PKC gamma Monoclonal Antibody (PKC66) | Invitrogen 13-3800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PKC gamma Monoclonal Antibody (PKC66)

catalog :

13-3800

quantity :

200 µg

price :

375 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PKC66

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1a	Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, et al. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017;31:685-696.e6 pubmed publisher
immunocytochemistry; mouse	Zhang F, Fang Z, Wang J. Hint1 knockout results in a compromised activation of protein kinase C gamma in the brain. Brain Res. 2015;1622:196-203 pubmed publisher
western blot; human; 1:2000	Schubert M, Panja D, Haugen M, Bramham C, Vedeler C. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol. 2014;128:835-52 pubmed publisher
immunohistochemistry - frozen section; rat; 1:100; fig 1	Nitzan Luques A, Minert A, Devor M, Tal M. Dynamic genotype-selective "phenotypic switching" of CGRP expression contributes to differential neuropathic pain phenotype. Exp Neurol. 2013;250:194-204 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:50; fig 4	Fleming M, Ramos D, Han S, Zhao J, Son Y, Luo W. The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol Pain. 2012;8:52 pubmed publisher
immunohistochemistry; rat; 1:100; fig 1	Nitzan Luques A, Devor M, Tal M. Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain. Pain. 2011;152:2413-26 pubmed publisher
	Antal C, Hudson A, Kang E, Zanca C, Wirth C, Stephenson N, et al. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015;160:489-502 pubmed publisher
	Takanami K, Sakamoto H, Matsuda K, Satoh K, Tanida T, Yamada S, et al. Distribution of gastrin-releasing peptide in the rat trigeminal and spinal somatosensory systems. J Comp Neurol. 2014;522:1858-73 pubmed publisher
	Giaroni C, Zanetti E, Pascale A, Oldrini R, Canciani L, Giuliani D, et al. Involvement of Ca2+-dependent PKCs in the adaptive changes of mu-opioid pathways to sympathetic denervation in the guinea pig colon. Biochem Pharmacol. 2009;78:1233-41 pubmed publisher
	Lim G, Wang S, Zeng Q, Sung B, Yang L, Mao J. Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor. J Neurosci. 2005;25:11145-54 pubmed
	Cejas P, Carlson L, Zhang J, Padmanabhan S, Kolonias D, Lindner I, et al. Protein kinase C betaII plays an essential role in dendritic cell differentiation and autoregulates its own expression. J Biol Chem. 2005;280:28412-23 pubmed
	Trojanowski J, Mantione J, Lee J, Seid D, You T, Inge L, et al. Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain. Exp Neurol. 1993;122:283-94 pubmed
	Li Y, Woodruff Pak D, Trojanowski J. Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites. Neurobiol Aging. 1994;15:1-9 pubmed
	Clark E, Leach K, Trojanowski J, Lee V. Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains. Lab Invest. 1991;64:35-44 pubmed
	Trojanowski J, Newman P, Hill W, Lee V. Human olfactory epithelium in normal aging, Alzheimer's disease, and other neurodegenerative disorders. J Comp Neurol. 1991;310:365-76 pubmed

product information

Product Type :

Antibody

Product Name :

PKC gamma Monoclonal Antibody (PKC66)

Catalog # :

13-3800

Quantity :

200 µg

Price :

375 USD

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: Assay Dependent, Western Blot: 2-5 µg/mL

Species :

Human, Mouse, Rat

Clone :

PKC66

Isotype :

IgG1

Storage :

-20°C

Description :

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

Immunogen :

Purified rat brain PKC.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: Assay Dependent, Western Blot: 2-5 µg/mL

Aliases :

PKC; Pkcc; PKCG; PKCgamma; PKC-gamma; PKCI; Prkc; Prkcc; Prkcg; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; RATPKCI; SCA14

more info or order :

Invitrogen product webpage