product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Transferrin Receptor Monoclonal Antibody (H68.4)
catalog :
13-6890
quantity :
500 µg
price :
US 990
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H68.4
reactivity :
cabbage looper, hamsters, Chinese hamsters, African green monkey, human, mouse, rat, dogs, chicken, pigs , brewer's yeast, cat, domestic horse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments, western blot knockout validation
more info or order :
Invitrogen product webpage
citations: 632
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; fig 1
Chen A, Donovan A, Ned Sykes R, Andrews N. Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. Proc Natl Acad Sci U S A. 2015;112:11714-9 pubmed publisher
  • western blot; human; loading ...; fig 6c
Moissoglu K, Stueland M, Gasparski A, Wang T, Jenkins L, Hastings M, et al. RNA localization and co-translational interactions control RAB13 GTPase function and cell migration. EMBO J. 2020;39:e104958 pubmed publisher
  • western blot; mouse; loading ...; fig s3b
Kapralov A, Yang Q, Dar H, Tyurina Y, Anthonymuthu T, Kim R, et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16:278-290 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Luteijn R, Zaver S, Gowen B, Wyman S, Garelis N, Onia L, et al. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2019;573:434-438 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s13a
Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, et al. Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science. 2018;362: pubmed publisher
  • western blot; human; 1:200; loading ...
Patwardhan A, Bardin S, Miserey Lenkei S, Larue L, Goud B, Raposo G, et al. Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes. Nat Commun. 2017;8:15835 pubmed publisher
  • western blot; hamsters; loading ...; fig 2F
Wright R, Newey S, Ilie A, Wefelmeyer W, Raimondo J, Ginham R, et al. Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex. J Neurosci. 2017;37:5447-5462 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 5a
Roy N, Pacini G, Berlioz Torrent C, Janvier K. Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2. J Cell Sci. 2017;130:1596-1611 pubmed publisher
  • western blot; human; loading ...; fig 7a
Lemler D, Lynch M, Tesfay L, Deng Z, Paul B, Wang X, et al. DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms. Breast Cancer Res. 2017;19:25 pubmed publisher
  • immunohistochemistry; human; 1:1000; fig 4d
Bruurs L, Zwakenberg S, van der Net M, Zwartkruis F, Bos J. A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, et al. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Sci Rep. 2016;6:39470 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5
Horniblow R, Henesy D, Iqbal T, Tselepis C. Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. Mol Nutr Food Res. 2017;61: pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, et al. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016;143:4509-4520 pubmed
  • immunocytochemistry; human; loading ...; fig 1
  • western blot; human; loading ...; fig 5d
Tanaka Y, Ono N, Shima T, Tanaka G, Katoh Y, Nakayama K, et al. The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane. Mol Biol Cell. 2016;27:3883-3893 pubmed
  • western blot; rat; loading ...; fig 3a
Sierra Valdez F, Ruiz Suárez J, Delint Ramirez I. Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABAA receptors. Biochim Biophys Acta. 2016;1858:2603-2610 pubmed publisher
  • western blot; mouse; 1:2000; fig s9
Sun X, Li L, Liu F, Huang Z, Bean J, Jiao H, et al. Lrp4 in astrocytes modulates glutamatergic transmission. Nat Neurosci. 2016;19:1010-8 pubmed publisher
  • western blot; rat; 1:2000; fig 1
Huebner S, Blohowiak S, Kling P, Smith S. Prenatal Alcohol Exposure Alters Fetal Iron Distribution and Elevates Hepatic Hepcidin in a Rat Model of Fetal Alcohol Spectrum Disorders. J Nutr. 2016;146:1180-8 pubmed publisher
  • immunocytochemistry; pigs ; 1:25; loading ...; fig 4c
Hernaez B, Guerra M, Salas M, Andres G. African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes. PLoS Pathog. 2016;12:e1005595 pubmed publisher
  • western blot; mouse; 1:500; fig 5
Bosch M, Nerbonne J, Townsend R, Miyazaki H, Nukina N, Ornitz D, et al. Proteomic analysis of native cerebellar iFGF14 complexes. Channels (Austin). 2016;10:297-312 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000; loading ...; fig 3a
Jhaveri D, Kim M, Thompson E, Huang L, Sharma R, Klein A, et al. Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer. Cancer Immunol Res. 2016;4:225-33 pubmed publisher
  • western blot; human; 1:1000; fig 5
Horton E, Humphries J, Stutchbury B, Jacquemet G, Ballestrem C, Barry S, et al. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. J Cell Biol. 2016;212:349-64 pubmed publisher
  • flow cytometry; human; 1:200
  • immunocytochemistry; human; 1:200
Ketel K, Krauss M, Nicot A, Puchkov D, Wieffer M, Müller R, et al. A phosphoinositide conversion mechanism for exit from endosomes. Nature. 2016;529:408-12 pubmed publisher
  • immunocytochemistry; human; fig 7
  • western blot; human; fig 1
Zhao Y, Feresin R, Falcon Perez J, Salazar G. Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity. Traffic. 2016;17:267-88 pubmed publisher
  • western blot; human; 1:1000; fig 2
Nelson J, Cook E, Loregger A, Hoeksema M, Scheij S, Kovacevic I, et al. Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake. J Biol Chem. 2016;291:4813-25 pubmed publisher
  • immunocytochemistry; hamsters; 1:200; fig 6
  • western blot; hamsters; fig 8
Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  • western blot; cabbage looper; fig 5
Patrone M, Coroadinha A, Teixeira A, Alves P. Palmitoylation Strengthens Cholesterol-dependent Multimerization and Fusion Activity of Human Cytomegalovirus Glycoprotein B (gB). J Biol Chem. 2016;291:4711-22 pubmed publisher
  • western blot; human; loading ...; fig 2d
Jabara H, Boyden S, Chou J, Ramesh N, Massaad M, Benson H, et al. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016;48:74-8 pubmed publisher
  • immunocytochemistry; African green monkey; fig 2
Billcliff P, Noakes C, Mehta Z, Yan G, Mak L, Woscholski R, et al. OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates. Mol Biol Cell. 2016;27:90-107 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig s1
Bruurs L, Donker L, Zwakenberg S, Zwartkruis F, Begthel H, Knisely A, et al. ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. J Cell Biol. 2015;210:1055-63 pubmed publisher
  • immunocytochemistry; human; 1:100; fig s5
David J, Stas J, Schmitt N, Bocksteins E. Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels. Sci Rep. 2015;5:12813 pubmed publisher
  • western blot; human
de Wilde A, Wannee K, Scholte F, Goeman J, Ten Dijke P, Snijder E, et al. A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins. J Virol. 2015;89:8318-33 pubmed publisher
  • immunocytochemistry; mouse; fig s6
Ruas M, Davis L, Chen C, Morgan A, Chuang K, Walseth T, et al. Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J. 2015;34:1743-58 pubmed publisher
  • western blot; human
Chen J, Tibroni N, Sauter D, Galaski J, Miura T, Alter G, et al. Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma. PLoS ONE. 2015;10:e0120434 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Robertson J, Jacquemet G, Byron A, Jones M, Warwood S, Selley J, et al. Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nat Commun. 2015;6:6265 pubmed publisher
  • immunocytochemistry; African green monkey; fig 1
Lee S, Uchida Y, Wang J, Matsudaira T, Nakagawa T, Kishimoto T, et al. Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase. EMBO J. 2015;34:669-88 pubmed publisher
  • western blot; mouse
Burhans M, Flowers M, Harrington K, Bond L, Guo C, Anderson R, et al. Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation. J Lipid Res. 2015;56:304-18 pubmed publisher
  • western blot; human
Ng D, Humphries J, Byron A, Millon Frémillon A, Humphries M. Microtubule-dependent modulation of adhesion complex composition. PLoS ONE. 2014;9:e115213 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000
  • western blot; human; 1:1000
Guo L, Alekseev O, Li Y, Song Y, Dunaief J. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res. 2014;129:31-7 pubmed publisher
  • immunocytochemistry; human
de Carvalho J, de Castro R, da Silva E, Silveira P, da Silva Januário M, Arruda E, et al. Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection. PLoS ONE. 2014;9:e113691 pubmed publisher
  • western blot; human; 1:2500; fig s2
Nijenhuis W, Vallardi G, Teixeira A, Kops G, Saurin A. Negative feedback at kinetochores underlies a responsive spindle checkpoint signal. Nat Cell Biol. 2014;16:1257-64 pubmed publisher
  • immunocytochemistry; human
Takatsu H, Tanaka G, Segawa K, Suzuki J, Nagata S, Nakayama K, et al. Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014;289:33543-56 pubmed publisher
  • western blot; human
McGough I, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom K, et al. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. J Cell Sci. 2014;127:4940-53 pubmed publisher
  • western blot; chicken
Pance A, Morrissey Wettey F, Craig H, Downing A, Talbot R, Jackson A. SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells. PLoS ONE. 2014;9:e106278 pubmed publisher
  • immunoprecipitation; human
  • western blot; human
Luteijn R, Hoelen H, Kruse E, van Leeuwen W, Grootens J, Horst D, et al. Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP. J Immunol. 2014;193:1578-89 pubmed publisher
  • western blot; human
McGough I, Steinberg F, Jia D, Barbuti P, McMillan K, Heesom K, et al. Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. Curr Biol. 2014;24:1670-1676 pubmed publisher
  • western blot; human; 1:200
Lakshminarayan R, Wunder C, Becken U, Howes M, Benzing C, Arumugam S, et al. Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers. Nat Cell Biol. 2014;16:595-606 pubmed publisher
  • western blot; human
Satoh D, Hirose T, Harita Y, Daimon C, Harada T, Kurihara H, et al. aPKC? maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface. J Biochem. 2014;156:115-28 pubmed publisher
  • western blot; mouse
Moissoglu K, Kiessling V, Wan C, Hoffman B, Norambuena A, Tamm L, et al. Regulation of Rac1 translocation and activation by membrane domains and their boundaries. J Cell Sci. 2014;127:2565-76 pubmed publisher
  • immunocytochemistry; mouse
Follit J, San Agustin J, Jonassen J, Huang T, Rivera Perez J, Tremblay K, et al. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014;10:e1004170 pubmed publisher
  • immunocytochemistry; human; 1:250
DeBosch B, Chen Z, Saben J, Finck B, Moley K. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289:10989-98 pubmed publisher
  • western blot; mouse; fig 7a
Schneppenheim J, Hüttl S, Mentrup T, Lüllmann Rauch R, Rothaug M, Engelke M, et al. The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo. Mol Cell Biol. 2014;34:1398-411 pubmed publisher
  • western blot; mouse; 1:2000; fig 1a
Bien Ly N, Yu Y, Bumbaca D, Elstrott J, Boswell C, Zhang Y, et al. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. J Exp Med. 2014;211:233-44 pubmed publisher
  • western blot; human; fig 1
Aida K, Hayashi H, Inamura K, Mizuno T, Sugiyama Y. Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2. Mol Pharmacol. 2014;85:482-91 pubmed publisher
  • western blot; human; fig 6
Even Desrumeaux K, Nevoltris D, Lavaut M, Alim K, Borg J, Audebert S, et al. Masked selection: a straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display. Mol Cell Proteomics. 2014;13:653-65 pubmed publisher
  • immunocytochemistry; human; 1:500
Ingle G, Scales S. DropArray™, a wall-less 96-well plate for uptake and immunofluorescence microscopy, confirms CD22 recycles. Traffic. 2014;15:255-72 pubmed publisher
  • western blot; human; fig 5
Landry M, Champagne C, Boulanger M, Jetté A, Fuchs M, Dziengelewski C, et al. A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases. J Biol Chem. 2014;289:2230-49 pubmed publisher
  • western blot; mouse; fig 9
Gabriel L, Wu S, Kearney P, Bellve K, Standley C, Fogarty K, et al. Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. J Neurosci. 2013;33:17836-46 pubmed publisher
  • western blot; mouse; fig s3
Das U, Scott D, Ganguly A, Koo E, Tang Y, Roy S. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013;79:447-60 pubmed publisher
  • western blot; human; fig 1
Byrne S, Buckett P, Kim J, Luo F, Sanford J, Chen J, et al. Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo. PLoS ONE. 2013;8:e70199 pubmed publisher
  • western blot; mouse
Huang M, Sivagurunathan S, Ting S, Jansson P, Austin C, Kelly M, et al. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2? phosphorylation, and the induction of downstream targets. Am J Pathol. 2013;183:745-57 pubmed publisher
  • western blot; human; fig 4
von Germar A, Barth K, Schwab W. Immunocytochemical and biochemical detection of the urokinase-type plasminogen activator receptor (uPAR) in the rat tooth germ and in lipid rafts of PMA-stimulated dental epithelial cells. Histochem Cell Biol. 2013;140:649-58 pubmed publisher
  • western blot; human; 1:1000; fig 2
Ahn J, Truesdell P, Meens J, Kadish C, Yang X, Boag A, et al. Fer protein-tyrosine kinase promotes lung adenocarcinoma cell invasion and tumor metastasis. Mol Cancer Res. 2013;11:952-63 pubmed publisher
  • western blot; human; fig 2
Sak M, Szymanska M, Bertelsen V, Hasmann M, Madshus I, Stang E. Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3. Carcinogenesis. 2013;34:2031-8 pubmed publisher
  • western blot; human; 1:1500; fig 3
Boczek N, Best J, Tester D, Giudicessi J, Middha S, Evans J, et al. Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome. Circ Cardiovasc Genet. 2013;6:279-89 pubmed
  • immunocytochemistry; human; fig s1a
Holloway Z, Velayos Baeza A, Howell G, Levecque C, Ponnambalam S, Sztul E, et al. Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps. Mol Biol Cell. 2013;24:1735-48, S1-8 pubmed publisher
  • western blot; human; 1:1000; fig 2
Steinberg F, Gallon M, Winfield M, Thomas E, Bell A, Heesom K, et al. A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nat Cell Biol. 2013;15:461-71 pubmed publisher
  • western blot; rat; fig 2
Martineau M, Shi T, Puyal J, Knolhoff A, Dulong J, Gasnier B, et al. Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci. 2013;33:3413-23 pubmed publisher
  • western blot; mouse; fig 4
Kota K, Eaton B, Lane D, Ulrich M, Ulrich R, Peyser B, et al. Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection. PLoS ONE. 2013;8:e55167 pubmed publisher
  • western blot; human
Dettmer U, Newman A, Luth E, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of ?-synuclein and ?-synuclein in neurons and non-neural cells. J Biol Chem. 2013;288:6371-85 pubmed publisher
  • immunocytochemistry; mouse; fig 5
Hitomi Y, Adachi T, Tsuchiya N, Honda Z, Tokunaga K, Tsubata T. Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. BMC Immunol. 2012;13:72 pubmed publisher
  • immunohistochemistry; human; fig 1
Poncelet L, Springinsfeld M, Ando K, Héraud C, Kabova A, Brion J. Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(Kip1) and calbindin in the fetal and neonatal feline cerebellar cortex. Vet J. 2013;196:388-93 pubmed publisher
  • western blot; human; fig 7f
Cortese K, Howes M, Lundmark R, Tagliatti E, Bagnato P, Petrelli A, et al. The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments. Mol Biol Cell. 2013;24:129-44 pubmed publisher
  • western blot; human; 1:1000; fig 3
Tillotson B, de Larrinoa I, Skinner C, Klavas D, Shusta E. Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources. Protein Eng Des Sel. 2013;26:101-12 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1600; fig 1
Raess P, Paessler M, Bagg A, Weiss M, Choi J. ?-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors. Am J Surg Pathol. 2012;36:1538-47 pubmed publisher
  • western blot; human; fig 4
Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, et al. Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. PLoS ONE. 2012;7:e37378 pubmed publisher
  • western blot; mouse; fig 3
Prox J, Willenbrock M, Weber S, Lehmann T, Schmidt Arras D, Schwanbeck R, et al. Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10. Cell Mol Life Sci. 2012;69:2919-32 pubmed publisher
  • western blot; human; fig 5
Patrushev N, Seidel Rogol B, Salazar G. Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells. PLoS ONE. 2012;7:e33211 pubmed publisher
  • western blot; human; fig 2
Riquelme G, de Gregorio N, Vallejos C, Berrios M, Morales B. Differential expression of potassium channels in placentas from normal and pathological pregnancies: targeting of the K(ir) 2.1 channel to lipid rafts. J Membr Biol. 2012;245:141-50 pubmed publisher
  • western blot; human
Huang Y, Chiang N, Hu C, Hsiao C, Cheng K, Tsai W, et al. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol Cell Biol. 2012;32:1408-20 pubmed publisher
  • western blot; mouse; 1:500; fig 4
Bläsche R, Ebeling G, Perike S, Weinhold K, Kasper M, Barth K. Activation of P2X7R and downstream effects in bleomycin treated lung epithelial cells. Int J Biochem Cell Biol. 2012;44:514-24 pubmed publisher
  • flow cytometry; human
  • western blot; human
Schneider C, Hudson A. The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB. PLoS Pathog. 2011;7:e1002362 pubmed publisher
  • western blot; human; fig 5
Magadán J, Bonifacino J. Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu. J Virol. 2012;86:757-72 pubmed publisher
  • immunocytochemistry; hamsters
  • western blot; hamsters
Sugiyama H, Kashimoto T, Ueno S, Ehara H, Kodama T, Iida T, et al. Relationship between localization on cellular membranes and cytotoxicity of Vibrio vulnificus hemolysin. PLoS ONE. 2011;6:e26018 pubmed publisher
  • western blot; human; fig 5
Bass M, Williamson R, Nunan R, Humphries J, Byron A, Morgan M, et al. A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev Cell. 2011;21:681-93 pubmed publisher
  • western blot; human; fig 4
Bachran D, Schneider S, Bachran C, Weng A, Melzig M, Fuchs H. The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins. Mol Pharm. 2011;8:2262-72 pubmed publisher
  • western blot; human; fig 4
Takatsu H, Baba K, Shima T, Umino H, Kato U, Umeda M, et al. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. J Biol Chem. 2011;286:38159-67 pubmed publisher
  • western blot; human; fig 2
Xinhan L, Matsushita M, Numaza M, Taguchi A, Mitsui K, Kanazawa H. Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin. Am J Physiol Cell Physiol. 2011;301:C1431-44 pubmed publisher
  • western blot; hamsters; fig 1
Mendes A, Matos P, Moniz S, Luz S, Amaral M, Farinha C, et al. Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase. Mol Cell Biol. 2011;31:4076-86 pubmed publisher
  • western blot; mouse; fig 1
Valapala M, Vishwanatha J. Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2. J Biol Chem. 2011;286:30911-25 pubmed publisher
  • flow cytometry; hamsters; fig 4
Breuer S, Schievink S, Schulte A, Blankenfeldt W, Fackler O, Geyer M. Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE. 2011;6:e20033 pubmed publisher
  • western blot; human; 1:500; fig 1
Riquelme G, Vallejos C, de Gregorio N, Morales B, Godoy V, Berrios M, et al. Lipid rafts and cytoskeletal proteins in placental microvilli membranes from preeclamptic and IUGR pregnancies. J Membr Biol. 2011;241:127-40 pubmed publisher
  • western blot; human; fig 1
Bijlmakers M, Kanneganti S, Barker J, Trembath R, Capon F. Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis. Hum Mol Genet. 2011;20:3129-37 pubmed publisher
  • western blot; human; 1 ug/ml; fig 7
Selvais C, D Auria L, Tyteca D, Perrot G, Lemoine P, Troeberg L, et al. Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function. FASEB J. 2011;25:2770-81 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Feldmann A, Amphornrat J, Sch nherr M, Winterstein C, M bius W, Ruhwedel T, et al. Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7. J Neurosci. 2011;31:5659-72 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 3
Drévillon L, Tanguy G, Hinzpeter A, Arous N, de Becdelievre A, Aissat A, et al. COMMD1-mediated ubiquitination regulates CFTR trafficking. PLoS ONE. 2011;6:e18334 pubmed publisher
  • western blot; human; 1:500; fig 1
Chiang N, Hsiao C, Huang Y, Chen H, Hsieh I, Chang G, et al. Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms. J Biol Chem. 2011;286:14215-25 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 2
  • western blot; human; 1:500; fig 1
Magro G, Cataldo I, Amico P, Torrisi A, Vecchio G, Parenti R, et al. Aberrant expression of TfR1/CD71 in thyroid carcinomas identifies a novel potential diagnostic marker and therapeutic target. Thyroid. 2011;21:267-77 pubmed publisher
  • western blot; human; fig 5
Best J, Foell J, Buss C, Delisle B, Balijepalli R, January C, et al. Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels. Am J Physiol Cell Physiol. 2011;300:C1023-33 pubmed publisher
  • western blot; rat; fig 1
Gil C, Falqués A, Sarró E, Cubi R, Blasi J, Aguilera J, et al. Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release. FEBS Lett. 2011;585:414-20 pubmed publisher
  • immunohistochemistry - paraffin section; domestic horse; 1:25; fig 3
Webb T, Burnett R, Avery A, Olver C. Cloning and tissue expression of the equine transferrin receptor. Vet Clin Pathol. 2010;39:424-32 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
Mandò C, Tabano S, Colapietro P, Pileri P, Colleoni F, Avagliano L, et al. Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas. Placenta. 2011;32:44-50 pubmed publisher
  • western blot; human; 1:500; fig 4
Linge A, Meleady P, Henry M, Clynes M, Kasper M, Barth K. Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts. Int J Biochem Cell Biol. 2011;43:98-105 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 1
Marsee D, Pinkus G, Yu H. CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens. Am J Clin Pathol. 2010;134:429-35 pubmed publisher
  • western blot; human; 1:1000
Skorokhod O, Caione L, Marrocco T, Migliardi G, Barrera V, Arese P, et al. Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal. Blood. 2010;116:4328-37 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 3
  • western blot; human; fig 4
Priest H, McDonough S, Erb H, Daddona J, Stokol T. Transferrin receptor expression in canine lymphoma. Vet Pathol. 2011;48:466-74 pubmed publisher
  • immunocytochemistry; human; fig 5
Yamamoto H, Koga H, Katoh Y, Takahashi S, Nakayama K, Shin H. Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4. Mol Biol Cell. 2010;21:2746-55 pubmed publisher
  • flow cytometry; brewer's yeast; 1:100; fig 3
Cho Y, Shusta E. Antibody library screens using detergent-solubilized mammalian cell lysates as antigen sources. Protein Eng Des Sel. 2010;23:567-77 pubmed publisher
  • western blot; human; fig 1
Nagano M, Hoshino D, Sakamoto T, Kawasaki N, Koshikawa N, Seiki M. ZF21 protein regulates cell adhesion and motility. J Biol Chem. 2010;285:21013-22 pubmed publisher
  • western blot; dogs; 1:1000; fig 2
Kato T, Hayashi H, Sugiyama Y. Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11). Biochim Biophys Acta. 2010;1801:1005-12 pubmed publisher
  • immunocytochemistry; African green monkey; fig 1
Fukura N, Ohgaki R, Matsushita M, Nakamura N, Mitsui K, Kanazawa H. A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes. J Membr Biol. 2010;234:149-58 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200; fig 2
Mizukami S, Ichimura R, Kemmochi S, Wang L, Taniai E, Mitsumori K, et al. Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model. Chem Biol Interact. 2010;185:189-201 pubmed publisher
  • western blot; human
Stolp B, Abraham L, Rudolph J, Fackler O. Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol. 2010;84:3935-48 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200; fig 1
Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, et al. Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats. Arch Toxicol. 2010;84:319-31 pubmed publisher
  • western blot; rat
Newell Litwa K, Chintala S, Jenkins S, Pare J, McGaha L, Smith Y, et al. Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus. J Neurosci. 2010;30:820-31 pubmed publisher
  • western blot; human; fig 4b
Rolando M, Stefani C, Flatau G, Auberger P, Mettouchi A, Mhlanga M, et al. Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity. Cell Microbiol. 2010;12:891-905 pubmed publisher
  • immunocytochemistry; mouse; fig s4
Nitta T, Kuznetsov Y, McPherson A, Fan H. Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts. Proc Natl Acad Sci U S A. 2010;107:1190-5 pubmed publisher
  • immunoprecipitation; human; 1 ug; fig 3
Kerr M, Gasperini R, Gibbs M, Hou X, Shepherd C, Strickland D, et al. Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein. J Neurochem. 2010;112:1199-209 pubmed publisher
  • western blot; rat; fig 2a
Barrès C, Blanc L, Bette Bobillo P, Andre S, Mamoun R, Gabius H, et al. Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages. Blood. 2010;115:696-705 pubmed publisher
  • ELISA; mouse; fig 4
Ishikawa H, Ma Z, Barber G. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature. 2009;461:788-92 pubmed publisher
  • western blot; human; fig 1
Humphries J, Byron A, Bass M, Craig S, Pinney J, Knight D, et al. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal. 2009;2:ra51 pubmed publisher
  • immunocytochemistry; human; fig s2
Skinner A, O Neill S, Kurre P. Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells. PLoS ONE. 2009;4:e6219 pubmed publisher
  • western blot; human; fig 8
Roepstorff K, Grandal M, Henriksen L, Knudsen S, Lerdrup M, Grøvdal L, et al. Differential effects of EGFR ligands on endocytic sorting of the receptor. Traffic. 2009;10:1115-27 pubmed publisher
  • western blot; rat; fig 2
Salazar G, Falcon Perez J, Harrison R, Faundez V. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. PLoS ONE. 2009;4:e5896 pubmed publisher
  • western blot; human; fig 2
Liefhebber J, Brandt B, Broer R, Spaan W, van Leeuwen H. Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain. Virol J. 2009;6:62 pubmed publisher
  • western blot; mouse
Rhee K, Wu S, Wu X, Huso D, Karim B, Franco A, et al. Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect Immun. 2009;77:1708-18 pubmed publisher
  • western blot; mouse
Feldmann A, Winterstein C, White R, Trotter J, Krämer Albers E. Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes. J Neurosci Res. 2009;87:1760-72 pubmed publisher
  • western blot; human; fig 4
Witte V, Laffert B, Gintschel P, Krautkrämer E, Blume K, Fackler O, et al. Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B. J Immunol. 2008;181:8425-32 pubmed
  • western blot; human
de Gassart A, Trentin B, Martin M, Hocquellet A, Bette Bobillo P, Mamoun R, et al. Exosomal sorting of the cytoplasmic domain of bovine leukemia virus TM Env protein. Cell Biol Int. 2009;33:36-48 pubmed publisher
  • western blot; human
Lineberry N, Su L, Soares L, Fathman C. The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. J Biol Chem. 2008;283:28497-505 pubmed publisher
  • immunocytochemistry; human; fig 7
Inoue H, Ha V, Prekeris R, Randazzo P. Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. Mol Biol Cell. 2008;19:4224-37 pubmed publisher
  • western blot; rat; fig 1h
Roberts L, Black D, Raman C, Woodford K, Zhou M, Haggerty J, et al. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience. 2008;155:423-38 pubmed publisher
  • flow cytometry; mouse; fig 3a
  • immunocytochemistry; mouse; 1:50; fig 1f
  • western blot; mouse; 1:1000; fig 1h
Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine J, et al. Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 2008;15:1723-33 pubmed publisher
  • western blot; human; fig 2
Kamemura K, Ito A, Shimazu T, Matsuyama A, Maeda S, Yao T, et al. Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells. Biochem Biophys Res Commun. 2008;374:84-9 pubmed publisher
  • western blot; human; fig 6
Stehling O, Netz D, Niggemeyer B, Rösser R, Eisenstein R, Puccio H, et al. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. Mol Cell Biol. 2008;28:5517-28 pubmed publisher
  • western blot; human
Hida T, Ikeda H, Kametaka S, Akazawa C, Kohsaka S, Ebisu S, et al. Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells. Arch Histol Cytol. 2007;70:303-12 pubmed
  • western blot; human
Koch A, Scherr M, Breyer B, Mancini A, Kardinal C, Battmer K, et al. Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover. Oncogene. 2008;27:4678-89 pubmed publisher
  • western blot; mouse; 1:500; fig 2
Barth K, Weinhold K, Guenther A, Linge A, Gereke M, Kasper M. Characterization of the molecular interaction between caveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells. Int J Biochem Cell Biol. 2008;40:2230-9 pubmed publisher
  • western blot; human; fig 1
Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimiopoulos S. Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. Neurobiol Dis. 2008;30:353-64 pubmed publisher
  • western blot; human
Nishimura N, Sasaki T. Cell-surface biotinylation to study endocytosis and recycling of occludin. Methods Mol Biol. 2008;440:89-96 pubmed publisher
  • western blot; human; fig 3
Jansen M, Pietiäinen V, Pölönen H, Rasilainen L, Koivusalo M, Ruotsalainen U, et al. Cholesterol substitution increases the structural heterogeneity of caveolae. J Biol Chem. 2008;283:14610-8 pubmed publisher
  • immunocytochemistry; human; fig 4
Fujibayashi A, Taguchi T, Misaki R, Ohtani M, Dohmae N, Takio K, et al. Human RME-8 is involved in membrane trafficking through early endosomes. Cell Struct Funct. 2008;33:35-50 pubmed
  • immunocytochemistry; rat
  • western blot; rat
Craige B, Salazar G, Faundez V. Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic. Mol Biol Cell. 2008;19:1415-26 pubmed publisher
  • western blot; rat; fig 3
Boudanova E, Navaroli D, Melikian H. Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology. 2008;54:605-12 pubmed publisher
  • western blot; human; fig 1
Rauch S, Pulkkinen K, Saksela K, Fackler O. Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity. J Virol. 2008;82:2918-29 pubmed
  • western blot; human; fig 4
van de Graaf S, Rescher U, Hoenderop J, Verkaart S, Bindels R, Gerke V. TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway. J Biol Chem. 2008;283:4077-86 pubmed
  • western blot; human; 1:500; fig 2C
  • western blot; cat; 1:500; fig 5A
  • western blot; hamsters; 1:500; fig 5A
  • western blot; mouse; 1:500; fig 3B
  • western blot; dogs; 1:500; fig 5A
Flanagan M, Oldenburg J, Reignier T, Holt N, Hamilton G, Martin V, et al. New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1. J Virol. 2008;82:938-48 pubmed publisher
  • western blot; hamsters; 1:500
Reignier T, Oldenburg J, Flanagan M, Hamilton G, Martin V, Cannon P. Receptor use by the Whitewater Arroyo virus glycoprotein. Virology. 2008;371:439-46 pubmed
  • western blot; mouse
Imai Y, Inoue H, Kataoka A, Hua Qin W, Masuda M, Ikeda T, et al. Pael receptor is involved in dopamine metabolism in the nigrostriatal system. Neurosci Res. 2007;59:413-25 pubmed
  • immunocytochemistry; dogs; fig 2
  • western blot; dogs
Oztan A, Silvis M, Weisz O, Bradbury N, Hsu S, Goldenring J, et al. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell. 2007;18:3978-92 pubmed
  • western blot; human; 1:500; fig 3
Schwab W, Harada H, Goetz W, Nowicki M, Witt M, Kasper M, et al. Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells. Histochem Cell Biol. 2007;128:195-203 pubmed
  • western blot; rat; fig 2
Li X, Serwanski D, Miralles C, Bahr B, De Blas A. Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex. J Neurochem. 2007;102:1329-45 pubmed
  • immunocytochemistry; human; 1:200
Grosse S, Aron Y, Thévenot G, Monsigny M, Fajac I. Cytoskeletal involvement in the cellular trafficking of plasmid/PEI derivative complexes. J Control Release. 2007;122:111-7 pubmed
  • western blot; dogs
Storch C, Ehehalt R, Haefeli W, Weiss J. Localization of the human breast cancer resistance protein (BCRP/ABCG2) in lipid rafts/caveolae and modulation of its activity by cholesterol in vitro. J Pharmacol Exp Ther. 2007;323:257-64 pubmed
  • immunocytochemistry; dogs; 1:200
Ducharme N, Williams J, Oztan A, Apodaca G, Lapierre L, Goldenring J. Rab11-FIP2 regulates differentiable steps in transcytosis. Am J Physiol Cell Physiol. 2007;293:C1059-72 pubmed
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; African green monkey; 1 ug/ml; fig 8
Ignoul S, Simaels J, Hermans D, Annaert W, Eggermont J. Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains. PLoS ONE. 2007;2:e474 pubmed
  • immunocytochemistry; human
Fu D, van Dam E, Brymora A, Duggin I, Robinson P, Roufogalis B. The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. Biochim Biophys Acta. 2007;1773:1062-72 pubmed
  • western blot; human
Goenaga A, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, et al. Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Mol Immunol. 2007;44:3777-88 pubmed
  • western blot; rat
Gil C, Cubi R, Aguilera J. Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts. FEBS Lett. 2007;581:1851-8 pubmed
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 5
Abache T, Le Naour F, Planchon S, Harper F, Boucheix C, Rubinstein E. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. J Cell Biochem. 2007;102:650-64 pubmed
  • immunocytochemistry; human; 1:200
  • western blot; human
Lakkaraju A, Luyet P, Parone P, Falguières T, Strub K. Inefficient targeting to the endoplasmic reticulum by the signal recognition particle elicits selective defects in post-ER membrane trafficking. Exp Cell Res. 2007;313:834-47 pubmed
  • western blot; human; fig 3
Gaggioli C, Robert G, Bertolotto C, Bailet O, Abbe P, Spadafora A, et al. Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway. J Invest Dermatol. 2007;127:400-10 pubmed
  • immunocytochemistry; human; fig 6
  • western blot; human; fig 4
Ng P, Helguera G, Daniels T, Lomas S, Rodriguez J, Schiller G, et al. Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor. Blood. 2006;108:2745-54 pubmed
  • western blot; rat; fig 5
Salazar G, Craige B, Styers M, Newell Litwa K, Doucette M, Wainer B, et al. BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Mol Biol Cell. 2006;17:4014-26 pubmed
  • western blot; human
  • western blot; rat
O Donnell K, Yu D, Zeller K, Kim J, Racke F, Thomas Tikhonenko A, et al. Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis. Mol Cell Biol. 2006;26:2373-86 pubmed
  • western blot; hamsters
Monzo P, Mari M, Kaddai V, Gonzalez T, Le Marchand Brustel Y, Cormont M. CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology. Methods Enzymol. 2005;403:107-18 pubmed
  • western blot; human; fig 3
Parisiadou L, Efthimiopoulos S. Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11alpha. Neurobiol Aging. 2007;28:377-88 pubmed
  • flow cytometry; human; fig 4
  • western blot; human; fig 3
  • flow cytometry; African green monkey; fig 4
Chen Z, Nomura J, Suzuki T, Suzuki N. Enhanced expression of transferrin receptor confers UV-resistance in human and monkey cells. J Radiat Res. 2005;46:443-51 pubmed
  • flow cytometry; mouse; fig 2
Barel M, Pizzato N, Le Bouteiller P, Wiertz E, Lenfant F. Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation. Int Immunol. 2006;18:173-82 pubmed
  • immunocytochemistry; rat; fig 3
Snyder C, Mardones G, Ladinsky M, Howell K. GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi. Mol Biol Cell. 2006;17:511-24 pubmed
  • western blot; human
Strick D, Elferink L. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. Mol Biol Cell. 2005;16:5699-709 pubmed
  • immunocytochemistry; human; fig 1
Theos A, Tenza D, Martina J, Hurbain I, Peden A, Sviderskaya E, et al. Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell. 2005;16:5356-72 pubmed
  • western blot; human; fig 2
Barel M, Hassink G, van Voorden S, Wiertz E. Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation. Mol Immunol. 2006;43:1258-66 pubmed
  • immunocytochemistry; cat; 1:200; fig 2
Park G, Best S, Bloom M. Two mink parvoviruses use different cellular receptors for entry into CRFK cells. Virology. 2005;340:1-9 pubmed
  • immunocytochemistry; human
Doyotte A, Russell M, Hopkins C, Woodman P. Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects. J Cell Sci. 2005;118:3003-17 pubmed
  • immunocytochemistry; hamsters
  • immunocytochemistry; human
Berryman S, Clark S, Monaghan P, Jackson T. Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus. J Virol. 2005;79:8519-34 pubmed
  • western blot; rat
Salazar G, Craige B, Wainer B, Guo J, De Camilli P, Faundez V. Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles. Mol Biol Cell. 2005;16:3692-704 pubmed
  • immunocytochemistry; human; fig 2
Choudhury R, Diao A, Zhang F, Eisenberg E, Saint Pol A, Williams C, et al. Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network. Mol Biol Cell. 2005;16:3467-79 pubmed
  • western blot; rat; fig 3D
Salazar G, Craige B, Love R, Kalman D, Faundez V. Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. J Cell Sci. 2005;118:1911-21 pubmed
  • immunocytochemistry; human; fig 4
Styers M, Salazar G, Love R, Peden A, Kowalczyk A, Faundez V. The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton. Mol Biol Cell. 2004;15:5369-82 pubmed
  • immunocytochemistry; human; fig 1E
Shin H, Morinaga N, Noda M, Nakayama K. BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity. Mol Biol Cell. 2004;15:5283-94 pubmed
  • western blot; human
Burgueno J, Canela E, Mallol J, Lluis C, Franco R, Ciruela F. Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity. Exp Cell Res. 2004;300:23-34 pubmed
  • immunocytochemistry; human
Chuang J, Vega C, Jun W, Sung C. Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes. J Clin Invest. 2004;114:131-40 pubmed
  • immunohistochemistry - frozen section; human; fig 3
  • immunocytochemistry; human; fig 2
Coumailleau F, Das V, Alcover A, Raposo G, Vandormael Pournin S, Le Bras S, et al. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell. 2004;15:4444-56 pubmed
  • immunocytochemistry; human; 1:200; fig 2
Fajac I, Grosse S, Collombet J, Thevenot G, Goussard S, Danel C, et al. Recombinant Escherichia coli as a gene delivery vector into airway epithelial cells. J Control Release. 2004;97:371-81 pubmed
  • western blot; mouse; fig 2
Katsumata O, Kimura T, Nagatsuka Y, Hirabayashi Y, Sugiya H, Furuyama S, et al. Charge-based separation of detergent-resistant membranes of mouse splenic B cells. Biochem Biophys Res Commun. 2004;319:826-31 pubmed
  • western blot; human; fig 4
Batista A, Millan J, Mittelbrunn M, Sanchez Madrid F, Alonso M. Recruitment of transferrin receptor to immunological synapse in response to TCR engagement. J Immunol. 2004;172:6709-14 pubmed
  • flow cytometry; cat
Hueffer K, Palermo L, Parrish C. Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains. J Virol. 2004;78:5601-11 pubmed
  • immunocytochemistry; human; fig 2
Williams R, Schlüter T, Roberts M, Knauth P, Bohnensack R, Cutler D. Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. Mol Biol Cell. 2004;15:3095-105 pubmed
  • immunocytochemistry; human
Arighi C, Hartnell L, Aguilar R, Haft C, Bonifacino J. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol. 2004;165:123-33 pubmed
  • western blot; rat; fig 3
Salazar G, Love R, Styers M, Werner E, Peden A, Rodriguez S, et al. AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells. J Biol Chem. 2004;279:25430-9 pubmed
  • immunocytochemistry; human; 10 ug/ml
  • western blot; human; 1 ug/ml
Eleme K, Taner S, Önfelt B, Collinson L, McCann F, Chalupny N, et al. Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. J Exp Med. 2004;199:1005-10 pubmed
  • immunoprecipitation; mouse
  • western blot; mouse
  • immunoprecipitation; human
  • western blot; human
Laham N, Rotem Yehudar R, Shechter C, Coligan J, Ehrlich R. Transferrin [corrected] receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis. J Cell Biochem. 2004;91:1130-45 pubmed
  • immunocytochemistry; human; 1:200; fig 3Aa
Grosse S, Aron Y, Honoré I, Thévenot G, Danel C, Roche A, et al. Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes. J Gene Med. 2004;6:345-56 pubmed
  • western blot; human; fig 5
Dudognon P, Maeder Garavaglia C, Carpentier J, Paccaud J. Regulation of a COPII component by cytosolic O-glycosylation during mitosis. FEBS Lett. 2004;561:44-50 pubmed
  • immunocytochemistry; mouse
Stoorvogel W, Kerstens S, Fritzsche I, den Hartigh J, Oud R, van der Heyden M, et al. Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain. J Biol Chem. 2004;279:11562-9 pubmed
  • western blot; dogs; fig 7d
Luton F, Klein S, Chauvin J, Le Bivic A, Bourgoin S, Franco M, et al. EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement. Mol Biol Cell. 2004;15:1134-45 pubmed
  • immunoprecipitation; mouse; fig 4
Barel M, Ressing M, Pizzato N, van Leeuwen D, Le Bouteiller P, Lenfant F, et al. Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation. J Immunol. 2003;171:6757-65 pubmed
  • western blot; rat; fig 3
Salazar G, Love R, Werner E, Doucette M, Cheng S, Levey A, et al. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. Mol Biol Cell. 2004;15:575-87 pubmed
  • immunoprecipitation; human; fig 1
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  • immunoprecipitation; human; fig 2
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product information
Product Type :
Antibody
Product Name :
Transferrin Receptor Monoclonal Antibody (H68.4)
Catalog # :
13-6890
Quantity :
500 µg
Price :
US 990
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Chicken, Hamster, Human, Mouse, Rat
Applications :
ELISA: Assay-dependent, Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): Assay-dependent, Immunomicroscopy: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 0.5 µg/mL
Species :
Chicken, Hamster, Human, Mouse, Rat
Clone :
H68.4
Isotype :
IgG1
Storage :
-20°C
Description :
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
Immunogen :
Recombinant human transferrin receptor.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): Assay-dependent, Immunomicroscopy: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 0.5 µg/mL
Aliases :
2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA