmed publisher
  • flow cytometry; rhesus macaque
Klatt N, Shudo E, Ortiz A, Engram J, Paiardini M, Lawson B, et al. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS Pathog. 2010;6:e1000747 pubmed publisher
Serra Peinado C, Grau Expósito J, Luque Ballesteros L, Astorga Gamaza A, Navarro J, Gallego Rodriguez J, et al. Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab. Nat Commun. 2019;10:3705 pubmed publisher
Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, et al. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe. 2019;25:578-587.e5 pubmed publisher
Chen Y, Ma D, Wang X, Fang J, Liu X, Song J, et al. Calnexin Impairs the Antitumor Immunity of CD4+ and CD8+ T Cells. Cancer Immunol Res. 2019;7:123-135 pubmed publisher
Brey C, Proff J, Teufert N, Salzer B, Brozy J, Munz M, et al. A gB/CD3 bispecific BiTE antibody construct for targeting Human Cytomegalovirus-infected cells. Sci Rep. 2018;8:17453 pubmed publisher
Arbore G, West E, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun. 2018;9:4186 pubmed publisher
Chen X, Wang Y, Wang J, Wen J, Jia X, Wang X, et al. Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients. Oncol Lett. 2018;16:253-261 pubmed publisher
Wallin E, Hill D, Linterman M, Wood K. The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells. Front Immunol. 2018;9:1184 pubmed publisher
Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher
Lebedeva A, Vorobyeva D, Vagida M, Ivanova O, Felker E, Fitzgerald W, et al. Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis. Atherosclerosis. 2017;267:90-98 pubmed publisher
Li Y, Brauer P, Singh J, Xhiku S, Yoganathan K, Zuniga Pflucker J, et al. Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis. Stem Cell Reports. 2017;9:779-795 pubmed publisher
Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, et al. Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight. 2017;2: pubmed publisher
Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, et al. Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing. Sci Immunol. 2017;2: pubmed publisher
Horwitz J, Bar On Y, Lu C, Fera D, Lockhart A, Lorenzi J, et al. Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo. Cell. 2017;170:637-648.e10 pubmed publisher
Richard J, Veillette M, Ding S, Zoubchenok D, Alsahafi N, Coutu M, et al. Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity. EBioMedicine. 2016;3:122-134 pubmed publisher
Lin Y, Winokur P, Blake A, Wu T, Manischewitz J, King L, et al. Patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination. Neurol Neuroimmunol Neuroinflamm. 2016;3:e196 pubmed publisher
Muller L, Mitsuhashi M, Simms P, Gooding W, Whiteside T. Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets. Sci Rep. 2016;6:20254 pubmed publisher
Quintremil S, Alberti C, Rivera M, Medina F, Puente J, Cartier L, et al. Tax and Semaphorin 4D Released from Lymphocytes Infected with Human Lymphotropic Virus Type 1 and Their Effect on Neurite Growth. AIDS Res Hum Retroviruses. 2016;32:68-79 pubmed publisher
Nduom E, Wei J, Yaghi N, Huang N, Kong L, Gabrusiewicz K, et al. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol. 2016;18:195-205 pubmed publisher
Taborda N, González S, Alvarez C, Correa L, Montoya C, Rugeles M. Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers. PLoS ONE. 2015;10:e0136292 pubmed publisher
Garcia Perez J, Staropoli I, Azoulay S, Heinrich J, Cascajero A, Colin P, et al. A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity. Retrovirology. 2015;12:50 pubmed publisher
Goodfellow H, Frushicheva M, Ji Q, Cheng D, Kadlecek T, Cantor A, et al. The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. Sci Signal. 2015;8:ra49 pubmed publisher
Preza G, Yang O, Elliott J, Anton P, Ochoa M. T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols. PLoS ONE. 2015;10:e0122723 pubmed publisher
Ji Q, Salomon A. Wide-scale quantitative phosphoproteomic analysis reveals that cold treatment of T cells closely mimics soluble antibody stimulation. J Proteome Res. 2015;14:2082-9 pubmed publisher
Magalhaes I, Pingris K, Poitou C, Bessoles S, Venteclef N, Kiaf B, et al. Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients. J Clin Invest. 2015;125:1752-62 pubmed publisher
Veillette M, Coutu M, Richard J, Batraville L, Dagher O, Bernard N, et al. The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals. J Virol. 2015;89:545-51 pubmed publisher
Ji Q, Ding Y, Salomon A. SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling. Mol Cell Proteomics. 2015;14:30-40 pubmed publisher
Zhen A, Krutzik S, Levin B, Kasparian S, Zack J, Kitchen S. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J Virol. 2014;88:9934-46 pubmed publisher
Chen C, Hsu H, Hudgens E, Telfer J, Baldwin C. Signal transduction by different forms of the ?? T cell-specific pattern recognition receptor WC1. J Immunol. 2014;193:379-90 pubmed publisher
Martínez Muñoz L, Barroso R, Dyrhaug S, Navarro G, Lucas P, Soriano S, et al. CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface. Proc Natl Acad Sci U S A. 2014;111:E1960-9 pubmed publisher
Tang Y, Xu X, Guo S, Zhang C, Tang Y, Tian Y, et al. An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma. PLoS ONE. 2014;9:e91551 pubmed publisher
Foley M, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, et al. High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. PLoS ONE. 2014;9:e87873 pubmed publisher
Colin S, Darne B, Kadi A, Ferry A, Favier M, Lesaffre C, et al. The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich mRNA stability by reducing 14-3-3?-tristetraprolin protein complex, reducing inflammation and psoriatic lesion size in patients. J Pharmacol Exp Ther. 2014;349:107-17 pubmed publisher
Wertheimer A, Bennett M, Park B, Uhrlaub J, Martinez C, Pulko V, et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol. 2014;192:2143-55 pubmed publisher
Harfuddin Z, Kwajah S, Chong Nyi Sim A, MacAry P, Schwarz H. CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses. Oncoimmunology. 2013;2:e26859 pubmed
Ryden A, Faresjö M. Efficient expansion of cryopreserved CD4(+)CD25(+)CD127(lo/-) cells in Type 1 diabetes. Results Immunol. 2011;1:36-44 pubmed publisher
Baker J, Hullsiek K, Singh A, Wilson E, Henry K, Lichtenstein K, et al. Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort. AIDS. 2014;28:831-40 pubmed publisher
Fujiyuki T, Yoneda M, Yasui F, Kuraishi T, Hattori S, Kwon H, et al. Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). PLoS ONE. 2013;8:e83551 pubmed publisher
Kim K, Srikanth S, Tan Y, Yee M, Jew M, Damoiseaux R, et al. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014;192:110-22 pubmed publisher
Shubin N, Monaghan S, Heffernan D, Chung C, Ayala A. B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients. Crit Care. 2013;17:R276 pubmed publisher
McGee K, Haim H, Korioth Schmitz B, Espy N, Javanbakht H, Letvin N, et al. The selection of low envelope glycoprotein reactivity to soluble CD4 and cold during simian-human immunodeficiency virus infection of rhesus macaques. J Virol. 2014;88:21-40 pubmed publisher
Sena A, Grishina I, Thai A, Goulart L, Macal M, Fenton A, et al. Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease. PLoS ONE. 2013;8:e76969 pubmed publisher
Blom L, Poulsen L. In vitro Th1 and Th2 cell polarization is severely influenced by the initial ratio of naïve and memory CD4+ T cells. J Immunol Methods. 2013;397:55-60 pubmed publisher
Haberthur K, Kraft A, Arnold N, Park B, Meyer C, Asquith M, et al. Genome-wide analysis of T cell responses during acute and latent simian varicella virus infections in rhesus macaques. J Virol. 2013;87:11751-61 pubmed publisher
Chen C, Yao S, Huang D, Wei H, Sicard H, Zeng G, et al. Phosphoantigen/IL2 expansion and differentiation of V?2V?2 T cells increase resistance to tuberculosis in nonhuman primates. PLoS Pathog. 2013;9:e1003501 pubmed publisher
Helou Y, Nguyen V, Beik S, Salomon A. ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells. PLoS ONE. 2013;8:e69641 pubmed publisher
Baan E, de Ronde A, Stax M, Sanders R, Luchters S, Vyankandondera J, et al. HIV-1 autologous antibody neutralization associates with mother to child transmission. PLoS ONE. 2013;8:e69274 pubmed publisher
Liu X, Gao N, Li M, Xu D, Hou Y, Wang Q, et al. Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS ONE. 2013;8:e64531 pubmed publisher
Cecil D, Park K, Gad E, Childs J, Higgins D, Plymate S, et al. T-helper I immunity, specific for the breast cancer antigen insulin-like growth factor-I receptor (IGF-IR), is associated with increased adiposity. Breast Cancer Res Treat. 2013;139:657-65 pubmed publisher
Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz A, et al. CD40L expression permits CD8+ T cells to execute immunologic helper functions. Blood. 2013;122:405-12 pubmed publisher
Tseng W, Huang Y, Chiang N, Chou Y, Wu Y, Luo S, et al. Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases. PLoS ONE. 2013;8:e63963 pubmed publisher
Melton A, Melrose J, Alajoki L, Privat S, Cho H, Brown N, et al. Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation. PLoS ONE. 2013;8:e58966 pubmed publisher
Balagopalan L, Barr V, Kortum R, Park A, Samelson L. Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. J Immunol. 2013;190:3849-53 pubmed publisher
Palin A, Ramachandran V, Acharya S, Lewis D. Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a. J Immunol. 2013;190:2682-91 pubmed publisher
Breitkopf T, Lo B, Leung G, Wang E, Yu M, Carr N, et al. Somatostatin expression in human hair follicles and its potential role in immune privilege. J Invest Dermatol. 2013;133:1722-30 pubmed publisher
Cai W, Qin A, Guo P, Yan D, Hu F, Yang Q, et al. Clinical significance and functional studies of myeloid-derived suppressor cells in chronic hepatitis C patients. J Clin Immunol. 2013;33:798-808 pubmed publisher
Marin N, Paris S, Rojas M, Garcia L. Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB. Tuberculosis (Edinb). 2013;93:155-66 pubmed publisher
Wheway J, Obeid S, Couraud P, Combes V, Grau G. The brain microvascular endothelium supports T cell proliferation and has potential for alloantigen presentation. PLoS ONE. 2013;8:e52586 pubmed publisher
Arndt B, Poltorak M, Kowtharapu B, Reichardt P, Philipsen L, Lindquist J, et al. Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation. J Immunol Methods. 2013;387:276-83 pubmed publisher
Esendagli G, Kurne A, Sayat G, Kilic A, Guc D, Karabudak R. Evaluation of Th17-related cytokines and receptors in multiple sclerosis patients under interferon ?-1 therapy. J Neuroimmunol. 2013;255:81-4 pubmed publisher
Terme M, Pernot S, Marcheteau E, Sandoval F, Benhamouda N, Colussi O, et al. VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. Cancer Res. 2013;73:539-49 pubmed publisher
Cao L, Ding Y, Hung N, Yu K, Ritz A, Raphael B, et al. Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells. PLoS ONE. 2012;7:e46725 pubmed publisher
Chueh F, Yu C. Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells. Biochem Biophys Res Commun. 2012;426:242-6 pubmed publisher
Marin N, Paris S, Rojas M, Garcia L. Reduced frequency of memory T cells and increased Th17 responses in patients with active tuberculosis. Clin Vaccine Immunol. 2012;19:1667-76 pubmed
Ramakrishnan S, Page A, Farris A, Singh K, Leopardi F, Hamby K, et al. Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. Am J Transplant. 2012;12:1755-64 pubmed publisher
Stemberger C, Dreher S, Tschulik C, Piossek C, Bet J, Yamamoto T, et al. Novel serial positive enrichment technology enables clinical multiparameter cell sorting. PLoS ONE. 2012;7:e35798 pubmed publisher
Müller A, Jun E, Conlon H, Sadiq S. Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis. BMC Neurosci. 2012;13:30 pubmed publisher
Jurado J, Pasquinelli V, Alvarez I, Peña D, Rovetta A, Tateosian N, et al. IL-17 and IFN-? expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease. J Leukoc Biol. 2012;91:991-1002 pubmed publisher
Schmitt D, O Dee D, Horzempa J, Carlson P, Russo B, Bales J, et al. A Francisella tularensis live vaccine strain that improves stimulation of antigen-presenting cells does not enhance vaccine efficacy. PLoS ONE. 2012;7:e31172 pubmed publisher
Luopajarvi K, Nieminen J, Ilonen J, Akerblom H, Knip M, Vaarala O. Expansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes. Pediatr Diabetes. 2012;13:400-7 pubmed publisher
de Kivit S, Saeland E, Kraneveld A, van de Kant H, Schouten B, van Esch B, et al. Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans. Allergy. 2012;67:343-52 pubmed publisher
Toda T, Kuwahara K, Kondo N, Matsuda Z, Maeda Y, Maeda K, et al. Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4. Immunobiology. 2012;217:864-72 pubmed publisher
Kim D, Seol J, Wu Y, Ji S, Kim G, Hyung J, et al. A quartz nanopillar hemocytometer for high-yield separation and counting of CD4(+) T lymphocytes. Nanoscale. 2012;4:2500-7 pubmed publisher
Gorska M, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012;119:1399-406 pubmed publisher
Legorreta Haquet M, Chavez Rueda K, Montoya Díaz E, Arriaga Pizano L, Silva Garcia R, Chavez Sanchez L, et al. Prolactin down-regulates CD4+CD25hiCD127low/- regulatory T cell function in humans. J Mol Endocrinol. 2012;48:77-85 pubmed publisher
Klatt N, Canary L, Vanderford T, Vinton C, Engram J, Dunham R, et al. Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. J Virol. 2012;86:1203-13 pubmed publisher
Herschhorn A, Finzi A, Jones D, Courter J, Sugawara A, Smith A, et al. An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors. PLoS ONE. 2011;6:e26731 pubmed publisher
Biswas S, Chang H, Sarkis P, Fikrig E, Zhu Q, Marasco W. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 2011;134:419-33 pubmed publisher
Kean L, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, et al. Significant mobilization of both conventional and regulatory T cells with AMD3100. Blood. 2011;118:6580-90 pubmed publisher
Klatt N, Vinton C, Lynch R, Canary L, Ho J, Darrah P, et al. SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination. Blood. 2011;118:5803-12 pubmed publisher
Andrew A, Kao S, Strebel K. C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif. J Biol Chem. 2011;286:39967-81 pubmed publisher
Page A, Srinivasan S, Singh K, Russell M, Hamby K, Deane T, et al. CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model. Am J Transplant. 2012;12:115-25 pubmed publisher
Kotturi M, Swann J, Peters B, Arlehamn C, Sidney J, Kolla R, et al. Human CD8? and CD4? T cell memory to lymphocytic choriomeningitis virus infection. J Virol. 2011;85:11770-80 pubmed publisher
Hioe C, Tuen M, Vasiliver Shamis G, Alvarez Y, Prins K, Banerjee S, et al. HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). PLoS ONE. 2011;6:e23202 pubmed publisher
Vinton C, Klatt N, Harris L, Briant J, Sanders Beer B, Herbert R, et al. CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus. J Virol. 2011;85:8702-8 pubmed publisher
Chakrabarti B, Walker L, Guenaga J, Ghobbeh A, Poignard P, Burton D, et al. Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity. J Virol. 2011;85:8217-26 pubmed publisher
Li H, Lasaro M, Jia B, Lin S, Haut L, High K, et al. Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates. Mol Ther. 2011;19:2021-30 pubmed publisher
Beswick E, Pinchuk I, Earley R, Schmitt D, Reyes V. Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection. Infect Immun. 2011;79:2737-45 pubmed publisher
Santos R, Lin K, Mansfield K, Wachtman L. Specific pathogen-free status alters immunophenotype in rhesus macaques: implications for the study of simian immunodeficiency virus. AIDS Res Hum Retroviruses. 2011;27:1033-42 pubmed publisher
Zhou X, McElhaney J. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine. 2011;29:2169-77 pubmed publisher
Fazekas de St Groth B, Zhu E, Asad S, Lee L. Flow cytometric detection of human regulatory T cells. Methods Mol Biol. 2011;707:263-79 pubmed publisher
Richmond M, McKinnon L, Kiazyk S, Wachihi C, Kimani M, Kimani J, et al. Epitope mapping of HIV-specific CD8+ T cell responses by multiple immunological readouts reveals distinct specificities defined by function. J Virol. 2011;85:1275-86 pubmed publisher
Rogers N, Kireta S, Coates P. Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo. Clin Exp Immunol. 2010;162:460-73 pubmed publisher
Gordon S, Cervasi B, Odorizzi P, Silverman R, Aberra F, Ginsberg G, et al. Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals. J Immunol. 2010;185:5169-79 pubmed publisher
Larsen C, Page A, Linzie K, Russell M, Deane T, Stempora L, et al. An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching. Am J Transplant. 2010;10:2396-409 pubmed publisher
Lai A, Fatemi M, Dhasarathy A, Malone C, Sobol S, Geigerman C, et al. DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med. 2010;207:1939-50 pubmed publisher
Harris L, Klatt N, Vinton C, Briant J, Tabb B, Ladell K, et al. Mechanisms underlying ?? T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood. 2010;116:4148-57 pubmed publisher
Raptopoulou A, Bertsias G, Makrygiannakis D, Verginis P, Kritikos I, Tzardi M, et al. The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis. Arthritis Rheum. 2010;62:1870-80 pubmed publisher
Friberg H, Burns L, Woda M, Kalayanarooj S, Endy T, Stephens H, et al. Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive. Immunol Cell Biol. 2011;89:122-9 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (OKT4 (OKT-4)), eBioscience™
Catalog # :
14-0048-80
Quantity :
25 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Immunoprecipitation: Assay-Dependent
Species :
Human
Clone :
OKT4 (OKT-4)
Isotype :
IgG2b, kappa
Storage :
4° C
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Immunoprecipitation: Assay-Dependent
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA