CD1d Monoclonal Antibody (51.1), eBioscience | Invitrogen 14-0016-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD1d Monoclonal Antibody (51.1), eBioscience

catalog :

14-0016-82

quantity :

100 µg

price :

US 145

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

51.1

reactivity :

human

application :

immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human	Liu J, Glosson N, Du W, Gervay Hague J, Brutkiewicz R. A Thr/Ser dual residue motif in the cytoplasmic tail of human CD1d is important for the down-regulation of antigen presentation following a herpes simplex virus 1 infection. Immunology. 2013;140:191-201 pubmed publisher
	Komlósi Z, Kovacs N, Van De Veen W, Kirsch A, Fahrner H, Wawrzyniak M, et al. Human CD40 ligand-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells. J Allergy Clin Immunol. 2018;142:178-194.e11 pubmed publisher
	Belo R, Santar xe9 m N, Pereira C, P xe9 rez Cabezas B, Macedo F, Leite de Moraes M, et al. Leishmania infantum Exoproducts Inhibit Human Invariant NKT Cell Expansion and Activation. Front Immunol. 2017;8:710 pubmed publisher
	Paquin Proulx D, Gibbs A, Bachle S, Checa A, Introini A, Leeansyah E, et al. Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion. J Immunol. 2016;197:1843-51 pubmed publisher
	Lameris R, de Bruin R, van Bergen en Henegouwen P, Verheul H, Zweegman S, de Gruijl T, et al. Generation and characterization of CD1d-specific single-domain antibodies with distinct functional features. Immunology. 2016;149:111-21 pubmed publisher
	Nambiar J, Clarke A, Shim D, Mabon D, Tian C, Windloch K, et al. Potent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model. MAbs. 2015;7:638-50 pubmed publisher
	Han J, Rho S, Lee J, Bae J, Park S, Lee S, et al. Human cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity. Mol Cells. 2013;36:455-64 pubmed publisher
	Yanagisawa K, Yue S, van der Vliet H, Wang R, Alatrakchi N, Golden Mason L, et al. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J Viral Hepat. 2013;20:556-65 pubmed publisher
	Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, et al. Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders. Blood. 2009;114:3208-15 pubmed publisher
	Durante Mangoni E, Wang R, Shaulov A, He Q, Nasser I, Afdhal N, et al. Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. J Immunol. 2004;173:2159-66 pubmed
	Exley M, Garcia J, Wilson S, Spada F, Gerdes D, Tahir S, et al. CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes. Immunology. 2000;100:37-47 pubmed
	Somnay Wadgaonkar K, Nusrat A, Kim H, Canchis W, Balk S, Colgan S, et al. Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. Int Immunol. 1999;11:383-92 pubmed
	Blumberg R, Terhorst C, Bleicher P, McDermott F, Allan C, Landau S, et al. Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells. J Immunol. 1991;147:2518-24 pubmed

product information

Product Type :

Antibody

Product Name :

CD1d Monoclonal Antibody (51.1), eBioscience

Catalog # :

14-0016-82

Quantity :

100 µg

Price :

US 145

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent

Species :

Human

Clone :

51.1

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by the CD1d gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent

Aliases :

AI747460; Antigen-presenting glycoprotein CD1d; antigen-presenting glycoprotein CD1d1; Cd1; CD1.1; CD1A; Cd1d; CD1D antigen; CD1D antigen, d polypeptide; CD1d molecule; CD1d.1; Cd1d1; CD1d1 antigen; CD1d1 molecule; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; Ly-38; R3; R3G1; T-cell surface glycoprotein CD1d; T-cell surface glycoprotein CD1d1; thymocyte antigen CD1D

more info or order :

Invitrogen product webpage