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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FceR1 alpha Monoclonal Antibody (MAR-1), Biotin, eBioscience™
catalog :
13-5898-85
quantity :
500 µg
price :
US 309.00
clonality :
monoclonal
host :
hamsters
conjugate :
biotin
clone name :
MAR-1
reactivity :
mouse
application :
flow cytometry, other
more info or order :
citations: 99
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse
Schwartz C, Oeser K, Prazeres da Costa C, Layland L, Voehringer D. T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils. J Immunol. 2014;193:3590-9 pubmed publisher
  • other; mouse
Sato K, Eizumi K, Fukaya T, Fujita S, Sato Y, Takagi H, et al. Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease. Blood. 2009;113:4780-9 pubmed publisher
Kobayashi T, Shimabukuro Demoto S, Tsutsui H, Toyama Sorimachi N. Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis. PLoS Biol. 2019;17:e3000530 pubmed publisher
Liu C, Zhang X, Liu J, Wang Y, Sukhova G, Wojtkiewicz G, et al. Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis. Nat Commun. 2019;10:3978 pubmed publisher
Potůčková L, Dráberová L, Hálová I, Paulenda T, Draber P. Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein. Front Immunol. 2018;9:1771 pubmed publisher
Yoon J, Leyva Castillo J, Wang G, Galand C, Oyoshi M, Kumar L, et al. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016;213:2147-66 pubmed publisher
Meurer S, Neß M, Weiskirchen S, Kim P, Tag C, Kauffmann M, et al. Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice. PLoS ONE. 2016;11:e0158104 pubmed publisher
Bambousková M, Polakovičová I, Hálová I, Goel G, Dráberová L, Bugajev V, et al. New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling. Mol Cell Biol. 2016;36:1366-82 pubmed publisher
Patel K, AVEN L, Shao F, Krishnamoorthy N, Duvall M, Levy B, et al. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life. Mucosal Immunol. 2016;9:1466-1476 pubmed publisher
Kanemaru K, Noguchi E, Tokunaga T, Nagai K, Hiroyama T, Nakamura Y, et al. Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin. PLoS ONE. 2015;10:e0144436 pubmed publisher
Lee Y, Liu C, Liao M, Sukhova G, Shirakawa J, Abdennour M, et al. Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015;156:4047-58 pubmed publisher
Rosenstein R, Bezbradica J, Yu S, Medzhitov R. Signaling pathways activated by a protease allergen in basophils. Proc Natl Acad Sci U S A. 2014;111:E4963-71 pubmed publisher
Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, et al. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014;20:1340-1347 pubmed publisher
Zhong W, Su W, Zhang Y, Liu Q, Wu J, Di C, et al. Basophils as a primary inducer of the T helper type 2 immunity in ovalbumin-induced allergic airway inflammation. Immunology. 2014;142:202-15 pubmed publisher
Ishijima Y, Ohmori S, Ohneda K. Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice. FEBS Open Bio. 2013;4:18-24 pubmed publisher
Siegel A, Stone K, Cruse G, Lawrence M, Olivera A, Jung M, et al. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol. 2013;132:1388-96 pubmed publisher
Kabata H, Moro K, Fukunaga K, Suzuki Y, Miyata J, Masaki K, et al. Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation. Nat Commun. 2013;4:2675 pubmed publisher
Khodoun M, Kucuk Z, Strait R, Krishnamurthy D, Janek K, Clay C, et al. Rapid desensitization of mice with anti-Fc?RIIb/Fc?RIII mAb safely prevents IgG-mediated anaphylaxis. J Allergy Clin Immunol. 2013;132:1375-87 pubmed publisher
Tung H, Plunkett B, Huang S, Zhou Y. Murine mast cells secrete and respond to interleukin-33. J Interferon Cytokine Res. 2014;34:141-7 pubmed publisher
Suzukawa M, Miller M, Rosenthal P, Cho J, Doherty T, Varki A, et al. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol. 2013;190:5939-48 pubmed publisher
Doyle A, Jacobsen E, Ochkur S, Willetts L, Shim K, Neely J, et al. Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils. J Leukoc Biol. 2013;94:17-24 pubmed publisher
Lee Y, Kumagai Y, Jang M, Kim J, Yang B, Lee E, et al. Intestinal Lin- c-Kit+ NKp46- CD4- population strongly produces IL-22 upon IL-1? stimulation. J Immunol. 2013;190:5296-305 pubmed publisher
Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, et al. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. J Immunol. 2013;190:4489-99 pubmed publisher
Nabe T, Matsuya K, Akamizu K, Fujita M, Nakagawa T, Shioe M, et al. Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of mice. Br J Pharmacol. 2013;169:462-76 pubmed publisher
Molofsky A, Nussbaum J, Liang H, Van Dyken S, Cheng L, Mohapatra A, et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013;210:535-49 pubmed publisher
Moniaga C, Jeong S, Egawa G, Nakajima S, Hara Chikuma M, Jeon J, et al. Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice. Am J Pathol. 2013;182:841-51 pubmed publisher
Cheng L, Hartmann K, Roers A, Krummel M, Locksley R. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013;38:166-75 pubmed publisher
Shiraishi Y, Jia Y, Domenico J, Joetham A, Karasuyama H, Takeda K, et al. Sequential engagement of Fc?RI on Mast Cells and Basophil Histamine H(4) Receptor and Fc?RI in Allergic Rhinitis. J Immunol. 2013;190:539-48 pubmed publisher
Giacomin P, Siracusa M, Walsh K, Grencis R, Kubo M, Comeau M, et al. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol. 2012;189:4371-8 pubmed publisher
Ohmori S, Takai J, Ishijima Y, Suzuki M, Moriguchi T, Philipsen S, et al. Regulation of GATA factor expression is distinct between erythroid and mast cell lineages. Mol Cell Biol. 2012;32:4742-55 pubmed publisher
Dahlin J, Feinstein R, Cui Y, Heyman B, Hallgren J. CD11c+ cells are required for antigen-induced increase of mast cells in the lung. J Immunol. 2012;189:3869-77 pubmed publisher
Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss M, et al. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A. 2012;109:14954-9 pubmed publisher
Garaycoechea J, Crossan G, Langevin F, Daly M, Arends M, Patel K. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature. 2012;489:571-5 pubmed publisher
Piliponsky A, Chen C, Rios E, Treuting P, Lahiri A, Abrink M, et al. The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol. 2012;181:875-86 pubmed publisher
Kawahara T. Establishment and characterization of mouse bone marrow-derived mast cell hybridomas. Exp Cell Res. 2012;318:2385-96 pubmed publisher
Larson D, Hübner M, Torrero M, Morris C, Brankin A, Swierczewski B, et al. Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. J Immunol. 2012;188:4188-99 pubmed publisher
Haenuki Y, Matsushita K, Futatsugi Yumikura S, Ishii K, Kawagoe T, Imoto Y, et al. A critical role of IL-33 in experimental allergic rhinitis. J Allergy Clin Immunol. 2012;130:184-94.e11 pubmed publisher
Ramon H, Beal A, Liu Y, Worthen G, Oliver P. The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J Immunol. 2012;188:4023-31 pubmed publisher
Nie X, Cai G, Zhang W, Wang H, Wu B, Li Q, et al. Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis. Clin Immunol. 2012;142:269-79 pubmed publisher
Carbonneau C, Despars G, Rojas Sutterlin S, Fortin A, Le O, Hoang T, et al. Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis. Blood. 2012;119:717-26 pubmed publisher
Forbes Blom E, Camberis M, Prout M, Tang S, Le Gros G. Staphylococcal-derived superantigen enhances peanut induced Th2 responses in the skin. Clin Exp Allergy. 2012;42:305-14 pubmed publisher
Brickshawana A, Shapiro V, Kita H, Pease L. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol. 2011;187:5795-804 pubmed publisher
Park K, Park J, Yang W, Lee J, Song M, Kim H. Transcriptional activation of the IL31 gene by NFAT and STAT6. J Leukoc Biol. 2012;91:245-57 pubmed publisher
Lilla J, Chen C, Mukai K, Benbarak M, Franco C, Kalesnikoff J, et al. Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood. 2011;118:6930-8 pubmed publisher
Suzuki K, Murphy S, Xia Y, Yokota M, Nakagomi D, Liu F, et al. Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation. PLoS ONE. 2011;6:e25412 pubmed publisher
Hübner M, Larson D, Torrero M, Mueller E, Shi Y, Killoran K, et al. Anti-Fc?R1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice. Clin Immunol. 2011;141:205-17 pubmed publisher
Tawara I, Nieves E, Liu C, Evers R, Toubai T, Sun Y, et al. Host basophils are dispensable for induction of donor T helper 2 cell differentiation and severity of experimental graft-versus-host disease. Biol Blood Marrow Transplant. 2011;17:1747-53 pubmed publisher
Anthony R, Kobayashi T, Wermeling F, Ravetch J. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature. 2011;475:110-3 pubmed publisher
Schneider E, Machavoine F, Bricard Rignault R, Levasseur M, Petit Bertron A, Gautron S, et al. Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands. J Allergy Clin Immunol. 2011;128:864-871.e2 pubmed publisher
Kageyama Yahara N, Suehiro Y, Yamamoto T, Kadowaki M. Rab5a regulates surface expression of Fc?RI and functional activation in mast cells. Biol Pharm Bull. 2011;34:760-3 pubmed
Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, et al. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS ONE. 2011;6:e18404 pubmed publisher
Nishikado H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H. NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J Immunol. 2011;186:5766-71 pubmed publisher
McDonald J, Cortini A, Rosas M, Fossati Jimack L, Ling G, Lewis K, et al. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB J. 2011;25:1972-82 pubmed publisher
Piconese S, Costanza M, Musio S, Tripodo C, Poliani P, Gri G, et al. Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice. Lab Invest. 2011;91:627-41 pubmed publisher
van Panhuys N, Prout M, Forbes E, Min B, Paul W, Le Gros G. Basophils are the major producers of IL-4 during primary helminth infection. J Immunol. 2011;186:2719-28 pubmed publisher
Kawahara T, Iizuka T. Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells. Cytotechnology. 2011;63:143-52 pubmed publisher
Ishida W, Fukuda K, Sumi T, Ebihara N, Kajisako M, Matsuda H, et al. Adjuvants determine the contribution of basophils to antigen sensitization in vivo. Immunol Lett. 2011;136:49-54 pubmed publisher
Kawahara T. Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells. Anim Sci J. 2010;81:714-21 pubmed publisher
Rodriguez Gomez M, Talke Y, Goebel N, Hermann F, Reich B, Mack M. Basophils support the survival of plasma cells in mice. J Immunol. 2010;185:7180-5 pubmed publisher
Qi Y, Operario D, Oberholzer C, Kobie J, Looney R, Georas S, et al. Human basophils express amphiregulin in response to T cell-derived IL-3. J Allergy Clin Immunol. 2010;126:1260-6.e4 pubmed publisher
Kalesnikoff J, Galli S. Antiinflammatory and immunosuppressive functions of mast cells. Methods Mol Biol. 2011;677:207-20 pubmed publisher
Cheung D, Ehlenbach S, Kitchens R, Riley D, Thomas L, Holtzman M, et al. Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. J Immunol. 2010;185:4983-7 pubmed publisher
Wang X, Reece S, Van Scott M, Brown J. A circadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro. Brain Behav Immun. 2011;25:127-34 pubmed publisher
de Vries V, Elgueta R, Lee D, Noelle R. Mast cell protease 6 is required for allograft tolerance. Transplant Proc. 2010;42:2759-62 pubmed publisher
Phythian Adams A, Cook P, Lundie R, Jones L, Smith K, Barr T, et al. CD11c depletion severely disrupts Th2 induction and development in vivo. J Exp Med. 2010;207:2089-96 pubmed publisher
Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart M, Kool M, et al. Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med. 2010;207:2097-111 pubmed publisher
Orinska Z, Föger N, Huber M, Marschall J, Mirghomizadeh F, Du X, et al. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. Blood. 2010;116:2665-75 pubmed publisher
de Haij S, Jansen J, Boross P, Beurskens F, Bakema J, Bos D, et al. In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling. Cancer Res. 2010;70:3209-17 pubmed publisher
Kageyama Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, et al. Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo. FEBS Lett. 2010;584:111-8 pubmed publisher
Gaudenzio N, Espagnolle N, Mars L, Liblau R, Valitutti S, Espinosa E. Cell-cell cooperation at the T helper cell/mast cell immunological synapse. Blood. 2009;114:4979-88 pubmed publisher
de Vries V, Wasiuk A, Bennett K, Benson M, Elgueta R, Waldschmidt T, et al. Mast cell degranulation breaks peripheral tolerance. Am J Transplant. 2009;9:2270-80 pubmed publisher
Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, et al. Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation. Blood. 2009;114:2639-48 pubmed publisher
Moore M, Newcomb D, Parekh V, Van Kaer L, Collins R, Zhou W, et al. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol. 2009;183:2016-26 pubmed publisher
Ota T, Aoki Ota M, Duong B, Nemazee D. Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE. J Immunol. 2009;182:8110-7 pubmed publisher
Perrigoue J, Saenz S, Siracusa M, Allenspach E, Taylor B, Giacomin P, et al. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol. 2009;10:697-705 pubmed publisher
Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, et al. Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol. 2009;123:74-81.e1 pubmed publisher
Watanabe M, Satoh T, Yamamoto Y, Kanai Y, Karasuyama H, Yokozeki H. Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol. 2008;181:5653-9 pubmed
Nakano N, Nishiyama C, Tokura T, Nagasako Akazome Y, Ohtake Y, Okumura K, et al. Procyanidin C1 from apple extracts inhibits Fc epsilon RI-mediated mast cell activation. Int Arch Allergy Immunol. 2008;147:213-21 pubmed publisher
Kondo Y, Yoshimoto T, Yasuda K, Futatsugi Yumikura S, Morimoto M, Hayashi N, et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol. 2008;20:791-800 pubmed publisher
Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, et al. Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro. J Med Food. 2008;11:14-20 pubmed publisher
Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008;28:581-9 pubmed publisher
Sokol C, Barton G, Farr A, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008;9:310-8 pubmed publisher
Grayson M, Cheung D, Rohlfing M, Kitchens R, Spiegel D, Tucker J, et al. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med. 2007;204:2759-69 pubmed
Ho L, Ohno T, Oboki K, Kajiwara N, Suto H, Iikura M, et al. IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol. 2007;82:1481-90 pubmed
Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, et al. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007;110:913-20 pubmed
Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, et al. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood. 2007;109:4846-55 pubmed
Oh K, Shen T, Le Gros G, Min B. Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood. 2007;109:2921-7 pubmed
Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi A, Migliaccio G, et al. The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood. 2007;109:1460-71 pubmed
Satoh T, Moroi R, Aritake K, Urade Y, Kanai Y, Sumi K, et al. Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J Immunol. 2006;177:2621-9 pubmed
Fallon P, Ballantyne S, Mangan N, Barlow J, Dasvarma A, Hewett D, et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med. 2006;203:1105-16 pubmed
Hirrlinger P, Scheller A, Braun C, Hirrlinger J, Kirchhoff F. Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia. 2006;54:11-20 pubmed
Kalesnikoff J, Rios E, Chen C, Nakae S, Zabel B, Butcher E, et al. RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells. Proc Natl Acad Sci U S A. 2006;103:2659-64 pubmed
Son A, Nakamura H, Kondo N, Matsuo Y, Liu W, Oka S, et al. Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice. Cell Res. 2006;16:230-9 pubmed
Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick J, Tsai M, et al. Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J Immunol. 2006;176:2238-48 pubmed
Arinobu Y, Iwasaki H, Gurish M, Mizuno S, Shigematsu H, Ozawa H, et al. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A. 2005;102:18105-10 pubmed
Tokura T, Nakano N, Ito T, Matsuda H, Nagasako Akazome Y, Kanda T, et al. Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in vitro targeting the binding between IgE and FcepsilonRI. Biosci Biotechnol Biochem. 2005;69:1974-7 pubmed
Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K, et al. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity. 2005;23:191-202 pubmed
Chen C, Grimbaldeston M, Tsai M, Weissman I, Galli S. Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci U S A. 2005;102:11408-13 pubmed
Alfredsson J, Puthalakath H, Martin H, Strasser A, Nilsson G. Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation. Cell Death Differ. 2005;12:136-44 pubmed
product information
Product Type :
Antibody
Product Name :
FceR1 alpha Monoclonal Antibody (MAR-1), Biotin, eBioscience™
Catalog # :
13-5898-85
Quantity :
500 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 µg/test
Species :
Mouse
Clone :
MAR-1
Isotype :
IgG
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 µg/test
Aliases :
alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA