This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-4), Biotin, eBioscience
catalog :
13-9018-80
quantity :
25 ug
price :
US 176.00
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
ITEM-4

The same clone is also sold as:
reactivity :
human, mouse
application :
flow cytometry
citations: 13
Reference
Pachel C, Mathes D, Bayer B, Dienesch C, Wangorsch G, Heitzmann W, et al. Exogenous administration of a recombinant variant of TWEAK impairs healing after myocardial infarction by aggravation of inflammation. PLoS ONE. 2013;8:e78938 pubmed publisher
Roos C, Wicovsky A, Muller N, Salzmann S, Rosenthal T, Kalthoff H, et al. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. J Immunol. 2010;185:1593-605 pubmed publisher
Muller N, Schneider B, Pfizenmaier K, Wajant H. Superior serum half life of albumin tagged TNF ligands. Biochem Biophys Res Commun. 2010;396:793-9 pubmed publisher
Tiller G, Fischer Posovszky P, Laumen H, Finck A, Skurk T, Keuper M, et al. Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes. Endocrinology. 2009;150:5373-83 pubmed publisher
Chorianopoulos E, Heger T, Lutz M, Frank D, Bea F, Katus H, et al. FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. Basic Res Cardiol. 2010;105:301-13 pubmed publisher
Moreno J, Munoz Garcia B, Martin Ventura J, Madrigal Matute J, Orbe J, Paramo J, et al. The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis. Atherosclerosis. 2009;207:103-10 pubmed publisher
Sanz A, Sanchez Nino M, Izquierdo M, Jakubowski A, Justo P, Blanco Colio L, et al. Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia. J Cell Mol Med. 2009;13:3329-42 pubmed publisher
Vincent C, Findlay D, Welldon K, Wijenayaka A, Zheng T, Haynes D, et al. Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. J Bone Miner Res. 2009;24:1434-49 pubmed publisher
Desplat Jego S, Feuillet L, Creidy R, Malikova I, Rance R, Khrestchatisky M, et al. TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. J Leukoc Biol. 2009;85:132-5 pubmed publisher
Sanz A, Justo P, Sanchez Nino M, Blanco Colio L, Winkles J, Kreztler M, et al. The cytokine TWEAK modulates renal tubulointerstitial inflammation. J Am Soc Nephrol. 2008;19:695-703 pubmed publisher
Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, et al. Novel function of TWEAK in inducing intervertebral disc degeneration. J Orthop Res. 2007;25:1438-46 pubmed
Perper S, Browning B, Burkly L, Weng S, Gao C, Giza K, et al. TWEAK is a novel arthritogenic mediator. J Immunol. 2006;177:2610-20 pubmed
Jakubowski A, Ambrose C, Parr M, Lincecum J, Wang M, Zheng T, et al. TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005;115:2330-40 pubmed
product information
Product Type :
Antibody
Product Name :
CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-4), Biotin, eBioscience
Catalog # :
13-9018-80
Quantity :
25 ug
Price :
US 176.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Human, Mouse
Clone :
ITEM-4
Isotype :
IgG2b, kappa
Storage :
4 C, do not freeze
Description :
TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA