This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD3 Monoclonal Antibody (UCHT1), eBioscience™
catalog :
14-0038-80
quantity :
25 µg
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
UCHT1
reactivity :
human
application :
immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
citations: 52
Reference
Shi L, Wang J, Ding N, Zhang Y, Zhu Y, Dong S, et al. Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nat Commun. 2019;10:5421 pubmed publisher
Randzavola L, Strege K, Juzans M, Asano Y, Stinchcombe J, Gawden Bone C, et al. Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. J Clin Invest. 2019;129:5600-5614 pubmed publisher
Maffucci P, Chavez J, Jurkiw T, O Brien P, Abbott J, Reynolds P, et al. Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies. J Clin Invest. 2018;128:5489-5504 pubmed publisher
Liu Z, Dang E, Li B, Qiao H, Jin L, Zhang J, et al. Dysfunction of CD19+CD24hiCD27+ B regulatory cells in patients with bullous pemphigoid. Sci Rep. 2018;8:703 pubmed publisher
Miller S, Miles B, Guo K, Folkvord J, Meditz A, McCarter M, et al. Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1. J Virol. 2017;91: pubmed publisher
Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, et al. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities. Oncoimmunology. 2017;6:e1283460 pubmed publisher
Tsuchiya K, Ikeda T, Batmunkh B, Choijookhuu N, Ishizaki H, Hotokezaka M, et al. Frequency of CD4+CD161+ T Cell and Interleukin-10 Expression in Inflammatory Bowel Diseases. Acta Histochem Cytochem. 2017;50:21-28 pubmed publisher
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
Alkayyal A, Tai L, Kennedy M, de Souza C, Zhang J, Lefebvre C, et al. NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine. Cancer Immunol Res. 2017;5:211-221 pubmed publisher
van der Aa E, Buschow S, Biesta P, Janssen H, Woltman A. The Effect of Chronic Hepatitis B Virus Infection on BDCA3+ Dendritic Cell Frequency and Function. PLoS ONE. 2016;11:e0161235 pubmed publisher
Schurich A, Pallett L, Jajbhay D, Wijngaarden J, Otano I, Gill U, et al. Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host. Cell Rep. 2016;16:1243-1252 pubmed publisher
Mo A, Jackson S, Varma K, Carpino A, Giardina C, Devers T, et al. Distinct Transcriptional Changes and Epithelial-Stromal Interactions Are Altered in Early-Stage Colon Cancer Development. Mol Cancer Res. 2016;14:795-804 pubmed publisher
Noack M, Ndongo Thiam N, Miossec P. Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion. Arthritis Res Ther. 2016;18:148 pubmed publisher
van Wilgenburg B, Scherwitzl I, Hutchinson E, Leng T, Kurioka A, Kulicke C, et al. MAIT cells are activated during human viral infections. Nat Commun. 2016;7:11653 pubmed publisher
Le Nours J, Praveena T, Pellicci D, Gherardin N, Ross F, Lim R, et al. Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens. Nat Commun. 2016;7:10570 pubmed publisher
Amicarella F, Muraro M, Hirt C, Cremonesi E, Padovan E, Mele V, et al. Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer. Gut. 2017;66:692-704 pubmed publisher
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
Venkatasubramanian S, Tripathi D, Tucker T, Paidipally P, Cheekatla S, Welch E, et al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. Eur J Immunol. 2016;46:464-79 pubmed publisher
Taborda N, González S, Alvarez C, Correa L, Montoya C, Rugeles M. Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers. PLoS ONE. 2015;10:e0136292 pubmed publisher
Margraf S, Garner L, Wilson T, Brown M. A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation. Immunology. 2015;146:392-400 pubmed publisher
Shimizu K, Shinga J, Yamasaki S, Kawamura M, Dörrie J, Schaft N, et al. Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells. PLoS ONE. 2015;10:e0131477 pubmed publisher
Monteiro Sepulveda M, Touch S, Mendes Sá C, André S, Poitou C, Allatif O, et al. Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling. Cell Metab. 2015;22:113-24 pubmed publisher
Turley A, Zagorski J, Rockwell C. The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells. Cytokine. 2015;71:289-95 pubmed publisher
Nunes Cabaço H, Matoso P, Foxall R, Tendeiro R, Pires A, Carvalho T, et al. Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes. J Virol. 2015;89:2201-8 pubmed publisher
Wiencke J, Bracci P, Hsuang G, Zheng S, Hansen H, Wrensch M, et al. A comparison of DNA methylation specific droplet digital PCR (ddPCR) and real time qPCR with flow cytometry in characterizing human T cells in peripheral blood. Epigenetics. 2014;9:1360-5 pubmed publisher
Mock U, Riecken K, Berdien B, Qasim W, Chan E, Cathomen T, et al. Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases. Sci Rep. 2014;4:6409 pubmed publisher
Satti I, Meyer J, Harris S, Manjaly Thomas Z, Griffiths K, Antrobus R, et al. Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial. Lancet Infect Dis. 2014;14:939-46 pubmed publisher
Krupna Gaylord M, Liveris D, Love A, Wormser G, Schwartz I, Petzke M. Induction of type I and type III interferons by Borrelia burgdorferi correlates with pathogenesis and requires linear plasmid 36. PLoS ONE. 2014;9:e100174 pubmed publisher
Chen C, Hsu H, Hudgens E, Telfer J, Baldwin C. Signal transduction by different forms of the ?? T cell-specific pattern recognition receptor WC1. J Immunol. 2014;193:379-90 pubmed publisher
Avelar Freitas B, Almeida V, Pinto M, Mourão F, Massensini A, Martins Filho O, et al. Trypan blue exclusion assay by flow cytometry. Braz J Med Biol Res. 2014;47:307-15 pubmed publisher
Colin S, Darne B, Kadi A, Ferry A, Favier M, Lesaffre C, et al. The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich mRNA stability by reducing 14-3-3?-tristetraprolin protein complex, reducing inflammation and psoriatic lesion size in patients. J Pharmacol Exp Ther. 2014;349:107-17 pubmed publisher
Cox J, Hussell S, Søndergaard H, Roepstorff K, Bui J, Deer J, et al. Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function. PLoS ONE. 2013;8:e82944 pubmed publisher
Dorronsoro A, Ferrin I, Salcedo J, Jakobsson E, Fernández Rueda J, Lang V, et al. Human mesenchymal stromal cells modulate T-cell responses through TNF-?-mediated activation of NF-?B. Eur J Immunol. 2014;44:480-8 pubmed publisher
Rodriguez M, Loyd C, Ding X, Karim A, MCDONALD D, Canaday D, et al. Mycobacterial phosphatidylinositol mannoside 6 (PIM6) up-regulates TCR-triggered HIV-1 replication in CD4+ T cells. PLoS ONE. 2013;8:e80938 pubmed publisher
Bharadwaj A, Schewitz Bowers L, Wei L, Lee R, Smith J. Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium. Invest Ophthalmol Vis Sci. 2013;54:6917-25 pubmed publisher
Dössinger G, Bunse M, Bet J, Albrecht J, Paszkiewicz P, Weißbrich B, et al. MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy. PLoS ONE. 2013;8:e61384 pubmed publisher
De Baets S, Schepens B, Sedeyn K, Schotsaert M, Roose K, Bogaert P, et al. Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice. J Virol. 2013;87:3314-23 pubmed publisher
Wiencke J, Accomando W, Zheng S, Patoka J, Dou X, Phillips J, et al. Epigenetic biomarkers of T-cells in human glioma. Epigenetics. 2012;7:1391-402 pubmed publisher
Suarez J, Romero Zerbo Y, Márquez L, Rivera P, Iglesias M, Bermudez Silva F, et al. Ulcerative colitis impairs the acylethanolamide-based anti-inflammatory system reversal by 5-aminosalicylic acid and glucocorticoids. PLoS ONE. 2012;7:e37729 pubmed publisher
Ou J, Wiedeman A, Stevens A. TNF-? and TGF-? counter-regulate PD-L1 expression on monocytes in systemic lupus erythematosus. Sci Rep. 2012;2:295 pubmed publisher
Wang B, Bao J, Wang J, Wang Y, Jiang M, Xing M, et al. Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma. World J Gastroenterol. 2011;17:3322-9 pubmed publisher
Sobel E, Brusko T, Butfiloski E, Hou W, Li S, Cuda C, et al. Defective response of CD4(+) T cells to retinoic acid and TGF? in systemic lupus erythematosus. Arthritis Res Ther. 2011;13:R106 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD3 Monoclonal Antibody (UCHT1), eBioscience™
Catalog # :
14-0038-80
Quantity :
25 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent
Species :
Human
Clone :
UCHT1
Isotype :
IgG1, kappa
Storage :
4° C
Description :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent
Aliases :
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; CD247; CD247 antigen; CD247 antigen, zeta subunit; CD247 molecule; Cd3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 type I transmembrane glycoprotein; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; CD3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; CD3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; CD3H; CD3Q; CD3Z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; CD3-ZETA; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T3/TCR complex; T3D; T3E; T3G; T3z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA