This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (OX35), eBioscience
catalog :
14-0040-82
quantity :
100 ug
price :
US 159.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OX35

The same clone is also sold as:
reactivity :
rat
application :
immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
citations: 37
Reference
Chen L, Huang Y, Chen Y, Chen J, You X, Zou L, et al. Resolvin D1 promotes the resolution of inflammation in the ACLF rat model by increasing the proportion of Treg cells. Immun Inflamm Dis. 2023;11:e1076 pubmed publisher
Pu S, Yang Z, Zhang X, Li M, Han N, Yang X, et al. Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response. Chin Med. 2023;18:131 pubmed publisher
Pan F, Du H, Tian W, Xie H, Zhang B, Fu W, et al. Effect of GnRH immunocastration on immune function in male rats. Front Immunol. 2022;13:1023104 pubmed publisher
Sesillo F, Rajesh V, Wong M, Durán P, Rudell J, Rundio C, et al. Muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury. NPJ Regen Med. 2022;7:72 pubmed publisher
Liu C, Zou Q. miR-21 Regulates Immune Balance Mediated by Th17/Treg in Peripheral Blood of Septic Rats during the Early Phase through Apoptosis Pathway. Biochem Res Int. 2022;2022:9948229 pubmed publisher
Zou Q, Liu C, Hu N, Wang W, Wang H. miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg. Mol Biol Rep. 2022;49:2985-2998 pubmed publisher
Wang D, Wu X, Dong J, Cheng X, Gu S, Olatunji O, et al. Qing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes. J Inflamm Res. 2021;14:7467-7486 pubmed publisher
Mathew D, Livne Bar I, Sivak J. An inducible rodent glaucoma model that exhibits gradual sustained increase in intraocular pressure with distinct inner retina and optic nerve inflammation. Sci Rep. 2021;11:22880 pubmed publisher
Wen X, He B, Tang X, Wang B, Chen Z. Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1. Mol Med Rep. 2021;24: pubmed publisher
Furesi G, Fert I, Beaufr xe8 re M, Araujo L, Glatigny S, Baschant U, et al. Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots. Front Immunol. 2021;12:665208 pubmed publisher
Stark K, Goncharov T, Varfolomeev E, Xie L, Ngu H, Peng I, et al. Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury. Cell Death Dis. 2021;12:379 pubmed publisher
Okuliarová M, Mazgutova N, Majzúnová M, Rumanova V, Zeman M. Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis. Front Immunol. 2020;11:614960 pubmed publisher
Luo Y, Wang B, Liu J, Ma F, Luo D, Zheng Z, et al. Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury. Aging (Albany NY). 2020;13:1132-1152 pubmed publisher
Ge N, Peng J, Yu L, Huang S, Xu L, Su Y, et al. Orthodontic treatment induces Th17/Treg cells to regulate tooth movement in rats with periodontitis. Iran J Basic Med Sci. 2020;23:1315-1322 pubmed publisher
Noto F, Sangodkar J, Adedeji B, Moody S, McClain C, Tong M, et al. The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies. PLoS ONE. 2020;15:e0240169 pubmed publisher
Yang C, Zhang P, Liu R, Zhang N, Zhang M, Li H, et al. CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells. J Neuroinflammation. 2019;16:282 pubmed publisher
Hartlage A, Murthy S, Kumar A, Trivedi S, Dravid P, Sharma H, et al. Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection. Nat Commun. 2019;10:1113 pubmed publisher
Liu Y, Sun L, Chen W, Chuai J, Shang Y, Zhang D, et al. Combined treatment with simvastatin and rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells. Exp Ther Med. 2018;15:1941-1949 pubmed publisher
Jiao Y, Tan S, Xiong J. Proteomic changes of CD4+/CD25+/forkhead box p3+ regulatory T cells in a 30-day rat model of sepsis survival. Exp Ther Med. 2017;14:5619-5628 pubmed publisher
Xie L, Zhong X, Liu D, Liu L, Xia Z. The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model. BMC Complement Altern Med. 2017;17:511 pubmed publisher
Li Y, Li H, Cao Y, Wu F, Ma W, Wang Y, et al. Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance. Mol Med Rep. 2017;16:8137-8145 pubmed publisher
Zheng W, Zhang B, Shen Z, Yin M, Cao Y, Song H. Biological effects of bone marrow mesenchymal stem cells on hepatitis B virus in vitro. Mol Med Rep. 2017;15:2551-2559 pubmed publisher
Sun C, Zhang J, Chen L, Liu T, Xu G, Li C, et al. IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines. Mol Med Rep. 2017;15:89-96 pubmed publisher
Hautz T, Krapf C, Grahammer J, Zelger B, Hickethier T, Seger C, et al. Targeting the Kv1.3 potassium channel for immunosuppression in vascularized composite allotransplantation - a pilot study. Transpl Int. 2013;26:552-61 pubmed publisher
Wang Y, Wang Y, Wang Y, Zheng G, Zhang G, Zhou J, et al. DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney Int. 2013;83:223-32 pubmed publisher
Bogdani M, Henschel A, Kansra S, Fuller J, Geoffrey R, Jia S, et al. Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. J Endocrinol. 2013;216:111-23 pubmed publisher
Wang G, Zhang Q, Yang Y, Chen W, Liu W, Jiang N, et al. Rapamycin combined with allogenic immature dendritic cells selectively expands CD4+CD25+Foxp3+ regulatory T cells in rats. Hepatobiliary Pancreat Dis Int. 2012;11:203-8 pubmed
Schu S, Nosov M, O Flynn L, Shaw G, Treacy O, Barry F, et al. Immunogenicity of allogeneic mesenchymal stem cells. J Cell Mol Med. 2012;16:2094-103 pubmed publisher
Wang G, Yang Y, Li H, Zhang J, Li M, Zhang Q, et al. Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4(+) CD25(+) Foxp3(+) regulatory T cell expansion. Hepatol Res. 2012;42:192-202 pubmed publisher
Wu C, Xia Y, Wang P, Lu L, Zhang F. Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production. Int Immunopharmacol. 2011;11:1564-72 pubmed publisher
Dominguez M, Lorenzo N, Barbera A, Darrasse Jèze G, Hernández M, Torres A, et al. An altered peptide ligand corresponding to a novel epitope from heat-shock protein 60 induces regulatory T cells and suppresses pathogenic response in an animal model of adjuvant-induced arthritis. Autoimmunity. 2011;44:471-82 pubmed publisher
Maenz M, Morcos M, Ritter T. A comprehensive flow-cytometric analysis of graft infiltrating lymphocytes, draining lymph nodes and serum during the rejection phase in a fully allogeneic rat cornea transplant model. Mol Vis. 2011;17:420-9 pubmed
Fahmi T, Esendagli G, Yilmaz G, Kansu E, Guc D. Immune compartmentalization of T cell subsets in chemically-induced breast cancer. Scand J Immunol. 2010;72:339-48 pubmed publisher
Visser J, Hillebrands J, Walther Boer M, Bos N, Rozing J. Prevention of diabetes by a hydrolysed casein-based diet in diabetes-prone BioBreeding rats does not involve restoration of the defective natural regulatory T cell function. Diabetologia. 2009;52:1445-7 pubmed publisher
Brugman S, Visser J, Hillebrands J, Bos N, Rozing J. Prolonged exclusive breastfeeding reduces autoimmune diabetes incidence and increases regulatory T-cell frequency in bio-breeding diabetes-prone rats. Diabetes Metab Res Rev. 2009;25:380-7 pubmed publisher
Tischner D, Weishaupt A, van den Brandt J, Müller N, Beyersdorf N, Ip C, et al. Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis. Brain. 2006;129:2635-47 pubmed
May E, Dorris M, Satumtira N, Iqbal I, Rehman M, Lightfoot E, et al. CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol. 2003;170:1099-105 pubmed
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (OX35), eBioscience
Catalog # :
14-0040-82
Quantity :
100 ug
Price :
US 159.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Rat
Applications :
Flow Cytometry: 0.25 ug/test, Immunohistochemistry (Frozen): Assay-Dependent
Species :
Rat
Clone :
OX35
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test, Immunohistochemistry (Frozen): Assay-Dependent
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA