This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TCR gamma/delta Monoclonal Antibody (eBioGL3 (GL-3, GL3)), Biotin, eBioscience
catalog :
13-5711-81
quantity :
50 ug
price :
US 124.00
clonality :
monoclonal
host :
hamsters
conjugate :
biotin
clone name :
eBioGL3 (GL-3, GL3)
reactivity :
mouse
application :
flow cytometry
citations: 38
Reference
Lehrke M, Shapiro M, Rajcula M, Kennedy M, McCue S, Medina K, et al. The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice. elife. 2021;10: pubmed publisher
Filtjens J, Roger A, Quatrini L, Wieduwild E, Gouilly J, Hoeffel G, et al. Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection. Nat Commun. 2021;12:2936 pubmed publisher
Romero Wolf M, Shin B, Zhou W, Koizumi M, Rothenberg E, Hosokawa H. Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development. J Cell Biol. 2020;219: pubmed publisher
Hurrell B, Galle Treger L, Jahani P, Howard E, Helou D, Banie H, et al. TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity. Cell Rep. 2019;29:4509-4524.e5 pubmed publisher
Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai K. Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 2019;10:3878 pubmed publisher
Yang B, Wang K, Wan S, Liang Y, Yuan X, Dong Y, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27:3629-3645.e6 pubmed publisher
Liu M, Hu Y, Yuan Y, Tian Z, Zhang C. γδT Cells Suppress Liver Fibrosis via Strong Cytolysis and Enhanced NK Cell-Mediated Cytotoxicity Against Hepatic Stellate Cells. Front Immunol. 2019;10:477 pubmed publisher
Galle Treger L, Sankaranarayanan I, Hurrell B, Howard E, Lo R, Maazi H, et al. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. Nat Commun. 2019;10:713 pubmed publisher
Ng K, Yui M, Mehta A, Siu S, Irwin B, Pease S, et al. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. elife. 2018;7: pubmed publisher
Spidale N, Sylvia K, Narayan K, Miu B, Frascoli M, Melichar H, et al. Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling. Immunity. 2018;49:857-872.e5 pubmed publisher
Hu G, Cui K, Fang D, Hirose S, Wang X, Wangsa D, et al. Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells. Immunity. 2018;48:227-242.e8 pubmed publisher
Hong M, Gu B, Madison M, Landers C, Tung H, Kim M, et al. Protective role of γδ T cells in cigarette smoke and influenza infection. Mucosal Immunol. 2018;11:894-908 pubmed publisher
Vannella K, Ramalingam T, Hart K, de Queiroz Prado R, Sciurba J, Barron L, et al. Acidic chitinase primes the protective immune response to gastrointestinal nematodes. Nat Immunol. 2016;17:538-44 pubmed publisher
Yong C, Westwood J, Schröder J, Papenfuss A, von Scheidt B, Moeller M, et al. Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice. PLoS ONE. 2015;10:e0140543 pubmed publisher
Akitsu A, Ishigame H, Kakuta S, Chung S, Ikeda S, Shimizu K, et al. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells. Nat Commun. 2015;6:7464 pubmed publisher
Franckaert D, Schlenner S, Heirman N, Gill J, Skogberg G, Ekwall O, et al. Premature thymic involution is independent of structural plasticity of the thymic stroma. Eur J Immunol. 2015;45:1535-47 pubmed publisher
Xia M, Hu S, Fu Y, Jin W, Yi Q, Matsui Y, et al. CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin. J Allergy Clin Immunol. 2014;134:634-644.e10 pubmed publisher
Yamamoto H, Nakamura Y, Sato K, Takahashi Y, Nomura T, Miyasaka T, et al. Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans. Infect Immun. 2014;82:1606-15 pubmed publisher
Grishkan I, Ntranos A, Calabresi P, Gocke A. Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells. Cell Immunol. 2013;284:68-74 pubmed publisher
Guo Y, Sun X, Shibata K, Yamada H, Muta H, Podack E, et al. CD30 is required for activation of a unique subset of interleukin-17A-producing ?? T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection. Infect Immun. 2013;81:3923-34 pubmed publisher
Kole A, He J, Rivollier A, Silveira D, Kitamura K, Maloy K, et al. Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis. J Immunol. 2013;191:2771-9 pubmed publisher
Gonzalo Gil E, Criado G, Santiago B, Dotor J, Pablos J, Galindo M. Transforming growth factor (TGF)-? signalling is increased in rheumatoid synovium but TGF-? blockade does not modify experimental arthritis. Clin Exp Immunol. 2013;174:245-55 pubmed publisher
Cheng H, Wu R, Gebre A, Hanna R, Smith D, Parks J, et al. Increased cholesterol content in gammadelta (??) T lymphocytes differentially regulates their activation. PLoS ONE. 2013;8:e63746 pubmed publisher
Mielke L, Jones S, Raverdeau M, Higgs R, Stefanska A, Groom J, et al. Retinoic acid expression associates with enhanced IL-22 production by ?? T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med. 2013;210:1117-24 pubmed publisher
Oda H, Tamehiro N, Patrick M, Hayakawa K, Suzuki H. Differential requirement for RhoH in development of TCR?? CD8?? IELs and other types of T cells. Immunol Lett. 2013;151:1-9 pubmed publisher
Jiang J, Champion C, Wei B, Liu G, Kelly K. CD8?CXCR5? T cells regulate pathology in the genital tract. Infect Dis Obstet Gynecol. 2013;2013:813238 pubmed publisher
Petersen B, Wolf M, Austermann J, van Lent P, Foell D, Ahlmann M, et al. The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J. 2013;32:100-11 pubmed publisher
Bahri R, Bollinger A, Bollinger T, Orinska Z, Bulfone Paus S. Ectonucleotidase CD38 demarcates regulatory, memory-like CD8+ T cells with IFN-?-mediated suppressor activities. PLoS ONE. 2012;7:e45234 pubmed publisher
Ribot J, deBarros A, Mancio Silva L, Pamplona A, Silva Santos B. B7-CD28 costimulatory signals control the survival and proliferation of murine and human ?? T cells via IL-2 production. J Immunol. 2012;189:1202-8 pubmed publisher
Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, et al. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am J Pathol. 2011;179:302-14 pubmed publisher
Do J, Visperas A, O Brien R, Min B. CD4 T cells play important roles in maintaining IL-17-producing ?? T-cell subsets in naive animals. Immunol Cell Biol. 2012;90:396-403 pubmed publisher
Heinonen K, Vanegas J, Lew D, Krosl J, Perreault C. Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS ONE. 2011;6:e19279 pubmed publisher
Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, et al. Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis. J Immunol. 2011;186:3462-71 pubmed publisher
Gossens K, Naus S, Hollander G, Ziltener H. Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity. PLoS ONE. 2010;5:e12766 pubmed publisher
Redford P, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, et al. Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Eur J Immunol. 2010;40:2200-10 pubmed publisher
Do J, Fink P, Li L, Spolski R, Robinson J, Leonard W, et al. Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism. J Immunol. 2010;184:1675-9 pubmed publisher
Shang L, Thirunarayanan N, Viejo Borbolla A, Martin A, Bogunovic M, Marchesi F, et al. Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine. Gastroenterology. 2009;137:1006-18, 1018.e1-3 pubmed publisher
Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, et al. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med. 2008;205:1381-93 pubmed publisher
product information
Product Type :
Antibody
Product Name :
TCR gamma/delta Monoclonal Antibody (eBioGL3 (GL-3, GL3)), Biotin, eBioscience
Catalog # :
13-5711-81
Quantity :
50 ug
Price :
US 124.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
eBioGL3 (GL-3, GL3)
Isotype :
IgG
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA