This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Biotin, eBioscience
catalog :
13-3249-82
quantity :
100 ug
price :
US 354.00
clonality :
monoclonal
host :
rat
conjugate :
biotin
clone name :
DECMA-1

The same clone is also sold as:
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
citations: 51
Reference
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Li L, Hu Y, Chen D, Zhu J, Bao W, Xu X, et al. CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway. Mol Med Rep. 2022;25: pubmed publisher
He Z, Lei S, Liang F, Tan L, Zhang W, Xie L, et al. Low-Dose Albendazole Inhibits Epithelial-Mesenchymal Transition of Melanoma Cells by Enhancing Phosphorylated GSK-3β/Tyr216 Accumulation. J Oncol. 2021;2021:4475192 pubmed publisher
Hsu S, Chou L, Hong C, Chang M, Tsai C, Tian Y, et al. Crosstalk between E-Cadherin/β-Catenin and NF-κB Signaling Pathways: The Regulation of Host-Pathogen Interaction during Leptospirosis. Int J Mol Sci. 2021;22: pubmed publisher
Troitskaya O, Novak D, Nushtaeva A, Savinkova M, Varlamov M, Ermakov M, et al. EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor. Int J Mol Sci. 2021;22: pubmed publisher
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Fujioka N, Kitabatake M, Ouji Sageshima N, Ibaraki T, Kumamoto M, Fujita Y, et al. Human Adipose-Derived Mesenchymal Stem Cells Ameliorate Elastase-Induced Emphysema in Mice by Mesenchymal-Epithelial Transition. Int J Chron Obstruct Pulmon Dis. 2021;16:2783-2793 pubmed publisher
Billings S, Myers N, Quiruz L, Cheng A. Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea. Development. 2021;148: pubmed publisher
Park S, Matte Martone C, Gonzalez D, Lathrop E, May D, Pineda C, et al. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis. Nat Cell Biol. 2021;23:476-484 pubmed publisher
Zeng X, Liao H, Wang F. MicroRNA-384 inhibits nasopharyngeal carcinoma growth and metastasis via binding to Smad5 and suppressing the Wnt/β-catenin axis. Cytotechnology. 2021;73:203-215 pubmed publisher
Kusuyama J, Alves Wagner A, Conlin R, Makarewicz N, Albertson B, Prince N, et al. Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health. Cell Metab. 2021;33:939-956.e8 pubmed publisher
Kim J, Mahiddine F, Kim G. Leptin Modulates the Metastasis of Canine Inflammatory Mammary Adenocarcinoma Cells Through Downregulation of Lysosomal Protective Protein Cathepsin A (CTSA). Int J Mol Sci. 2020;21: pubmed publisher
Leavitt T, Hu M, Borrelli M, Januszyk M, Garcia J, Ransom R, et al. Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis. Cell Rep. 2020;33:108356 pubmed publisher
Gabitova Cornell L, Surumbayeva A, Peri S, Franco Barraza J, Restifo D, Weitz N, et al. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell. 2020;38:567-583.e11 pubmed publisher
Foster D, Marshall C, Gulati G, Chinta M, Nguyen A, Salhotra A, et al. Elucidating the fundamental fibrotic processes driving abdominal adhesion formation. Nat Commun. 2020;11:4061 pubmed publisher
DIXON E, Maxim D, Halperin Kuhns V, Lane Harris A, Outeda P, Ewald A, et al. GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD. J Cell Sci. 2020;133: pubmed publisher
Vila Ellis L, Cain M, Hutchison V, Flodby P, Crandall E, Borok Z, et al. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020;52:617-630.e6 pubmed publisher
Bornes L, van Scheppingen R, Beerling E, Schelfhorst T, Ellenbroek S, Seinstra D, et al. Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT. Cell Rep. 2019;29:2565-2569.e3 pubmed publisher
Malik V, Glaser L, Zimmer D, Velychko S, Weng M, Holzner M, et al. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 2019;10:3477 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Biotin, eBioscience
Catalog # :
13-3249-82
Quantity :
100 ug
Price :
US 354.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Canine, Human, Mouse
Applications :
Flow Cytometry: 0.25 ug/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
Species :
Canine, Human, Mouse
Clone :
DECMA-1
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA