product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
F4/80 Monoclonal Antibody (BM8), Biotin, eBioscience
catalog :
13-4801-82
quantity :
100 ug
price :
US 251.00
clonality :
monoclonal
host :
rat
conjugate :
biotin
clone name :
BM8
reactivity :
mouse
application :
immunohistochemistry, flow cytometry
more info or order :
citations: 425
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:100; fig 1
Yao Y, Norris E, Mason C, Strickland S. Laminin regulates PDGFR?(+) cell stemness and muscle development. Nat Commun. 2016;7:11415 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7
Singh N, Kotla S, Dyukova E, Traylor J, Orr A, Chernoff J, et al. Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nat Commun. 2015;6:7450 pubmed publisher
  • flow cytometry; mouse; fig s1
Opata M, Carpio V, Ibitokou S, Dillon B, Obiero J, Stephens R. Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells. J Immunol. 2015;194:5346-54 pubmed publisher
  • flow cytometry; mouse; fig 1
Sadri N, Lu J, Badura M, Schneider R. AUF1 is involved in splenic follicular B cell maintenance. BMC Immunol. 2010;11:1 pubmed publisher
Hu J, Zhang X, Ma F, Huang C, Jiang Y. LncRNA CASC2 Alleviates Renal Interstitial Inflammation and Fibrosis through MEF2C Downregulation-Induced Hinderance of M1 Macrophage Polarization. Nephron. 2024;148:245-263 pubmed publisher
Cao X, Xu Y, Zhou C, Huo J, Su S, Liu L, et al. Oral Immunotherapy Reshapes Intestinal Immunosuppression via Metabolic Reprogramming to Enhance Systemic Anti-Tumor Immunity. Adv Sci (Weinh). 2023;10:e2302910 pubmed publisher
Gonzatti M, Freire B, Antunes M, de Menezes G, Talbot J, Peron J, et al. Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury. iScience. 2023;26:107947 pubmed publisher
Qi H, Zheng Z, Liu Q. Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. Cell Mol Biol Lett. 2023;28:79 pubmed publisher
Verboom L, Anderson C, Jans M, Petta I, Blancke G, Martens A, et al. OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection. Cell Death Dis. 2023;14:534 pubmed publisher
Schroer A, Ventura P, Sucharov J, Misra R, Chui M, Bieri G, et al. Platelet factors attenuate inflammation and rescue cognition in ageing. Nature. 2023;620:1071-1079 pubmed publisher
Tomitsuka Y, Imaeda H, Ito H, Asou I, Ohbayashi M, Ishikawa F, et al. Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation. Redox Biol. 2023;66:102850 pubmed publisher
Wang C, Shen N, Guo Q, Tan X, He S. YAP/STAT3 inhibited CD8+ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages. Cancer Med. 2023;12:16295-16309 pubmed publisher
Zuo B, Li T, Liu X, Wang S, Cheng J, Liu X, et al. Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer. Clin Transl Oncol. 2023;25:3188-3202 pubmed publisher
Wang S, Zhang Q, Lu D, Fang Y, Yan X, Chen J, et al. GPR84 regulates pulmonary inflammation by modulating neutrophil functions. Acta Pharmacol Sin. 2023;44:1665-1675 pubmed publisher
Scinicariello S, Soderholm A, Sch xe4 fer M, Shulkina A, Schwartz I, Hacker K, et al. HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation. elife. 2023;12: pubmed publisher
Qin H, Luo Z, Sun Y, He Z, Qi B, Chen Y, et al. Low-intensity pulsed ultrasound promotes skeletal muscle regeneration via modulating the inflammatory immune microenvironment. Int J Biol Sci. 2023;19:1123-1145 pubmed publisher
Huang J, Leng X, Jiang T, Xu L, Zheng J, Fang M, et al. Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy. Mater Today Bio. 2023;19:100555 pubmed publisher
An X, Qin J, Hu X, Zhou Y, Fu B, Wei H. Overexpression of lipocalin 2 in PBX1-deficient decidual NK cells promotes inflammation at the maternal-fetal interface. Am J Reprod Immunol. 2023;89:e13676 pubmed publisher
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Vu R, Jin S, Sun P, Haensel D, Nguyen Q, Dragan M, et al. Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication. Cell Rep. 2022;40:111155 pubmed publisher
Weber A, Yang X, Mennillo E, Ding J, Watrous J, Jain M, et al. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022;13:4346 pubmed publisher
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Duan H, Jing L, Xiang J, Ju C, Wu Z, Liu J, et al. CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity. Adv Sci (Weinh). 2022;9:e2103719 pubmed publisher
Subramanian S, Busch C, Molawi K, Geirsdóttir L, Maurizio J, Vargas Aguilar S, et al. Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo. Nat Immunol. 2022;23:458-468 pubmed publisher
Foglia B, Sutti S, Cannito S, Rosso C, Maggiora M, Autelli R, et al. Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation. Cell Mol Gastroenterol Hepatol. 2022;13:459-482 pubmed publisher
Azuma Y, Fujita T, Izawa T, Hirota K, Nishiyama K, Ikegami A, et al. IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. Cells. 2021;10: pubmed publisher
Medina Buelvas D, Rodr xed guez Sosa M, Vega L. Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi. Pathogens. 2021;10: pubmed publisher
Ji W, Li D, Wei D, Gu A, Yang Y, Peng J. Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period. Front Immunol. 2021;12:763067 pubmed publisher
Zhu X, Liu J, Pan H, Geng Z, Huang W, Liu T, et al. Thymopentin treatment of murine premature ovarian failure via attenuation of immune cell activity and promotion of the BMP4/Smad9 signalling pathway. Int J Med Sci. 2021;18:3544-3555 pubmed publisher
Oladiran O, Shi X, Fournier S, Zhang J. CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice. Front Immunol. 2021;12:720733 pubmed publisher
Chow S, Cui C, Cheng K, Chim Y, Wang J, Wong C, et al. Acute Inflammatory Response in Osteoporotic Fracture Healing Augmented with Mechanical Stimulation is Regulated In Vivo through the p38-MAPK Pathway. Int J Mol Sci. 2021;22: pubmed publisher
DORA D, Ferenczi S, Stavely R, Tóth V, Varga Z, Kovacs T, et al. Evidence of a Myenteric Plexus Barrier and Its Macrophage-Dependent Degradation During Murine Colitis: Implications in Enteric Neuroinflammation. Cell Mol Gastroenterol Hepatol. 2021;12:1617-1641 pubmed publisher
Cheng Y, Zhang Z, Lan B, Lin J, Chen X, Kong L, et al. PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice. J Exp Med. 2021;218: pubmed publisher
Bereswill S, Mousavi S, Weschka D, Heimesaat M. Disease-Alleviating Effects of Peroral Activated Charcoal Treatment in Acute Murine Campylobacteriosis. Microorganisms. 2021;9: pubmed publisher
Heimesaat M, Weschka D, Mousavi S, Bereswill S. Treatment with the Probiotic Product Aviguard® Alleviates Inflammatory Responses during Campylobacter jejuni-Induced Acute Enterocolitis in Mice. Int J Mol Sci. 2021;22: pubmed publisher
Cai C, Zeng D, Gao Q, Ma L, Zeng B, Zhou Y, et al. Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis. Sci Rep. 2021;11:13386 pubmed publisher
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Zhao Q, Shi M, Yin C, Zhao Z, Zhang J, Wang J, et al. Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis. Nanomicro Lett. 2020;13:28 pubmed publisher
Shan Z, Li L, Atkins C, Wang M, Wen Y, Jeong J, et al. Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment. elife. 2021;10: pubmed publisher
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Ganguly S, Muench G, Shang L, Rosenthal S, Rahman G, Wang R, et al. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Cell Mol Gastroenterol Hepatol. 2021;12:891-920 pubmed publisher
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Mousavi S, Weschka D, Bereswill S, Heimesaat M. Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10-/- Mice. Pathogens. 2020;10: pubmed publisher
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Ding X, Wang S, Wang Y, Yang J, Bao N, Liu J, et al. Neonatal Heart Responds to Pressure Overload With Differential Alterations in Various Cardiomyocyte Maturation Programs That Accommodate Simultaneous Hypertrophy and Hyperplasia. Front Cell Dev Biol. 2020;8:596960 pubmed publisher
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Pavlovic N, Kopsida M, Gerwins P, Heindryckx F. Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype. Int J Mol Sci. 2020;21: pubmed publisher
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Fan A, Oladiran O, Shi X, Zhang J. High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism. J Neuroinflammation. 2020;17:179 pubmed publisher
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Lu C, Shiau A, Su B, Hsu T, Wang C, Su Y, et al. Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer. J Hematol Oncol. 2020;13:62 pubmed publisher
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Heimesaat M, Mrazek K, Bereswill S. Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota. Front Immunol. 2019;10:2272 pubmed publisher
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Mousavi S, Lobo de Sá F, Schulzke J, Bücker R, Bereswill S, Heimesaat M. Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Campylobacter jejuni Induced Enterocolitis Model. Front Immunol. 2019;10:2094 pubmed publisher
Seo J, Riopel M, Cabrales P, Huh J, Bandyopadhyay G, Andreyev A, et al. Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab. 2019;1:86-97 pubmed publisher
Zhang Z, Sliter D, Bleck C, Ding S. Fis1 deficiencies differentially affect mitochondrial quality in skeletal muscle. Mitochondrion. 2019;49:217-226 pubmed publisher
Zhang R, Earnest J, Kim A, Winkler E, Desai P, Adams L, et al. Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. Cell Rep. 2019;28:2647-2658.e5 pubmed publisher
Liu C, Li P, Li H, Wang S, Ding L, Wang H, et al. TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding. J Transl Med. 2019;17:300 pubmed publisher
Di Mitri D, Mirenda M, Vasilevska J, Calcinotto A, Delaleu N, Revandkar A, et al. Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer. Cell Rep. 2019;28:2156-2168.e5 pubmed publisher
Mohankumar K, Namachivayam K, Song T, Jake Cha B, Slate A, Hendrickson J, et al. A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions. Nat Commun. 2019;10:3494 pubmed publisher
Fu R, Han C, Ni T, Di L, Liu L, Lv W, et al. A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours. Nat Commun. 2019;10:3210 pubmed publisher
Wang N, Yang X, Sun J, Sun Z, Ma Q, Wang Z, et al. Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection. Cell Death Discov. 2019;5:111 pubmed publisher
Nunes N, Chandran P, Sundby M, Visioli F, da Costa Gonçalves F, Burks S, et al. Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway. EBioMedicine. 2019;45:495-510 pubmed publisher
Rothweiler S, Feldbrügge L, Jiang Z, Csizmadia E, Longhi M, Vaid K, et al. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019;15:375-385 pubmed publisher
Gautam A, Park B, Kim T, Akauliya M, Kim D, Maharjan S, et al. Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus. Front Immunol. 2019;10:1160 pubmed publisher
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Ohashi K, Wang Z, Yang Y, Billet S, Tu W, Pimienta M, et al. NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019;70:1582-1599 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
F4/80 Monoclonal Antibody (BM8), Biotin, eBioscience
Catalog # :
13-4801-82
Quantity :
100 ug
Price :
US 251.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
BM8
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
ADGRE1; Adhesion G protein-coupled receptor E1; Adhesion G protein-coupled receptor E2; cell surface glycoprotein EMR1; cell surface glycoprotein F4/80; DD7A5-7; EGF-like module containing, mucin-like, hormone receptor-like 1; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-TM7; Emr1; EMR1 hormone receptor; F4/80; Gpf480; Ly71; lymphocyte antigen 71; TM7LN3
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA