PKC beta-2 Monoclonal Antibody (8/1) | Invitrogen 13-3700 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PKC beta-2 Monoclonal Antibody (8/1)

catalog :

13-3700

quantity :

200 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1-Aug

reactivity :

human, rat

application :

western blot, ELISA, immunoprecipitation

citations: 1

Reference
O Malley H, Park Y, Isom L, Gnegy M. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neurosci Lett. 2010;480:40-3 pubmed

product information

Product Type :

Antibody

Product Name :

PKC beta-2 Monoclonal Antibody (8/1)

Catalog # :

13-3700

Quantity :

200 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Rat

Applications :

ELISA: Assay-dependent, Immunoprecipitation: 2-5 ug, Western Blot: 2-5 ug/mL

Species :

Human, Rat

Clone :

1-Aug

Isotype :

IgG1

Storage :

-20 C

Description :

The PKC family of serine/threonine kinases, including PRKCB2 (PKC beta II), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Immunogen :

Purified rat brain PKC.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunoprecipitation: 2-5 ug, Western Blot: 2-5 ug/mL

Aliases :

A130082F03Rik; PKCB; PKC-B; PKC-beta; Prkcb; PRKCB1; Prkcb2; protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide