product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GL7 Monoclonal Antibody (GL-7 (GL7)), Biotin, eBioscience
catalog :
13-5902-81
quantity :
50 µg
price :
US 90.75
clonality :
monoclonal
host :
rat
conjugate :
biotin
clone name :
GL-7 (GL7)
reactivity :
mouse
application :
immunohistochemistry, flow cytometry
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig s7c
Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, et al. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun. 2021;12:3754 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, et al. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • flow cytometry; mouse; 1:120; loading ...; fig 1s1b
Koike T, Harada K, Horiuchi S, Kitamura D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s4f
Zhang C, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun. 2018;9:2745 pubmed publisher
  • flow cytometry; mouse; ; loading ...; fig 1a
  • immunohistochemistry; mouse; 1:20; loading ...; fig 1b
Barwick B, Scharer C, Martinez R, Price M, Wein A, Haines R, et al. B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nat Commun. 2018;9:1900 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Nadafi R, Koning J, Veninga H, Stachtea X, Konijn T, Zwiers A, et al. Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude. Front Immunol. 2018;9:206 pubmed publisher
  • flow cytometry; mouse
Purtha W, Tedder T, Johnson S, Bhattacharya D, Diamond M. Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants. J Exp Med. 2011;208:2599-606 pubmed publisher
Ligon M, Wang C, DeJong E, Schulz C, Bowdish D, Mysorekar I. Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation. Mucosal Immunol. 2020;13:908-918 pubmed publisher
Rosser E, Piper C, Matei D, Blair P, Rendeiro A, Orford M, et al. Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells. Cell Metab. 2020;31:837-851.e10 pubmed publisher
Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, et al. αv Integrins regulate germinal center B cell responses through noncanonical autophagy. J Clin Invest. 2018;128:4163-4178 pubmed publisher
Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136 pubmed publisher
Wang X, Zhang Y, Wang Z, Liu X, Zhu G, Han G, et al. Anti?IL?39 (IL?23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus?like mice. Mol Med Rep. 2017;: pubmed publisher
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, et al. Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017;8:978 pubmed publisher
Sun J, Holmgren J, Larena M, Terrinoni M, Fang Y, Bresnick A, et al. Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin. Front Immunol. 2017;8:1119 pubmed publisher
Bemark M, Hazanov H, Strömberg A, Komban R, Holmqvist J, Köster S, et al. Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization. Nat Commun. 2016;7:12698 pubmed publisher
Srikakulapu P, Hu D, Yin C, Mohanta S, Bontha S, Peng L, et al. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2016;36:1174-85 pubmed publisher
Ali J, Negus M, Conlon T, Harper I, Qureshi M, Motallebzadeh R, et al. Diversity of the CD4 T Cell Alloresponse: The Short and the Long of It. Cell Rep. 2016;14:1232-1245 pubmed publisher
Ioannidis L, Nie C, Ly A, Ryg Cornejo V, Chiu C, Hansen D. Monocyte- and Neutrophil-Derived CXCL10 Impairs Efficient Control of Blood-Stage Malaria Infection and Promotes Severe Disease. J Immunol. 2016;196:1227-38 pubmed publisher
Muppidi J, Lu E, Cyster J. The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. J Exp Med. 2015;212:2213-22 pubmed publisher
Gupta S, Clark E, Termini J, Boucher J, Kanagavelu S, LeBranche C, et al. DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titers. J Virol. 2015;89:4158-69 pubmed publisher
Funakoshi S, Shimizu T, Numata O, Ato M, Melchers F, Ohnishi K. BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. PLoS ONE. 2015;10:e0117566 pubmed publisher
Cao A, Yao S, Gong B, Nurieva R, Elson C, Cong Y. Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunol. 2015;8:1072-82 pubmed publisher
Decalf J, Godinho Silva C, Fontinha D, Marques S, Simas J. Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event. PLoS Pathog. 2014;10:e1004269 pubmed publisher
Bökers S, Urbat A, Daniel C, Amann K, Smith K, Espéli M, et al. Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice. J Immunol. 2014;192:2994-3002 pubmed publisher
Senejani A, Liu Y, Kidane D, Maher S, Zeiss C, Park H, et al. Mutation of POLB causes lupus in mice. Cell Rep. 2014;6:1-8 pubmed publisher
Hua Z, Gross A, Lamagna C, Ramos Hernández N, Scapini P, Ji M, et al. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014;192:875-85 pubmed publisher
Talay O, Yan D, Brightbill H, Straney E, Zhou M, Ladi E, et al. Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway. Nat Immunol. 2013;14:1302-4 pubmed publisher
Panda S, Zhang J, Tan N, Ho B, Ding J. Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria. EMBO J. 2013;32:2905-19 pubmed publisher
Block K, Huang H. The cellular source and target of IL-21 in K/BxN autoimmune arthritis. J Immunol. 2013;191:2948-55 pubmed publisher
Detre C, Yigit B, Keszei M, Castro W, Magelky E, Terhorst C. SAP modulates B cell functions in a genetic background-dependent manner. Immunol Lett. 2013;153:15-21 pubmed publisher
Anginot A, Espeli M, Chasson L, Mancini S, Schiff C. Galectin 1 modulates plasma cell homeostasis and regulates the humoral immune response. J Immunol. 2013;190:5526-33 pubmed publisher
Bergqvist P, Stensson A, Hazanov L, Holmberg A, Mattsson J, Mehr R, et al. Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses. Mucosal Immunol. 2013;6:122-35 pubmed publisher
Shen S, Manser T. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing. J Immunol. 2012;188:47-56 pubmed publisher
Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa M, et al. DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood. 2011;118:3559-69 pubmed publisher
Cato M, Yau I, Rickert R. Magnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysis. Nat Protoc. 2011;6:953-60 pubmed publisher
Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang Z, Avanesyan L, et al. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011;121:1154-62 pubmed publisher
Kasturi S, Skountzou I, Albrecht R, Koutsonanos D, Hua T, Nakaya H, et al. Programming the magnitude and persistence of antibody responses with innate immunity. Nature. 2011;470:543-7 pubmed publisher
Lochner M, Ohnmacht C, Presley L, Bruhns P, Si Tahar M, Sawa S, et al. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells. J Exp Med. 2011;208:125-34 pubmed publisher
Freire T, Zhang X, Deriaud E, Ganneau C, Vichier Guerre S, Azria E, et al. Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant. Blood. 2010;116:3526-36 pubmed publisher
Carlucci F, Fossati Jimack L, Dumitriu I, Heidari Y, Walport M, Szajna M, et al. Identification and characterization of a lupus suppressor 129 locus on chromosome 3. J Immunol. 2010;184:6256-65 pubmed publisher
Liu Y, Zhang W. Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. J Leukoc Biol. 2008;84:842-51 pubmed publisher
DiLillo D, Hamaguchi Y, Ueda Y, Yang K, Uchida J, Haas K, et al. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. J Immunol. 2008;180:361-71 pubmed
El Shikh M, El Sayed R, Wu Y, Szakal A, Tew J. TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity. J Immunol. 2007;179:4444-50 pubmed
Kimura N, Ohmori K, Miyazaki K, Izawa M, Matsuzaki Y, Yasuda Y, et al. Human B-lymphocytes express alpha2-6-sialylated 6-sulfo-N-acetyllactosamine serving as a preferred ligand for CD22/Siglec-2. J Biol Chem. 2007;282:32200-7 pubmed
Meier D, Bornmann C, Chappaz S, Schmutz S, Otten L, Ceredig R, et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity. 2007;26:643-54 pubmed
Genton C, Wang Y, Izui S, Malissen B, Delsol G, Fournié G, et al. The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity. J Immunol. 2006;177:2285-93 pubmed
product information
Product Type :
Antibody
Product Name :
GL7 Monoclonal Antibody (GL-7 (GL7)), Biotin, eBioscience
Catalog # :
13-5902-81
Quantity :
50 µg
Price :
US 90.75
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Human, Mouse
Clone :
GL-7 (GL7)
Isotype :
IgM
Storage :
4° C, do not freeze
Description :
GL7 is a cell-surface protein found on T and B lymphocytes activated in vitro, on bone marrow pre-B-II cells, germinal center B cells, and also human B cell lines Ramos and Daudi. There is strain variability with respect to antigen distribution on thymocytes and Con A-activated spleen cells, with expression in BALB/c greater than that in C57BL/6. GL7 is commonly used as a marker for mouse germinal center B cells. The epitope of GL7 has been identified as a sialic acid glycan moiety called Neu5Ac. This moiety is recognized by CD22.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
GL7 antigen; Ly77; Ly-77
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA