P-cadherin Monoclonal Antibody (NCC-CAD-299) | Invitrogen 13-5800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

P-cadherin Monoclonal Antibody (NCC-CAD-299)

catalog :

13-5800

quantity :

100µg

price :

US 345.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

NCC-CAD-299

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; fig 2b	Ribeiro A, Albergaria A, Sousa B, Correia A, Bracke M, Seruca R, et al. Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. Oncogene. 2010;29:392-402 pubmed publisher
immunohistochemistry - paraffin section; human immunoprecipitation; human immunocytochemistry; human; 1:10 western blot; human	Mannello F, Tonti G, Medda V, Pederzoli A, Sauter E. Increased shedding of soluble fragments of P-cadherin in nipple aspirate fluids from women with breast cancer. Cancer Sci. 2008;99:2160-9 pubmed publisher
blocking or activating experiments; human	Bryan R, Atherfold P, Yeo Y, Jones L, Harrison R, Wallace D, et al. Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: ex vivo and in vitro studies. J Pathol. 2008;215:184-94 pubmed publisher
western blot; human	Schmeiser K, Grand R. The fate of E- and P-cadherin during the early stages of apoptosis. Cell Death Differ. 1999;6:377-86 pubmed
	Muller N, Reinacher Schick A, Baldus S, van Hengel J, Berx G, Baar A, et al. Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells. Oncogene. 2002;21:6049-58 pubmed
	Braga V, Machesky L, Hall A, Hotchin N. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol. 1997;137:1421-31 pubmed

product information

Product Type :

Antibody

Product Name :

P-cadherin Monoclonal Antibody (NCC-CAD-299)

Catalog # :

13-5800

Quantity :

100µg

Price :

US 345.00

Clonality :

Monoclonal

Purity :

Ion-exchange chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Frozen): 5-10 µg/mL, Inhibition Assays: 100 µg/mL, Western Blot: 5-10 µg/mL

Species :

Human

Clone :

NCC-CAD-299

Isotype :

IgG1

Storage :

4° C

Description :

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

Immunogen :

Epidermoid carcinoma cell line A431.

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry (Frozen): 5-10 µg/mL, Inhibition Assays: 100 µg/mL, Western Blot: 5-10 µg/mL

Aliases :

AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); Cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH15; CDH3; CDHP; HJMD; Pcad; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin

more info or order :

Invitrogen product webpage