CaMKII alpha Monoclonal Antibody (Cba-2) | Invitrogen 13-7300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CaMKII alpha Monoclonal Antibody (Cba-2)

catalog :

13-7300

quantity :

100 µg

price :

US 482

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Cba-2

reactivity :

human, mouse, rat, domestic sheep

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 2a	Wilkinson B, Li J, Coba M. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Sci Rep. 2017;7:5272 pubmed publisher
immunohistochemistry; mouse; 1:1000; loading ...; fig 4b	Zagrebelsky M, Lonnemann N, Fricke S, Kellner Y, PreuÃŸ E, Michaelsen Preusse K, et al. Nogo-A regulates spatial learning as well as memory formation and modulates structural plasticity in the adult mouse hippocampus. Neurobiol Learn Mem. 2017;138:154-163 pubmed publisher
immunocytochemistry; rat; 1:1000; fig 3	Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
immunocytochemistry; rat; 1:200; fig s4	Gu Q, Yu D, Hu Z, Liu X, Yang Y, Luo Y, et al. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun. 2015;6:6789 pubmed publisher
western blot; rat	DomÃnguez Alonso A, ValdÃ©s Tovar M, SolÃs ChagoyÃ¡n H, BenÃtez King G. Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex. Int J Mol Sci. 2015;16:1907-27 pubmed publisher
immunocytochemistry; rat immunocytochemistry; mouse western blot; mouse; 1:1000	Jia J, Hu Z, Nordman J, Li Z. The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. J Neurosci. 2014;34:13725-36 pubmed publisher
western blot; mouse; fig 2	Huang Y, Ruiz C, Eyler E, Lin K, Meffert M. Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis. Cell. 2012;148:933-46 pubmed publisher
western blot; mouse; 1:1000; fig 2	Huang K, Huang F, Shetty P. Stimulation-mediated translocation of calmodulin and neurogranin from soma to dendrites of mouse hippocampal CA1 pyramidal neurons. Neuroscience. 2011;178:1-12 pubmed publisher
western blot; human; fig 4	Lapchak P, SCHUBERT D, Maher P. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. J Neurochem. 2011;116:122-31 pubmed publisher
	Desch K, Langer J, Schuman E. Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling. Cell Rep. 2021;36:109583 pubmed publisher
	Zhan Q, Jeon J, Li Y, Huang Y, Xiong J, Wang Q, et al. CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy. 2021;:1-19 pubmed publisher
	McKay S, Ryan T, McQueen J, Indersmitten T, Marwick K, Hasel P, et al. The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences. Cell Rep. 2018;25:841-851.e4 pubmed publisher
	Lee S, Shin S, Zhong P, Kim H, Kim D, Kim J, et al. Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018;9:3434 pubmed publisher
	Cohen S, Suutari B, He X, Wang Y, Sanchez S, Tirko N, et al. Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory. Nat Commun. 2018;9:2451 pubmed publisher
	Nobili A, Latagliata E, Viscomi M, Cavallucci V, Cutuli D, Giacovazzo G, et al. Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease. Nat Commun. 2017;8:14727 pubmed publisher
	Nehra S, Bhardwaj V, Kar S, Saraswat D. Chronic Hypobaric Hypoxia Induces Right Ventricular Hypertrophy and Apoptosis in Rats: Therapeutic Potential of Nanocurcumin in Improving Adaptation. High Alt Med Biol. 2016;17:342-352 pubmed
	Millon Fremillon A, Brunner M, Abed N, Collomb E, Ribba A, Block M, et al. Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1?) negatively regulates ?1 integrins. J Biol Chem. 2013;288:20248-60 pubmed publisher
	Tang F, Kalil K. Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways. J Neurosci. 2005;25:6702-15 pubmed
	Fang L, Wu J, Lin Q, Willis W. Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci. 2002;22:4196-204 pubmed
	Christopherson K, Hillier B, Lim W, Bredt D. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem. 1999;274:27467-73 pubmed

product information

Product Type :

Antibody

Product Name :

CaMKII alpha Monoclonal Antibody (Cba-2)

Catalog # :

13-7300

Quantity :

100 µg

Price :

US 482

Clonality :

Monoclonal

Purity :

Antigen affinity chromatography

Host :

Mouse

Reactivity :

Fish, Human, Mouse, Ovine, Rat

Applications :

ELISA: 0.1-1 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Immunoprecipitation: 2 µg, Western Blot: 0.5-1 µg/mL

Species :

Fish, Human, Mouse, Ovine, Rat

Clone :

Cba-2

Isotype :

IgG2a, kappa

Storage :

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Description :

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.

Immunogen :

Purified rat brain CaM Kinase.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.1-1 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Immunoprecipitation: 2 µg, Western Blot: 0.5-1 µg/mL

Aliases :

alpha CaM kinase II; alpha-CaMKII; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; Calci; calcium/calmodulin dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II alpha subunit; caM kinase II subunit alpha; CaMK II; CAMK2; Camk2a; CAMKA; CaMKII; CaMK-II alpha subunit; caMK-II subunit alpha; CaMKIINalpha; CaM-kinase II alpha chain; EC 2.7.11.17; KIAA0968; mKIAA0968; OTTHUMP00000165787; OTTHUMP00000165788; Phospho-CaMKI; PK2CDD; PKCCD; R74975

more info or order :

Invitrogen product webpage