IL-1 beta Polyclonal Antibody, Biotin, eBioscience | Invitrogen 13-7112-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-1 beta Polyclonal Antibody, Biotin, eBioscience

catalog :

13-7112-81

quantity :

50 ug

price :

US 156.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

biotin

reactivity :

mouse

citations: 15

Reference
Lin Y, Jamin A, Wolfheimer S, Fiedler A, Junker A, Goretzki A, et al. A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages. Front Immunol. 2023;14:1136669 pubmed publisher
Simanullang R, Situmorang P, Herlina M, Noradina -, Silalahi B, Manurung S. Histological changes of cervical tumours following Zanthoxylum acanthopodium DC treatment, and its impact on cytokine expression. Saudi J Biol Sci. 2022;29:2706-2718 pubmed publisher
Lin Y, Flaczyk A, Wolfheimer S, Goretzki A, Jamin A, Wangorsch A, et al. The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE2 from Epithelial Cells. Cells. 2021;10: pubmed publisher
Kato A, Adachi S, Kawano S, Takeshima K, Watanabe M, Kitazume S, et al. Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics. Nat Commun. 2020;11:4894 pubmed publisher
Muri J, Wolleb H, Broz P, Carreira E, Kopf M. Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose. Redox Biol. 2020;36:101647 pubmed publisher
Qing H, Desrouleaux R, Israni Winger K, Mineur Y, Fogelman N, Zhang C, et al. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell. 2020;182:372-387.e14 pubmed publisher
Tenthorey J, Chavez R, Thompson T, Deets K, Vance R, Rauch I. NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma. J Exp Med. 2020;217: pubmed publisher
Muri J, Feng Q, Wolleb H, Shamshiev A, Ebner C, Tortola L, et al. Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways. Cell Rep. 2020;30:4399-4417.e7 pubmed publisher
Muri J, Thut H, Feng Q, Kopf M. Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip. elife. 2020;9: pubmed publisher
Dai D, Yuan J, Wang Y, Xu J, Mao C, Xiao Y. Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation. Sci Rep. 2019;9:8034 pubmed publisher
Yanagisawa N, Ueshiba H, Abe Y, Kato H, Higuchi T, Yagi J. Outer Membrane Protein of Gut Commensal Microorganism Induces Autoantibody Production and Extra-Intestinal Gland Inflammation in Mice. Int J Mol Sci. 2018;19: pubmed publisher
den Hartigh A, Fink S. Pyroptosis Induction and Detection. Curr Protoc Immunol. 2018;122:e52 pubmed publisher
Ono K, Nimura S, Hideshima Y, Nabeshima K, Nakashima M. Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice. Exp Ther Med. 2017;14:5485-5490 pubmed publisher
Shi G, Abbott K, Wu W, Salter R, Keyel P. Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion. Front Immunol. 2017;8:522 pubmed publisher
Kim K, Kim N, Kim S, Kim I, Kim K, Lee G. Cyclo(Phe-Pro) produced by the human pathogen Vibrio vulnificus inhibits host innate immune responses through the NF-ÎºB pathway. Infect Immun. 2015;83:1150-61 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-1 beta Polyclonal Antibody, Biotin, eBioscience

Catalog # :

13-7112-81

Quantity :

50 ug

Price :

US 156.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Mouse

Applications :

ELISA: 1-6 ug/mL

Species :

Mouse

Isotype :

IgG

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1-6 ug/mL

Aliases :

catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta