Ea52-68 peptide bound to I-Ab Monoclonal Antibody (eBioY-Ae (YAe, Y-Ae)), Biotin, eBioscience | Invitrogen 13-5741-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ea52-68 peptide bound to I-Ab Monoclonal Antibody (eBioY-Ae (YAe, Y-Ae)), Biotin, eBioscience

catalog :

13-5741-82

quantity :

100 µg

price :

US 224

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

eBioY-Ae (YAe, Y-Ae)

reactivity :

mouse

application :

flow cytometry

citations: 17

Reference
Jing Z, McCarron M, Dustin M, Fooksman D. Germinal center expansion but not plasmablast differentiation is proportional to peptide-MHCII density via CD40-CD40L signaling strength. Cell Rep. 2022;39:110763 pubmed publisher
Si Y, Tian Q, Zhao F, Kelly S, Shores L, Camacho D, et al. Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses. Sci Adv. 2020;6:eaba0995 pubmed publisher
Wiesner D, Merkhofer R, Ober C, Kujoth G, Niu M, Keller N, et al. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020;27:614-628.e6 pubmed publisher
Bonacina F, Coe D, Wang G, Longhi M, Baragetti A, Moregola A, et al. Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation. Nat Commun. 2018;9:3083 pubmed publisher
Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed publisher
Benson R, Macleod M, Hale B, Patakas A, Garside P, Brewer J. Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. elife. 2015;4: pubmed publisher
Dang Z, Kuffova L, Liu L, Forrester J. Soluble antigen traffics rapidly and selectively from the corneal surface to the eye draining lymph node and activates T cells when codelivered with CpG oligonucleotides. J Leukoc Biol. 2014;95:431-40 pubmed publisher
Hepworth M, Monticelli L, Fung T, Ziegler C, Grunberg S, Sinha R, et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013;498:113-7 pubmed publisher
Ghimire T, Benson R, Garside P, Brewer J. Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro. Immunol Lett. 2012;147:55-62 pubmed publisher
Mantegazza A, Guttentag S, El Benna J, Sasai M, Iwasaki A, Shen H, et al. Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells. Immunity. 2012;36:782-94 pubmed publisher
Markey K, Koyama M, Kuns R, Lineburg K, Wilson Y, Olver S, et al. Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets. Blood. 2012;119:5918-30 pubmed publisher
Anandasabapathy N, Victora G, Meredith M, Feder R, Dong B, Kluger C, et al. Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med. 2011;208:1695-705 pubmed publisher
Brown K, Sacks S, Wong W. Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection. Eur J Immunol. 2011;41:89-96 pubmed publisher
Lee H, Mattei L, Steinberg B, Alberts P, Lee Y, Chervonsky A, et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity. 2010;32:227-39 pubmed publisher
Rehm K, Connor R, Jones G, Yimbu K, Roper R. Vaccinia virus A35R inhibits MHC class II antigen presentation. Virology. 2010;397:176-86 pubmed publisher
Onabajo O, Seeley M, Kale A, Qualmann B, Kessels M, Han J, et al. Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. J Immunol. 2008;180:6685-95 pubmed
Pepper M, Dzierszinski F, Wilson E, Tait E, Fang Q, Yarovinsky F, et al. Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines. J Immunol. 2008;180:6229-36 pubmed

product information

Product Type :

Antibody

Product Name :

Ea52-68 peptide bound to I-Ab Monoclonal Antibody (eBioY-Ae (YAe, Y-Ae)), Biotin, eBioscience

Catalog # :

13-5741-82

Quantity :

100 µg

Price :

US 224

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

eBioY-Ae (YAe, Y-Ae)

Isotype :

IgG2b

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2Eb; H-2Eb; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; Ia4; Ia-4; IAb; I-Abeta; major histocompatibility complex class II beta chain; MGC163794; MGC163796; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1