IL-6 Monoclonal Antibody (MP5-32C11), Biotin, eBioscience | Invitrogen 13-7062-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-6 Monoclonal Antibody (MP5-32C11), Biotin, eBioscience

catalog :

13-7062-81

quantity :

50 µg

price :

US 121

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

MP5-32C11

reactivity :

mouse

application :

ELISA

more info or order :

Invitrogen product webpage

citations: 45

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse; loading ...; fig 5c	Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed publisher
ELISA; mouse; fig 5a	Raynor J, Karns R, Almanan M, Li K, Divanovic S, Chougnet C, et al. IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. J Immunol. 2015;195:944-52 pubmed publisher
	Lee G, Liao T, Wu J, Wu K, Kuo C. Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE-/- mice fed high fat diet. J Biomed Sci. 2021;28:74 pubmed publisher
	Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother T, Tourtellotte W, et al. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021;54:1463-1477.e11 pubmed publisher
	Alford M, Choi K, Trimble M, Masoudi H, Kalsi P, Pletzer D, et al. Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies. Front Cell Infect Microbiol. 2021;11:621081 pubmed publisher
	Yeh C, Wu J, Lee G, Wen H, Lin P, Kuo C. Vanadium Derivative Exposure Promotes Functional Alterations of VSMCs and Consequent Atherosclerosis via ROS/p38/NF-κB-Mediated IL-6 Production. Int J Mol Sci. 2019;20: pubmed publisher
	Dai D, Yuan J, Wang Y, Xu J, Mao C, Xiao Y. Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation. Sci Rep. 2019;9:8034 pubmed publisher
	Sanchez Lopez E, Zhong Z, Stubelius A, Sweeney S, Booshehri L, Antonucci L, et al. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019;29:1350-1362.e7 pubmed publisher
	Martínez López M, Iborra S, Conde Garrosa R, Mastrangelo A, Danne C, Mann E, et al. Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity. 2019;50:446-461.e9 pubmed publisher
	Muccioli M, Nandigam H, Loftus T, Singh M, Venkatesh A, Wright J, et al. Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues. Oncotarget. 2018;9:36666-36683 pubmed publisher
	Moreno Fernandez M, Giles D, Stankiewicz T, Sheridan R, Karns R, Cappelletti M, et al. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI Insight. 2018;3: pubmed publisher
	Ono K, Nimura S, Hideshima Y, Nabeshima K, Nakashima M. Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice. Exp Ther Med. 2017;14:5485-5490 pubmed publisher
	Penkert R, Jones B, Hacker H, Partridge J, Hurwitz J. Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines. Cytokine. 2017;91:1-5 pubmed publisher
	Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed publisher
	Stemmer K, Kotzbeck P, Zani F, Bauer M, Neff C, MÃ¼ller T, et al. Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice. Int J Obes (Lond). 2015;39:791-7 pubmed publisher
	ONTIVEROS E, Halwani A, Stunz L, Kamberos N, Olivier A, Janz S, et al. A new model of LMP1-MYC interaction in B cell lymphoma. Leuk Lymphoma. 2014;55:2917-23 pubmed publisher
	Zhang X, Wu C, Song J, Götte M, Sorokin L. Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis. J Immunol. 2013;191:4551-61 pubmed publisher
	Maldonado M, Kapphahn R, Terluk M, Heuss N, Yuan C, Gregerson D, et al. Immunoproteasome deficiency modifies the alternative pathway of NF?B signaling. PLoS ONE. 2013;8:e56187 pubmed publisher
	Namjoshi D, Martin G, Donkin J, Wilkinson A, Stukas S, Fan J, et al. The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS ONE. 2013;8:e53529 pubmed publisher
	Park S, Kang S, Min K, Woo Hwang K, Min H. Age-associated changes in microRNA expression in bone marrow derived dendritic cells. Immunol Invest. 2013;42:179-90 pubmed publisher
	Poovassery J, Bishop G. Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J Immunol. 2012;189:1757-64 pubmed publisher
	Glowacka W, Alberts P, Ouchida R, Wang J, Rotin D. LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. J Biol Chem. 2012;287:27691-702 pubmed publisher
	Osterbur J, Sprague L, Muccioli M, Pate M, Mansfield K, McGinty J, et al. Adhesion to substrates induces dendritic cell endothelization and decreases immunological response. Immunobiology. 2013;218:64-75 pubmed publisher
	Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev A, Kisielow J, et al. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol. 2011;41:2040-51 pubmed publisher
	Ashman R, Goeken J, Latz E, Lenert P. Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding. Int Immunol. 2011;23:203-14 pubmed publisher
	Helmersson S, Stenstrom M, Leanderson T, Ivars F. Specific effect of immunomodulatory quinoline-3-carboxamide ABR-215757 in GM-CSF stimulated bone marrow cell cultures: block of initiation of proliferation of Gr-1+ cells. Int Immunopharmacol. 2011;11:1045-51 pubmed publisher
	Ashman R, Goeken J, Lenert P. Aggregation and secondary loop structure of oligonucleotides do not determine their ability to inhibit TLR9. Int Immunopharmacol. 2011;11:1032-7 pubmed publisher
	Layer T, Steele A, Goeken J, Fleenor S, Lenert P. Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice. Clin Exp Immunol. 2011;163:392-403 pubmed publisher
	Hwang W, Jung K, Jeon Y, Yun S, Kim T, Choi I. Knockdown of the interleukin-6 receptor alpha chain of dendritic cell vaccines enhances the therapeutic potential against IL-6 producing tumors. Vaccine. 2010;29:34-44 pubmed publisher
	Nakatsukasa H, Tsukimoto M, Tokunaga A, Kojima S. Repeated gamma irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells but not by damaging lymphocytes directly. Radiat Res. 2010;174:313-24 pubmed publisher
	Goeken J, Layer T, Fleenor S, Laccheo M, Lenert P. B-cell receptor for antigen modulates B-cell responses to complex TLR9 agonists and antagonists: implications for systemic lupus erythematosus. Lupus. 2010;19:1290-301 pubmed publisher
	Zha W, Liang G, Xiao J, Studer E, Hylemon P, Pandak W, et al. Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. PLoS ONE. 2010;5:e9069 pubmed publisher
	Sakai M, Yamashita K, Takemoto N, Ohshima Y, Tsukimoto M, Shinkai Y, et al. Diesel exhaust (DE) aggravates pathology of delayed-type hypersensitivity (DTH) induced by methyl-bovine serum albumin (mBSA) in mice. J Toxicol Sci. 2009;34:483-92 pubmed
	Yamashita K, Sakai M, Takemoto N, Tsukimoto M, Uchida K, Yajima H, et al. Attenuation of delayed-type hypersensitivity by fullerene treatment. Toxicology. 2009;261:19-24 pubmed publisher
	Tsukimoto M, Nakatsukasa H, Sugawara K, Yamashita K, Kojima S. Repeated 0.5-Gy gamma irradiation attenuates experimental autoimmune encephalomyelitis with up-regulation of regulatory T cells and suppression of IL17 production. Radiat Res. 2008;170:429-36 pubmed
	Sonderegger I, Iezzi G, Maier R, Schmitz N, Kurrer M, Kopf M. GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival. J Exp Med. 2008;205:2281-94 pubmed publisher
	Vanden Bush T, Bishop G. TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation. Eur J Immunol. 2008;38:400-9 pubmed publisher
	Tago F, Tsukimoto M, Nakatsukasa H, Kojima S. Repeated 0.5-Gy gamma irradiation attenuates autoimmune disease in MRL-lpr/lpr mice with suppression of CD3+CD4-CD8-B220+ T-cell proliferation and with up-regulation of CD4+CD25+Foxp3+ regulatory T cells. Radiat Res. 2008;169:59-66 pubmed
	Minges Wols H, Ippolito J, Yu Z, Palmer J, White F, Le P, et al. The effects of microenvironment and internal programming on plasma cell survival. Int Immunol. 2007;19:837-46 pubmed
	Mutou Y, Ibuki Y, Kojima S. Immunomodulatory effects of ultraviolet B irradiation on atopic dermatitis in NC/Nga mice. Photodermatol Photoimmunol Photomed. 2007;23:135-44 pubmed
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	Grigorian A, Lee S, Tian W, Chen I, Gao G, Mendelsohn R, et al. Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem. 2007;282:20027-35 pubmed
	Le Barillec K, Magalhaes J, Corcuff E, Thuizat A, Sansonetti P, Phalipon A, et al. Roles for T and NK cells in the innate immune response to Shigella flexneri. J Immunol. 2005;175:1735-40 pubmed
	Finkelman F, Morris S. Development of an assay to measure in vivo cytokine production in the mouse. Int Immunol. 1999;11:1811-8 pubmed
	Sander B, Höidén I, Andersson U, Moller E, Abrams J. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining. J Immunol Methods. 1993;166:201-14 pubmed

product information

Product Type :

Antibody

Product Name :

IL-6 Monoclonal Antibody (MP5-32C11), Biotin, eBioscience

Catalog # :

13-7062-81

Quantity :

50 µg

Price :

US 121

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: 0.5-2 µg/mL

Species :

Mouse

Clone :

MP5-32C11

Isotype :

IgG2a, kappa

Storage :

4° C, do not freeze

Description :

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.5-2 µg/mL

Aliases :

B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6

more info or order :

Invitrogen product webpage