product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PCNA Monoclonal Antibody (PC10)
catalog :
13-3900
quantity :
200 µg
price :
US 500
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
PC10
reactivity :
Pacific oyster, budgerigar, Saccharomyces cerevisiae S288C, fission yeast, hamsters, duck, human, mouse, rat, pigs , zebrafish , domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 124
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rat; loading ...; fig 2f
Fong L, Taccioli C, Palamarchuk A, Tagliazucchi G, Jing R, Smalley K, et al. Abrogation of esophageal carcinoma development in miR-31 knockout rats. Proc Natl Acad Sci U S A. 2020;117:6075-6085 pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; tbl 1
Mousa H, Shalaby S, Gouda Z, Ahmed F, El Khodary A. Efficacy of human umbilical cord derived-mesenchymal stem cells in treatment of rat bone marrow exposed to gamma irradiation. Ann Anat. 2017;210:64-75 pubmed publisher
  • immunohistochemistry - paraffin section; domestic rabbit; loading ...; fig 4a
Dönmez M, Inci K, Zeybek N, Dogan H, Ergen A. The Early Histological Effects of Intravesical Instillation of Platelet-Rich Plasma in Cystitis Models. Int Neurourol J. 2016;20:188-196 pubmed
  • immunohistochemistry; zebrafish ; fig 4
Olsen J, Wong L, Deimling S, Miles A, Guo H, Li Y, et al. G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis. Stem Cell Reports. 2016;7:454-470 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:150; fig 1b
Di Pietro C, Marazziti D, La Sala G, Abbaszadeh Z, Golini E, Matteoni R, et al. Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma. Cell Mol Neurobiol. 2017;37:145-154 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:50; loading ...; fig 1d
Eltony S, Elmottaleb N, Gomaa A, Anwar M, el Metwally T. Effect of All-Trans Retinoic Acid on the Pancreas of Streptozotocin-Induced Diabetic Rat. Anat Rec (Hoboken). 2016;299:334-51 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 7
Carbone A, Carballo C, Ma R, Wang H, Deng X, Dahia C, et al. Indian hedgehog signaling and the role of graft tension in tendon-to-bone healing: Evaluation in a rat ACL reconstruction model. J Orthop Res. 2016;34:641-9 pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 3a
Othman E, Al Adly D, Elgamal D, Ghandour N, El Sharkawy S. Bisphenol A Concentrates Preferentially in Human Uterine Leiomyoma and Induces Proliferation in Rat Myometrium. Reprod Sci. 2016;23:508-14 pubmed publisher
  • immunohistochemistry - paraffin section; rat
Erboga M, Aktas C, Kurt O, Uygur R, Caglar V, Turan B, et al. Protective effects of thymoquinone on experimental testicular ischaemia-reperfusion injury: an apoptotic, proliferative and biochemical study. Andrologia. 2016;48:222-30 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; fig 3
  • western blot; mouse; 1:1000; fig 3
Lin X, Xu W, Shao M, Fan Q, Wen G, Li C, et al. Shenling Baizhu San supresses colitis associated colorectal cancer through inhibition of epithelial-mesenchymal transition and myeloid-derived suppressor infiltration. BMC Complement Altern Med. 2015;15:126 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:150; fig 4
La Sala G, Marazziti D, Di Pietro C, Golini E, Matteoni R, Tocchini Valentini G. Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015;29:2059-69 pubmed publisher
  • immunohistochemistry - paraffin section; rat
Kamel Ismail Z, Morcos M, Eldin Mohammad M, Gamal Aboulkhair A. Enhancement of Neural Stem Cells after Induction of Depression in Male Albino Rats (A histological & Immunohistochemical Study). Int J Stem Cells. 2014;7:70-8 pubmed publisher
  • western blot; human
Whittom A, Villarreal A, Soni M, Owusu Duku B, Meshram A, Rajkowska G, et al. Markers of apoptosis induction and proliferation in the orbitofrontal cortex in alcohol dependence. Alcohol Clin Exp Res. 2014;38:2790-9 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 3
Rigueur D, Brugger S, Anbarchian T, Kim J, Lee Y, Lyons K. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res. 2015;30:733-41 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100
Felix Patrício B, Medeiros J, de Souza D, Costa W, Sampaio F. Penile histomorphometrical evaluation in hypertensive rats treated with sildenafil or enalapril alone or in combination: a comparison with normotensive and untreated hypertensive rats. J Sex Med. 2015;12:39-47 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100
Ahmed H, Shousha W, Shalby A, El Mezayen H, Ismaiel N, Mahmoud N. Curcumin: a unique antioxidant offers a multimechanistic approach for management of hepatocellular carcinoma in rat model. Tumour Biol. 2015;36:1667-78 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; fig 1
Medeiros Júnior J, Oliveira F, Silva P, Furriel A, Sampaio F, Gregório B. Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model. Acta Cir Bras. 2014;29 Suppl 1:39-44 pubmed
  • immunohistochemistry - paraffin section; mouse
Kienzl Wagner K, Moschen A, Geiger S, Bichler A, Aigner F, Brandacher G, et al. The role of lipocalin-2 in liver regeneration. Liver Int. 2015;35:1195-202 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100
Furriel A, Campos Silva P, Silva P, Costa W, Sampaio F, Gregório B. Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate. PLoS ONE. 2014;9:e102876 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000
Gonzalez Gomez M, Meyer G. Dynamic expression of calretinin in embryonic and early fetal human cortex. Front Neuroanat. 2014;8:41 pubmed publisher
  • immunohistochemistry; human; 1:400
Chen W, Ho C, Chang Y, Chen H, Lin C, Ling T, et al. Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nat Commun. 2014;5:3472 pubmed publisher
  • immunohistochemistry - paraffin section; rat
Uygur R, Aktas C, Caglar V, Uygur E, Erdogan H, Ozen O. Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. Toxicol Ind Health. 2016;32:848-59 pubmed publisher
  • immunohistochemistry; human; 1:400; tbl 1
Li M, Zhang Q, Liu L, Lu W, Wei H, Li R, et al. Expression of the mismatch repair gene hMLH1 is enhanced in non-small cell lung cancer with EGFR mutations. PLoS ONE. 2013;8:e78500 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Xu W, Liu C, Kaartinen V, Chen H, Lu C, Zhang W, et al. TACE in perinatal mouse lung epithelial cells promotes lung saccular formation. Am J Physiol Lung Cell Mol Physiol. 2013;305:L953-63 pubmed publisher
  • immunohistochemistry; pigs ; tbl 3
Bracarense A, Yamasaki L, Silva E, Oliveira R, Alfieri A. Helicobacter spp. infection induces changes in epithelial proliferation and E-cadherin expression in the gastric mucosa of pigs. J Comp Pathol. 2013;149:402-9 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Estrada K, Wang W, Retting K, Chien C, Elkhoury F, Heuchel R, et al. Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013;382:375-84 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 200 ug/ml
Kaplanoglu G, Bahcelioglu M, Gozil R, Helvacioglu F, Buru E, Tekindal M, et al. Effects of green tea and vitamin E in the testicular tissue of streptozotocin-induced diabetic rats. Saudi Med J. 2013;34:734-43 pubmed
  • immunohistochemistry - paraffin section; rat; 1:50
Toydemir T, Kanter M, Erboga M, Oguz S, Erenoglu C. Antioxidative, antiapoptotic, and proliferative effect of curcumin on liver regeneration after partial hepatectomy in rats. Toxicol Ind Health. 2015;31:162-72 pubmed publisher
  • western blot; rat; 1:300; fig 4
Li R, Strykowski R, Meyer M, Mulcrone P, Krakora D, Suzuki M. Male-specific differences in proliferation, neurogenesis, and sensitivity to oxidative stress in neural progenitor cells derived from a rat model of ALS. PLoS ONE. 2012;7:e48581 pubmed publisher
  • immunohistochemistry; human; fig 2
Zhang C, Gurevich I, Aneskievich B. Organotypic modeling of human keratinocyte response to peroxisome proliferators. Cells Tissues Organs. 2012;196:431-41 pubmed publisher
  • immunohistochemistry - paraffin section; domestic rabbit; fig 3
Wen Q, Jin D, Zhou C, Zhou M, Luo W, Ma L. HGF-transgenic MSCs can improve the effects of tissue self-repair in a rabbit model of traumatic osteonecrosis of the femoral head. PLoS ONE. 2012;7:e37503 pubmed publisher
  • immunohistochemistry; human; 1:200; fig 1
Bollain y Goytia J, González Castañeda M, Torres Del Muro F, Daza Benítez L, Zapata Benavides P, Rodriguez Padilla C, et al. Increased excretion of urinary podocytes in lupus nephritis. Indian J Nephrol. 2011;21:166-71 pubmed publisher
  • immunocytochemistry; mouse; fig 5
Estrada K, Retting K, Chin A, Lyons K. Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res. 2011;26:2498-510 pubmed publisher
  • western blot; human; fig 2
Baydoun H, Pancewicz J, Bai X, Nicot C. HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression. Mol Cancer. 2010;9:302 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; fig 2
Barnouti Z, Owtad P, Shen G, Petocz P, Darendeliler M. The biological mechanisms of PCNA and BMP in TMJ adaptive remodeling. Angle Orthod. 2011;81:91-99 pubmed publisher
  • immunohistochemistry - frozen section; zebrafish ; 1:150; fig 4
Maurer C, Schonthaler H, Mueller K, Neuhauss S. Distinct retinal deficits in a zebrafish pyruvate dehydrogenase-deficient mutant. J Neurosci. 2010;30:11962-72 pubmed publisher
  • immunohistochemistry - paraffin section; Pacific oyster; 1:100
  • western blot; Pacific oyster; 1:500
Franco A, Jouaux A, Mathieu M, Sourdaine P, Lelong C, Kellner K, et al. Proliferating cell nuclear antigen in gonad and associated storage tissue of the Pacific oyster Crassostrea gigas: seasonal immunodetection and expression in laser microdissected tissues. Cell Tissue Res. 2010;340:201-10 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
Craig V, Arnold I, Gerke C, Huynh M, Wündisch T, Neubauer A, et al. Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins. Blood. 2010;115:581-91 pubmed publisher
  • western blot; human; 1:400; fig 2
Chimploy K, Díaz G, Li Q, Carter O, Dashwood W, Mathews C, et al. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int J Cancer. 2009;125:2086-94 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:10; fig 1
Sayi A, Kohler E, Hitzler I, Arnold I, Schwendener R, Rehrauer H, et al. The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk. J Immunol. 2009;182:7085-101 pubmed publisher
  • immunocytochemistry; human
Gupta V, Bhasin S, Guo W, Singh R, Miki R, Chauhan P, et al. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol. 2008;296:32-40 pubmed publisher
  • immunohistochemistry - paraffin section; budgerigar; 1:100
Striedter G, Charvet C. Developmental origins of species differences in telencephalon and tectum size: morphometric comparisons between a parakeet (Melopsittacus undulatus) and a quail (Colinus virgianus). J Comp Neurol. 2008;507:1663-75 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; fig 1
Li M, Liu L, Wang Z, Wang L, Liu Z, Xu G, et al. Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Oncol Rep. 2008;19:401-6 pubmed
  • western blot; human; 1:300; fig 4
Wang J, Liu L, Brinton R. Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. Endocrinology. 2008;149:208-18 pubmed
  • immunohistochemistry - paraffin section; pigs ; 1:100; fig 4
Fu X, Fang L, Li H, Li X, Cheng B, Sheng Z. Adipose tissue extract enhances skin wound healing. Wound Repair Regen. 2007;15:540-8 pubmed
  • immunoprecipitation; human; fig 3e
Klaile E, Müller M, Kannicht C, Otto W, Singer B, Reutter W, et al. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. J Biol Chem. 2007;282:26629-40 pubmed
  • western blot; mouse; 1:2000; fig 7
Dupasquier C, Dibrov E, Kneesh A, Cheung P, Lee K, Alexander H, et al. Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Am J Physiol Heart Circ Physiol. 2007;293:H2394-402 pubmed
  • western blot; mouse; 1:2000; fig 7
Boyle S, Shioda T, Perantoni A, De Caestecker M. Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev Dyn. 2007;236:2321-30 pubmed
  • immunohistochemistry - paraffin section; rat; 1:100; tbl 1
Fuller T, Rose F, Singleton K, Linde Y, Hoff U, Freise C, et al. Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury. J Surg Res. 2007;140:77-83 pubmed
  • immunohistochemistry - paraffin section; human
Hammoud Z, Badve S, Saxena R, Kesler K, Rieger K, Malkas L, et al. A novel biomarker for the detection of esophageal adenocarcinoma. J Thorac Cardiovasc Surg. 2007;133:82-7 pubmed
  • immunohistochemistry - paraffin section; pigs ; 2 ug/ml; fig 3
Masters R, Crean B, Yan W, Moss A, Ryan P, Wiley A, et al. Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin. Domest Anim Endocrinol. 2007;33:335-46 pubmed
  • immunohistochemistry - paraffin section; rat; 1:100; fig 8
Arellanes Robledo J, Marquez Rosado L, Perez Carreon J, Fattel Fazenda S, Aguirre García J, Villa Treviño S. Celecoxib induces regression of putative preneoplastic lesions in rat liver. Anticancer Res. 2006;26:1271-80 pubmed
  • immunohistochemistry; mouse; 1:100; fig 2
Adolphe C, Hetherington R, Ellis T, Wainwright B. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 2006;66:2081-8 pubmed
  • immunohistochemistry; human; 1:50
Cao Y, Zhang M, Wang J, Zhang W, Li G, Zhao J. Recurrent intracranial hemangiopericytoma with multiple metastases. Chin Med J (Engl). 2006;119:169-73 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:200
Allen T, van Tuyl M, Iyengar P, Jothy S, Post M, Tsao M, et al. Grg1 acts as a lung-specific oncogene in a transgenic mouse model. Cancer Res. 2006;66:1294-301 pubmed
  • immunohistochemistry - paraffin section; human; fig 1
  • immunohistochemistry - paraffin section; mouse; fig 1
Ray P, Tassi E, Liu X, Wellstein A. Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. Am J Physiol Regul Integr Comp Physiol. 2006;290:R105-13 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:10; fig 3
Mueller A, O Rourke J, Chu P, Chu A, Dixon M, Bouley D, et al. The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Am J Pathol. 2005;167:797-812 pubmed
  • immunohistochemistry; mouse
Nesslein L, Melton K, Ikegami M, Na C, Wert S, Rice W, et al. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005;288:L1154-61 pubmed
  • immunoprecipitation; hamsters; fig 3
  • western blot; hamsters; fig 1
Naryzhny S, Lee H. The post-translational modifications of proliferating cell nuclear antigen: acetylation, not phosphorylation, plays an important role in the regulation of its function. J Biol Chem. 2004;279:20194-9 pubmed
  • immunohistochemistry; human; 1:40; fig 1
Bar Shira Maymon B, Yogev L, Yavetz H, Lifschitz Mercer B, Schreiber L, Kleiman S, et al. Spermatogonial proliferation patterns in men with azoospermia of different etiologies. Fertil Steril. 2003;80:1175-80 pubmed
  • immunohistochemistry - paraffin section; human; 1:4000; fig 4
Chang K, Huang X, Medeiros L, Jones D. Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma. J Pathol. 2003;201:404-12 pubmed
  • immunocytochemistry; human
Hoek M, Stillman B. Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo. Proc Natl Acad Sci U S A. 2003;100:12183-8 pubmed
  • immunohistochemistry - paraffin section; mouse
Ritter C, Martin D, Lu Y, Slatopolsky E, Brown A. Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function. J Bone Miner Res. 2002;17:2206-13 pubmed
  • immunohistochemistry; duck; fig 3
Addison W, Walters K, Wong W, Wilson J, Madej D, Jewell L, et al. Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication. J Virol. 2002;76:6356-63 pubmed
  • immunohistochemistry - paraffin section; rat
Ritter C, Finch J, Slatopolsky E, Brown A. Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor. Kidney Int. 2001;60:1737-44 pubmed
  • immunohistochemistry - paraffin section; human; fig 2
Liu X, Aigner A, Wellstein A, Ray P. Up-regulation of a fibroblast growth factor binding protein in children with renal diseases. Kidney Int. 2001;59:1717-28 pubmed
  • immunohistochemistry - paraffin section; rat
  • western blot; rat
Dusso A, Pavlopoulos T, Naumovich L, Lu Y, Finch J, Brown A, et al. p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growth. Kidney Int. 2001;59:855-65 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Yakirevich E, Maroun L, Cohen O, Izhak O, Rennert G, Resnick M. Apoptosis, proliferation, and Fas (APO-1, CD95)/Fas ligand expression in medullary carcinoma of the breast. J Pathol. 2000;192:166-73 pubmed
  • flow cytometry; human
Naora H, Gougeon M. Interleukin-15 is a potent survival factor in the prevention of spontaneous but not CD95-induced apoptosis in CD4 and CD8 T lymphocytes of HIV-infected individuals. Correlation with its ability to increase BCL-2 expression. Cell Death Differ. 1999;6:1002-11 pubmed
  • immunohistochemistry - paraffin section; pigs ; 1:100
Southgate K, Mehta D, Izzat M, Newby A, Angelini G. Increased secretion of basement membrane-degrading metalloproteinases in pig saphenous vein into carotid artery interposition grafts. Arterioscler Thromb Vasc Biol. 1999;19:1640-9 pubmed
  • western blot; fission yeast; fig 5
Liang D, Hodson J, Forsburg S. Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay. J Cell Sci. 1999;112 ( Pt 4):559-67 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:200
Pozzi A, Wary K, Giancotti F, Gardner H. Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol. 1998;142:587-94 pubmed
Yang M, Luo J, Zhang S, Huang Q, Cao Q. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway. Open Med (Wars). 2023;18:20230687 pubmed publisher
Huang X, Zhang W, Shen X, Ma S, Liu L. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4. Open Med (Wars). 2023;18:20230667 pubmed publisher
Subedi U, Manikandan S, Bhattarai S, Sharma P, Sharma S, Sun H, et al. The Autotaxin-LPA Axis Emerges as a Novel Regulator of Smooth Muscle Cell Phenotypic Modulation during Intimal Hyperplasia. Int J Mol Sci. 2023;24: pubmed publisher
Ren M, Yang Y, Heng K, Ng L, Chong C, Ng Y, et al. MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration. Cell Rep. 2022;41:111852 pubmed publisher
Amer M, Othman A, Abozaid H, El Missiry M. Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties. Biol Res. 2022;55:33 pubmed publisher
Bałaban J, Zielińska M, Wierzbicki M, Ostaszewska T, Fajkowska M, Rzepakowska M, et al. Effect of Muscle Extract and Graphene Oxide on Muscle Structure of Chicken Embryos. Animals (Basel). 2021;11: pubmed publisher
Ćwiek A, Suzuki M, Deronde K, Conaway M, Bennett K, El Dahr S, et al. Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth. Sci Rep. 2021;11:21667 pubmed publisher
Zhang X, Xu H, Bi X, Hou G, Liu A, Zhao Y, et al. Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways. Cell Death Dis. 2021;12:931 pubmed publisher
Li D, Chen L, Zhang X, Wang Y, Huang C, Li J, et al. miR‑125a‑5p reverses epithelial‑mesenchymal transition and restores drug sensitivity by negatively regulating TAFAZZIN signaling in breast cancer. Mol Med Rep. 2021;24: pubmed publisher
Chen J, Zhao C, Chen F, Feng G, Luo F, Jiang T. KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer. J Oncol. 2021;2021:5572402 pubmed publisher
Nagalingam A, Siddharth S, Parida S, Muniraj N, Avtanski D, Kuppusamy P, et al. Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR205 and ErbB. NPJ Breast Cancer. 2021;7:105 pubmed publisher
Deng Q, Wu L, Li Y, Zou L. MYBL2 in synergy with CDC20 promotes the proliferation and inhibits apoptosis of gastric cancer cells. Adv Clin Exp Med. 2021;30:957-966 pubmed publisher
Acharya A, Tang Y, Bertero T, Tai Y, Harvey L, Woodcock C, et al. Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension. J Am Heart Assoc. 2021;10:e019091 pubmed publisher
Pach E, Brinckmann J, Rübsam M, Kümper M, Mauch C, Zigrino P. Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth. Cancers (Basel). 2021;13: pubmed publisher
Willsey H. Whole-Mount RNA In Situ Hybridization and Immunofluorescence of Xenopus Embryos and Tadpoles. Cold Spring Harb Protoc. 2021;2021:pdb.prot105635 pubmed publisher
Zhao X, Dong W, Luo G, Xie J, Liu J, Yu F. Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7. Mol Cell Biol. 2021;41:e0063120 pubmed publisher
Villanueva A, Sanchez Gomez P, Muñoz Palma E, Puvogel S, Casas B, Arriagada C, et al. The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation. Cell Adh Migr. 2021;15:58-73 pubmed publisher
Fysikopoulos A, Seimetz M, Hadžić S, Knoepp F, Wu C, Malkmus K, et al. Amelioration of elastase-induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice. Br J Pharmacol. 2021;178:152-171 pubmed publisher
Olah M, Menon V, Habib N, Taga M, Ma Y, Yung C, et al. Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease. Nat Commun. 2020;11:6129 pubmed publisher
Barske L, Fabian P, Hirschberger C, Jandzik D, Square T, Xu P, et al. Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Proc Natl Acad Sci U S A. 2020;117:24876-24884 pubmed publisher
Kurowska P, Mlyczynska E, Dupont J, Rak A. Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3/1 Kinase Pathways. Int J Mol Sci. 2020;21: pubmed publisher
Ullah M, Liu D, Rai S, Razavi M, Concepcion W, Thakor A. Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury. Stem Cell Res Ther. 2020;11:398 pubmed publisher
Lin D, Alberton P, Delgado Caceres M, Prein C, Clausen Schaumann H, Dong J, et al. Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration. Aging Cell. 2020;19:e13091 pubmed publisher
Sosnowska M, Kutwin M, Jaworski S, Strojny B, Wierzbicki M, Szczepaniak J, et al. Mechano-signalling, induced by fullerene C60 nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells. Int J Nanomedicine. 2019;14:6197-6215 pubmed publisher
Miltner A, Mercado Ayon Y, Cheema S, Zhang P, Zawadzki R, La Torre A. A Novel Reporter Mouse Uncovers Endogenous Brn3b Expression. Int J Mol Sci. 2019;20: pubmed publisher
Prati B, da Silva Abjaude W, Termini L, Morale M, Herbster S, Longatto Filho A, et al. Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo. Sci Rep. 2019;9:351 pubmed publisher
Robson J, Remke M, Kool M, Julian E, Korshunov A, Pfister S, et al. Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells. PLoS ONE. 2019;14:e0210665 pubmed publisher
Bertero T, Oldham W, Grasset E, Bourget I, Boulter E, Pisano S, et al. Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy. Cell Metab. 2019;29:124-140.e10 pubmed publisher
Ha Thi H, Kim H, Lee Y, Kim S, Hong S. SMAD7 in keratinocytes promotes skin carcinogenesis by activating ATM-dependent DNA repair and an EGFR-mediated cell proliferation pathway. Carcinogenesis. 2019;40:112-120 pubmed publisher
Roy S, Hooiveld G, Seehawer M, Caruso S, Heinzmann F, Schneider A, et al. microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology. 2018;155:1951-1966.e26 pubmed publisher
Villanueva A, Puvogel S, Lois P, Muñoz Palma E, Ramírez Orellana M, Lubieniecki F, et al. The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells. Cell Adh Migr. 2019;13:33-40 pubmed publisher
Liu E, Martins J, Zhang W, Demay M. Molecular analysis of enthesopathy in a mouse model of hypophosphatemic rickets. Development. 2018;145: pubmed publisher
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product information
Product Type :
Antibody
Product Name :
PCNA Monoclonal Antibody (PC10)
Catalog # :
13-3900
Quantity :
200 µg
Price :
US 500
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human, Insect, Mouse, Non-human primate, Rat, Yeast
Applications :
Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: 2-5 µg, Western Blot: 0.1-1 µg/mL
Species :
Human, Insect, Mouse, Non-human primate, Rat, Yeast
Clone :
PC10
Isotype :
IgG2a
Storage :
-20°C
Description :
PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.
Immunogen :
Rat recombinant PCNA polypeptides.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: 2-5 µg, Western Blot: 0.1-1 µg/mL
Aliases :
ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; MGC8367; Pcna; pcna protein; Pcna/cyclin; PCNAR; POL30; Proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA