This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Biotin, eBioscience
catalog :
13-5899-82
quantity :
100 ug
price :
US 363.00
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
AER-37 (CRA1)

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 30
Reference
Prakash P, Barwary N, Weber M, Wan D, Conejeros I, Pereira Moreira B, et al. The Humanised NPY-mRFP RBL Reporter Cell Line Is a Fast and Inexpensive Tool for Detection of Allergen-Specific IgE in Human Sera. Diagnostics (Basel). 2022;12: pubmed publisher
Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, et al. Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep. 2018;24:169-180 pubmed publisher
Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki Sakamoto T, et al. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J Allergy Clin Immunol. 2014;134:622-633.e9 pubmed publisher
Suurmond J, Stoop J, Rivellese F, Bakker A, Huizinga T, Toes R. Activation of human basophils by combined toll-like receptor- and Fc?RI-triggering can promote Th2 skewing of naive T helper cells. Eur J Immunol. 2014;44:386-96 pubmed publisher
Okayama Y, Matsuda A, Kashiwakura J, Sasaki Sakamoto T, Nunomura S, Shimokawa T, et al. Highly expressed cytoplasmic Fc?RI? in human mast cells functions as a negative regulator of the FcR?-mediated cell activation signal. Clin Exp Allergy. 2014;44:238-49 pubmed publisher
Hatada Y, Kashiwakura J, Hayama K, Fujisawa D, Sasaki Sakamoto T, Terui T, et al. Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients. Int Arch Allergy Immunol. 2013;161 Suppl 2:154-8 pubmed publisher
Kashiwakura J, Yanagisawa M, Lee H, Okamura Y, Sasaki Sakamoto T, Saito S, et al. Interleukin-33 synergistically enhances immune complex-induced tumor necrosis factor alpha and interleukin-8 production in cultured human synovium-derived mast cells. Int Arch Allergy Immunol. 2013;161 Suppl 2:32-6 pubmed publisher
Alcañiz L, Vega A, Chacón P, El Bekay R, Ventura I, Aroca R, et al. Histamine production by human neutrophils. FASEB J. 2013;27:2902-10 pubmed publisher
Herrmann N, Koch S, Leib N, Bedorf J, Wilms H, Schnautz S, et al. TLR2 down-regulates Fc?RI and its transcription factor PU.1 in human Langerhans cells. Allergy. 2013;68:621-8 pubmed publisher
Bratke K, Prieschenk C, Garbe K, Kuepper M, Lommatzsch M, Virchow J. Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment. Clin Exp Allergy. 2013;43:312-21 pubmed publisher
Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto Sasaki T, Matsumoto K, et al. Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fc? receptor I and Fc? receptor II. Arthritis Rheum. 2013;65:109-19 pubmed publisher
Lexmond W, der Mee J, Ruiter F, Platzer B, Stary G, Yen E, et al. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011;373:192-9 pubmed publisher
Schneider E, Machavoine F, Bricard Rignault R, Levasseur M, Petit Bertron A, Gautron S, et al. Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands. J Allergy Clin Immunol. 2011;128:864-871.e2 pubmed publisher
Dehlink E, Platzer B, Baker A, Larosa J, Pardo M, Dwyer P, et al. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS ONE. 2011;6:e19098 pubmed publisher
Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow J. Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus. Allergy. 2011;66:386-95 pubmed publisher
Cabezón R, Sintes J, Llinàs L, Benitez Ribas D. Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Immunol Lett. 2011;134:167-73 pubmed publisher
Dehlink E, Baker A, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS ONE. 2010;5:e12204 pubmed publisher
Yen E, Hornick J, Dehlink E, Dokter M, Baker A, Fiebiger E, et al. Comparative analysis of Fc?RI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010;51:584-92 pubmed publisher
Manzouri B, Ohbayashi M, Leonardi A, Fattah D, Larkin D, Ono S. Characterisation of the phenotype and function of monocyte-derived dendritic cells in allergic conjunctiva. Br J Ophthalmol. 2010;94:1662-7 pubmed publisher
Schroeder J, Bieneman A, Chichester K, Hamilton R, Xiao H, Saini S, et al. Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J Allergy Clin Immunol. 2010;125:896-901.e6 pubmed publisher
Singleton T, Platzer B, Dehlink E, Fiebiger E. The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex. Mol Immunol. 2009;46:2333-9 pubmed publisher
Le T, Tversky J, Chichester K, Bieneman A, Huang S, Wood R, et al. Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells. J Allergy Clin Immunol. 2009;123:217-23 pubmed publisher
Monteseirín J, Vega A, Chacón P, Camacho M, El Bekay R, Asturias J, et al. Neutrophils as a novel source of eosinophil cationic protein in IgE-mediated processes. J Immunol. 2007;179:2634-41 pubmed
Hasannejad H, Takahashi R, Kimishima M, Hayakawa K, Shiohara T. Selective impairment of Toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis. J Allergy Clin Immunol. 2007;120:69-75 pubmed
Oldhoff J, Knol E, Laaper Ertmann M, Bruijnzeel Koomen C, de Bruin Weller M. Modulation of the atopy patch test: tacrolimus 0.1% compared with triamcinolone acetonide 0.1%. Allergy. 2006;61:622-8 pubmed
Bachelet I, Munitz A, Moretta A, Moretta L, Levi Schaffer F. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J Immunol. 2005;175:7989-95 pubmed
Suzukawa M, Hirai K, Iikura M, Nagase H, Komiya A, Yoshimura Uchiyama C, et al. IgE- and FcepsilonRI-mediated migration of human basophils. Int Immunol. 2005;17:1249-55 pubmed
Chacón P, Vega A, Monteseirín J, El Bekay R, Alba G, Pérez Formoso J, et al. Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. Eur J Immunol. 2005;35:2313-24 pubmed
Munitz A, Bachelet I, Fraenkel S, Katz G, Mandelboim O, Simon H, et al. 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol. 2005;174:110-8 pubmed
Yamaguchi M, Sayama K, Yano K, Lantz C, Noben Trauth N, Ra C, et al. IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and me. J Immunol. 1999;162:5455-65 pubmed
product information
Product Type :
Antibody
Product Name :
FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Biotin, eBioscience
Catalog # :
13-5899-82
Quantity :
100 ug
Price :
US 363.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Human
Clone :
AER-37 (CRA1)
Isotype :
IgG2b, kappa
Storage :
4 C, do not freeze
Description :
FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA