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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), Biotin, eBioscience™
catalog :
13-5971-85
quantity :
500 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
biotin
clone name :
DX5
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 34
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1-s1
Allison K, Sajti E, Collier J, Gosselin D, Troutman T, Stone E, et al. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. elife. 2016;5: pubmed publisher
  • flow cytometry; mouse; fig 4
Fahl S, Crittenden R, Allman D, Bender T. c-Myb is required for pro-B cell differentiation. J Immunol. 2009;183:5582-92 pubmed publisher
  • flow cytometry; mouse
Nakae S, Suto H, Kakurai M, Sedgwick J, Tsai M, Galli S. Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci U S A. 2005;102:6467-72 pubmed
Ng K, Yui M, Mehta A, Siu S, Irwin B, Pease S, et al. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. elife. 2018;7: pubmed publisher
Llewellyn R, Gutknecht M, Thomas K, Conaway M, Bouton A. Focal adhesion kinase (FAK) deficiency in mononuclear phagocytes alters murine breast tumor progression. Am J Cancer Res. 2018;8:675-687 pubmed
Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore A, et al. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 2017;46:818-834.e4 pubmed publisher
Iwata A, Durai V, Tussiwand R, Briseño C, Wu X, Grajales Reyes G, et al. Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex. Nat Immunol. 2017;18:563-572 pubmed publisher
Yoon J, Leyva Castillo J, Wang G, Galand C, Oyoshi M, Kumar L, et al. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016;213:2147-66 pubmed publisher
Vannella K, Ramalingam T, Hart K, de Queiroz Prado R, Sciurba J, Barron L, et al. Acidic chitinase primes the protective immune response to gastrointestinal nematodes. Nat Immunol. 2016;17:538-44 pubmed publisher
Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
Galvani R, Lemos R, Areal R, Salvador P, Zamboni D, Wanderley J, et al. Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease. PLoS ONE. 2015;10:e0118079 pubmed publisher
Ziegler T, Rausch S, Steinfelder S, Klotz C, Hepworth M, Kühl A, et al. A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation. J Immunol. 2015;194:1555-64 pubmed publisher
Binsfeld M, Beguin Y, Belle L, Otjacques E, Hannon M, Briquet A, et al. Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation. PLoS ONE. 2014;9:e113764 pubmed publisher
Takada I. DGCR14 induces Il17a gene expression through the RORγ/BAZ1B/RSKS2 complex. Mol Cell Biol. 2015;35:344-55 pubmed publisher
Jiang H, Wang P, Li X, Wang Q, Deng Z, Zhuang X, et al. Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2. Cancer Immunol Res. 2014;2:789-99 pubmed publisher
Leyva Castillo J, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, et al. Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Nat Commun. 2013;4:2847 pubmed publisher
Zook E, Zhang S, Gerstein R, Witte P, Le P. Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche. J Immunol. 2013;191:5583-93 pubmed publisher
Kaanta A, Virtanen C, Selfors L, Brugge J, Neel B. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res. 2013;15:R65 pubmed
Bulliard Y, Jolicoeur R, Windman M, Rue S, Ettenberg S, Knee D, et al. Activating Fc ? receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med. 2013;210:1685-93 pubmed publisher
Molofsky A, Nussbaum J, Liang H, Van Dyken S, Cheng L, Mohapatra A, et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013;210:535-49 pubmed publisher
Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, et al. Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med. 2012;209:2079-97 pubmed publisher
Goulding J, Bogue R, Tahiliani V, Croft M, Salek Ardakani S. CD8 T cells are essential for recovery from a respiratory vaccinia virus infection. J Immunol. 2012;189:2432-40 pubmed publisher
Kreisel D, Sugimoto S, Zhu J, Nava R, Li W, Okazaki M, et al. Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance. Blood. 2011;118:6172-82 pubmed publisher
Yu Y, Wang D, Liu C, Kaosaard K, Semple K, Anasetti C, et al. Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR?t in mice. Blood. 2011;118:5011-20 pubmed publisher
Heiber J, Barber G. Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent. J Virol. 2011;85:10440-50 pubmed publisher
Ficarro S, Zhang Y, Carrasco Alfonso M, Garg B, Adelmant G, Webber J, et al. Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis. Mol Cell Proteomics. 2011;10:O111.011064 pubmed publisher
Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, et al. Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-? is mediated by suppression of eomesodermin. Immunity. 2011;34:741-54 pubmed publisher
Edelson B, Kc W, Juang R, Kohyama M, Benoit L, Klekotka P, et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med. 2010;207:823-36 pubmed publisher
Karamitros D, Kotantaki P, Lygerou Z, Veiga Fernandes H, Pachnis V, Kioussis D, et al. Differential geminin requirement for proliferation of thymocytes and mature T cells. J Immunol. 2010;184:2432-41 pubmed publisher
Miyagi T, Lee S, Biron C. Intracellular staining for analysis of the expression and phosphorylation of signal transducers and activators of transcription (STATs) in NK cells. Methods Mol Biol. 2010;612:159-75 pubmed publisher
Cheung T, Oborne L, Steinberg M, Macauley M, Fukuyama S, Sanjo H, et al. T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. J Immunol. 2009;183:7286-96 pubmed publisher
Lee H, Zamora M, Linehan M, Iijima N, Gonzalez D, Haberman A, et al. Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. J Exp Med. 2009;206:359-70 pubmed publisher
Heffner M, Fearon D. Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte. Proc Natl Acad Sci U S A. 2007;104:13414-9 pubmed
Nakae S, Suto H, Berry G, Galli S. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood. 2007;109:3640-8 pubmed
product information
Product Type :
Antibody
Product Name :
CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), Biotin, eBioscience™
Catalog # :
13-5971-85
Quantity :
500 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
DX5
Isotype :
IgM, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
alpha 2 subunit of VLA-2 receptor; BDPLT9; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; DX5; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Itga2; platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA2 receptor; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLAA2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA