IL-21 Monoclonal Antibody (eBio2B2-G20 (2B2-G20)), Biotin, eBioscience | Invitrogen 13-7218-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-21 Monoclonal Antibody (eBio2B2-G20 (2B2-G20)), Biotin, eBioscience

catalog :

13-7218-81

quantity :

50 µg

price :

US 105

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

eBio2B2-G20 (2B2-G20)

reactivity :

human

application :

ELISA, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1d	Lebre M, Vieira P, Tang M, Aarrass S, Helder B, Newsom Davis T, et al. Synovial IL-21/TNF-producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes. J Leukoc Biol. 2017;101:775-783 pubmed publisher
	Azzopardi L, Thompson S, Harding K, Cossburn M, Robertson N, Compston A, et al. Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2014;85:795-8 pubmed publisher
	Palandra J, Finelli A, Zhu M, Masferrer J, Neubert H. Highly specific and sensitive measurements of human and monkey interleukin 21 using sequential protein and tryptic peptide immunoaffinity LC-MS/MS. Anal Chem. 2013;85:5522-9 pubmed publisher
	Parrish Novak J, Dillon S, Nelson A, Hammond A, Sprecher C, Gross J, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408:57-63 pubmed

product information

Product Type :

Antibody

Product Name :

IL-21 Monoclonal Antibody (eBio2B2-G20 (2B2-G20)), Biotin, eBioscience

Catalog # :

13-7218-81

Quantity :

50 µg

Price :

US 105

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 0.5-2 µg/mL

Species :

Human

Clone :

eBio2B2-G20 (2B2-G20)

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.5-2 µg/mL

Aliases :

CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11

more info or order :

Invitrogen product webpage