CD278 (ICOS) Monoclonal Antibody (ISA-3), Biotin, eBioscience | Invitrogen 13-9948-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD278 (ICOS) Monoclonal Antibody (ISA-3), Biotin, eBioscience

catalog :

13-9948-82

quantity :

100 ug

price :

US 412.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

ISA-3

The same clone is also sold as:

Beckman Coulter: A49080

reactivity :

human

application :

flow cytometry

citations: 33

Reference
Li D, Chen L, Miao S, Zhou M, Wu J, Sun S, et al. Inducible Costimulator-C-X-C Motif Chemokine Receptor 3 Signaling is Involved in Chronic Obstructive Pulmonary Disease Pathogenesis. Int J Chron Obstruct Pulmon Dis. 2022;17:1847-1861 pubmed publisher
Hill D, Whyte C, Innocentin S, Lee J, Dooley J, Wang J, et al. Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans. elife. 2021;10: pubmed publisher
Dart S, Cook A, Millward M, McDonnell A, Chin W, Hakeem M, et al. Changes in expression of PD-L1 on peripheral T cells in patients with melanoma and lung cancer treated with PD-1 inhibitors. Sci Rep. 2021;11:15312 pubmed publisher
Minassian A, Silk S, Barrett J, Nielsen C, Miura K, Diouf A, et al. Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination. Med (N Y). 2021;2:701-719.e19 pubmed publisher
Nielsen C, Ogbe A, Pedroza Pacheco I, Doeleman S, Chen Y, Silk S, et al. Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors. Cell Rep Med. 2021;2:100207 pubmed publisher
Khanam A, Ayithan N, Tang L, Poonia B, Kottilil S. IL-21-Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B. Front Immunol. 2020;11:599648 pubmed publisher
Rodda L, Netland J, Shehata L, Pruner K, Morawski P, Thouvenel C, et al. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021;184:169-183.e17 pubmed publisher
Hill D, Pierson W, Bolland D, Mkindi C, Carr E, Wang J, et al. The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes. J Exp Med. 2019;: pubmed publisher
Wang H, Kang X, Chu S, Li H, Li X, Yin X, et al. Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis. Exp Ther Med. 2018;16:3728-3734 pubmed publisher
Essig K, Kronbeck N, Guimaraes J, Lohs C, Schlundt A, Hoffmann A, et al. Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation. Nat Commun. 2018;9:3810 pubmed publisher
Meng X, Yu X, Dong Q, Xu X, Li J, Xu Q, et al. Distribution of circulating follicular helper T cells and expression of interleukin-21 and chemokine C-X-C ligand 13 in gastric cancer. Oncol Lett. 2018;16:3917-3922 pubmed publisher
Gu Trantien C, Migliori E, Buisseret L, de Wind A, Brohée S, Garaud S, et al. CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer. JCI Insight. 2017;2: pubmed publisher
Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, et al. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203 pubmed publisher
Tang Z, Hao Y, Zhang E, Xu C, Zhou Y, Zheng X, et al. CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade. Mol Med Rep. 2016;14:1107-16 pubmed publisher
Pedroza Gonzalez A, Zhou G, Vargas Mendez E, Boor P, Mancham S, Verhoef C, et al. Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors. Oncoimmunology. 2015;4:e1008355 pubmed
Vonderheide R, Burg J, Mick R, Trosko J, Li D, Shaik M, et al. Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors. Oncoimmunology. 2013;2:e23033 pubmed
Schmitt N, Bustamante J, Bourdery L, Bentebibel S, Boisson Dupuis S, Hamlin F, et al. IL-12 receptor ?1 deficiency alters in vivo T follicular helper cell response in humans. Blood. 2013;121:3375-85 pubmed publisher
Heninger A, Theil A, Wilhelm C, Petzold C, Huebel N, Kretschmer K, et al. IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol. 2012;189:5649-58 pubmed publisher
Kroenke M, Eto D, Locci M, Cho M, Davidson T, Haddad E, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol. 2012;188:3734-44 pubmed publisher
Ghourbani Gazar S, Andalib A, Hashemi M, Rezaei A. CD4?Foxp3? Treg and its ICOS? subsets in patients with myocardial infarction. Iran J Immunol. 2012;9:53-60 pubmed publisher
Bentebibel S, Schmitt N, Banchereau J, Ueno H. Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. Proc Natl Acad Sci U S A. 2011;108:E488-97 pubmed publisher
Baseggio L, Traverse Glehen A, Berger F, Ffrench M, Jallades L, Morel D, et al. CD10 and ICOS expression by multiparametric flow cytometry in angioimmunoblastic T-cell lymphoma. Mod Pathol. 2011;24:993-1003 pubmed publisher
Antonelli L, Mahnke Y, Hodge J, Porter B, Barber D, DerSimonian R, et al. Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood. 2010;116:3818-27 pubmed publisher
Otani T, Tsuji Takayama K, Okochi A, Yamamoto M, Takeuchi M, Yamasaki F, et al. Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line. Immunol Cell Biol. 2011;89:246-54 pubmed publisher
Vonderheide R, LoRusso P, Khalil M, Gartner E, Khaira D, Soulieres D, et al. Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Clin Cancer Res. 2010;16:3485-94 pubmed publisher
Carthon B, Wolchok J, Yuan J, Kamat A, Ng Tang D, Sun J, et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res. 2010;16:2861-71 pubmed publisher
Geiger R, Duhen T, Lanzavecchia A, Sallusto F. Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells. J Exp Med. 2009;206:1525-34 pubmed publisher
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, et al. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol. 2009;182:5515-27 pubmed publisher
Botturi K, Lacoeuille Y, Thomas P, Boniface S, Reynaud Gaubert M, Magnan A. CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients. Eur Respir J. 2008;31:1167-76 pubmed publisher
Wiesemann E, Deb M, Trebst C, Hemmer B, Stangel M, Windhagen A. Effects of interferon-beta on co-signaling molecules: upregulation of CD40, CD86 and PD-L2 on monocytes in relation to clinical response to interferon-beta treatment in patients with multiple sclerosis. Mult Scler. 2008;14:166-76 pubmed
Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
Nanki T, Shimaoka T, Hayashida K, Taniguchi K, Yonehara S, Miyasaka N. Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis. Arthritis Rheum. 2005;52:3004-14 pubmed

product information

Product Type :

Antibody

Product Name :

CD278 (ICOS) Monoclonal Antibody (ISA-3), Biotin, eBioscience

Catalog # :

13-9948-82

Quantity :

100 ug

Price :

US 412.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Human

Clone :

ISA-3

Isotype :

IgG1, kappa

Storage :

4 C, do not freeze

Description :

ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115