ERK1 Monoclonal Antibody (ERK-6B11) | Invitrogen 13-8600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ERK1 Monoclonal Antibody (ERK-6B11)

catalog :

13-8600

quantity :

100 µg

price :

US 449.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ERK-6B11

reactivity :

human, mouse, rat, dogs

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; fig 3 western blot; mouse; fig 3	Kurioka T, Matsunobu T, Satoh Y, Niwa K, Endo S, Fujioka M, et al. ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss. Sci Rep. 2015;5:16839 pubmed publisher
western blot; mouse; 1:3000; fig 3	Muller M, Triaca V, Besusso D, Costanzi M, Horn J, Koudelka J, et al. Loss of NGF-TrkA signaling from the CNS is not sufficient to induce cognitive impairments in young adult or intermediate-aged mice. J Neurosci. 2012;32:14885-98 pubmed publisher
western blot; mouse; 1:3000	Musumeci G, Sciarretta C, Rodríguez Moreno A, Al Banchaabouchi M, Negrete Díaz V, Costanzi M, et al. TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites. J Neurosci. 2009;29:10131-43 pubmed publisher
western blot; human; fig 5	Wu J, Jin Y, Calaf G, Huang W, Yin Y. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene. 2007;26:6526-35 pubmed
western blot; rat; fig 3	Farnier C, Krief S, Blache M, Diot Dupuy F, Mory G, Ferre P, et al. Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway. Int J Obes Relat Metab Disord. 2003;27:1178-86 pubmed
	Ullah M, Liu D, Rai S, Razavi M, Concepcion W, Thakor A. Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury. Stem Cell Res Ther. 2020;11:398 pubmed publisher
	Areiza Mazo N, Robles J, Zamudio Rodriguez J, Giraldez L, Echeverria V, Barrera Bailón B, et al. Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone. Front Chem. 2018;6:276 pubmed publisher
	Bach S, Knockaert M, Reinhardt J, Lozach O, Schmitt S, Baratte B, et al. Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem. 2005;280:31208-19 pubmed
	Lim C, Kim S, Jung J, Kim J, Song W. Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion. J Biol Chem. 2003;278:52116-23 pubmed
	Kruger J, Reddy K. Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells. Mol Cancer Res. 2003;1:801-9 pubmed
	Wang H, Li W, Benedetti N, Lee D. Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. J Biol Chem. 2003;278:31547-53 pubmed

product information

Product Type :

Antibody

Product Name :

ERK1 Monoclonal Antibody (ERK-6B11)

Catalog # :

13-8600

Quantity :

100 µg

Price :

US 449.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:250, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Species :

Canine, Human, Mouse, Rat

Clone :

ERK-6B11

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.

Immunogen :

Synthetic Peptide corresponding to a section of the C-terminus of rat ERK1.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:250, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Aliases :

ERK; Erk1; ERK-1; Ert2; Esrk1; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK 3; MAPK1; MAPK2; MAPK3; Microtubule-associated protein 2 kinase; mitogen activated protein kinase 3; mitogen-activated 3; mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; MNK1; Mtap2k; p44; p44 MAP kinase; P44ERK1; p44-ERK1; P44MAPK; p44-MAPK; pp42/MAP kinase; PRKM3

more info or order :

Invitrogen product webpage