product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
beta Catenin Monoclonal Antibody (CAT-5H10)
catalog :
13-8400
quantity :
100 µg
price :
US 455.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CAT-5H10
reactivity :
human, mouse, rat, dogs, chicken, bovine, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other
more info or order :
Invitrogen product webpage
citations: 126
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; tbl 1
Wilhelm F, Böger C, Krüger S, Behrens H, Rocken C. Troy is expressed in human stomach mucosa and a novel putative prognostic marker of intestinal type gastric cancer. Oncotarget. 2017;8:50557-50569 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5b
Wan H, Cai J, Chen F, Zhu J, Zhong J, Zhong H. SOX12: a novel potential target for acute myeloid leukaemia. Br J Haematol. 2017;176:421-430 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3b
Lobato Álvarez J, Roldán M, López Murillo T, González Ramírez R, Bonilla Delgado J, Shoshani L. The Apical Localization of Na+, K+-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the ?2 Subunit. Front Physiol. 2016;7:450 pubmed
  • immunocytochemistry; human; fig 1
Arévalo Romero H, Meza I, Vallejo Flores G, Fuentes Panana E. Helicobacter pylori CagA and IL-1? Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model. Gastroenterol Res Pract. 2016;2016:4969163 pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
De Pauw A, Massion P, Sekkali B, André E, Dubroca C, Kmecova J, et al. Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/?-catenin inhibition. Cardiovasc Res. 2016;112:478-90 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 1
  • western blot; rat; 1:500; fig 1
Li N, Mruk D, Chen H, Wong C, Lee W, Cheng C. Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43. Sci Rep. 2016;6:29667 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 1:100; loading ...; fig 1a
Payan Carreira R, Pires M, Santos C, Holst B, Colaco J, Rodriguez Martinez H. Immunolocalization of E-cadherin and ?-catenin in the cyclic and early pregnant canine endometrium. Theriogenology. 2016;86:1092-1101 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 7
  • western blot; mouse; fig 8
Falcão V, Maschio D, de Fontes C, Oliveira R, Santos Silva J, Almeida A, et al. Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMS) in diabetic mice after prolonged high-fat diet. Histochem Cell Biol. 2016;146:13-31 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 3
  • western blot; rat; 1:300; fig 3
Chen H, Mruk D, Lee W, Cheng C. Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats. Endocrinology. 2016;157:2140-59 pubmed publisher
  • western blot; human; fig 5
Xu X, Zhang Y, Jasper J, Lykken E, Alexander P, Markowitz G, et al. MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget. 2016;7:20381-94 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • immunocytochemistry; human; 1:50
  • western blot; human; 1:2000; fig 2a
Martínez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300
Figueira A, Gomes C, Vilhena H, Miranda S, Carvalheira J, de Matos A, et al. Characterization of α-, β- and p120-Catenin Expression in Feline Mammary Tissues and their Relation with E- and P-Cadherin. Anticancer Res. 2015;35:3361-9 pubmed
  • immunocytochemistry; human; 1:100; fig 1d
Zhu D, Wang Z, Zhao J, Calimeri T, Meng J, Hideshima T, et al. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med. 2015;21:572-80 pubmed publisher
  • immunohistochemistry; rat; 1:500
Tennakoon A, Izawa T, Wijesundera K, Katou Ichikawa C, Tanaka M, Golbar H, et al. Analysis of glial fibrillary acidic protein (GFAP)-expressing ductular cells in a rat liver cirrhosis model induced by repeated injections of thioacetamide (TAA). Exp Mol Pathol. 2015;98:476-85 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 6
Whish S, Dziegielewska K, Møllgård K, Noor N, Liddelow S, Habgood M, et al. The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions. Front Neurosci. 2015;9:16 pubmed publisher
  • western blot; human; 1:1000; fig 4
Chong K, Hsu C, Hung T, Hu H, Huang T, Wang T, et al. Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells. Cancer Biol Ther. 2015;16:149-59 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000
Xu X, Kim J, Sun P, Yoo S, Kim H, Jin Y, et al. Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer. Exp Ther Med. 2015;9:311-318 pubmed
  • immunohistochemistry - frozen section; rat; 1:100
  • western blot; rat; 1:300
Tang E, Mok K, Lee W, Cheng C. EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study. Endocrinology. 2015;156:680-93 pubmed publisher
  • western blot; human
Hung T, Hsu S, Cheng C, Choo K, Tseng C, Chen T, et al. Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway. Oncotarget. 2014;5:12273-90 pubmed
  • immunocytochemistry; human
Hagos Y, Wegner W, Kuehne A, Floerl S, Marada V, Burckhardt G, et al. HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma. J Pharm Sci. 2014;103:3326-34 pubmed publisher
  • western blot; human
Jin G, Liu B, You Z, Bambakidis T, Dekker S, Maxwell J, et al. Development of a novel neuroprotective strategy: combined treatment with hypothermia and valproic acid improves survival in hypoxic hippocampal cells. Surgery. 2014;156:221-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000
Li J, Bai X, Zou Y, Hao Y, Xu X. Aberration of the Wnt signaling pathway in pulmonary fatal adenocarcinoma: a case report. Chin J Cancer Res. 2014;26:E13-6 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 1:150
Rodrigues M, Rema A, Gartner M, Laufer Amorim R. Role of adhesion molecules and proliferation hyperplasic, pre neoplastic and neoplastic lesions in canine prostate. Pak J Biol Sci. 2013;16:1324-9 pubmed
  • immunohistochemistry; human; 1:2000
Kim S, Kim M, Kim M, Kim S, Choi J, Yu E, et al. Pleomorphic solid pseudopapillary neoplasm of the pancreas: degenerative change rather than high-grade malignant potential. Hum Pathol. 2014;45:166-74 pubmed publisher
  • immunohistochemistry; human; fig 2
Krabbe L, Westerman M, Bagrodia A, Gayed B, Darwish O, Haddad A, et al. Dysregulation of ?-catenin is an independent predictor of oncologic outcomes in patients with clear cell renal cell carcinoma. J Urol. 2014;191:1671-7 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Gu M, Choi J. Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma. J Clin Pathol. 2014;67:229-34 pubmed publisher
  • immunohistochemistry; human; 1:1500; tbl 1
Lee P, Yau D, Lau P, Chan J. Plexiform fibromyxoma (plexiform angiomyxoid myofibroblastic tumor) of stomach: an unusual presentation as a fistulating abscess. Int J Surg Pathol. 2014;22:286-90 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; tbl 4
Lee S, Kim H, Kim W, Han H, Lim S, Kim W, et al. Genetic alteration and immunohistochemical staining patterns of ovarian high-grade serous adenocarcinoma with special emphasis on p53 immnnostaining pattern. Pathol Int. 2013;63:252-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 1
Shi Y, Wu H, Zhang M, Ding L, Meng F, Fan X. Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinoma. Diagn Pathol. 2013;8:89 pubmed publisher
  • immunohistochemistry; human; 1:150; fig 2
Min H, Lee C, Jung K. Correlation of immunohistochemical markers and BRAF mutation status with histological variants of papillary thyroid carcinoma in the Korean population. J Korean Med Sci. 2013;28:534-41 pubmed publisher
  • western blot; human; fig 5
Qiu H, Zhang L, Ren C, Zeng Z, Wu W, Luo H, et al. Targeting CDH17 suppresses tumor progression in gastric cancer by downregulating Wnt/β-catenin signaling. PLoS ONE. 2013;8:e56959 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:75; fig 2
Vasconcelos Nóbrega C, Costa C, Vala H, Colaco A, Santos L, Lopes C, et al. E-cadherin and ?-catenin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice. Urol Int. 2013;91:462-6 pubmed publisher
  • immunohistochemistry; human; 1:100; tbl 1
Souazé F, Bou Hanna C, Kandel C, Leclair F, Devalliere J, Charreau B, et al. Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study. PLoS ONE. 2013;8:e55904 pubmed publisher
  • immunohistochemistry; human; 1:3000; fig 1
Avoranta S, Korkeila E, Ristamäki R, Syrjanen K, Carpén O, Pyrhönen S, et al. ALDH1 expression indicates chemotherapy resistance and poor outcome in node-negative rectal cancer. Hum Pathol. 2013;44:966-74 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Wang Q, Lin J, Chan S, Lin J. The Xin repeat-containing protein, mXinβ, initiates the maturation of the intercalated discs during postnatal heart development. Dev Biol. 2013;374:264-80 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250; fig 6
Carlsson E, Krohn K, Ovaska K, Lindberg P, Häyry V, Maliniemi P, et al. Neuron navigator 3 alterations in nervous system tumors associate with tumor malignancy grade and prognosis. Genes Chromosomes Cancer. 2013;52:191-201 pubmed publisher
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 3
Langer M, Duggan E, Booth J, Patel V, Zander R, Silasi Mansat R, et al. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun. 2012;80:4374-87 pubmed publisher
  • immunohistochemistry; mouse; 1:600
Gil da Costa R, Oliveira P, Bastos M, Lopes C, Lopes C. Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact ?-catenin and E-cadherin expression. Environ Toxicol. 2014;29:763-9 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Raposo C, Odorissi P, Oliveira A, Aoyama H, Ferreira C, Verinaud L, et al. Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier. Neurochem Res. 2012;37:1967-81 pubmed publisher
  • immunohistochemistry; human; fig 2
Zhang J, Liang Z, Gao J, Luo Y, Liu T. Pulmonary adenocarcinoma with a micropapillary pattern: a clinicopathological, immunophenotypic and molecular analysis. Histopathology. 2011;59:1204-14 pubmed publisher
  • western blot; human; fig 5
Jin G, Bausch D, Knightly T, Liu Z, Li Y, Liu B, et al. Histone deacetylase inhibitors enhance endothelial cell sprouting angiogenesis in vitro. Surgery. 2011;150:429-35 pubmed publisher
  • western blot; human; 1:250; fig 2
Kolegraff K, Nava P, Laur O, Parkos C, Nusrat A. Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines. Cell Adh Migr. 2011;5:306-14 pubmed
  • immunohistochemistry; rhesus macaque; fig 3
Hirt B, Gleiser C, Eckhard A, Mack A, Muller M, Wolburg H, et al. All functional aquaporin-4 isoforms are expressed in the rat cochlea and contribute to the formation of orthogonal arrays of particles. Neuroscience. 2011;189:79-92 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 4
  • western blot; mouse; 1:1000; fig 4
MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Im M, Kim D, Park J, Chung H, Lee Y, Kim C, et al. Alteration of the ?-catenin pathway in spiradenoma. J Cutan Pathol. 2011;38:657-62 pubmed publisher
  • western blot; mouse; fig 8
Li J, Swope D, Raess N, Cheng L, Muller E, Radice G. Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011;31:1134-44 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Yong Jiang -, Huawei Liu -, Hu Long -, Yingying Yang -, Dianying Liao -, Xiuhui Zhang -. Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. Int J Surg Pathol. 2010;18:488-92 pubmed publisher
  • western blot; human; fig s7
Tonge P, Andrews P. Retinoic acid directs neuronal differentiation of human pluripotent stem cell lines in a non-cell-autonomous manner. Differentiation. 2010;80:20-30 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Huvila J, Brandt A, Rojas C, Pasanen S, Talve L, Hirsimäki P, et al. Gene expression profiling of endometrial adenocarcinomas reveals increased apolipoprotein E expression in poorly differentiated tumors. Int J Gynecol Cancer. 2009;19:1226-31 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; tbl 2
Gil da Costa R, Santos M, Amorim I, Lopes C, Pereira P, Faustino A. An immunohistochemical study of feline endometrial adenocarcinoma. J Comp Pathol. 2009;140:254-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Patriarca C, Colombo P, Pio Taronna A, Wesseling J, Franchi G, Guddo F, et al. Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1). Int J Surg Pathol. 2009;17:99-106 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Elzagheid A, Buhmeida A, Korkeila E, Collan Y, Syrjanen K, Pyrhonen S. Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma. World J Gastroenterol. 2008;14:3866-71 pubmed
  • immunohistochemistry - paraffin section; human; 1:200
Buhmeida A, Elzagheid A, Algars A, Collan Y, Syrjanen K, Pyrhonen S. Expression of the cell-cell adhesion molecule beta-catenin in colorectal carcinomas and their metastases. APMIS. 2008;116:1-9 pubmed publisher
  • immunohistochemistry - paraffin section; human
Hervieu V, Lombard Bohas C, Dumortier J, Boillot O, Scoazec J. Primary acinar cell carcinoma of the liver. Virchows Arch. 2008;452:337-41 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1500; fig 2
Reichel O, Mayr D, Durst F, Berghaus A. E-cadherin but not beta-catenin expression is decreased in laryngeal biopsies from patients with laryngopharyngeal reflux. Eur Arch Otorhinolaryngol. 2008;265:937-42 pubmed publisher
  • immunocytochemistry; rat; fig 3
Lim S, Lim K, Giuliano R, Federoff H. Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. J Comp Neurol. 2008;507:1228-44 pubmed publisher
  • immunohistochemistry; chicken; 1:100; fig 2H
Thompson J, Wong L, Lau P, Bannigan J. Adherens junction breakdown in the periderm following cadmium administration in the chick embryo: distribution of cadherins and associated molecules. Reprod Toxicol. 2008;25:39-46 pubmed
  • immunohistochemistry; dogs; 1:100
Gama A, Paredes J, Gartner F, Alves A, Schmitt F. Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival. Vet J. 2008;177:45-53 pubmed
  • immunohistochemistry - paraffin section; human; 1:100
  • immunocytochemistry; human; 1:100
Huang D, Casale G, Tian J, Wehbi N, Abrahams N, Kaleem Z, et al. Quantitative fluorescence imaging analysis for cancer biomarker discovery: application to beta-catenin in archived prostate specimens. Cancer Epidemiol Biomarkers Prev. 2007;16:1371-81 pubmed
  • immunohistochemistry - paraffin section; human; fig 2
Mahomed F, Altini M, Meer S. Altered E-cadherin/beta-catenin expression in oral squamous carcinoma with and without nodal metastasis. Oral Dis. 2007;13:386-92 pubmed
  • immunohistochemistry - paraffin section; human; 1:100; fig 2
Canavese G, Bernardi A, Candelaresi G, Lovadina P, Amerio S, Rossetti V, et al. Expression of the E-cadherin-catenins complex in sentinel node is related to tumor morphology but not to spread to nonsentinel nodes. Pathol Res Pract. 2007;203:517-23 pubmed
  • immunohistochemistry - paraffin section; human; fig 4
De Matos A, Lopes C, Faustino A, Carvalheira J, Rutteman G, Gärtner M. E-cadherin, beta-catenin, invasion and lymph node metastases in canine malignant mammary tumours. APMIS. 2007;115:327-34 pubmed
  • western blot; mouse; 1:1000
Chang M, Boulden J, Sutanto Ward E, DuHadaway J, Soler A, Muller A, et al. Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression. Cancer Res. 2007;67:100-7 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:400
Gritli Linde A, Hallberg K, Harfe B, Reyahi A, Kannius Janson M, Nilsson J, et al. Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell. 2007;12:99-112 pubmed
  • immunohistochemistry; human; 1:250
Tiemann K, Kosmahl M, Ohlendorf J, Krams M, Kloppel G. Solid pseudopapillary neoplasms of the pancreas are associated with FLI-1 expression, but not with EWS/FLI-1 translocation. Mod Pathol. 2006;19:1409-13 pubmed
  • immunocytochemistry; dogs
Larre I, Ponce A, Fiorentino R, Shoshani L, Contreras R, Cereijido M. Contacts and cooperation between cells depend on the hormone ouabain. Proc Natl Acad Sci U S A. 2006;103:10911-6 pubmed
  • immunohistochemistry; human; 1:400; fig 1
Goldstein N. Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol. 2006;125:132-45 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Lee J, Choi K, Lee S, Gye M. Expression of beta-catenin in human testes with spermatogenic defects. Arch Androl. 2005;51:271-6 pubmed
  • immunohistochemistry - frozen section; human
Kaplan S, Gard J, Protonotarios N, Tsatsopoulou A, Spiliopoulou C, Anastasakis A, et al. Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm. 2004;1:3-11 pubmed
  • immunohistochemistry - paraffin section; mouse
Knudsen K, Sauer C, Johnson K, Wheelock M. Effect of N-cadherin misexpression by the mammary epithelium in mice. J Cell Biochem. 2005;95:1093-107 pubmed
  • immunocytochemistry; mouse; fig 3
  • western blot; mouse; fig 4A-B
Modarresi R, Lafond T, Roman Blas J, Danielson K, Tuan R, Seghatoleslami M. N-cadherin mediated distribution of beta-catenin alters MAP kinase and BMP-2 signaling on chondrogenesis-related gene expression. J Cell Biochem. 2005;95:53-63 pubmed
  • immunohistochemistry - paraffin section; human; fig 2
Ramburan A, Oladiran F, Smith C, Hadley G, Govender D. Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of beta catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy. J Clin Pathol. 2005;58:44-50 pubmed
  • immunohistochemistry - paraffin section; human; 1:250
Sedivy R, Peters K, Kloppel G. Osteopontin expression in ductal adenocarcinomas and undifferentiated carcinomas of the pancreas. Virchows Arch. 2005;446:41-5 pubmed
  • immunohistochemistry - frozen section; human; 1:2000
  • immunohistochemistry - paraffin section; human; 1:2000
Honecker F, Kersemaekers A, Molier M, Van Weeren P, Stoop H, de Krijger R, et al. Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development. J Pathol. 2004;204:167-74 pubmed
  • immunohistochemistry - paraffin section; human
Lyakhovitsky A, Barzilai A, Fogel M, Trau H, Huszar M. Expression of e-cadherin and beta-catenin in cutaneous squamous cell carcinoma and its precursors. Am J Dermatopathol. 2004;26:372-8 pubmed
  • immunohistochemistry - paraffin section; human; 1:250; tbl 1
Marques F, Fonsechi Carvasan G, de Angelo Andrade L, Bottcher Luiz F. Immunohistochemical patterns for alpha- and beta-catenin, E- and N-cadherin expression in ovarian epithelial tumors. Gynecol Oncol. 2004;94:16-24 pubmed
  • immunohistochemistry - paraffin section; human; 1:750; fig 3
Zhang P, Furth E, Cai X, Goldblum J, Pasha T, Min K. The role of beta-catenin, TGF beta 3, NGF2, FGF2, IGFR2, and BMP4 in the pathogenesis of mesenteric sclerosis and angiopathy in midgut carcinoids. Hum Pathol. 2004;35:670-4 pubmed
  • immunohistochemistry - paraffin section; human; 1:100
Zhu P, Martin E, Mengwasser J, Schlag P, Janssen K, Göttlicher M. Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell. 2004;5:455-63 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Song S, Kim S, Kim D, Son H, Rhee J, Kim Y. Abnormal expression of E-cadherin in early gastric carcinoma: its relationship with macroscopic growth patterns and catenin alpha and beta. J Clin Gastroenterol. 2004;38:252-9 pubmed
  • immunohistochemistry - paraffin section; human
Fidder H, Barshack I, Chen Shtoyerman R, Onaca N, Goldberg I, Rath P, et al. Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers. Dig Dis Sci. 2003;48:1102-5 pubmed
  • immunocytochemistry; mouse; 1:100
Luo Y, Radice G. Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus. J Cell Sci. 2003;116:1471-9 pubmed
  • EMSA; human; fig 1
Wu S, Morin P, Maouyo D, Sears C. Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation. Gastroenterology. 2003;124:392-400 pubmed
  • ELISA; human; 1:400
Swinney D, Xu Y, Scarafia L, Lee I, Mak A, Gan Q, et al. A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats. J Biol Chem. 2002;277:23573-81 pubmed
  • immunocytochemistry; chicken; 5 ug/ml; fig 5
Warchol M. Cell density and N-cadherin interactions regulate cell proliferation in the sensory epithelia of the inner ear. J Neurosci. 2002;22:2607-16 pubmed
  • immunohistochemistry - paraffin section; human; tbl 1
Wheelock M, Soler A, Knudsen K. Cadherin junctions in mammary tumors. J Mammary Gland Biol Neoplasia. 2001;6:275-85 pubmed
  • immunohistochemistry - paraffin section; human
Barshack I, Goldberg I, Chowers Y, Weiss B, Horowitz A, Kopolovic J. Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. J Clin Pathol. 2001;54:684-8 pubmed
  • immunohistochemistry - paraffin section; human; 1:250
Rahn J, Dabbagh L, Pasdar M, Hugh J. The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature. Cancer. 2001;91:1973-82 pubmed
  • immunoprecipitation; human
  • western blot; human
Rashid M, Sanda M, Vallorosi C, Rios Doria J, Rubin M, Day M. Posttranslational truncation and inactivation of human E-cadherin distinguishes prostate cancer from matched normal prostate. Cancer Res. 2001;61:489-92 pubmed
  • immunohistochemistry - paraffin section; human
Han A, Soler A, Tang C, Knudsen K, Salazar H. Nuclear localization of E-cadherin expression in Merkel cell carcinoma. Arch Pathol Lab Med. 2000;124:1147-51 pubmed
  • immunocytochemistry; bovine; 1:100
Carbajal J, Gratrix M, Yu C, Schaeffer R. ROCK mediates thrombin's endothelial barrier dysfunction. Am J Physiol Cell Physiol. 2000;279:C195-204 pubmed
  • immunocytochemistry; human
Elliott D, Clark D. Cryptosporidium parvum induces host cell actin accumulation at the host-parasite interface. Infect Immun. 2000;68:2315-22 pubmed
  • immunoprecipitation; human; fig 7
Vallorosi C, Day K, Zhao X, Rashid M, Rubin M, Johnson K, et al. Truncation of the beta-catenin binding domain of E-cadherin precedes epithelial apoptosis during prostate and mammary involution. J Biol Chem. 2000;275:3328-34 pubmed
  • immunohistochemistry - paraffin section; human; fig 3
Peralta Soler A, Knudsen K, Salazar H, Han A, Keshgegian A. P-cadherin expression in breast carcinoma indicates poor survival. Cancer. 1999;86:1263-72 pubmed
Zhou B, Magana L, Hong Z, Huang L, Chakraborty S, Tsukasaki Y, et al. The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury. Nat Immunol. 2020;21:1430-1443 pubmed publisher
Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester D, et al. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. J Am Heart Assoc. 2020;9:e017055 pubmed publisher
Parvathaneni V, Kulkarni N, Shukla S, Farrales P, Kunda N, Muth A, et al. Systematic Development and Optimization of Inhalable Pirfenidone Liposomes for Non-Small Cell Lung Cancer Treatment. Pharmaceutics. 2020;12: pubmed publisher
Yan M, Li L, Mao B, Li H, Li S, Mruk D, et al. mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model. Am J Physiol Endocrinol Metab. 2019;317:E121-E138 pubmed publisher
Castillo A, Ortuño Pineda C, Flores Maldonado C, Larre I, Martínez Rendón J, Hinojosa L, et al. Ouabain Modulates the Adherens Junction in Renal Epithelial Cells. Cell Physiol Biochem. 2019;52:1381-1397 pubmed publisher
Rodriguez Bravo V, Pippa R, Song W, Carceles Cordon M, Dominguez Andres A, Fujiwara N, et al. Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Cell. 2018;174:1200-1215.e20 pubmed publisher
Robilliard L, Kho D, Johnson R, Anchan A, O Carroll S, Graham E. The Importance of Multifrequency Impedance Sensing of Endothelial Barrier Formation Using ECIS Technology for the Generation of a Strong and Durable Paracellular Barrier. Biosensors (Basel). 2018;8: pubmed publisher
Li S, Yan M, Chen H, Jesus T, Lee W, Xiao X, et al. mTORC1/rpS6 regulates blood-testis barrier dynamics and spermatogenetic function in the testis in vivo. Am J Physiol Endocrinol Metab. 2018;314:E174-E190 pubmed publisher
Zhu R, Antoku S, Gundersen G. Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning. Curr Biol. 2017;27:3097-3110.e5 pubmed publisher
Walker C, O Hern M, Serna V, Kurita T, Miranda M, Sapp C, et al. Novel SOX17 frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations. Oncotarget. 2017;8:68758-68768 pubmed publisher
De Pauw A, André E, Sekkali B, Bouzin C, Esfahani H, Barbier N, et al. Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction. JCI Insight. 2017;2: pubmed publisher
Chen H, Mruk D, Lee W, Cheng C. Regulation of spermatogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptide. FASEB J. 2017;31:3587-3607 pubmed publisher
Merino V, Cho S, Liang X, Park S, Jin K, Chen Q, et al. Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors. Mol Oncol. 2017;11:552-566 pubmed publisher
Domínguez Calderón A, Ávila Flores A, Ponce A, López Bayghen E, Calderón Salinas J, Luis Reyes J, et al. ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway. Mol Biol Cell. 2016;27:1581-95 pubmed publisher
Xi Z, van Blitterswijk M, Zhang M, McGoldrick P, McLean J, Yunusova Y, et al. Jump from pre-mutation to pathologic expansion in C9orf72. Am J Hum Genet. 2015;96:962-70 pubmed publisher
Gungor Ordueri N, Celik Ozenci C, Cheng C. Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis. Am J Physiol Endocrinol Metab. 2014;307:E738-53 pubmed publisher
Warneke V, Behrens H, Haag J, Kruger S, Simon E, Mathiak M, et al. Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis. Br J Cancer. 2013;109:2217-27 pubmed publisher
Cuello Carrión F, Cayado Gutiérrez N, Natoli A, Restall C, Anderson R, Nadin S, et al. In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1-/- alters PTEN and NHERF1 but not ?-catenin expression. Cell Stress Chaperones. 2013;18:559-67 pubmed publisher
Narayanan B, Doudican N, Park J, Xu D, Narayanan N, DasGupta R, et al. Antagonistic effect of small-molecule inhibitors of Wnt/?-catenin in multiple myeloma. Anticancer Res. 2012;32:4697-707 pubmed
Huang C, Yan S, Chen D, Chen B, Zhao N. Application of on-line nanoLC-IT-TOF in the identification of serum ?-catenin complex in mice scald model. PLoS ONE. 2012;7:e46530 pubmed publisher
Ding H, Keller K, Martinez I, Geransar R, Zur Nieden K, Nishikawa S, et al. NO-?-catenin crosstalk modulates primitive streak formation prior to embryonic stem cell osteogenic differentiation. J Cell Sci. 2012;125:5564-77 pubmed publisher
Engelund M, Yu A, Li J, Madsen S, Færgeman N, Tipsmark C. Functional characterization and localization of a gill-specific claudin isoform in Atlantic salmon. Am J Physiol Regul Integr Comp Physiol. 2012;302:R300-11 pubmed publisher
Tabbekh M, Franciszkiewicz K, Haouas H, Lecluse Y, Benihoud K, Raman C, et al. Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice. J Immunol. 2011;187:102-9 pubmed publisher
Vidal F, de Araujo W, Cruz A, Tanaka M, Viola J, Morgado Diaz J. Lithium reduces tumorigenic potential in response to EGF signaling in human colorectal cancer cells. Int J Oncol. 2011;38:1365-73 pubmed publisher
McConnell B, Bialkowska A, Nandan M, Ghaleb A, Gordon F, Yang V. Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res. 2009;69:4125-33 pubmed publisher
Sukhdeo K, Mani M, Zhang Y, Dutta J, Yasui H, Rooney M, et al. Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. Proc Natl Acad Sci U S A. 2007;104:7516-21 pubmed
Contreras R, Flores Maldonado C, Lazaro A, Shoshani L, Flores Benitez D, Larre I, et al. Ouabain binding to Na+,K+-ATPase relaxes cell attachment and sends a specific signal (NACos) to the nucleus. J Membr Biol. 2004;198:147-58 pubmed
Kaplan D, Meigs T, Kelly P, Casey P. Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem. 2004;279:10829-32 pubmed
Li W, Huey C, Yu A. Expression of claudin-7 and -8 along the mouse nephron. Am J Physiol Renal Physiol. 2004;286:F1063-71 pubmed
Rios Doria J, Day K, Kuefer R, Rashid M, Chinnaiyan A, Rubin M, et al. The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells. J Biol Chem. 2003;278:1372-9 pubmed
Adam L, Vadlamudi R, McCrea P, Kumar R. Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem. 2001;276:28443-50 pubmed
Sakanaka C, Weiss J, Williams L. Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. Proc Natl Acad Sci U S A. 1998;95:3020-3 pubmed
product information
Product Type :
Antibody
Product Name :
beta Catenin Monoclonal Antibody (CAT-5H10)
Catalog # :
13-8400
Quantity :
100 µg
Price :
US 455.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Chicken, Human, Mouse
Applications :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Species :
Chicken, Human, Mouse
Clone :
CAT-5H10
Isotype :
IgG1, kappa
Storage :
-20°C
Description :
Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.
Immunogen :
Fusion protein consisting of the maltose binding protein fused to a 100 amino acid segment of the C-terminus of chicken beta-Catenin.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Aliases :
armadillo; armadillo homolog; Bcatenin; b-catenin; beta 1 88kDa; beta catenin; Betacatenin; beta-catenin; beta-catenin 1; Bfc; C20orf33; Cadherin associated protein; catenin; catenin (cadherin associated protein), beta 1; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein) beta 1; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; catenin beta; catenin beta 1; catenin beta 1 L homeolog; Catenin beta1; Catenin beta-1; Catenin ß 1; Catenin ß1; Catnb; CHBCAT; CTNB1; CTNNB; ctnnb1; ctnnb1.L; ctnnb1-a; ctnnb1-b; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; id:ibd2058; Mesc; MRD19; NAP; NYD-SP19; OK/SW-cl.35; OTTHUMP00000209289; P14L; PP8304; PRO2286; RP5-1118M15.1; wu:fb73e10; wu:fi81c06; wu:fk25h01; XELAEV_18031149mg; ß catenin; ßcatenin
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA