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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Ly-6A/E (Sca-1) Monoclonal Antibody (D7), Biotin, eBioscience
catalog :
13-5981-85
quantity :
500 µg
price :
US 290
clonality :
monoclonal
host :
rat
conjugate :
biotin
clone name :
D7
reactivity :
mouse
application :
immunohistochemistry, flow cytometry
more info or order :
citations: 66
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; fig 2
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Zheng Y, Wang N, Wang S, Yang B, Situ H, Zhong L, et al. XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling. Cell Commun Signal. 2020;18:48 pubmed publisher
Hou M, Han J, Li G, Kwon M, Jiang J, Emani S, et al. Multipotency of mouse trophoblast stem cells. Stem Cell Res Ther. 2020;11:55 pubmed publisher
Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577:676-681 pubmed publisher
Naipauer J, Rosario S, Gupta S, Premer C, Méndez Solís O, Schlesinger M, et al. PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment. PLoS Pathog. 2019;15:e1008221 pubmed publisher
Wang J, Wang D, Chu K, Li W, Zeng Y. Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium. Nat Commun. 2019;10:4966 pubmed publisher
Madaro L, Torcinaro A, De Bardi M, Contino F, Pelizzola M, Diaferia G, et al. Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice. PLoS Genet. 2019;15:e1008408 pubmed publisher
van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed publisher
Huang J, Zhao L, Fan Y, Liao L, Ma P, Xiao G, et al. The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression. Nat Commun. 2019;10:2876 pubmed publisher
Li J, Ayoub A, Xiu Y, Yin X, Sanders J, Mesfin A, et al. TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. Nat Commun. 2019;10:2795 pubmed publisher
Li H, Natarajan A, Ezike J, Barrasa M, Le Y, Feder Z, et al. Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production. Dev Cell. 2019;49:118-129.e7 pubmed publisher
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. elife. 2018;7: pubmed publisher
Xu C, Gao X, Wei Q, Nakahara F, Zimmerman S, Mar J, et al. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow. Nat Commun. 2018;9:2449 pubmed publisher
Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth B, et al. The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice. elife. 2018;7: pubmed publisher
Reismann D, Stefanowski J, Gunther R, Rakhymzhan A, Matthys R, Nützi R, et al. Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature. Nat Commun. 2017;8:2153 pubmed publisher
Chaudhary J, Rath P. Microgrooved-surface topography enhances cellular division and proliferation of mouse bone marrow-derived mesenchymal stem cells. PLoS ONE. 2017;12:e0182128 pubmed publisher
Gao S, Zheng G, Wang L, Liang Y, Zhang S, Lao X, et al. Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB. PLoS ONE. 2017;12:e0179248 pubmed publisher
Li H, Liu P, Xu S, Li Y, Dekker J, Li B, et al. FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging. J Clin Invest. 2017;127:1241-1253 pubmed publisher
Géraud C, Koch P, Zierow J, Klapproth K, Busch K, Olsavszky V, et al. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017;127:1099-1114 pubmed publisher
Cabañero D, Irie T, Celorrio M, Trousdale C, Owens D, Virley D, et al. Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities. Pain Rep. 2016;1: pubmed publisher
Tao L, Xiang D, Xie Y, Bronson R, Li Z. Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours. Nat Commun. 2017;8:14431 pubmed publisher
Shirai C, White B, Tripathi M, Tapia R, Ley J, Ndonwi M, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017;8:14060 pubmed publisher
Hahm E, Wei C, Fernandez I, Li J, Tardi N, Tracy M, et al. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nat Med. 2017;23:100-106 pubmed publisher
Weng L, Hu X, Kumar B, García M, Todorov I, Jung X, et al. Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor. Sci Rep. 2016;6:38632 pubmed publisher
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher
Baerenwaldt A, von Burg N, Kreuzaler M, Sitte S, Horvath E, Peter A, et al. Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice. J Immunol. 2016;196:2561-71 pubmed publisher
Moehrle B, Nattamai K, Brown A, Florian M, Ryan M, Vogel M, et al. Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs. Cell Rep. 2015;13:2412-2424 pubmed publisher
Kadri Z, Lefevre C, Goupille O, Penglong T, Granger Locatelli M, Fucharoen S, et al. Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis. Genes Dev. 2015;29:2603-16 pubmed publisher
Johnson K, Kong G, Gao X, Chang Y, Hewitt K, Sanalkumar R, et al. Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci Adv. 2015;1:e1500503 pubmed publisher
Kraut B, Maier H, Kókai E, Fiedler K, Boettger T, Illing A, et al. Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality. PLoS ONE. 2015;10:e0141591 pubmed publisher
Hettmer S, Lin M, Tchessalova D, Tortorici S, Castiglioni A, Desai T, et al. Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res. 2016;340:43-52 pubmed publisher
Shankman L, Gomez D, Cherepanova O, Salmon M, Alencar G, Haskins R, et al. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015;21:628-37 pubmed publisher
Vahdat S, Mousavi S, Omrani G, Gholampour M, Sotoodehnejadnematalahi F, Ghazizadeh Z, et al. Cellular and molecular characterization of human cardiac stem cells reveals key features essential for their function and safety. Stem Cells Dev. 2015;24:1390-404 pubmed publisher
Jeffery E, Church C, Holtrup B, Colman L, Rodeheffer M. Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity. Nat Cell Biol. 2015;17:376-85 pubmed publisher
Danielson L, Reavie L, Coussens M, Davalos V, Castillo Martin M, Guijarro M, et al. Limited miR-17-92 overexpression drives hematologic malignancies. Leuk Res. 2015;39:335-41 pubmed publisher
Arnett A, Konieczny P, Ramos J, Hall J, ODOM G, Yablonka Reuveni Z, et al. Adeno-associated viral (AAV) vectors do not efficiently target muscle satellite cells. Mol Ther Methods Clin Dev. 2014;1: pubmed
Samant M, Jackson C, Felix C, Jones A, Goodrich D, Foster B, et al. Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation. Stem Cells Dev. 2015;24:1236-51 pubmed publisher
Kimura Y, Komaki M, Iwasaki K, Sata M, Izumi Y, Morita I. Recruitment of bone marrow-derived cells to periodontal tissue defects. Front Cell Dev Biol. 2014;2:19 pubmed publisher
Boomsma R, Geenen D. Evidence for Transfer of Membranes from Mesenchymal Stem Cells to HL-1 Cardiac Cells. Stem Cells Int. 2014;2014:653734 pubmed publisher
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed publisher
Xiao G, Liu I, Cheng C, Chang C, Lee Y, Cheng W, et al. Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy. PLoS ONE. 2014;9:e106538 pubmed publisher
Furtado M, Costa M, Pranoto E, Salimova E, Pinto A, Lam N, et al. Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ Res. 2014;114:1422-34 pubmed publisher
Cheng C, Lee Y, Lin S, HuangFu W, Liu I. Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells. J Biomed Sci. 2014;21:21 pubmed publisher
Wu T, Chou Y, Chiu P, Tang M, Hu C, Yeh M. Validation of the effects of TGF-?1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties. Cancer Cell Int. 2014;14:20 pubmed publisher
Hong S, Alapure B, Lu Y, Tian H, Wang Q. Immunohistological localization of endogenous unlabeled stem cells in wounded skin. J Histochem Cytochem. 2014;62:276-85 pubmed publisher
Pratumvinit B, Reesukumal K, Janebodin K, Ieronimakis N, Reyes M. Isolation, characterization, and transplantation of cardiac endothelial cells. Biomed Res Int. 2013;2013:359412 pubmed publisher
Tesio M, Oser G, Baccelli I, Blanco Bose W, Wu H, Gothert J, et al. Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization. J Exp Med. 2013;210:2337-49 pubmed publisher
Campaner S, Viale A, De Fazio S, Doni M, De Franco F, D Artista L, et al. A non-redundant function of cyclin E1 in hematopoietic stem cells. Cell Cycle. 2013;12:3663-72 pubmed publisher
Huang C, Tang M, Yehling E, Zhang X. Overexpressing sonic hedgehog peptide restores periosteal bone formation in a murine bone allograft transplantation model. Mol Ther. 2014;22:430-439 pubmed publisher
Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
Johnson K, Hsu A, Ryu M, Wang J, Gao X, Boyer M, et al. Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity. J Clin Invest. 2012;122:3692-704 pubmed publisher
Grajales L, García J, Geenen D. Induction of cardiac myogenic lineage development differs between mesenchymal and satellite cells and is accelerated by bone morphogenetic protein-4. J Mol Cell Cardiol. 2012;53:382-91 pubmed publisher
Xu K, Usary J, Kousis P, Prat A, Wang D, Adams J, et al. Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell. 2012;21:626-41 pubmed publisher
Gu P, Min J, Wang Y, Huang C, Peng T, Chai W, et al. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012;31:2309-21 pubmed publisher
Wang Y, Shen M, Chang S. Essential roles for Pot1b in HSC self-renewal and survival. Blood. 2011;118:6068-77 pubmed publisher
Sherwood R, Maehr R, Mazzoni E, Melton D. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev. 2011;128:387-400 pubmed publisher
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Esplin B, Shimazu T, Welner R, Garrett K, Nie L, Zhang Q, et al. Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol. 2011;186:5367-75 pubmed publisher
Bhullar J, Sollars V. YBX1 expression and function in early hematopoiesis and leukemic cells. Immunogenetics. 2011;63:337-50 pubmed publisher
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De Vocht N, Bergwerf I, Vanhoutte G, Daans J, De Visscher G, Chatterjee S, et al. Labeling of Luciferase/eGFP-expressing bone marrow-derived stromal cells with fluorescent micron-sized iron oxide particles improves quantitative and qualitative multimodal imaging of cellular grafts in vivo. Mol Imaging Biol. 2011;13:1133-45 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
Ly-6A/E (Sca-1) Monoclonal Antibody (D7), Biotin, eBioscience
Catalog # :
13-5981-85
Quantity :
500 µg
Price :
US 290
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
D7
Isotype :
IgG2a, kappa
Storage :
4° C, do not freeze
Description :
Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
9804; locus A/E; Locus AE; Ly6; Ly67; Ly6a; Ly-6A.2; Ly-6A.2/Ly-6E.1; Ly6A/E; Ly-6A/E; ly6a-e; Ly6e; Ly-6E; Ly-6E.1; lymphocyte antigen 6 complex; lymphocyte antigen 6 complex, locus A; lymphocyte antigen 6 complex, locus E; lymphocyte antigen 6A-2/6E-1; Lymphocyte antigen 6E; RIG-E; Sca1; Sca-1; Sca-2; stem cell antigen 1; Stem cell antigen 2; TAP; T-cell-activating protein; thymic shared antigen 1; Tsa1; TSA-1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA