PCNA Monoclonal Antibody (PC10), Biotin | Invitrogen 13-3940 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PCNA Monoclonal Antibody (PC10), Biotin

catalog :

13-3940

quantity :

100 µg

price :

425 USD

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

PC10

reactivity :

Saccharomyces cerevisiae S288C, human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:300	Li X, Nadauld L, Ootani A, Corney D, Pai R, Gevaert O, et al. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat Med. 2014;20:769-77 pubmed publisher
immunohistochemistry - paraffin section; mouse; fig 5	Das M, Garlick D, Greiner D, Davis R. The role of JNK in the development of hepatocellular carcinoma. Genes Dev. 2011;25:634-45 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:10; fig 1	Sayi A, Kohler E, Hitzler I, Arnold I, Schwendener R, Rehrauer H, et al. The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk. J Immunol. 2009;182:7085-101 pubmed publisher
immunohistochemistry; mouse	Nesslein L, Melton K, Ikegami M, Na C, Wert S, Rice W, et al. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005;288:L1154-61 pubmed
immunohistochemistry - paraffin section; mouse	Piechocki M, Lonardo F, Ensley J, Nguyen T, Kim H, Yoo G. Anticancer activity of docetaxel in murine salivary gland carcinoma. Clin Cancer Res. 2002;8:870-7 pubmed
	Girnius N, Edwards Y, Garlick D, Davis R. The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. elife. 2018;7: pubmed publisher
	Girnius N, Davis R. JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Rep. 2017;21:1910-1921 pubmed publisher
	Foster K, Liu Z, Nail C, Li X, Fitzgerald T, Bailey S, et al. Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005;24:1491-500 pubmed
	Kramer B, Kramer S, Ikegami M, Jobe A. Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin. Am J Physiol Lung Cell Mol Physiol. 2002;283:L452-9 pubmed
	Datta K, Sundberg C, Karumanchi S, Mukhopadhyay D. The 104-123 amino acid sequence of the beta-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion. Cancer Res. 2001;61:1768-75 pubmed

product information

Product Type :

Antibody

Product Name :

PCNA Monoclonal Antibody (PC10), Biotin

Catalog # :

13-3940

Quantity :

100 µg

Price :

425 USD

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Insect, Mouse, Non-human primate, Rat, Yeast

Applications :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1000

Species :

Human, Insect, Mouse, Non-human primate, Rat, Yeast

Clone :

PC10

Isotype :

IgG2a

Storage :

4° C

Description :

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.

Immunogen :

Rat recombinant PCNA polypeptides.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1000

Aliases :

ATLD2; cb16; cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; LOC100339381; MGC8367; PCNA; pcna protein; Pcna/cyclin; PCNAR; POL30; proliferating cell nuclear antigen; proliferating cell nuclear antigen-like; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C

more info or order :

Invitrogen product webpage