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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CaMKII beta Monoclonal Antibody (CB-beta-1)
catalog :
13-9800
quantity :
100 µg
price :
US 400.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CB-beta-1
reactivity :
human, mouse, rat, domestic sheep
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation
more info or order :
Invitrogen product webpage
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:10,000; fig 2
Kool M, van de Bree J, Bodde H, Elgersma Y, van Woerden G. The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. Sci Rep. 2016;6:26989 pubmed publisher
  • western blot; human; 1:4000; loading ...; fig 2c
Stephenson J, Wang X, Perfitt T, Parrish W, Shonesy B, Marks C, et al. A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J Neurosci. 2017;37:2216-2233 pubmed publisher
  • western blot; rat; 1:100
Farley M, Swulius M, Waxham M. Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities. Neuroscience. 2015;304:286-301 pubmed publisher
  • western blot; human; 1:1000; fig 1
Cipolletta E, Rusciano M, Maione A, Santulli G, Sorriento D, Del Giudice C, et al. Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy. PLoS ONE. 2015;10:e0130477 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 3
Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
  • western blot; human; 1:3000; fig 1
Shonesy B, Wang X, Rose K, Ramikie T, Cavener V, Rentz T, et al. CaMKII regulates diacylglycerol lipase-? and striatal endocannabinoid signaling. Nat Neurosci. 2013;16:456-63 pubmed publisher
  • immunohistochemistry; rat; 1:100; fig 2
Swulius M, Farley M, Bryant M, Waxham M. Electron cryotomography of postsynaptic densities during development reveals a mechanism of assembly. Neuroscience. 2012;212:19-29 pubmed publisher
  • immunocytochemistry; rat; 1:100
  • western blot; rat; 1:1000
Swulius M, Kubota Y, Forest A, Waxham M. Structure and composition of the postsynaptic density during development. J Comp Neurol. 2010;518:4243-60 pubmed publisher
  • western blot; mouse; 1:4000; fig 1
Brigman J, Wright T, Talani G, Prasad Mulcare S, Jinde S, Seabold G, et al. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci. 2010;30:4590-600 pubmed publisher
  • western blot; mouse
Baucum A, Jalan Sakrikar N, Jiao Y, Gustin R, Carmody L, Tabb D, et al. Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach. Mol Cell Proteomics. 2010;9:1243-59 pubmed publisher
  • western blot; rat; fig 5
Guttman M, Betts G, Barnes H, Ghassemian M, van der Geer P, Komives E. Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. Proteomics. 2009;9:5016-28 pubmed publisher
Kool M, Onori M, Borgesius N, van de Bree J, Elgersma Hooisma M, Nio E, et al. CAMK2-dependent signaling in neurons is essential for survival. J Neurosci. 2019;: pubmed publisher
Yamagata Y, Yanagawa Y, Imoto K. Differential Involvement of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase IIα in Hippocampus- and Amygdala-Dependent Memory Revealed by Kinase-Dead Knock-In Mouse. Eneuro. 2018;5: pubmed publisher
Lee S, Shin S, Zhong P, Kim H, Kim D, Kim J, et al. Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018;9:3434 pubmed publisher
Cohen S, Suutari B, He X, Wang Y, Sanchez S, Tirko N, et al. Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory. Nat Commun. 2018;9:2451 pubmed publisher
Sui S, Tian J, Gauba E, Wang Q, Guo L, Du H. Cyclophilin D regulates neuronal activity-induced filopodiagenesis by fine-tuning dendritic mitochondrial calcium dynamics. J Neurochem. 2018;: pubmed publisher
Nicole O, Bell D, Leste Lasserre T, Doat H, Guillemot F, Pacary E. A novel role for CAMKIIβ in the regulation of cortical neuron migration: implications for neurodevelopmental disorders. Mol Psychiatry. 2018;23:2209-2226 pubmed publisher
Yamazaki H, Sasagawa Y, Yamamoto H, Bito H, Shirao T. CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools. J Neurochem. 2018;146:145-159 pubmed publisher
Sugawara T, Hisatsune C, Miyamoto H, Ogawa N, Mikoshiba K. Regulation of spinogenesis in mature Purkinje cells via mGluR/PKC-mediated phosphorylation of CaMKIIβ. Proc Natl Acad Sci U S A. 2017;114:E5256-E5265 pubmed publisher
Nair R, Patil S, Tiron A, Kanhema T, Panja D, Schiro L, et al. Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo. Front Synaptic Neurosci. 2017;9:8 pubmed publisher
Zhang L, Wang L, Hiremath U, Bisoyi H, Nair G, Yelamaggad C, et al. Dynamic Orthogonal Switching of a Thermoresponsive Self-Organized Helical Superstructure. Adv Mater. 2017;29: pubmed publisher
Wills T, Klug J, Silberman Y, Baucum A, Weitlauf C, Colbran R, et al. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A. 2012;109:E278-87 pubmed publisher
Elgersma Y, Fedorov N, Ikonen S, Choi E, Elgersma M, Carvalho O, et al. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 2002;36:493-505 pubmed
Schell M, Erneux C, Irvine R. Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus. J Biol Chem. 2001;276:37537-46 pubmed
Christopherson K, Hillier B, Lim W, Bredt D. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem. 1999;274:27467-73 pubmed
product information
Product Type :
Antibody
Product Name :
CaMKII beta Monoclonal Antibody (CB-beta-1)
Catalog # :
13-9800
Quantity :
100 µg
Price :
US 400.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Fish, Human, Mouse, Ovine, Rat, Sea urchin
Applications :
ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
Species :
Fish, Human, Mouse, Ovine, Rat, Sea urchin
Clone :
CB-beta-1
Isotype :
IgG2b, kappa
Storage :
-20°C
Description :
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
Immunogen :
Purified rat brain CaM Kinase.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
Aliases :
Ca++/calmodulin-dependent protein kinase II beta subunit; calcium/calmodulin dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase II, beta; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; caM kinase II subunit beta; CAM2; CaMK II; CAMK2; CAMK2B; Camk2d; CAMKB; caMK-II subunit beta; caM-kinase II beta chain; Ck2b; hypothetical protein LOC525416; MGC29528; proline rich calmodulin-dependent protein kinase; ß CaMKII; ßCaMKII
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA