product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD3 Monoclonal Antibody (HIT3a), eBioscience™
catalog :
14-0039-82
quantity :
100 µg
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HIT3a
reactivity :
human
application :
flow cytometry, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 54
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Ryan P, Sumaria N, Holland C, Bradford C, Izotova N, Grandjean C, et al. Heterogeneous yet stable Vδ2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals. Proc Natl Acad Sci U S A. 2016;113:14378-14383 pubmed
  • flow cytometry; human; loading ...; fig e3d
Mitson Salazar A, Yin Y, Wansley D, Young M, Bolan H, Arceo S, et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function. J Allergy Clin Immunol. 2016;137:907-18.e9 pubmed publisher
  • flow cytometry; human; fig s3
Mende N, Kuchen E, Lesche M, Grinenko T, Kokkaliaris K, Hanenberg H, et al. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015;212:1171-83 pubmed publisher
  • blocking or activating experiments; human; 0.5 ug/ml; fig 1
Rapetti L, Chavele K, Evans C, Ehrenstein M. B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis. Ann Rheum Dis. 2015;74:294-302 pubmed publisher
  • flow cytometry; human; fig 4
Xin K, Mizukami H, Urabe M, Toda Y, Shinoda K, Yoshida A, et al. Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells. J Virol. 2006;80:11899-910 pubmed
Ravell J, Matsuda Lennikov M, Chauvin S, Zou J, Biancalana M, Deeb S, et al. Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease. J Clin Invest. 2020;130:507-522 pubmed publisher
Yoyen Ermis D, Tunali G, Tavukcuoglu E, Horzum U, Ozkazanç D, Sutlu T, et al. Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS. Sci Rep. 2019;9:11697 pubmed publisher
Yi J, Balagopalan L, Nguyen T, McIntire K, Samelson L. TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps. Nat Commun. 2019;10:277 pubmed publisher
Swain S, Roe M, Sebrell T, Sidar B, Dankoff J, VanAusdol R, et al. CD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion. Front Immunol. 2018;9:2989 pubmed publisher
Oja A, Piet B, van der Zwan D, Blaauwgeers H, Mensink M, de Kivit S, et al. Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC. Front Immunol. 2018;9:2654 pubmed publisher
Wang L, Yang X, Li D, Liang Z, Chen Y, Ma G, et al. The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ. Onco Targets Ther. 2018;11:7229-7243 pubmed publisher
Anderson M, Pleet M, Enose Akahata Y, Erickson J, Monaco M, Akpamagbo Y, et al. Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease: functional role of exosomes. Clin Transl Med. 2018;7:24 pubmed publisher
Langenhorst D, Haack S, Göb S, Uri A, Luhder F, Vanhove B, et al. CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo. Front Immunol. 2018;9:1060 pubmed publisher
Akuffo A, Alontaga A, Metcalf R, Beatty M, Becker A, McDaniel J, et al. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. J Biol Chem. 2018;293:6187-6200 pubmed publisher
Titanji K, Vunnava A, Foster A, Sheth A, Lennox J, Knezevic A, et al. T-cell receptor activator of nuclear factor-κB ligand/osteoprotegerin imbalance is associated with HIV-induced bone loss in patients with higher CD4+ T-cell counts. AIDS. 2018;32:885-894 pubmed publisher
Kishore M, Cheung K, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47:875-889.e10 pubmed publisher
Wu Y, Kumar A, Smith C, Ardiel E, Chandris P, Christensen R, et al. Reflective imaging improves spatiotemporal resolution and collection efficiency in light sheet microscopy. Nat Commun. 2017;8:1452 pubmed publisher
Hui K, Upadhyaya A. Dynamic microtubules regulate cellular contractility during T-cell activation. Proc Natl Acad Sci U S A. 2017;114:E4175-E4183 pubmed publisher
Vladimer G, Snijder B, Krall N, Bigenzahn J, Huber K, Lardeau C, et al. Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol. 2017;13:681-690 pubmed publisher
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
Hasan M, Ryan P, Bergmeier L, Fortune F. Circulating NK cells and their subsets in Behçet's disease. Clin Exp Immunol. 2017;188:311-322 pubmed publisher
Nguyen D, Ehrenstein M. Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis. J Exp Med. 2016;213:1241-53 pubmed publisher
Chavele K, Merry E, Ehrenstein M. Cutting edge: circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production. J Immunol. 2015;194:2482-5 pubmed publisher
Boland B, Widjaja C, Banno A, Zhang B, Kim S, Stoven S, et al. Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol. 2015;194:2551-60 pubmed publisher
Liao Y, Guo S, Chen Y, Cao D, Xu H, Yang C, et al. VSIG4 expression on macrophages facilitates lung cancer development. Lab Invest. 2014;94:706-15 pubmed publisher
Li S, Joseph C, Becourt C, Klibi J, Luce S, Dubois Laforgue D, et al. Potential role of IL-17-producing iNKT cells in type 1 diabetes. PLoS ONE. 2014;9:e96151 pubmed publisher
Lee J, Yeh C, Jung C, Chen C, Du M, Yu H, et al. Skewed distribution of IL-7 receptor-?-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma. PLoS ONE. 2014;9:e85521 pubmed publisher
Takahashi R, Sato Y, Kurata M, Yamazaki Y, Kimishima M, Shiohara T. Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. J Immunol. 2014;192:969-78 pubmed publisher
Aucher A, Rudnicka D, Davis D. MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation. J Immunol. 2013;191:6250-60 pubmed publisher
Wang H, Henry O, Distefano M, Wang Y, Räikkönen J, Mönkkönen J, et al. Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2V?2 T cells. J Immunol. 2013;191:1029-42 pubmed publisher
Sanchez F, Berges B. Characterization of HIV-1 infection in the humanized Rag2-/-?c-/- mouse model. Methods Mol Biol. 2013;1031:215-22 pubmed publisher
Méndez Reguera A, Pérez Montesinos G, Alcántara Hernández M, Martínez Estrada V, Cazarin Barrientos J, Rojas Espinosa O, et al. Pathogenic CCR6+ dendritic cells in the skin lesions of discoid lupus patients: a role for damage-associated molecular patterns. Eur J Dermatol. 2013;23:169-82 pubmed publisher
Wheway J, Obeid S, Couraud P, Combes V, Grau G. The brain microvascular endothelium supports T cell proliferation and has potential for alloantigen presentation. PLoS ONE. 2013;8:e52586 pubmed publisher
Riches J, Davies J, McClanahan F, Fatah R, Iqbal S, Agrawal S, et al. T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. Blood. 2013;121:1612-21 pubmed publisher
Lorenzo N, Barbera A, Dominguez M, Torres A, Hernandez M, Hernandez I, et al. Therapeutic effect of an altered peptide ligand derived from heat-shock protein 60 by suppressing of inflammatory cytokines secretion in two animal models of rheumatoid arthritis. Autoimmunity. 2012;45:449-59 pubmed publisher
Hoerning A, Kohler S, Jun C, Tebbe B, Fu J, Menke J, et al. Peripherally circulating CD4? FOXP3? CXCR3? T regulatory cells correlate with renal allograft function. Scand J Immunol. 2012;76:320-8 pubmed publisher
Wu W, Shi Y, Li S, Zhang Y, Liu Y, Wu Y, et al. Blockade of Tim-3 signaling restores the virus-specific CD8? T-cell response in patients with chronic hepatitis B. Eur J Immunol. 2012;42:1180-91 pubmed publisher
Lee J, Park M, Park S, Lee E. Differential expression of T cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) according to activity of Behçet's disease. J Dermatol Sci. 2012;65:220-2 pubmed publisher
Kashiwakura J, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho M, et al. Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest. 2012;122:218-28 pubmed publisher
De Gobbi M, Garrick D, Lynch M, Vernimmen D, Hughes J, Goardon N, et al. Generation of bivalent chromatin domains during cell fate decisions. Epigenetics Chromatin. 2011;4:9 pubmed publisher
Andorsky D, Yamada R, Said J, Pinkus G, Betting D, Timmerman J. Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells. Clin Cancer Res. 2011;17:4232-44 pubmed publisher
Akbar M, Brewer J, Grant M. Effect of chromium and cobalt ions on primary human lymphocytes in vitro. J Immunotoxicol. 2011;8:140-9 pubmed publisher
Manzouri B, Ohbayashi M, Leonardi A, Fattah D, Larkin D, Ono S. Characterisation of the phenotype and function of monocyte-derived dendritic cells in allergic conjunctiva. Br J Ophthalmol. 2010;94:1662-7 pubmed publisher
Lopez Verges S, Milush J, Pandey S, York V, Arakawa Hoyt J, Pircher H, et al. CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset. Blood. 2010;116:3865-74 pubmed publisher
Hall C, Kassel R, Tacke R, Hahn Y. HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta. PLoS ONE. 2010;5:e12154 pubmed publisher
Beriou G, Bradshaw E, Lozano E, Costantino C, Hastings W, Orban T, et al. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010;185:46-54 pubmed publisher
Diou J, Tardif M, Barat C, Tremblay M. Dendritic cells derived from hemozoin-loaded monocytes display a partial maturation phenotype that promotes HIV-1 trans-infection of CD4+ T cells and virus replication. J Immunol. 2010;184:2899-907 pubmed publisher
Brusko T, Wasserfall C, Hulme M, Cabrera R, Schatz D, Atkinson M. Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation. PLoS ONE. 2009;4:e7980 pubmed publisher
Takahashi R, Kano Y, Yamazaki Y, Kimishima M, Mizukawa Y, Shiohara T. Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome. J Immunol. 2009;182:8071-9 pubmed publisher
Cummings K, Rosen H, Hahn Y. Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clin Immunol. 2009;132:401-11 pubmed publisher
Malik N, Gilroy D, Kabouridis P. Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras. FEBS Lett. 2009;583:61-9 pubmed publisher
Campbell G, Spector S. CCL2 increases X4-tropic HIV-1 entry into resting CD4+ T cells. J Biol Chem. 2008;283:30745-53 pubmed publisher
Brusko T, Wasserfall C, Clare Salzler M, Schatz D, Atkinson M. Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes. 2005;54:1407-14 pubmed
Bunnell S, Hong D, Kardon J, Yamazaki T, McGlade C, Barr V, et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol. 2002;158:1263-75 pubmed
product information
Product Type :
Antibody
Product Name :
CD3 Monoclonal Antibody (HIT3a), eBioscience™
Catalog # :
14-0039-82
Quantity :
100 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Human
Clone :
HIT3a
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA